Title: Correlation of BMI to Magnesium Levels in Patients With Preeclampsia [24M]
Abstract:INTRODUCTION: To determine the relationship between BMI and magnesium blood levels following a 4 or 6 gram bolus of IV magnesium in preeclamptic women. METHODS: Retrospective chart review from 2005 to...INTRODUCTION: To determine the relationship between BMI and magnesium blood levels following a 4 or 6 gram bolus of IV magnesium in preeclamptic women. METHODS: Retrospective chart review from 2005 to 2015 analyzing magnesium levels in preeclamptic women. Patients received IV magnesium bolus (4 or 6 grams) followed by a basal rate of 2 grams/hour. Magnesium levels were then drawn approximately 4 hours after the bolus dose. Magnesium levels from 4.8 to 8.4 mg/dL were considered therapeutic. BMI and labs (creatinine, ALT, AST, platelets) were compared between therapeutic and sub-therapeutic groups. RESULTS: 508 patient charts reviewed; 207 met inclusion criteria. Patients with BMI less than or equal to 30 had fewer sub-therapeutic levels than therapeutic levels (Sub-therapeutic: 38.5%; Therapeutic: 61.5%; P-value less than 0.001). Patients with a BMI less than 30 had more sub-therapeutic levels than therapeutic (Sub-therapeutic: 76%; Therapeutic: 24%; P-value less than 0.001). In patients with BMI greater than 35, there were more patients in the sub-therapeutic group (Sub-therapeutic: 83%; Therapeutic: 17%; P-value 0.024). Creatinine was lower in the sub-therapeutic group compared to therapeutic group (Subtherapeutic: 0.66; Therapeutic: 0.73; P-value: 0.003). ROC curve demonstrated 4 gram magnesium bolus with BMI greater than or equal to 30 likely will not reach a therapeutic level (Sensitivity: 0.84, Specificity: 0.51), nor will 6 gram magnesium bolus with BMI greater than or equal to 35 (Sensitivity: 0.74, Specificity: 0.38). CONCLUSION: There is an inverse relationship between BMI and blood magnesium levels. When BMI reaches above 30, patients are more likely to be sub-therapeutic than therapeutic.Read More
Publication Year: 2017
Publication Date: 2017-05-01
Language: en
Type: article
Indexed In: ['crossref']
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