Mechanisms of Deubiquitinase Specificity and Regulation

Name: Work Video:
Duration: 3 min 30 s
Tycho E.T. Mevissen; David Komander
{'id': 'https://openalex.org/W2613065881', 'doi': 'https://doi.org/10.1146/annurev-biochem-061516-044916', 'title': 'Mechanisms of Deubiquitinase Specificity and Regulation', 'display_name': 'Mechanisms of Deubiquitinase Specificity and Regulation', 'publication_year': 2017, 'publication_date': '2017-05-12', 'ids': {'openalex': 'https://openalex.org/W2613065881', 'doi': 'https://doi.org/10.1146/annurev-biochem-061516-044916', 'mag': '2613065881', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28498721'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1146/annurev-biochem-061516-044916', 'pdf_url': 'https://www.annualreviews.org/doi/pdf/10.1146/annurev-biochem-061516-044916', 'source': {'id': 'https://openalex.org/S53860259', 'display_name': 'Annual Review of Biochemistry', 'issn_l': '0066-4154', 'issn': ['0066-4154', '1545-4509'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.annualreviews.org/doi/pdf/10.1146/annurev-biochem-061516-044916', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5081354649', 'display_name': 'Tycho E.T. Mevissen', 'orcid': 'https://orcid.org/0000-0002-2324-5292'}, 'institutions': [{'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I90344618', 'display_name': 'Medical Research Council', 'ror': 'https://ror.org/03x94j517', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['GB', 'US'], 'is_corresponding': True, 'raw_author_name': 'Tycho E.T. Mevissen', 'raw_affiliation_strings': ['Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115;', 'Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom;', 'institution_ids': ['https://openalex.org/I170203145', 'https://openalex.org/I90344618']}, {'raw_affiliation_string': 'Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115;', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5086480636', 'display_name': 'David Komander', 'orcid': 'https://orcid.org/0000-0002-8092-4320'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I90344618', 'display_name': 'Medical Research Council', 'ror': 'https://ror.org/03x94j517', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'David Komander', 'raw_affiliation_strings': ['Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115;', 'Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115;', 'institution_ids': ['https://openalex.org/I136199984']}, {'raw_affiliation_string': 'Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom;', 'institution_ids': ['https://openalex.org/I170203145', 'https://openalex.org/I90344618']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5081354649'], 'corresponding_institution_ids': ['https://openalex.org/I170203145', 'https://openalex.org/I90344618', 'https://openalex.org/I136199984'], 'apc_list': None, 'apc_paid': None, 'fwci': 9.011, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 817, 'citation_normalized_percentile': {'value': 0.999737, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '86', 'issue': '1', 'first_page': '159', 'last_page': '192'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10587', 'display_name': 'Autophagy in Disease and Therapy', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10602', 'display_name': 'Glycosylation and Glycoproteins Research', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/deubiquitinating-enzyme', 'display_name': 'Deubiquitinating enzyme', 'score': 0.88641346}, {'id': 'https://openalex.org/keywords/nedd8', 'display_name': 'NEDD8', 'score': 0.8153188}, {'id': 'https://openalex.org/keywords/sumo-enzymes', 'display_name': 'SUMO enzymes', 'score': 0.5927672}], 'concepts': [{'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.9048459}, {'id': 'https://openalex.org/C102658986', 'wikidata': 'https://www.wikidata.org/wiki/Q5266092', 'display_name': 'Deubiquitinating enzyme', 'level': 4, 'score': 0.88641346}, {'id': 'https://openalex.org/C2779231659', 'wikidata': 'https://www.wikidata.org/wiki/Q6953444', 'display_name': 'NEDD8', 'level': 5, 'score': 0.8153188}, {'id': 'https://openalex.org/C144519050', 'wikidata': 'https://www.wikidata.org/wiki/Q7394994', 'display_name': 'SUMO enzymes', 'level': 5, 'score': 0.5927672}, {'id': 'https://openalex.org/C119157956', 'wikidata': 'https://www.wikidata.org/wiki/Q796604', 'display_name': 'Acetylation', 'level': 3, 'score': 0.56434023}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.51634586}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.48825172}, {'id': 'https://openalex.org/C134459356', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin ligase', 'level': 4, 'score': 0.42362708}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.3693002}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3272718}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.12173039}], 'mesh': [{'descriptor_ui': 'D000072017', 'descriptor_name': 'Deubiquitinating Enzymes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005057', 'descriptor_name': 'Eukaryotic Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011499', 'descriptor_name': 'Protein Processing, Post-Translational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014452', 'descriptor_name': 'Ubiquitins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000107', 'descriptor_name': 'Acetylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000494', 'descriptor_name': 'Allosteric Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072017', 'descriptor_name': 'Deubiquitinating Enzymes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000072017', 'descriptor_name': 'Deubiquitinating Enzymes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000072017', 'descriptor_name': 'Deubiquitinating Enzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005057', 'descriptor_name': 'Eukaryotic Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000075687', 'descriptor_name': 'NEDD8 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059748', 'descriptor_name': 'Proteolysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013379', 'descriptor_name': 'Substrate Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058207', 'descriptor_name': 'Sumoylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054875', 'descriptor_name': 'Ubiquitination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014452', 'descriptor_name': 'Ubiquitins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014452', 'descriptor_name': 'Ubiquitins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1146/annurev-biochem-061516-044916', 'pdf_url': 'https://www.annualreviews.org/doi/pdf/10.1146/annurev-biochem-061516-044916', 'source': {'id': 'https://openalex.org/S53860259', 'display_name': 'Annual Review of Biochemistry', 'issn_l': '0066-4154', 'issn': ['0066-4154', '1545-4509'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28498721', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1146/annurev-biochem-061516-044916', 'pdf_url': 'https://www.annualreviews.org/doi/pdf/10.1146/annurev-biochem-061516-044916', 'source': {'id': 'https://openalex.org/S53860259', 'display_name': 'Annual Review of Biochemistry', 'issn_l': '0066-4154', 'issn': ['0066-4154', '1545-4509'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 197, 'referenced_works': ['https://openalex.org/W1554981631', 'https://openalex.org/W1557263829', 'https://openalex.org/W1596248927', 'https://openalex.org/W1605455268', 'https://openalex.org/W1617606969', 'https://openalex.org/W1749499757', 'https://openalex.org/W1800844013', 'https://openalex.org/W1900297117', 'https://openalex.org/W1923712792', 'https://openalex.org/W1925142678', 'https://openalex.org/W1941369368', 'https://openalex.org/W1965667503', 'https://openalex.org/W1967098715', 'https://openalex.org/W1967402966', 'https://openalex.org/W1968943627', 'https://openalex.org/W1970826261', 'https://openalex.org/W1973743880', 'https://openalex.org/W1975715657', 'https://openalex.org/W1979652500', 'https://openalex.org/W1980300257', 'https://openalex.org/W1986429623', 'https://openalex.org/W1987667299', 'https://openalex.org/W1988545399', 'https://openalex.org/W1990283498', 'https://openalex.org/W1991841644', 'https://openalex.org/W1992174702', 'https://openalex.org/W1992682414', 'https://openalex.org/W1993287528', 'https://openalex.org/W1994751787', 'https://openalex.org/W1995392239', 'https://openalex.org/W1995740655', 'https://openalex.org/W1995789798', 'https://openalex.org/W1999290683', 'https://openalex.org/W2000017794', 'https://openalex.org/W2001499126', 'https://openalex.org/W2004134367', 'https://openalex.org/W2006548753', 'https://openalex.org/W2007277647', 'https://openalex.org/W2008207745', 'https://openalex.org/W2008310735', 'https://openalex.org/W2009401164', 'https://openalex.org/W2012296420', 'https://openalex.org/W2013057562', 'https://openalex.org/W2013068694', 'https://openalex.org/W2014593228', 'https://openalex.org/W2014751404', 'https://openalex.org/W2015031034', 'https://openalex.org/W2016899606', 'https://openalex.org/W2017033636', 'https://openalex.org/W2020053733', 'https://openalex.org/W2021565943', 'https://openalex.org/W2022553982', 'https://openalex.org/W2025266637', 'https://openalex.org/W2026512029', 'https://openalex.org/W2028070445', 'https://openalex.org/W2028140379', 'https://openalex.org/W2028157992', 'https://openalex.org/W2028730574', 'https://openalex.org/W2029827764', 'https://openalex.org/W2032459218', 'https://openalex.org/W2032997281', 'https://openalex.org/W2033701307', 'https://openalex.org/W2034346780', 'https://openalex.org/W2034894297', 'https://openalex.org/W2035203778', 'https://openalex.org/W2037239543', 'https://openalex.org/W2037305493', 'https://openalex.org/W2039090083', 'https://openalex.org/W2040611862', 'https://openalex.org/W2043274355', 'https://openalex.org/W2045089261', 'https://openalex.org/W2046073277', 'https://openalex.org/W2047134964', 'https://openalex.org/W2047161080', 'https://openalex.org/W2047809194', 'https://openalex.org/W2047822292', 'https://openalex.org/W2048224115', 'https://openalex.org/W2048915877', 'https://openalex.org/W2052247259', 'https://openalex.org/W2057926548', 'https://openalex.org/W2058065156', 'https://openalex.org/W2058434102', 'https://openalex.org/W2060354742', 'https://openalex.org/W2062508865', 'https://openalex.org/W2066745745', 'https://openalex.org/W2070463829', 'https://openalex.org/W2070867726', 'https://openalex.org/W2070873221', 'https://openalex.org/W2071711205', 'https://openalex.org/W2071891309', 'https://openalex.org/W2073566499', 'https://openalex.org/W2077457197', 'https://openalex.org/W2078376874', 'https://openalex.org/W2079428226', 'https://openalex.org/W2082425146', 'https://openalex.org/W2086956798', 'https://openalex.org/W2087437632', 'https://openalex.org/W2087608460', 'https://openalex.org/W2089624946', 'https://openalex.org/W2090120584', 'https://openalex.org/W2092382164', 'https://openalex.org/W2094181164', 'https://openalex.org/W2095803950', 'https://openalex.org/W2099826949', 'https://openalex.org/W2101622956', 'https://openalex.org/W2103059173', 'https://openalex.org/W2103552916', 'https://openalex.org/W2106142195', 'https://openalex.org/W2106969933', 'https://openalex.org/W2107100789', 'https://openalex.org/W2107216455', 'https://openalex.org/W2109337196', 'https://openalex.org/W2109511371', 'https://openalex.org/W2111797871', 'https://openalex.org/W2112158920', 'https://openalex.org/W2115214832', 'https://openalex.org/W2118225942', 'https://openalex.org/W2118337455', 'https://openalex.org/W2119415370', 'https://openalex.org/W2120619403', 'https://openalex.org/W2120715236', 'https://openalex.org/W2127215376', 'https://openalex.org/W2128579113', 'https://openalex.org/W2131232694', 'https://openalex.org/W2132249118', 'https://openalex.org/W2133819225', 'https://openalex.org/W2134095164', 'https://openalex.org/W2136412949', 'https://openalex.org/W2137949264', 'https://openalex.org/W2139364069', 'https://openalex.org/W2139813967', 'https://openalex.org/W2141035944', 'https://openalex.org/W2143322707', 'https://openalex.org/W2143538182', 'https://openalex.org/W2143878771', 'https://openalex.org/W2145311451', 'https://openalex.org/W2145493337', 'https://openalex.org/W2147363233', 'https://openalex.org/W2147718057', 'https://openalex.org/W2147917253', 'https://openalex.org/W2150091336', 'https://openalex.org/W2152630268', 'https://openalex.org/W2158668670', 'https://openalex.org/W2158866061', 'https://openalex.org/W2159781519', 'https://openalex.org/W2160938666', 'https://openalex.org/W2162223351', 'https://openalex.org/W2164253678', 'https://openalex.org/W2164578159', 'https://openalex.org/W2166790177', 'https://openalex.org/W2166987747', 'https://openalex.org/W2167536088', 'https://openalex.org/W2168718892', 'https://openalex.org/W2169018921', 'https://openalex.org/W2170634643', 'https://openalex.org/W2174055199', 'https://openalex.org/W2175530476', 'https://openalex.org/W2191666140', 'https://openalex.org/W2225782005', 'https://openalex.org/W2231663276', 'https://openalex.org/W2232997241', 'https://openalex.org/W2272704264', 'https://openalex.org/W2281048538', 'https://openalex.org/W2287689805', 'https://openalex.org/W2290894813', 'https://openalex.org/W2294047283', 'https://openalex.org/W2313629931', 'https://openalex.org/W2316880913', 'https://openalex.org/W2327577222', 'https://openalex.org/W2328753773', 'https://openalex.org/W2332083897', 'https://openalex.org/W2335833703', 'https://openalex.org/W2340572980', 'https://openalex.org/W2379073606', 'https://openalex.org/W2418951526', 'https://openalex.org/W2430738920', 'https://openalex.org/W2436312957', 'https://openalex.org/W2461384588', 'https://openalex.org/W2466579264', 'https://openalex.org/W2468329560', 'https://openalex.org/W2471938860', 'https://openalex.org/W2477420580', 'https://openalex.org/W2481104931', 'https://openalex.org/W2495215685', 'https://openalex.org/W2499269053', 'https://openalex.org/W2501186188', 'https://openalex.org/W2507824656', 'https://openalex.org/W2510683315', 'https://openalex.org/W2510750944', 'https://openalex.org/W2514355059', 'https://openalex.org/W2517895740', 'https://openalex.org/W2522240652', 'https://openalex.org/W2530082208', 'https://openalex.org/W2561685088', 'https://openalex.org/W2577226088', 'https://openalex.org/W2587027025', 'https://openalex.org/W4210757594'], 'related_works': ['https://openalex.org/W4246998185', 'https://openalex.org/W4230120306', 'https://openalex.org/W2337340383', 'https://openalex.org/W2168979257', 'https://openalex.org/W2142575821', 'https://openalex.org/W2135178058', 'https://openalex.org/W2065886910', 'https://openalex.org/W2021846401', 'https://openalex.org/W2002407276', 'https://openalex.org/W166838764'], 'abstract_inverted_index': {'Protein': [0], 'ubiquitination': [1, 80], 'is': [2], 'one': [3], 'of': [4, 10, 17, 31, 57, 106, 136], 'the': [5, 33, 103, 113, 127, 133], 'most': [6], 'powerful': [7], 'posttranslational': [8, 46], 'modifications': [9, 47], 'proteins,': [11], 'as': [12, 64], 'it': [13], 'regulates': [14], 'a': [15, 83, 140, 151], 'plethora': [16], 'cellular': [18, 79], 'processes': [19], 'in': [20, 119, 157], 'distinct': [21], 'manners.': [22], 'Simple': [23], 'monoubiquitination': [24], 'events': [25, 81], 'coexist': [26], 'with': [27, 60, 94, 139], 'more': [28], 'complex': [29], 'forms': [30], 'polyubiquitination,': [32], 'latter': [34], 'featuring': [35], 'many': [36, 104, 134], 'different': [37], 'chain': [38], 'architectures.': [39], 'Ubiquitin': [40], 'can': [41, 53], 'be': [42, 55], 'subjected': [43], 'to': [44, 111, 153], 'further': [45, 131], '(e.g.,': [48], 'phosphorylation': [49], 'and': [50, 52, 85, 116], 'acetylation)': [51], 'also': [54], 'part': [56], 'mixed': [58], 'polymers': [59], 'ubiquitin-like': [61], 'modifiers': [62], 'such': [63], 'SUMO': [65], '(small': [66], 'ubiquitin-related': [67], 'modifier)': [68], 'or': [69], 'NEDD8': [70], '(neural': [71], 'precursor': [72], 'cell': [73], 'expressed,': [74], 'developmentally': [75], 'downregulated': [76], '8).': [77], 'Together,': [78], 'form': [82], 'sophisticated': [84], 'versatile': [86], 'ubiquitin': [87, 92, 114], 'code.': [88], 'Deubiquitinases': [89], '(DUBs)': [90], 'reverse': [91], 'signals': [93], 'equally': [95], 'high': [96], 'sophistication.': [97], 'In': [98], 'this': [99], 'review,': [100], 'we': [101], 'conceptualize': [102], 'layers': [105], 'specificity': [107, 122], 'that': [108, 144], 'DUBs': [109], 'encompass': [110], 'control': [112], 'code': [115], 'discuss': [117, 132], 'examples': [118], 'which': [120], 'DUB': [121, 137, 158], 'has': [123], 'been': [124], 'understood': [125], 'at': [126], 'molecular': [128], 'level.': [129], 'We': [130], 'mechanisms': [135], 'regulation': [138], 'focus': [141], 'on': [142], 'those': [143], 'modulate': [145], 'catalytic': [146], 'activity.': [147], 'Our': [148], 'review': [149], 'provides': [150], 'framework': [152], 'tackle': [154], 'lingering': [155], 'questions': [156], 'biology.': [159]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2613065881', 'counts_by_year': [{'year': 2024, 'cited_by_count': 128}, {'year': 2023, 'cited_by_count': 124}, {'year': 2022, 'cited_by_count': 126}, {'year': 2021, 'cited_by_count': 145}, {'year': 2020, 'cited_by_count': 140}, {'year': 2019, 'cited_by_count': 86}, {'year': 2018, 'cited_by_count': 54}, {'year': 2017, 'cited_by_count': 14}], 'updated_date': '2025-01-02T13:15:25.483699', 'created_date': '2017-05-19'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
