First Steps Toward a DNA-Based Anthrax Vaccine

Name: Work Video:
Duration: 3 min 30 s
Description: Dissemination of anthrax spores through the U.S. postal system in 2001 highlighted the need for a vaccine that is effective against inhaled anthrax. Bacillus anthracis leads to disease by secreting a protein, protective antigen (PA), that combines individually with two other proteins secreted by the pathogen, lethal factor (LF) and edema …
Richard T. Ellison
{'id': 'https://openalex.org/W2610603865', 'doi': 'https://doi.org/10.1056/id200410250000008', 'title': 'First Steps Toward a DNA-Based Anthrax Vaccine', 'display_name': 'First Steps Toward a DNA-Based Anthrax Vaccine', 'publication_year': 2004, 'publication_date': '2004-01-01', 'ids': {'openalex': 'https://openalex.org/W2610603865', 'doi': 'https://doi.org/10.1056/id200410250000008', 'mag': '2610603865'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://www.jwatch.org/ID200410250000008/2004/10/25/first-steps-toward-dna-based-anthrax-vaccine.abstract', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764501393', 'display_name': 'Journal watch', 'issn_l': '0896-7210', 'issn': ['0896-7210'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5067644625', 'display_name': 'Richard T. Ellison', 'orcid': 'https://orcid.org/0000-0003-1335-9832'}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'Richard T. Ellison', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5067644625'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 61}, 'biblio': {'volume': '2004', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11515', 'display_name': 'Bacillus and Francisella bacterial research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11515', 'display_name': 'Bacillus and Francisella bacterial research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11048', 'display_name': 'Bacteriophages and microbial interactions', 'score': 0.9704, 'subfield': {'id': 'https://openalex.org/subfields/2303', 'display_name': 'Ecology'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11581', 'display_name': 'Viral Infections and Outbreaks Research', 'score': 0.9693, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bacillus-anthracis', 'display_name': 'Bacillus anthracis', 'score': 0.9822892}, {'id': 'https://openalex.org/keywords/anthrax-toxin', 'display_name': 'Anthrax toxin', 'score': 0.9520282}, {'id': 'https://openalex.org/keywords/anthrax-vaccines', 'display_name': 'Anthrax vaccines', 'score': 0.9025036}], 'concepts': [{'id': 'https://openalex.org/C2780239966', 'wikidata': 'https://www.wikidata.org/wiki/Q614156', 'display_name': 'Bacillus anthracis', 'level': 3, 'score': 0.9822892}, {'id': 'https://openalex.org/C41810244', 'wikidata': 'https://www.wikidata.org/wiki/Q1935986', 'display_name': 'Anthrax toxin', 'level': 5, 'score': 0.9520282}, {'id': 'https://openalex.org/C2777289321', 'wikidata': 'https://www.wikidata.org/wiki/Q4007170', 'display_name': 'Anthrax vaccines', 'level': 5, 'score': 0.9025036}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.6601531}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.56984186}, {'id': 'https://openalex.org/C2776460866', 'wikidata': 'https://www.wikidata.org/wiki/Q170065', 'display_name': 'Pathogen', 'level': 2, 'score': 0.5651185}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5469199}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.47418365}, {'id': 'https://openalex.org/C167508917', 'wikidata': 'https://www.wikidata.org/wiki/Q578537', 'display_name': 'DNA vaccination', 'level': 4, 'score': 0.41275805}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.350968}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3081191}, {'id': 'https://openalex.org/C123894998', 'wikidata': 'https://www.wikidata.org/wiki/Q425158', 'display_name': 'Fusion protein', 'level': 4, 'score': 0.24505872}, {'id': 'https://openalex.org/C2780801004', 'wikidata': 'https://www.wikidata.org/wiki/Q1415366', 'display_name': 'Immunization', 'level': 3, 'score': 0.21665195}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.17774269}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.118341595}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.08645016}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.08449203}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://www.jwatch.org/ID200410250000008/2004/10/25/first-steps-toward-dna-based-anthrax-vaccine.abstract', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764501393', 'display_name': 'Journal watch', 'issn_l': '0896-7210', 'issn': ['0896-7210'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.69, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 1, 'referenced_works': ['https://openalex.org/W2140614989'], 'related_works': ['https://openalex.org/W3179241746', 'https://openalex.org/W3137257442', 'https://openalex.org/W3039870649', 'https://openalex.org/W3023891383', 'https://openalex.org/W2910148073', 'https://openalex.org/W2895888270', 'https://openalex.org/W2744345244', 'https://openalex.org/W2521054335', 'https://openalex.org/W2436777946', 'https://openalex.org/W2401701102', 'https://openalex.org/W2377332183', 'https://openalex.org/W2338907471', 'https://openalex.org/W2155010341', 'https://openalex.org/W2024981220', 'https://openalex.org/W2004292086', 'https://openalex.org/W1997987258', 'https://openalex.org/W1979958088', 'https://openalex.org/W1881461524', 'https://openalex.org/W1774143086', 'https://openalex.org/W1549788765'], 'abstract_inverted_index': {'Dissemination': [0], 'of': [1], 'anthrax': [2], 'spores': [3], 'through': [4], 'the': [5, 12, 44], 'U.S.': [6], 'postal': [7], 'system': [8], 'in': [9], '2001': [10], 'highlighted': [11], 'need': [13], 'for': [14], 'a': [15, 30], 'vaccine': [16], 'that': [17, 35], 'is': [18], 'effective': [19], 'against': [20], 'inhaled': [21], 'anthrax.': [22], 'Bacillus': [23], 'anthracis': [24], 'leads': [25], 'to': [26], 'disease': [27], 'by': [28, 43], 'secreting': [29], 'protein,': [31], 'protective': [32], 'antigen': [33], '(PA),': [34], 'combines': [36], 'individually': [37], 'with': [38], 'two': [39], 'other': [40], 'proteins': [41], 'secreted': [42], 'pathogen,': [45], 'lethal': [46], 'factor': [47], '(LF)': [48], 'and': [49], 'edema': [50], '…': [51]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2610603865', 'counts_by_year': [], 'updated_date': '2024-12-14T12:38:33.571289', 'created_date': '2017-05-12'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
