Publication Information

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[145, 156, 390, 401, 1183, 1308, 1673, 2224, 2240, 2879, 2897, 2926, 3010, 3371, 3388, 3624, 3638], 'was': [147, 392, 598, 1590, 1660, 1929, 1942, 1985, 2000, 2131, 2156, 2199, 2208, 2229, 2249, 2279, 2340, 2369, 2381, 2392, 2433, 2588, 2594, 2663, 2704, 2737, 2836, 2865, 2880, 2893, 2910, 2920, 2927, 3012, 3023, 3035, 3078, 3110, 3159, 3240, 3364, 3390, 3400, 3446, 3724], 'similar': [148, 393, 1591, 1651, 1930, 1986, 2001, 2136, 2295, 2341, 3013], 'in': [149, 394, 509, 576, 611, 653, 673, 733, 842, 922, 954, 974, 1058, 1091, 1095, 1151, 1185, 1220, 1254, 1310, 1330, 1415, 1529, 1547, 1592, 1625, 1664, 1674, 1842, 1931, 1946, 1970, 2002, 2008, 2024, 2030, 2140, 2166, 2173, 2203, 2225, 2311, 2319, 2327, 2335, 2342, 2353, 2384, 2425, 2435, 2541, 2585, 2597, 2619, 2645, 2653, 2668, 2687, 2700, 2764, 2828, 3006, 3014, 3025, 3039, 3047, 3086, 3094, 3102, 3112, 3129, 3137, 3149, 3163, 3336, 3377, 3385, 3402, 3450, 3460, 3515, 3598, 3605, 3637, 3654, 3668, 3713, 3720, 3728, 3739, 3771, 3864, 3904, 3948, 3955], 'all': [150, 395, 1593, 2385, 2708, 2719, 2996, 3015, 3465, 3949], 'three': [151, 396], 'groups.': [152, 397, 1532, 1670, 2367, 2606], 'Predictors': [153, 398], 'poor': [155, 400], 'included': [158, 403], 'advanced': [159, 404], 'age,': [160, 405, 3905], 'failure,': [163, 408], 'No': [169, 414, 3383, 3535], 'experienced': [173, 418], 'relapse,': [175, 420], 'whereas': [176, 421, 1641, 2967, 3734], 'approximately': [177, 422, 2031, 2200, 3560], 'half': [178, 423], 'surviving': [180, 425, 3564], 'AAV': [183, 428, 1502, 1610, 1656, 1687, 1933, 2183, 3027, 3103, 3404, 3462, 3485, 3729], 'recurrent': [188, 433, 3546, 3571], 'during': [190, 435, 2077, 3392], 'median': [192, 437, 1799, 1881, 2515, 2561, 2581, 3360], 'follow-up': [193, 216, 438, 461, 3143, 3363, 3478], '4.8': [195, 440, 3365], 'years.': [196, 441, 3861, 3899], 'Thus,': [197, 442], 'have': [200, 445, 883, 899, 997, 1005, 1239, 1465, 1492, 1523, 2111, 3208, 3430, 3752], 'truly': [202, 447], 'hybrid': [203, 448], 'phenotype,': [205, 450], 'requiring': [206, 451, 3271, 3320, 3512, 3909], 'aggressive': [207, 452], 'early': [208, 453, 3507], 'for': [210, 219, 222, 455, 464, 467, 1480, 1500, 1568, 1717, 1731, 1741, 1756, 1828, 1836, 1967, 2101, 2148, 2192, 2232, 2251, 2397, 2410, 2463, 2472, 2535, 2612, 2706, 2716, 2798, 2846, 2913, 2995, 3289, 3293, 3315, 3790, 3952, 3980], 'careful': [214, 459], 'consideration': [218, 463], 'maintenance': [220, 465, 3701], 'immunosuppression': [221, 466], 'AAV.': [223, 468, 2872, 3613], 'Since': [224, 469], 'double-positivity': [225, 470], 'appears': [226, 471], 'common,': [227, 472], 'work': [229, 474], 'required': [231, 476, 2859, 3045], 'define': [233, 241, 478, 486], 'underlying': [235, 480], 'mechanisms': [236, 481, 873], 'association': [239, 484, 876], 'optimum': [242, 487], 'strategies.': [244, 489], 'Anti-glomerular': [490, 522], 'basement': [491, 523, 631, 728, 772, 834, 956, 1053, 1088, 1126, 1160, 1212, 1386, 1407, 1779, 1860, 2507, 2552, 3303, 3347, 3842, 3880], 'membrane': [492, 524, 632, 729, 773, 835, 957, 1054, 1089, 1161, 1213, 1387, 1408], '(GBM)': [493], 'anti-neutrophil': [497, 626, 948, 1766, 1847, 3297, 3341, 3831, 3869], 'cytoplasm': [498, 652, 830, 921, 1767, 1848, 3298, 3342, 3832, 3870], 'antibody': [499, 555, 769, 815, 1157, 1383, 2198], '(ANCA)-associated': [500, 556], 'vasculitides': [501], '(AAV)': [502], 'are': [503, 821, 877, 891, 1002, 1623], 'rare': [504], 'conditions,': [505], 'estimated': [507, 1773, 1854, 2501, 2546], 'incidences': [508], 'Europe': [510], '1': [512, 1672, 1910, 2714, 2878, 2896, 2925, 3076, 3267, 3283, 3332, 3622], '20': [514, 1250], 'per': [515, 518], 'million': [516], 'population': [517], 'year,': [519], 'respectively.1Pusey': [520], 'C.D.': [521, 616], 'disease.Kidney': [525], 'Int.': [526, 657, 703, 926, 1028], '2003;': [527, 987], '64:': [528], '1535-1550Abstract': [529], 'Full': [530, 532, 661, 707, 709, 742, 744, 854, 930, 1032, 1034, 1067, 1069], 'Text': [531, 533, 662, 708, 710, 743, 745, 855, 931, 1033, 1035, 1068, 1070], 'PDF': [534, 663, 711, 746, 856, 932, 1036, 1071], 'PubMed': [535, 563, 664, 712, 747, 780, 804, 857, 933, 990, 1037, 1072, 1133, 1167, 1199, 1231, 1292, 1324, 1394, 1426], 'Scopus': [536, 564, 665, 713, 748, 781, 805, 858, 934, 991, 1038, 1073, 1134, 1168, 1200, 1232, 1293, 1325, 1395, 1427], '(173)': [537], 'Google': [538, 566, 638, 667, 715, 750, 783, 807, 860, 936, 963, 993, 1040, 1075, 1104, 1136, 1170, 1202, 1234, 1295, 1327, 1397, 1429], 'Scholar,': [539, 639, 716, 751, 784, 937, 964, 1041, 1076, 1105, 1137, 1171, 1203, 1296, 1398], '2Watts': [540], 'R.A.': [541], 'Mahr': [542], 'A.': [543, 689, 718, 1014, 1043, 1109, 1139], 'Mohammad': [544], 'A.J.': [545], 'et': [546, 619, 646, 690, 724, 758, 791, 915, 944, 1015, 1049, 1083, 1112, 1144, 1178, 1210, 1279, 1303, 1372, 1405], 'al.Classification,': [547], 'epidemiology': [548], 'subgrouping': [551], 'antineutrophil': [553, 767, 1119, 1155, 1381], 'cytoplasmic': [554, 627, 768, 949, 1120, 1156, 1382], 'vasculitis.Nephrol': [557], 'Dial': [558, 1194, 1319], 'Transplant.': [559, 1195, 1320], '2015;': [560, 1196, 1321], '30:': [561, 1197, 1322], 'i14-i22Crossref': [562], '(165)': [565], 'Scholar': [567, 668, 808, 861, 994, 1235, 1328, 1430], 'The': [568, 971, 1431, 1582, 1617, 1628, 1920, 1995, 2330, 2580, 3057, 3359], 'concurrence': [569], 'individual': [577, 1815, 1897], 'patients,': [578, 1463, 2853, 3950], 'however,': [579, 1238, 1598, 2372, 2609], 'well-recognized,': [581], 'occurs': [583], 'much': [586], 'higher': [587], 'than': [589, 1249, 1340, 1945, 2118, 3434, 3532, 3659, 3704], 'would': [590], 'expected': [592], 'by': [593, 1243, 1805, 1821, 1887, 1903, 1976, 2089, 2521, 2528, 2567, 2574, 2729, 3311, 3356], 'chance': [594], 'alone.': [595], 'This': [596], 'phenomenon': [597, 865], 'first': [599, 607, 3139, 3517, 3584], 'reported': [600, 884], 'within': [601, 3125], 'few': [603], 'years': [604, 1689, 3366], 'description': [608], '1980s,3O’Donoghue': [613], 'D.J.': [614], 'Short': [615], 'Brenchley': [617], 'P.E.': [618, 1143], 'al.Sequential': [620], 'development': [621], 'systemic': [623], 'complicating': [629], 'anti-glomerular': [630, 727, 833, 955, 1052, 1159], 'disease.Clin': [633, 958], 'Nephrol.': [634, 959, 1100], '1989;': [635], '32:': [636, 1165], '251-255PubMed': [637], '4Jayne': [640], 'D.R.': [641, 910], 'Marshall': [642, 911], 'P.D.': [643, 912], 'Jones': [644, 913], 'S.J.': [645, 914], 'al.Autoantibodies': [647, 916], 'GBM': [649, 918], 'neutrophil': [651, 920], 'rapidly': [654, 845, 923], 'progressive': [655, 846, 924], 'glomerulonephritis.Kidney': [656, 925], '1990;': [658, 927], '37:': [659, 928], '965-970Abstract': [660, 929], '(234)': [666, 935], 'has': [670, 3768], 'been': [671, 1241, 3769], 'observed': [672, 900, 2618, 2644, 3391], 'several': [674], 'series': [675, 1333], 'around': [677], 'world': [679], 'over': [680, 2272], 'subsequent': [682], '30': [683], 'years.5Levy': [684], 'J.B.': [685, 1010], 'Hammad': [686, 1011], 'T.': [687, 968, 1012], 'Coulthart': [688, 1013], 'al.Clinical': [691, 1016, 1113], 'outcome': [694, 761, 1019, 1114, 1147, 1375], 'antibodies.Kidney': [702, 1027], '2004;': [704, 1029], '66:': [705, 1030], '1535-1540Abstract': [706, 1031], '(251)': [714, 1039], '6Rutgers': [717, 1042], 'Slot': [719, 1044], 'M.': [720, 966, 1045, 1175, 1177, 1300, 1302], 'van': [721, 1046], 'Paassen': [722, 1047], 'P.': [723, 1048], 'al.Coexistence': [725, 1050], 'myeloperoxidase-ANCAs': [732, 1057], 'crescentic': [734, 1059, 1149, 2601], 'glomerulonephritis.Am': [735, 847, 1060], 'J': [736, 848, 1061], 'Kidney': [737, 849, 1062], 'Dis.': [738, 850, 1063], '2005;': [739, 1064], '46:': [740, 1065], '253-262Abstract': [741, 1066], '(155)': [749, 1074], '7Zhao': [752], 'J.': [753, 943, 970, 1107, 1207, 1367, 1402], 'Yang': [754, 1368], 'R.': [755, 1369], 'Cui': [756, 1370], 'Z.': [757, 1205, 1371, 1400], 'al.Characteristics': [759, 1145, 1373], 'Chinese': [763, 1224, 1337, 1377, 1419], 'antiglomerular': [771, 1087, 1385], 'antibodies.Nephron': [774, 984, 1388], 'Clin': [775, 985, 1389], 'Pract.': [776, 986, 1390], '2007;': [777, 1391], '107:': [778, 1392], 'c56-c62Crossref': [779, 1393], '(27)': [782, 1396], '8J': [785], 'DEZ': [786, 1274], 'Taylor': [787, 1275], 'D.': [788, 1111, 1276], 'Thein': [789, 1277], 'H.': [790, 1278], 'al.Incidence': [792, 1280], 'dual': [796, 1284], 'anti-GBM-positive': [797, 1285], 'ANCA-positive': [799, 1287, 3666], 'patients.Nephrology.': [800, 1288], '2011;': [801, 1228, 1289, 1423], '16:': [802, 1290], '725-729Crossref': [803, 1291], '(28)': [806, 1294], 'It': [809, 2368], 'clear': [811], 'that': [812, 863, 999, 1988, 2358, 3727], '2': [814, 1531, 1688, 2313, 2605, 2679, 2814, 3107], 'populations': [816], 'associated': [817, 3618, 3650], 'these': [819, 888, 1462, 1481, 1530, 2142, 2153, 2312, 2678, 3953], 'diseases': [820], 'antigenically': [822], 'distinct,9Short': [823], 'A.K.': [824], 'Esnault': [825], 'V.L.': [826], 'Lockwood': [827], 'C.M.': [828], 'Anti-neutrophil': [829], 'antibodies:': [836], 'two': [837], 'coexisting': [838], 'distinct': [839], 'autoreactivities': [840], 'detectable': [841, 2739], '1995;': [851], '26:': [852], '439-445Abstract': [853], '(94)': [859], 'not': [867, 878, 1974, 2132, 2280, 2370, 2382, 2794, 2808, 2922, 3241, 3447, 3699], 'due': [868, 2393, 3111], 'cross-reactivity,': [870], 'although': [871, 894, 2126, 3033, 3200, 3443], 'fully': [879], 'understood.': [880], 'Several': [881], 'who': [890, 1001, 1564, 1600, 1643, 1972, 1991, 2036, 2105, 2122, 2189, 2337, 2430, 2621, 2655, 2943, 3044, 3061, 3068, 3096, 3151, 3188, 3192, 3196, 3202, 3227, 3230, 3275, 3324, 3424, 3436, 3492, 3566, 3639, 3748], 'double': [892, 1003, 1566, 1602, 1645, 1993, 2038, 2107, 2623, 2657, 2945, 3098, 3417, 3426, 3471, 3494, 3568, 3750, 3931], 'positive,': [893, 2125, 3642], 'conflicting': [896], 'findings;': [897], 'some': [898, 2389], 'better': [901, 3431], 'those': [905, 1499, 1515, 2336, 2698, 2868, 3185, 3195, 3201, 3435], 'disease,4Jayne': [909], '10Bosch': [938], 'X.': [939], 'Mirapeix': [940], 'E.': [941], 'Font': [942], 'al.Prognostic': [945], 'implication': [946], 'autoantibodies': [950], 'myeloperoxidase': [952], 'specificity': [953], '1991;': [960], '36:': [961], '107-113PubMed': [962], '11Segelmark': [965], 'Hellmark': [967], 'Wieslander': [969], 'prognostic': [972], 'significance': [973], "Goodpasture's": [975], 'specificity,': [978], 'titre': [979], 'affinity': [981], 'anti-glomerular-basement-membrane': [983], '94:': [988], 'c59-c68Crossref': [989], '(105)': [992], 'while': [995], 'others': [996, 2404], 'suggested': [998], 'positive': [1004, 1567, 1603, 1646, 2039, 2108, 2191, 2231, 2250, 2624, 2946, 3099, 3427, 3439, 3495, 3569, 3751], 'comparable': [1006, 1477, 2365, 3725], 'or': [1007, 1820, 1902, 1979, 2527, 2573, 2858, 2953, 3173, 3545, 3661, 3765, 3970], 'worse': [1008], 'outcomes.5Levy': [1009], '12Weber': [1077], 'M.F.': [1078], 'Andrassy': [1079], 'K.': [1080], 'Pullig': [1081], 'O.': [1082], 'al.Antineutrophil-cytoplasmic': [1084], 'Goodpasture’s': [1092], 'syndrome': [1093], "Wegener's": [1096], 'granulomatosis.J': [1097], 'Am': [1098], 'Soc': [1099], '1992;': [1101], '2:': [1102], '1227-1234PubMed': [1103], '13Lindic': [1106], 'Vizjak': [1108], 'Ferluga': [1110], 'coexistent': [1118], 'against': [1124, 3603], 'glomerular': [1125, 1774, 1778, 1855, 1859, 2502, 2506, 2547, 2551, 3302, 3346, 3841, 3879], 'membrane.Ther': [1127], 'Apher': [1128], 'Dial.': [1129], '2009;': [1130], '13:': [1131], '278-281Crossref': [1132], '(37)': [1135], '14Srivastava': [1138], 'Rao': [1140], 'G.K.': [1141], 'Segal': [1142], 'glomerulonephritis': [1150], 'antibody.Clin': [1162], 'Rheumatol.': [1163], '2013;': [1164], '1317-1322Crossref': [1166], '(33)': [1169], '15Alchi': [1172, 1297], 'B.': [1173, 1298], 'Griffiths': [1174, 1299], 'Sivalingam': [1176, 1301], 'al.Predictors': [1179, 1304], 'disease:': [1187, 1214, 1312, 1409], 'clinicopathologic': [1188, 1313], 'analysis': [1189, 1314, 2304, 2731, 3452, 3937], 'two-centre': [1192, 1317], 'cohort.Nephrol': [1193, 1318], '814-821Crossref': [1198, 1323], '(69)': [1201, 1326], '16Cui': [1204, 1399], 'Zhao': [1206, 1401], 'Jia': [1208, 1403], 'X.Y.': [1209, 1404], 'al.Anti-glomerular': [1211, 1406], 'different': [1217, 1362, 1412, 2083, 3080], 'therapeutic': [1218, 1363, 1413, 2309], 'regimens': [1219, 1364, 1414], 'single-center': [1223, 1418], 'study.Medicine': [1226, 1421], '(Baltimore).': [1227, 1422], '90:': [1229, 1424], '303-311Crossref': [1230, 1425], '(88)': [1233, 1428], 'These': [1236, 2839, 3575], 'studies,': [1237], 'generally': [1240], 'limited': [1242], 'size': [1245], '(many': [1246], 'describing': [1247], 'fewer': [1248, 1339], 'cases)': [1251], 'variations': [1253], 'severity': [1256, 1961, 2297, 2331, 2349], 'presentation,': [1260, 1521, 2299], 'between': [1262, 1667, 1803, 1814, 1885, 1896, 2129, 2366, 2418, 2519, 2565, 2603, 2677, 2741, 3081, 3184, 3309, 3354, 3923], '0%': [1263], '100%': [1265, 2763, 2821], 'dependent': [1269, 2817, 2882], 'dialysis': [1271, 2816, 2881, 3046, 3117], 'diagnosis.8J': [1273], 'Furthermore,': [1329], 'largest': [1332], 'date,': [1335, 3757], 'centers,': [1338, 1474], '25%': [1341], 'were': [1344, 1542, 1565, 1601, 1644, 1973, 1992, 2021, 2037, 2075, 2087, 2106, 2123, 2146, 2190, 2266, 2405, 2622, 2656, 2815, 2944, 2947, 3073, 3097, 3152, 3189, 3228, 3276, 3325, 3425, 3437, 3458, 3493, 3567, 3597, 3640, 3649, 3698, 3736, 3749, 3901], 'treated': [1345, 1359], 'plasma': [1347, 1484, 2401, 2781, 2796, 2810, 2834, 2908, 2935, 3176], 'exchange,': [1348, 1485, 2402], 'so': [1350, 2891, 2907, 3238], 'applicability': [1352], 'findings': [1355, 1917, 2360], 'substantially': [1361], 'limited.7Zhao': [1366], 'aim': [1432], 'present': [1435], 'describe': [1439], 'disease.': [1457, 1506, 2180, 3677], 'Given': [1458], 'rarity': [1460], 'identified': [1466, 1543], '4': [1469, 1545, 3679, 3802], 'Northern': [1471], 'nephrology': [1473], 'which': [1475, 2701, 3130, 3523], 'employ': [1476], 'protocols': [1479], 'cases,': [1482, 2154, 2390, 2768], 'including': [1483, 1550, 2044, 2260], 'cyclophosphamide,': [1486], 'steroids,': [1488], 'unless': [1489], 'contraindicated.': [1490], 'We': [1491, 3933], 'Because': [1507, 2069, 2255, 2288], 'closely': [1513], 'resemble': [1514], 'also': [1524], 'histopathology': [1526], 'Between': [1533], '2000': [1534], '2013,': [1536], 'total': [1538], '646': [1540], 'centers': [1546], '3': [1548, 1594, 1669, 2194, 2710, 2997, 3000, 3140, 3256], 'countries,': [1549], 'AAV,': [1555, 1574, 1846, 2027, 3340, 3927], '(hereafter': [1573], 'anti-GBM,': [1575, 1757, 2717], 'groups,': [1578, 2006, 2421, 2680, 3082], 'respectively)': [1579], '(Table': [1580, 3958], '1).': [1581, 1658], 'ratio': [1583, 1666], 'countries': [1595], '(47%': [1596], 'overall);': [1597], 'represented': [1604], 'proportion': [1607, 2137, 2186, 2599, 3041, 3058, 3133, 3556, 3906, 3915], '(3%': [1612], '10.5%;': [1614], '6.1%': [1615], 'overall).': [1616], 'demographic': [1618], 'summarized': [1624, 3005, 3376], 'Table': [1626, 1909, 2328, 3007, 3678], '1.': [1627], 'group': [1631, 1677, 2228, 2438, 3028, 3052, 3405, 3411, 3742, 3979], 'demonstrated': [1632], 'typical': [1634, 2866], 'bimodal': [1635], 'an': [1648], 'isolated': [1655, 1683, 2871, 3612], '(Figure': [1657, 3573], 'There': [1659, 2593, 2607, 2662, 2736, 3158, 3900], 'no': [1661, 2595, 2738, 2884, 3036, 3160, 3737, 3758], 'significant': [1662, 2666, 3037, 3161, 3449, 3555, 3902], 'difference': [1663, 2128, 2417, 2596, 2667, 2740, 3038, 3162, 3384, 3445], 'gender': [1665], 'Notably,': [1671, 2238, 3693], 'previous': [1680], 'diagnosis': [1681, 1928, 3674], 'anti-myeloperoxidase': [1684], '(MPO)': [1685], 'prior': [1690, 1924, 3672], 'presenting': [1692, 2869], 'disease.Table': [1695], '1Case': [1696], 'identification,': [1697], 'demographics,': [1698], 'features,': [1700], 'serologyAAVAnti-GBMDouble': [1702], 'positiveP': [1703, 2445], 'valueAAVversusDPversusGBMAAVversusDPGBMversusDPAAVversusGBMCases,': [1704], 'n5684137––––•United': [1705], 'Kingdom1711920•Sweden100138•Czech': [1706], 'Republic29799Cases,': [1707], '%87.9%6.3%5.7%DemographicsAge,': [1708], 'yr': [1709, 2455], '(range)62.3': [1710], '(11–95)58.3': [1711], '(13–91)63.6': [1712], '(17–88)0.170.990.310.21Gender•Male54%46%38%0.110.060.490.34•Female46%54%62%Clinical': [1713], 'FeaturesDuration': [1714], 'symptoms,aCalculated': [1716], 'sample': [1719, 1830], '48': [1721, 1832], 'cases.': [1723, 2034, 3104], 'wk': [1724], '(range)12': [1725], '(0–56)2': [1726], '(0–20)10': [1727], '(1–26)<0.010.99<0.01<0.01Lunghemorrhage131/56823%16/4140%14/3738%0.010.040.850.02Required': [1728], 'RRT': [1729, 3272, 3321], 'atpresentation132/56823%26/4163%21/3757%<0.01<0.010.55<0.01eGFR,bCensored': [1730], 'RRT.': [1734, 1744, 1839, 2466, 2475, 2538], 'ml/min': [1735, 2467], '(range)29': [1736], '(5–90)20': [1737], '(5–90)19': [1738], '(6–76)0.060.110.990.67Serum': [1739], 'creatinine,bCensored': [1740], 'μmol/l': [1745, 2476], '(range)186': [1746], '(39–693)275': [1747], '(62–667)309': [1748], '(71–606)0.060.180.990.37SerologyAnti-GBM': [1749], 'level,': [1750], 'xULN': [1751], '(range)–5.4': [1752], '(1–29.1)14.2': [1753], '(1–50.4)–0.06–Proportion': [1754], 'seronegative': [1755, 2147], '%–4/4111%4/3711%–1.00–ANCA': [1758], 'serology,': [1759], '%<0.01––•Anti-MPO48%70%•Anti-PR351%27%•Anti-MPO': [1760], '&': [1761], 'PR3<1%': [1762], '(n': [1763, 3557], '=': [1764, 2630, 2660, 2771, 2778, 2787, 3156, 3171, 3182, 3220, 3396, 3454, 3558, 3732], '2)3%AAV,': [1765], 'antibody–associated': [1768, 1849, 3299, 3343], 'vasculitis;': [1769, 1850, 3300, 3344], 'DP,': [1770, 1851], 'double-positive;': [1771, 1852], 'eGFR,': [1772, 1853, 2545], 'filtration': [1775, 1856, 2503, 2548], 'rate;': [1776, 1857, 2504, 2549], 'GBM,': [1777, 1858, 2505, 2550, 3301, 3345, 3840, 3878], 'membrane;': [1780, 1861, 2508, 2553, 3304, 3348, 3843, 3881], 'MPO,': [1781, 1862, 3848, 3886], 'myeloperoxidase;': [1782, 1863, 3849, 3887], 'PR3,': [1783, 1864, 3604, 3855, 3893], 'proteinase': [1784, 1865, 3856, 3894], '3;': [1785, 1866, 3857, 3895], 'RRT,': [1786, 1867, 2509, 2554, 3305, 3349], 'replacement': [1788, 1869, 2511, 2556, 3307, 3351, 3911], 'therapy;': [1789, 1870], 'xULN,': [1790, 1871, 3217], 'multiples': [1791, 1872, 2093], 'upper': [1793, 1874, 2096], 'limit': [1794, 1875, 2097], 'normal.Results': [1796], 'expressed': [1797, 1879, 2513, 2559], '±': [1800, 1882, 2516, 2562], 'range.': [1801, 1883, 2517, 2563], 'Comparison': [1802, 1884, 2518, 2564, 3353], 'groups': [1804, 1816, 1886, 1898, 1936, 2130, 2143, 2206, 2293, 2321, 2344, 2520, 2566, 2746, 3016, 3310, 3355, 3419], 'Kruskall–Wallis': [1806, 1888], 'test': [1807, 1823, 1889, 1905, 2523, 2530, 2569, 2576], 'Dunn’s': [1809, 1891], 'post-test': [1810, 1892], 'ascertain': [1812, 1894], 'differences': [1813, 1895, 2310, 3903, 3954], '(for': [1817, 1824, 1899, 1906, 2524, 2531, 2570, 2577], 'continuous': [1818, 1900, 2525, 2571], 'data),': [1819, 1901, 2526, 2572], 'chi-square': [1822, 1904, 2529, 2575, 3312, 3357], 'categorical': [1825, 1907, 2532, 2578], 'data).a': [1826, 2533], 'Calculated': [1827], 'cases.b': [1834], 'Censored': [1835, 2534, 3314], 'Open': [1840, 2539, 3334, 3862], 'table': [1841, 2540, 3335, 3863], 'new': [1844, 2543, 3338, 3866], 'tab': [1845, 2544, 3339, 3867], 'normal.': [1877], 'Results': [1878, 2558], 'data).': [1908, 2579], 'summarizes': [1911, 3680], 'key': [1912], 'serological': [1916], 'symptoms': [1923, 2056, 2067], 'receiving': [1926, 2755, 2948, 3700], '(median:': [1937, 2625, 2690], '10–12': [1938], 'weeks),': [1939], 'significantly': [1943, 3079], '(2': [1950, 2712], 'weeks;': [1951], 'P': [1952, 2220, 2629, 2659, 2694, 2770, 2777, 2786, 3155, 3170, 3181, 3219], '<': [1953, 2221, 2695, 2980, 3413, 3421, 3744], '0.01).': [1954, 2222, 3422, 3745], 'shorter': [1956], 'symptoms,': [1959], 'disease—whether': [1963], 'defined': [1964], 'need': [1966, 2396], 'hemodialysis': [1968], 'or,': [1969], 'dialysis-dependent,': [1975], 'GFR': [1977], 'estimations': [1978], 'serum': [1980], 'creatinine': [1981], 'measurements—in': [1982], 'positive.': [1994], 'alveolar': [1998, 2856], 'occurring': [2007, 2029], 'about': [2009], 'one-third': [2010], 'Severe': [2013], 'manifestations': [2015], '(dialysis': [2016], 'requirement': [2017], 'hemorrhage)': [2020], 'less': [2022], 'common': [2023], 'each': [2028, 2102, 2586, 3685], 'one-quarter': [2032], 'Patients': [2035, 2104, 3423], 'additional': [2041], 'extrarenal': [2042], 'manifestations,': [2043], 'nonhemorrhage': [2045], 'lower': [2046, 2112, 2434, 3209, 3845, 3883], 'respiratory': [2047, 3846, 3884], 'tract': [2048], '(in': [2050], '26%),': [2051], 'otorhinolaryngological': [2052], 'involvement': [2053], '(18%),': [2054, 2057], 'musculoskeletal': [2055], 'cutaneous': [2058], '(13%),': [2060], 'neurological': [2061], '(8%),': [2062], 'gastrointestinal': [2063], '(5%),': [2064], 'ocular': [2066], '(3%).': [2068], 'variety': [2071, 2257], 'assays': [2074], 'used': [2076, 2267], 'period': [2080, 2274], 'hospital': [2084], 'sites,': [2085], 'results': [2086], 'standardized': [2088], 'expressing': [2090], 'them': [2091], 'normal': [2099, 2885], '(xULN)': [2100], 'assay.': [2103], 'tended': [2109, 2639, 3206, 3428, 3577], 'levels': [2113, 3210], 'circulating': [2115, 2149, 2721], 'did': [2119, 2793, 2807, 3197], 'single': [2124, 3153, 3438], 'statistically': [2133, 3448], 'significant.': [2134], 'A': [2135], '(approximately': [2144], '10%)': [2145], 'antibodies.': [2151, 2237, 3633], 'In': [2152, 2181, 2388, 2412, 2697, 2789, 2801, 2873], 'there': [2155, 2207, 3034, 3735], 'convincing': [2157], 'linear': [2160, 2725], 'IgG': [2161, 2728], 'deposition': [2162, 2726], 'biopsy,': [2165, 2324, 2447, 2454, 2826, 2889, 3236], 'absence': [2168, 2830], 'another': [2170], 'attributable': [2171], 'cause,': [2172], 'keeping': [2174, 2413, 3606], 'our': [2176], 'definition': [2177], 'group,': [2184, 2804, 2877, 3128], 'anti-proteinase': [2193], '(PR3)': [2195], 'versus': [2196], 'anti-MPO': [2197, 2215], 'equal.': [2201], 'comparative': [2210], 'over-representation': [2211], '(70%': [2217], 'vs.': [2218, 2627, 2651, 2692, 2762, 2775, 2784, 3146, 3167, 3179, 3215], '48%,': [2219], 'One': [2223], 'triple': [2230], 'anti-MPO,': [2233], 'anti-PR3,': [2234], 'history': [2243, 3610], 'recreational': [2245], 'drug': [2246], 'use': [2247], 'hepatitis': [2252], 'C': [2253], 'virus.': [2254], 'methodologies,': [2259], 'indirect': [2261], 'immunofluorescence': [2262, 2730], 'antigen-specific': [2264], 'assays,': [2265], 'confirm': [2269], 'positivity': [2271, 3472], 'study,': [2277], 'it': [2278, 3239], 'possible': [2281, 3242], 'standardize': [2283], 'comparisons': [2284], 'titer.': [2287], 'performed': [2301, 3935], 'detailed': [2303], 'compare': [2306], 'histopathological': [2307, 3246], 'cohorts.': [2314], 'Approximately': [2315], 'two-thirds': [2316], 'underwent': [2322, 2338, 2431, 3234], 'described': [2326, 3770], '2.': [2329], 'equivalent': [2346], 'parent': [2355, 2420], 'cohort,': [2356], 'suggesting': [2357], 'may': [2361], 'representative': [2363], 'possible,': [2371], 'identify': [2375, 3245, 3939], 'reasons': [2377], 'why': [2378], 'undertaken': [2383], 'remaining': [2386], 'immediate': [2398], 'considered': [2406], 'too': [2407], 'clinically': [2408, 2928], 'unstable': [2409, 2929], 'biopsy.': [2411, 2735], 'mean': [2423], 'subset': [2427], 'group.Table': [2443], '2HistopathologyAnti-GBMDouble': [2444], 'valueUnderwent': [2446], 'n': [2448], '(%)29': [2449], '(71%)25': [2450], '(68%)0.81Mean': [2451], '(range)46': [2456], '(13–91)62': [2457], '(46–76)<0.01Renal': [2458], 'status': [2459], 'biopsy•Required': [2461], 'RRT52%54%1.00•eGFR,aCensored': [2462], '(range)21': [2468], '(5–90)16': [2469], '(8–73)0.78•Serum': [2470], 'creatinineaCensored': [2471], '(range)275': [2477], '(62–677)315': [2478], '(71–606)0.75Glomerular': [2479], 'findings•Crescentic': [2480], 'glomeruli,': [2481, 2485, 2489], '%64%': [2482], '(0–100)64%': [2483], '(25–100)0.98•Sclerotic': [2484], '%0%': [2486], '(0–80)15%': [2487], '(0–100)0.19•Normal': [2488], '%5%': [2490], '(0–100)0%': [2491], '(0–67)0.56Tubular': [2492], 'atrophy,': [2493], '%': [2494], '(range)5%': [2495], '(0%–30%)27%': [2496], '(0%–80%)<0.01Immunofluorescence': [2497], 'pattern0.69•Linear': [2498], 'IgG79%80%•Pauci-immune3%8%•Technically': [2499], 'inadequate17%12%eGFR,': [2500], 'therapy.Results': [2512], 'Mann-Whitney': [2522, 2568], 'therapy.': [2557, 3352], 'number': [2582], 'glomeruli': [2584, 2602, 2615, 2886], '15': [2589], '(interquartile': [2590], 'range:': [2591, 3588], '10–20).': [2592], 'was,': [2608], 'sclerotic': [2614], '15%': [2626], '0%;': [2628], '0.188).': [2631], 'Likewise,': [2632], 'finding': [2634], '“synchronous”': [2636], 'crescent': [2637, 2822], 'formation': [2638, 2823], 'commonly': [2643], '(73%': [2650], '33%': [2652], 'positive;': [2658, 3154], '0.092).': [2661], 'highly': [2665], 'degree': [2670], 'interstitial': [2672], 'fibrosis': [2673], 'tubular': [2675], 'atrophy': [2676], 'damage': [2686], '27%': [2691], '5%,': [2693], '0.001).': [2696], 'adequate': [2702], 'tissue': [2703], 'available': [2705, 3459], 'analysis,': [2707], 'but': [2709], 'double-positive,': [2713], 'antibodies)': [2723], 'kidney': [2734, 2825, 2888], 'regard': [2748], 'initial': [2750, 2863, 3521, 3528], 'administered,': [2752], 'majority': [2754, 3593, 3645, 3695], 'standard': [2756], 'care': [2758], 'steroids': [2760, 2845], '(97%': [2761], 'respectively;': [2769, 3218], '0.47),': [2772], 'cyclophosphamide': [2773], '(100%': [2774, 3178], '92%;': [2776], '0.24),': [2779], 'exchange': [2782, 2797, 2835, 2909, 3177], '(80%': [2783], '89%;': [2785], '0.33).': [2788], 'total,': [2790], '10': [2791, 3216, 3818], 'undergo': [2795, 2934], 'various': [2799], 'reasons.': [2800], '7': [2805], 'receive': [2809], 'exchange.': [2811, 2936], 'Of': [2812, 2849], 'these,': [2813], 'presentation': [2819, 3274, 3323, 3922], 'hemorrhage,': [2833], 'deemed': [2837, 2894], 'futile.': [2838], 'received': [2841, 2976, 2985, 2989], 'cytotoxic': [2842], 'therapy': [2843, 2978, 3912], 'nonrenal': [2847], 'manifestations.': [2848], 'other': [2851, 3703], '5': [2852, 3823], 'none': [2854], 'dialysis,': [2860], 'their': [2862], 'futile;': [2895], 'well-preserved': [2899], 'function': [2901, 3071, 3136, 3205, 3233, 3281, 3330], '(serum': [2902], 'creatinine:': [2903], '78': [2904], 'μmol/l)': [2905], 'initially': [2911], 'reserved': [2912], 'nonresponse': [2914], 'immunosuppressive': [2916, 2950, 3691], 'alone,': [2918], 'ultimately': [2921], 'required;': [2923], 'therefore': [2931, 3934], 'unable': [2932], 'At': [2937], '6': [2938, 3518, 3549, 3670], 'months,': [2939], '74%': [2940], 'ongoing': [2949, 2977], 'without': [2954], 'corticosteroids': [2955, 3705], '(71%': [2956], 'azathioprine,': [2958], '21%': [2959], 'mycophenolate': [2961, 3851, 3889], 'mofetil,': [2962], '8%': [2964], 'methotrexate),': [2966], 'only': [2968], '14%': [2969], '(P': [2979, 3395, 3412, 3420, 3453, 3731, 3743], '0.001),': [2981], 'whom': [2983], '80%': [2984], 'azathioprine': [2986], '20%': [2988], 'MMF.': [2990], 'Patient': [2991], 'cohorts': [2998], '12': [3002, 3258, 3827], 'months': [3003, 3141, 3259, 3519, 3671], '3.': [3008], 'Overall': [3009], 'time': [3019, 3031, 3055, 3582, 3708, 3787], 'points.': [3020], 'Renal': [3021, 3398], 'favorable': [3024, 3401], 'points,': [3032], 'either': [3054, 3763], 'point.': [3056], 'presented': [3062], 'failure': [3066], 'recovered': [3069, 3134, 3193, 3203, 3231], 'alive': [3074, 3277, 3326], 'year': [3077], 'varying': [3083], '17%': [3085], '29%': [3093], '49%': [3101], 'As': [3105, 3711], 'Figure': [3106, 3378, 3714, 3960], 'demonstrates,': [3108], 'part': [3113], 'cross-over': [3115], 'dependence': [3118], 'independence,': [3120], 'vice': [3122], 'versa,': [3123], 'particularly': [3124], 'substantial': [3132], '(35%': [3144], 'recovery': [3145, 3148, 3265], '10%': [3147], '0.11).': [3157], '(mean:': [3165], '65': [3166], '64': [3168], 'years;': [3169, 3587], '0.88)': [3172], 'receipt': [3174], '82%;': [3180], '0.52)': [3183], 'not,': [3198], 'respectively,': [3199], '(3.8': [3214], '0.07).': [3221], 'Only': [3222], 'one-half': [3223], 'reliably': [3244], 'predictors': [3247, 3940], 'response.Table': [3250], '3Patient': [3251], 'diagnosisDiagnosis0': [3261], 'Months3': [3262], 'months12': [3263], 'monthsRenal': [3264], 'yearbProportion': [3268], 'independent': [3279, 3328], 'year.Independent': [3284], 'RRTPatient': [3286], 'survivalRenal': [3287, 3291], 'survivalaCensored': [3288, 3292], 'death.Patient': [3290], 'death.AAV437/56877%540/56895%490/54091%512/56890%452/51288%64/13149%Anti-GBM15/4137%37/4190%15/3642%36/4187%15/3444%4/2417%Double': [3294], 'positive16/3743%33/3789%16/3250%31/3783%16/3053%6/2129%P': [3295], 'value<0.010.13<0.010.38<0.01<0.01AAV,': [3296], 'therapy.Comparison': [3308], 'test.a': [3313], 'death.b': [3316], 'Proportion': [3317], 'year.': [3333], 'test.': [3358], '(range:': [3367], '0–15': [3368], 'years).': [3369], 'Long-term': [3370], '3a': [3379], 'b,': [3381], 'respectively.': [3382], 'unadjusted': [3386, 3451], '0.49).': [3397], '0.01)': [3414], '0.17).': [3455], 'Relapse': [3456], 'data': [3457], '316': [3461, 3482], 'until': [3473], 'last': [3474], 'follow-up.': [3475], 'Within': [3476], 'period,': [3479], '116': [3480], '(37%)': [3486], '8': [3488], '(22%)': [3496], 'relapse.': [3499, 3534, 3710], 'Two': [3500, 3614, 3746], 'recrudescence': [3508], 'augmented': [3513], 'following': [3520], 'believe': [3525], 'reflected': [3526], 'inadequate': [3527], 'control': [3530], 'rather': [3531], 'exhibited': [3541], 'relapse': [3544, 3627, 3686, 3719, 3782], 'beyond': [3548], 'months.': [3550], 'During': [3551], 'follow-up,': [3553], '8;': [3559], '50%)': [3561], 'developed': [3570], '3c).': [3574], 'relapses': [3576, 3617, 3635, 3738], 'occur': [3579], 'late': [3580], '(median': [3581], 'relapse:': [3585], '4.4': [3586], '1.1–7.9': [3589], 'years),': [3590], '(5': [3594], '8)': [3596, 3648], 'directed': [3602], 'natural': [3609], 'MPO-ANCA,': [3620], 'notable': [3623], 'MPO-ANCA': [3630], 'All': [3634], 'occurred': [3636], '(6': [3646], 'rise': [3653], 'titer': [3656], '25%,': [3660], 'seroconversion': [3662], 'ANCA-negative': [3664], 'status,': [3667], 'relapsing': [3676], 'its': [3688], 'relation': [3689], 'treatment.': [3692], 'shown': [3712], '3c,': [3715], '0.29),': [3733], 'undergone': [3753], 'transplantation.': [3755], 'recurrence': [3760], 'related': [3761], 'allografts.Table': [3774], '4Details': [3775], 'relapseCaseTime': [3780], '(months)ANCAGBM': [3783], 'AbOrgan': [3784], 'involvementTreatment': [3785], 'relapseTreatment': [3789], 'relapseSubsequent': [3791], 'relapse113PR3NegRenal,': [3792], 'skinCS': [3793], 'only;CYC': [3794], 'stopped': [3795, 3801, 3807, 3817], '9': [3796], 'mo': [3797, 3803, 3809, 3819], 'priorCYC,': [3798], 'CSYes216PR3NegLRTCS': [3799], 'only;AZA': [3800, 3806, 3816], 'priorAZA,': [3804, 3820], 'CSNo322MPONegLRTCS': [3805], '18': [3808], 'priorCSYes436PR3NegRenal,': [3810], 'SkinMMF,': [3811], 'CSRTX,': [3812], 'CYC,': [3813, 3829, 3838, 3876], 'CSYes571PR3NegRenalAZAAZA,': [3814], 'CSNo681PR3NegConstitutionalCS': [3815], 'CSYes787MPONegRenalNone;off': [3821], 'yrCSNo895MPOPositiveLRT,': [3824], 'RenalNone;off': [3825], 'moRTX,': [3828], 'CSNoANCA,': [3830], 'antibody;': [3833, 3871], 'AZA,': [3834, 3872], 'azathioprine;': [3835, 3873], 'CS,': [3836, 3874], 'corticosteroids;': [3837, 3875], 'cyclophosphamide;': [3839, 3877], 'LRT,': [3844, 3882], 'tract;': [3847, 3885], 'MMF,': [3850, 3888], 'mofetil;': [3852, 3890], 'mo,': [3853, 3891], 'months;': [3854, 3892], 'RTX,': [3858, 3896], 'rituximab;': [3859, 3897], 'y,': [3860, 3898], 'ANCA,': [3868], '(RRT),': [3913], 'diagnosed': [3925], 'positivity.': [3932], 'regression': [3936], 'death': [3942, 3964], 'end-stage': [3944, 3966], '(ESRD)': [3947], 'correcting': [3951], 'baseline': [3956], 'variables': [3957], '5;': [3959], '4).Table': [3961], '5Predictors': [3962], 'diseaseUnadjusted': [3968], 'analysisDeathESRDDeath': [3969], 'ESRDHR': [3971], '(CI)P': [3972, 3974, 3976], 'valueHR': [3973, 3975], 'valueDiagnosis–0.25–<0.01–<0.01': [3977], 'DPaReference': [3978], 'estimates': [3981], 'hazard': [3983], 'ratios.': [3984], 'vers': [3985]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2613744835', 'counts_by_year': [{'year': 2024, 'cited_by_count': 35}, {'year': 2023, 'cited_by_count': 29}, {'year': 2022, 'cited_by_count': 27}, {'year': 2021, 'cited_by_count': 32}, {'year': 2020, 'cited_by_count': 24}, {'year': 2019, 'cited_by_count': 29}, {'year': 2018, 'cited_by_count': 17}, {'year': 2017, 'cited_by_count': 3}], 'updated_date': '2025-01-08T08:32:48.763236', 'created_date': '2017-05-19'}