Title: New Hydrazides and Hydrazide‐Hydrazones of 2,3‐Dihalogen Substituted Propionic Acids: Synthesis and <i>in vitro</i> Antimicrobial Activity Evaluation
Abstract: The main aim of this research was the synthesis, spectral identification and in vitro antimicrobial evaluation of new hydrazides and hydrazide‐hydrazones of 2,3‐dihalogen substituted propionic acids. New hydrazides were obtained by the substitution reaction of appropriate ethyl esters of 2,3‐dihalogen substituted propionic acids with hydrazine hydrate. Then obtained hydrazides were subjected to condensation reaction with various aldehydes which yielded with new hydrazide‐hydrazone derivatives. All obtained compounds were identified on the basis of spectral methods ( 1 H‐ NMR , 13 C‐ NMR ) and in vitro screened against a panel of bacterial and fungal strains according to EUCAST and CLSI guidelines.
Publication Year: 2017
Publication Date: 2017-06-26
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 10
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