Publication Information

{'id': 'https://openalex.org/W2612087418', 'doi': 'https://doi.org/10.18632/oncotarget.17695', 'title': 'Novel PPARα agonist MHY553 alleviates hepatic steatosis by increasing fatty acid oxidation and decreasing inflammation during aging', 'display_name': 'Novel PPARα agonist MHY553 alleviates hepatic steatosis by increasing fatty acid oxidation and decreasing inflammation during aging', 'publication_year': 2017, 'publication_date': '2017-05-08', 'ids': {'openalex': 'https://openalex.org/W2612087418', 'doi': 'https://doi.org/10.18632/oncotarget.17695', 'mag': '2612087418', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28545035', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5542266'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.17695', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=17695&path%5B%5D=56671', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=17695&path%5B%5D=56671', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100452218', 'display_name': 'Seong Min Kim', 'orcid': 'https://orcid.org/0000-0003-3359-7504'}, 'institutions': [{'id': 'https://openalex.org/I4921948', 'display_name': 'Pusan National University', 'ror': 'https://ror.org/01an57a31', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4921948']}, {'id': 'https://openalex.org/I189442560', 'display_name': 'Gyeongsang National University', 'ror': 'https://ror.org/00saywf64', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I189442560']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Seong Min Kim', 'raw_affiliation_strings': ['Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea', 'Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea', 'institution_ids': ['https://openalex.org/I4921948']}, {'raw_affiliation_string': 'Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea', 'institution_ids': ['https://openalex.org/I189442560']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049988026', 'display_name': 'Bonggi Lee', 'orcid': 'https://orcid.org/0000-0003-3265-1310'}, 'institutions': [{'id': 'https://openalex.org/I4921948', 'display_name': 'Pusan National University', 'ror': 'https://ror.org/01an57a31', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4921948']}, {'id': 'https://openalex.org/I4210087584', 'display_name': 'Korea Institute of Oriental Medicine', 'ror': 'https://ror.org/005rpmt10', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210087584']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Bonggi Lee', 'raw_affiliation_strings': ['Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu 41062, Republic of Korea', 'Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea', 'institution_ids': ['https://openalex.org/I4921948']}, {'raw_affiliation_string': 'Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu 41062, Republic of Korea', 'institution_ids': ['https://openalex.org/I4210087584']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077334131', 'display_name': 'Hye Jin An', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4921948', 'display_name': 'Pusan National University', 'ror': 'https://ror.org/01an57a31', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4921948']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hye Jin An', 'raw_affiliation_strings': ['Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea', 'institution_ids': ['https://openalex.org/I4921948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100374585', 'display_name': 'Dae Hyun Kim', 'orcid': 'https://orcid.org/0000-0003-4391-5502'}, 'institutions': [{'id': 'https://openalex.org/I4921948', 'display_name': 'Pusan National University', 'ror': 'https://ror.org/01an57a31', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4921948']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Dae Hyun Kim', 'raw_affiliation_strings': ['Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea', 'institution_ids': ['https://openalex.org/I4921948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065397246', 'display_name': 'Kyung Chul Park', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4921948', 'display_name': 'Pusan National University', 'ror': 'https://ror.org/01an57a31', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4921948']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Kyung Chul Park', 'raw_affiliation_strings': ['Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea', 'institution_ids': ['https://openalex.org/I4921948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110491490', 'display_name': 'Sang‐Gyun Noh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4921948', 'display_name': 'Pusan National University', 'ror': 'https://ror.org/01an57a31', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4921948']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Sang-Gyun Noh', 'raw_affiliation_strings': ['Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea', 'institution_ids': ['https://openalex.org/I4921948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090261269', 'display_name': 'Ki Wung Chung', 'orcid': 'https://orcid.org/0000-0003-0049-0735'}, 'institutions': [{'id': 'https://openalex.org/I4921948', 'display_name': 'Pusan National University', 'ror': 'https://ror.org/01an57a31', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4921948']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Ki Wung Chung', 'raw_affiliation_strings': ['Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea', 'institution_ids': ['https://openalex.org/I4921948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082525528', 'display_name': 'Eun Kyeong Lee', 'orcid': 'https://orcid.org/0000-0002-1079-2182'}, 'institutions': [{'id': 'https://openalex.org/I4921948', 'display_name': 'Pusan National University', 'ror': 'https://ror.org/01an57a31', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4921948']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Eun Kyeong Lee', 'raw_affiliation_strings': ['Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea', 'institution_ids': ['https://openalex.org/I4921948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011222813', 'display_name': 'Kyung Mok Kim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4921948', 'display_name': 'Pusan National University', 'ror': 'https://ror.org/01an57a31', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4921948']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Kyung Mok Kim', 'raw_affiliation_strings': ['Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea', 'institution_ids': ['https://openalex.org/I4921948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100336709', 'display_name': 'Do Hyun Kim', 'orcid': 'https://orcid.org/0000-0001-6716-7962'}, 'institutions': [{'id': 'https://openalex.org/I4921948', 'display_name': 'Pusan National University', 'ror': 'https://ror.org/01an57a31', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4921948']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Do Hyun Kim', 'raw_affiliation_strings': ['Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea', 'institution_ids': ['https://openalex.org/I4921948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101791810', 'display_name': 'Su Jeong Kim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4921948', 'display_name': 'Pusan National University', 'ror': 'https://ror.org/01an57a31', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4921948']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Su Jeong Kim', 'raw_affiliation_strings': ['Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea', 'institution_ids': ['https://openalex.org/I4921948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048529563', 'display_name': 'Pusoon Chun', 'orcid': 'https://orcid.org/0000-0002-7349-9880'}, 'institutions': [{'id': 'https://openalex.org/I104338594', 'display_name': 'Inje University', 'ror': 'https://ror.org/04xqwq985', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I104338594']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Pusoon Chun', 'raw_affiliation_strings': ['College of Pharmacy, Inje University, Gimhae 621-749, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'College of Pharmacy, Inje University, Gimhae 621-749, Republic of Korea', 'institution_ids': ['https://openalex.org/I104338594']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022371355', 'display_name': 'Ho Jeong Lee', 'orcid': 'https://orcid.org/0000-0001-9646-195X'}, 'institutions': [{'id': 'https://openalex.org/I189442560', 'display_name': 'Gyeongsang National University', 'ror': 'https://ror.org/00saywf64', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I189442560']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Ho Jeong Lee', 'raw_affiliation_strings': ['Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea', 'institution_ids': ['https://openalex.org/I189442560']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028089671', 'display_name': 'Hyung Ryong Moon', 'orcid': 'https://orcid.org/0000-0003-1119-7112'}, 'institutions': [{'id': 'https://openalex.org/I4921948', 'display_name': 'Pusan National University', 'ror': 'https://ror.org/01an57a31', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4921948']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hyung Ryong Moon', 'raw_affiliation_strings': ['Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea', 'institution_ids': ['https://openalex.org/I4921948']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5054492574', 'display_name': 'Hae Young Chung', 'orcid': 'https://orcid.org/0000-0002-3215-8828'}, 'institutions': [{'id': 'https://openalex.org/I4921948', 'display_name': 'Pusan National University', 'ror': 'https://ror.org/01an57a31', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4921948']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hae Young Chung', 'raw_affiliation_strings': ['Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea', 'institution_ids': ['https://openalex.org/I4921948']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.12, 'has_fulltext': False, 'cited_by_count': 19, 'citation_normalized_percentile': {'value': 0.694668, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '8', 'issue': '28', 'first_page': '46273', 'last_page': '46285'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11072', 'display_name': 'Peroxisome Proliferator-Activated Receptors', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11072', 'display_name': 'Peroxisome Proliferator-Activated Receptors', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10351', 'display_name': 'Liver Disease Diagnosis and Treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/steatosis', 'display_name': 'Steatosis', 'score': 0.87079054}], 'concepts': [{'id': 'https://openalex.org/C2776175330', 'wikidata': 'https://www.wikidata.org/wiki/Q1365091', 'display_name': 'Steatosis', 'level': 2, 'score': 0.87079054}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.7430546}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.67035544}, {'id': 'https://openalex.org/C82714985', 'wikidata': 'https://www.wikidata.org/wiki/Q306213', 'display_name': 'Beta oxidation', 'level': 3, 'score': 0.5858409}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5432838}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.48529026}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.46387777}, {'id': 'https://openalex.org/C187345961', 'wikidata': 'https://www.wikidata.org/wiki/Q419629', 'display_name': 'Peroxisome proliferator-activated receptor', 'level': 3, 'score': 0.44275486}, {'id': 'https://openalex.org/C2778772119', 'wikidata': 'https://www.wikidata.org/wiki/Q6058862', 'display_name': 'Fatty liver', 'level': 3, 'score': 0.43785495}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.2303862}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.20986539}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.10687068}], 'mesh': [{'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005227', 'descriptor_name': 'Fatty Acids', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005234', 'descriptor_name': 'Fatty Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010084', 'descriptor_name': 'Oxidation-Reduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D047493', 'descriptor_name': 'PPAR alpha', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': True}, {'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001835', 'descriptor_name': 'Body Weight', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001835', 'descriptor_name': 'Body Weight', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005227', 'descriptor_name': 'Fatty Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005234', 'descriptor_name': 'Fatty Liver', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D005234', 'descriptor_name': 'Fatty Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005234', 'descriptor_name': 'Fatty Liver', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D056945', 'descriptor_name': 'Hep G2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D018836', 'descriptor_name': 'Inflammation Mediators', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018836', 'descriptor_name': 'Inflammation Mediators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050356', 'descriptor_name': 'Lipid Metabolism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008968', 'descriptor_name': 'Molecular Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047493', 'descriptor_name': 'PPAR alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047493', 'descriptor_name': 'PPAR alpha', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D047493', 'descriptor_name': 'PPAR alpha', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.17695', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=17695&path%5B%5D=56671', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5542266', 'pdf_url': 'https://europepmc.org/articles/pmc5542266?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542266', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28545035', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.17695', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=17695&path%5B%5D=56671', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1506249422', 'https://openalex.org/W1765719311', 'https://openalex.org/W1964216244', 'https://openalex.org/W1976023760', 'https://openalex.org/W1993266217', 'https://openalex.org/W2009947577', 'https://openalex.org/W2022104878', 'https://openalex.org/W2022266817', 'https://openalex.org/W2028331753', 'https://openalex.org/W2034565459', 'https://openalex.org/W2039333506', 'https://openalex.org/W2061864595', 'https://openalex.org/W2065612971', 'https://openalex.org/W2066092624', 'https://openalex.org/W2078434599', 'https://openalex.org/W2090213675', 'https://openalex.org/W2104958630', 'https://openalex.org/W2111251212', 'https://openalex.org/W2152601874', 'https://openalex.org/W2164153195', 'https://openalex.org/W2286324767', 'https://openalex.org/W4251528475'], 'related_works': ['https://openalex.org/W4294123679', 'https://openalex.org/W3194558401', 'https://openalex.org/W3011122423', 'https://openalex.org/W2994642861', 'https://openalex.org/W2883354468', 'https://openalex.org/W2419316219', 'https://openalex.org/W2382688610', 'https://openalex.org/W2151429631', 'https://openalex.org/W2120956425', 'https://openalex.org/W2109444927'], 'abstract_inverted_index': {'//': [0], 'Seong': [1], 'Min': [2], 'Kim': [3, 19, 43, 48, 53], '1,': [4, 9], '2': [5, 63, 94], ',': [6, 11, 16, 21, 26, 30, 35, 40, 45, 50, 55, 59, 64], 'Bonggi': [7], 'Lee': [8, 38, 62], '3': [10, 113], 'Hye': [12], 'Jin': [13], 'An': [14], '1': [15, 20, 25, 29, 34, 39, 44, 49, 54, 68, 73, 74], 'Dae': [17], 'Hyun': [18, 47], 'Kyung': [22, 41], 'Chul': [23], 'Park': [24], 'Sang-Gyun': [27], 'Noh': [28], 'Ki': [31], 'Wung': [32], 'Chung': [33, 72], 'Eun': [36], 'Kyeong': [37], 'Mok': [42], 'Do': [46], 'Su': [51], 'Jeong': [52, 61], 'Pusoon': [56], 'Chun': [57], '4': [58, 129], 'Ho': [60], 'Hyung': [65, 147], 'Ryong': [66, 148], 'Moon': [67], 'and': [69, 100, 182, 198, 224, 234, 238, 243, 279, 315, 330, 367], 'Hae': [70, 142], 'Young': [71, 143], 'Molecular': [75], 'Inflammation': [76], 'Research': [77, 95], 'Center': [78], 'for': [79, 379], 'Aging': [80], 'Intervention': [81], '(MRCA),': [82], 'College': [83, 101, 130], 'of': [84, 92, 97, 102, 111, 120, 127, 131, 138, 250, 255, 282, 319], 'Pharmacy,': [85, 132], 'Pusan': [86], 'National': [87, 106], 'University,': [88, 107, 134], 'Busan': [89], '46241,': [90], 'Republic': [91, 110, 126, 137], 'Korea': [93, 112, 118, 128, 139], 'Institute': [96, 119], 'Life': [98], 'Science': [99], 'Veterinary': [103], 'Medicine,': [104], 'Gyeongsang': [105], 'Jinju': [108], '52828,': [109], 'Korean': [114], 'Medicine': [115, 122], '(KM)-Application': [116], 'Center,': [117], 'Oriental': [121], '(KIOM),': [123], 'Daegu': [124], '41062,': [125], 'Inje': [133], 'Gimhae': [135], '621-749,': [136], 'Correspondence': [140], 'to:': [141], 'Chung,': [144], 'email:': [145, 150], '[email protected]': [146], 'Moon,': [149], '[email protected]': [151], 'Keywords:': [152], 'MHY553,': [153], 'PPARα': [154, 310, 354], 'agonist,': [155, 219], 'hepatic': [156, 186, 230, 272, 359, 381], 'steatosis,': [157, 360], 'fatty': [158, 325], 'acid': [159, 326], 'oxidation,': [160, 327], 'aging': [161], 'Received:': [162], 'February': [163], '08,': [164, 172], '2017': [165, 169, 173], 'Accepted:': [166], 'March': [167], '26,': [168], 'Published:': [170], 'May': [171], 'ABSTRACT': [174], 'Hepatic': [175], 'steatosis': [176, 187, 231, 273, 382], 'is': [177, 188, 351, 374], 'frequently': [178], 'observed': [179], 'in': [180, 276, 288, 302, 335, 345, 361, 370, 383], 'obese': [181], 'aged': [183], 'individuals.': [184], 'Because': [185], 'closely': [189], 'associated': [190], 'with': [191, 287], 'metabolic': [192], 'syndromes,': [193], 'including': [194, 328], 'insulin': [195], 'resistance,': [196], 'dyslipidemia,': [197], 'inflammation,': [199], 'numerous': [200], 'efforts': [201], 'have': [202], 'been': [203], 'made': [204], 'to': [205, 324], 'develop': [206], 'compounds': [207], 'that': [208, 247, 254, 356], 'ameliorate': [209], 'it.': [210], 'Here,': [211], 'a': [212, 297, 352, 375], 'novel': [213, 353], 'peroxisome': [214], 'proliferator-activated': [215], 'receptor': [216, 300], '(PPAR)': [217], 'α': [218], '4-(benzo[d]thiazol-2-yl)benzene-1,3-diol': [220], '(MHY553)': [221], 'was': [222, 260], 'developed,': [223], 'investigated': [225], 'its': [226, 320], 'beneficial': [227], 'effects': [228], 'on': [229], 'using': [232], 'young': [233], 'old': [235, 346], 'Sprague-Dawley': [236], 'rats': [237], 'HepG2': [239, 303], 'cells.': [240, 304], 'Docking': [241], 'simulation': [242], 'Western': [244], 'blotting': [245], 'confirmed': [246], 'the': [248, 256, 313, 371], 'activity': [249], 'PPARα,': [251], 'but': [252], 'not': [253], 'other': [257], 'PPAR': [258], 'subtypes,': [259], 'increased': [261, 316], 'by': [262, 296, 363], 'MHY553': [263, 268, 291, 308, 339, 350, 373], 'treatment.': [264], 'When': [265], 'administered': [266], 'orally,': [267], 'markedly': [269], 'ameliorated': [270], 'aging-induced': [271], 'without': [274, 332], 'changes': [275], 'body': [277], 'weight': [278], 'serum': [280], 'levels': [281, 318], 'liver': [283, 298], 'injury': [284], 'markers.': [285], 'Consistent': [286], 'vivo': [289], 'results,': [290], 'inhibited': [292], 'triglyceride': [293], 'accumulation': [294], 'induced': [295], 'X': [299], 'agonist': [301, 355], 'Regarding': [305], 'underlying': [306], 'mechanisms,': [307], 'stimulated': [309], 'translocation': [311], 'into': [312], 'nucleus': [314], 'mRNA': [317, 343], 'downstream': [321], 'genes': [322], 'related': [323], 'CPT-1A': [329], 'ACOX1,': [331], 'apparent': [333], 'change': [334], 'lipogenesis': [336], 'signaling.': [337], 'Furthermore,': [338], 'significantly': [340], 'suppresses': [341], 'inflammatory': [342], 'expression': [344], 'rats.': [347], 'In': [348], 'conclusion,': [349], 'improved': [357], 'aged-induced': [358], 'part': [362], 'increasing': [364], 'β-oxidation': [365], 'signaling': [366], 'decreasing': [368], 'inflammation': [369], 'liver.': [372], 'potential': [376], 'pharmaceutical': [377], 'agent': [378], 'treating': [380], 'aging.': [384]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2612087418', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 5}], 'updated_date': '2024-12-25T08:16:58.670718', 'created_date': '2017-05-19'}