Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2608647103', 'doi': 'https://doi.org/10.5144/0256-4947.1981.131', 'title': 'Rheumatic Fever and its Cardiac Manifestations in Children: An Update', 'display_name': 'Rheumatic Fever and its Cardiac Manifestations in Children: An Update', 'publication_year': 1981, 'publication_date': '1981-10-01', 'ids': {'openalex': 'https://openalex.org/W2608647103', 'doi': 'https://doi.org/10.5144/0256-4947.1981.131', 'mag': '2608647103'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.5144/0256-4947.1981.131', 'pdf_url': 'http://www.annsaudimed.net/files.php?force&file=PDF/ansmej_01_02_131_842538172.pdf', 'source': {'id': 'https://openalex.org/S61805644', 'display_name': 'Annals of Saudi Medicine', 'issn_l': '0256-4947', 'issn': ['0256-4947', '0975-4466'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319312', 'host_organization_name': 'King Faisal Specialist Hospital and Research Centre', 'host_organization_lineage': ['https://openalex.org/P4310319312'], 'host_organization_lineage_names': ['King Faisal Specialist Hospital and Research Centre'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.annsaudimed.net/files.php?force&file=PDF/ansmej_01_02_131_842538172.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5005486906', 'display_name': 'Mohammed K. Mardini', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800965796', 'display_name': 'King Faisal Specialist Hospital & Research Centre', 'ror': 'https://ror.org/05n0wgt02', 'country_code': 'SA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800965796']}], 'countries': ['SA'], 'is_corresponding': True, 'raw_author_name': 'Mohamed K. Mardini', 'raw_affiliation_strings': ['Pediatric Cardiologist, Department of Pediatrics, King Faisal Specialist Hospital and Research Centre'], 'affiliations': [{'raw_affiliation_string': 'Pediatric Cardiologist, Department of Pediatrics, King Faisal Specialist Hospital and Research Centre', 'institution_ids': ['https://openalex.org/I2800965796']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5005486906'], 'corresponding_institution_ids': ['https://openalex.org/I2800965796'], 'apc_list': {'value': 0, 'currency': 'USD', 'value_usd': 0, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.55164, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 63, 'max': 67}, 'biblio': {'volume': '1', 'issue': '2', 'first_page': '131', 'last_page': '139'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11153', 'display_name': 'Global Burden of Group A Streptococcal Diseases', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11153', 'display_name': 'Global Burden of Group A Streptococcal Diseases', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11078', 'display_name': 'Molecular Mechanisms of Inflammasome Activation and Regulation', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11922', 'display_name': 'Diagnosis and Management of Arrhythmogenic Right Ventricular Cardiomyopathy', 'score': 0.9878, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rheumatic-heart-disease', 'display_name': 'Rheumatic Heart Disease', 'score': 0.532599}, {'id': 'https://openalex.org/keywords/cardiac-remodeling', 'display_name': 'Cardiac Remodeling', 'score': 0.519022}, {'id': 'https://openalex.org/keywords/cardiac-screening', 'display_name': 'Cardiac Screening', 'score': 0.50323}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9626844}, {'id': 'https://openalex.org/C2781236483', 'wikidata': 'https://www.wikidata.org/wiki/Q753904', 'display_name': 'Rheumatic fever', 'level': 2, 'score': 0.43295288}, {'id': 'https://openalex.org/C187212893', 'wikidata': 'https://www.wikidata.org/wiki/Q123028', 'display_name': 'Pediatrics', 'level': 1, 'score': 0.42776227}, {'id': 'https://openalex.org/C2779473830', 'wikidata': 'https://www.wikidata.org/wiki/Q1540899', 'display_name': 'MEDLINE', 'level': 2, 'score': 0.42242554}, {'id': 'https://openalex.org/C177713679', 'wikidata': 'https://www.wikidata.org/wiki/Q679690', 'display_name': 'Intensive care medicine', 'level': 1, 'score': 0.38074166}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2863267}, {'id': 'https://openalex.org/C17744445', 'wikidata': 'https://www.wikidata.org/wiki/Q36442', 'display_name': 'Political science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C199539241', 'wikidata': 'https://www.wikidata.org/wiki/Q7748', 'display_name': 'Law', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.5144/0256-4947.1981.131', 'pdf_url': 'http://www.annsaudimed.net/files.php?force&file=PDF/ansmej_01_02_131_842538172.pdf', 'source': {'id': 'https://openalex.org/S61805644', 'display_name': 'Annals of Saudi Medicine', 'issn_l': '0256-4947', 'issn': ['0256-4947', '0975-4466'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319312', 'host_organization_name': 'King Faisal Specialist Hospital and Research Centre', 'host_organization_lineage': ['https://openalex.org/P4310319312'], 'host_organization_lineage_names': ['King Faisal Specialist Hospital and Research Centre'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.5144/0256-4947.1981.131', 'pdf_url': 'http://www.annsaudimed.net/files.php?force&file=PDF/ansmej_01_02_131_842538172.pdf', 'source': {'id': 'https://openalex.org/S61805644', 'display_name': 'Annals of Saudi Medicine', 'issn_l': '0256-4947', 'issn': ['0256-4947', '0975-4466'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319312', 'host_organization_name': 'King Faisal Specialist Hospital and Research Centre', 'host_organization_lineage': ['https://openalex.org/P4310319312'], 'host_organization_lineage_names': ['King Faisal Specialist Hospital and Research Centre'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.58}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 49, 'referenced_works': ['https://openalex.org/W1562765380', 'https://openalex.org/W1967807363', 'https://openalex.org/W1969700601', 'https://openalex.org/W1971844271', 'https://openalex.org/W1972403632', 'https://openalex.org/W1973621736', 'https://openalex.org/W1979466089', 'https://openalex.org/W1986955981', 'https://openalex.org/W1990659956', 'https://openalex.org/W1991987854', 'https://openalex.org/W1997035616', 'https://openalex.org/W1999189159', 'https://openalex.org/W2001232593', 'https://openalex.org/W2001520813', 'https://openalex.org/W2005700133', 'https://openalex.org/W2010754948', 'https://openalex.org/W2016948860', 'https://openalex.org/W2018409894', 'https://openalex.org/W2021398923', 'https://openalex.org/W2024571200', 'https://openalex.org/W2047057871', 'https://openalex.org/W2061267435', 'https://openalex.org/W2071147137', 'https://openalex.org/W2081629148', 'https://openalex.org/W2090170356', 'https://openalex.org/W2093437803', 'https://openalex.org/W2096645345', 'https://openalex.org/W2097713397', 'https://openalex.org/W2098732003', 'https://openalex.org/W2099614431', 'https://openalex.org/W2101434693', 'https://openalex.org/W2103269964', 'https://openalex.org/W2148364486', 'https://openalex.org/W2156549532', 'https://openalex.org/W2164081159', 'https://openalex.org/W2166707082', 'https://openalex.org/W2208924008', 'https://openalex.org/W2337178040', 'https://openalex.org/W2396051764', 'https://openalex.org/W2405944570', 'https://openalex.org/W2412363148', 'https://openalex.org/W2415255060', 'https://openalex.org/W2415551568', 'https://openalex.org/W2422092458', 'https://openalex.org/W2422219594', 'https://openalex.org/W2460054591', 'https://openalex.org/W2976813566', 'https://openalex.org/W4212903788', 'https://openalex.org/W57823546'], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2748952813', 'https://openalex.org/W2604872355', 'https://openalex.org/W2586801360', 'https://openalex.org/W2080531066', 'https://openalex.org/W1995515455', 'https://openalex.org/W1506200166'], 'abstract_inverted_index': {'Current': [0], 'Concepts': [1], 'in': [2, 9, 63, 156, 158, 210, 226, 239, 246, 254, 265, 271, 285, 308, 340, 343, 349, 366, 378, 470, 509, 543, 556, 673, 723, 763, 782, 810, 848, 907, 951, 958, 974, 979, 1085, 1108, 1137, 1151, 1161, 1221, 1242, 1534, 1574, 1658, 1674, 1756, 1762, 1784, 1790, 1872, 1891, 1897, 1920, 1968, 1992, 2271, 2305, 2375, 2377, 2381, 2404, 2416, 2418, 2427, 2433, 2539, 2555, 2613, 2643, 2839, 2858, 2864, 2900, 2923, 2971, 2979, 2991, 3016, 3046, 3119, 3147, 3237, 3247, 3259, 3273, 3598, 3639, 3792, 3885, 3905, 3913, 4026, 4122, 4149, 4187, 4235, 4371, 4486, 4551, 4582, 4715, 4750, 4767, 4773, 4812, 4828, 4874, 4941, 4968, 4986, 5120, 5148, 5204, 5298, 5336, 5360, 5374, 5426], 'MedicineRheumatic': [3], 'Fever': [4], 'and': [5, 28, 66, 93, 187, 215, 277, 294, 318, 435, 449, 577, 598, 655, 779, 844, 852, 860, 892, 898, 930, 976, 1022, 1062, 1121, 1148, 1165, 1175, 1189, 1319, 1327, 1364, 1446, 1487, 1503, 1514, 1568, 1602, 1613, 1617, 1639, 1652, 1668, 1676, 1725, 1857, 1924, 1985, 2017, 2146, 2163, 2192, 2254, 2279, 2436, 2484, 2495, 2508, 2521, 2571, 2579, 2609, 2617, 2630, 2640, 2660, 2665, 2670, 2693, 2700, 2703, 2716, 2765, 2773, 2927, 3002, 3010, 3023, 3049, 3068, 3082, 3090, 3127, 3133, 3219, 3256, 3346, 3355, 3369, 3381, 3555, 3563, 3573, 3609, 3662, 3706, 3724, 3747, 3768, 3799, 3811, 3816, 3873, 3940, 3953, 3972, 3975, 3981, 3999, 4016, 4037, 4057, 4080, 4142, 4190, 4259, 4285, 4325, 4404, 4433, 4435, 4458, 4465, 4481, 4489, 4509, 4534, 4577, 4687, 4712, 4744, 4777, 4853, 4919, 4937, 4966, 5071, 5080, 5116, 5134, 5150, 5178, 5271, 5436], 'its': [6, 53, 195, 799, 3950, 4002], 'Cardiac': [7, 1006, 2024, 2071], 'Manifestations': [8], 'Children:': [10], 'An': [11], 'Update': [12], 'Mohamed': [13, 16], 'K.': [14, 17], 'MardiniMD': [15], 'Mardini': [18], 'Pediatric': [19], 'Cardiologist,': [20], 'Department': [21], 'of': [22, 76, 98, 109, 115, 118, 130, 138, 152, 166, 173, 206, 235, 306, 316, 333, 353, 388, 401, 427, 452, 458, 483, 495, 498, 527, 536, 580, 585, 614, 617, 676, 692, 700, 711, 730, 736, 766, 785, 834, 836, 863, 883, 895, 904, 910, 938, 954, 963, 983, 991, 1014, 1027, 1040, 1056, 1069, 1080, 1091, 1094, 1101, 1124, 1144, 1157, 1179, 1182, 1206, 1246, 1264, 1269, 1274, 1294, 1299, 1305, 1380, 1395, 1405, 1418, 1424, 1452, 1480, 1553, 1577, 1595, 1609, 1622, 1679, 1690, 1697, 1708, 1720, 1730, 1738, 1780, 1798, 1807, 1823, 1886, 1928, 1941, 1948, 2037, 2046, 2057, 2064, 2084, 2093, 2104, 2111, 2117, 2167, 2196, 2209, 2244, 2263, 2282, 2296, 2301, 2322, 2337, 2343, 2351, 2358, 2371, 2383, 2388, 2400, 2424, 2466, 2481, 2512, 2531, 2557, 2604, 2622, 2657, 2667, 2684, 2705, 2723, 2737, 2751, 2756, 2797, 2813, 2822, 2869, 2881, 2890, 2935, 2939, 2976, 2981, 3000, 3005, 3077, 3099, 3124, 3141, 3153, 3176, 3183, 3199, 3204, 3278, 3286, 3291, 3409, 3442, 3449, 3480, 3510, 3542, 3561, 3590, 3595, 3618, 3620, 3671, 3699, 3729, 3785, 3814, 3848, 3870, 3897, 3928, 3966, 3969, 3977, 3990, 3996, 4001, 4014, 4019, 4059, 4077, 4086, 4102, 4118, 4204, 4219, 4248, 4254, 4276, 4282, 4327, 4339, 4344, 4363, 4368, 4382, 4430, 4437, 4513, 4529, 4549, 4554, 4598, 4601, 4628, 4657, 4673, 4691, 4742, 4794, 4848, 4924, 4958, 4994, 5000, 5012, 5039, 5044, 5069, 5077, 5097, 5174, 5217, 5262, 5274, 5293, 5442], 'Pediatrics,': [23], 'King': [24, 89, 1018, 2033, 2080, 2152, 2181, 5432], 'Faisal': [25, 90, 1019, 2034, 2081, 2153, 2182, 5433], 'Specialist': [26, 91, 1020, 2035, 2082, 2154, 2183, 5434], 'Hospital': [27, 92, 1021, 1150, 1257, 1411, 1477, 2036, 2083, 2155, 2184, 2319, 2475, 3300, 4047, 5435], 'Research': [29, 94, 1023, 5437], 'Centre': [30, 1024], 'Search': [31], 'for': [32, 124, 440, 604, 1170, 1225, 1605, 1746, 2159, 2188, 2242, 2327, 2802, 2809, 2933, 3028, 3062, 3074, 3342, 3352, 3358, 3366, 3372, 3406, 3451, 3477, 3532, 3581, 3625, 3694, 3750, 3762, 3796, 3851, 3856, 3994, 4035, 4056, 4061, 5050, 5181, 5200, 5215, 5241, 5259], 'more': [33, 1103, 2460, 2742, 3234], 'papers': [34], 'by': [35, 626, 1237, 1325, 1474, 1551, 1570, 1648, 2011, 3019, 3268, 3962, 4251, 4962, 5042], 'this': [36, 162, 177, 287, 520, 1092, 1140, 1256, 1376, 1410, 1433, 1659, 2144, 2318, 2474, 2959, 2963, 3017, 3188, 3299, 3330, 3392, 3445, 3566], 'author': [37, 3270, 5414], 'Published': [38, 5399], 'Online::1': [39], 'Oct': [40], '1981https://doi.org/10.5144/0256-4947.1981.131SectionsPDF': [41], 'ToolsAdd': [42], 'to': [43, 185, 222, 267, 290, 347, 363, 385, 412, 424, 561, 567, 634, 639, 659, 670, 740, 750, 926, 933, 997, 1037, 1048, 1052, 1077, 1097, 1217, 1271, 1280, 1309, 1359, 1390, 1398, 1420, 1437, 1441, 1461, 1472, 1516, 1631, 1850, 1915, 2444, 2458, 2585, 2635, 2681, 2710, 2720, 2847, 2906, 2911, 2917, 2942, 3034, 3055, 3096, 3121, 3130, 3150, 3160, 3217, 3399, 3472, 3483, 3493, 3504, 3529, 3534, 3544, 3584, 3614, 3637, 3684, 3737, 3753, 3765, 3773, 3776, 3878, 4378, 4649, 4770, 5024, 5269, 5416], 'favoritesDownload': [44], 'citationTrack': [45], 'citations': [46], 'ShareShare': [47], 'onFacebookTwitterLinked': [48], 'InRedditEmail': [49], 'AboutINTRODUCTIONRheumatic': [50], 'fever': [51, 488, 514, 533, 587, 597, 619, 941, 1034, 1173, 1227, 2645, 2715, 3143, 3628, 3872, 4079, 4141, 4169, 4258, 4480, 4488, 4624, 4827, 5041, 5099, 5115, 5133], 'with': [52, 134, 149, 169, 176, 194, 391, 404, 460, 486, 546, 768, 857, 988, 1011, 1031, 1361, 1370, 1414, 1489, 1501, 1523, 1626, 1694, 1701, 1714, 1727, 1735, 1804, 1826, 1874, 1893, 1912, 1977, 1994, 2040, 2087, 2123, 2171, 2200, 2237, 2258, 2309, 2347, 2367, 2451, 2587, 2615, 2627, 2691, 2786, 2973, 3031, 3038, 3207, 3455, 3464, 3501, 3514, 3600, 3644, 3646, 3701, 3830, 3900, 3949, 4084, 4256, 4287, 4335, 4427, 4651, 4720, 4775, 5339], 'cardiac': [54, 104, 196, 829, 985, 1000, 1195, 1253, 1832, 2048, 2095, 4959], 'involvement': [55, 986, 1001, 1007, 3513], 'remains': [56], 'a': [57, 135, 143, 164, 170, 199, 570, 652, 671, 728, 760, 815, 854, 949, 1066, 1081, 1223, 1292, 1496, 1532, 1691, 1695, 1821, 1913, 2272, 2348, 2413, 2459, 2524, 2529, 2810, 2818, 2840, 2872, 2877, 3104, 3114, 3233, 3378, 3407, 3429, 3478, 3540, 3559, 3631, 3808, 3861, 3880, 4652, 5010, 5239], 'significant': [58, 554, 761, 1754, 1796, 3702], 'public': [59, 3882], 'health': [60, 201, 3883], 'problem': [61, 3380, 3884], 'especially': [62, 1761, 2784], 'developing': [64, 3886, 5121], 'countries': [65, 2438, 3241], 'the': [67, 77, 88, 159, 167, 216, 233, 258, 303, 314, 323, 329, 344, 354, 364, 371, 379, 416, 446, 474, 490, 496, 510, 528, 574, 578, 593, 605, 615, 647, 665, 674, 686, 689, 693, 698, 708, 737, 751, 775, 783, 804, 807, 823, 827, 849, 864, 875, 880, 884, 896, 908, 922, 928, 931, 935, 952, 989, 998, 1003, 1012, 1015, 1017, 1028, 1049, 1057, 1060, 1078, 1086, 1088, 1098, 1109, 1113, 1118, 1142, 1155, 1218, 1231, 1238, 1247, 1275, 1340, 1352, 1378, 1392, 1402, 1406, 1415, 1438, 1444, 1447, 1450, 1453, 1455, 1462, 1469, 1475, 1536, 1541, 1561, 1571, 1575, 1578, 1585, 1593, 1596, 1607, 1610, 1680, 1711, 1721, 1731, 1739, 1750, 1757, 1763, 1768, 1781, 1795, 1799, 1811, 1861, 1864, 1880, 1921, 1939, 1946, 1956, 1973, 1982, 2001, 2051, 2065, 2098, 2112, 2118, 2131, 2137, 2210, 2240, 2245, 2277, 2284, 2291, 2378, 2397, 2419, 2428, 2434, 2441, 2467, 2479, 2486, 2545, 2685, 2738, 2746, 2770, 2779, 2787, 2795, 2798, 2830, 2866, 2888, 2894, 2918, 2992, 3029, 3047, 3097, 3100, 3125, 3131, 3164, 3184, 3205, 3238, 3243, 3248, 3269, 3281, 3304, 3333, 3339, 3383, 3403, 3413, 3415, 3421, 3437, 3440, 3447, 3487, 3588, 3596, 3616, 3621, 3717, 3725, 3730, 3741, 3769, 3790, 3849, 3893, 3898, 3901, 3906, 3914, 3923, 3964, 3988, 3997, 4020, 4027, 4046, 4252, 4340, 4438, 4510, 4552, 4599, 4716, 5013, 5025, 5074, 5179, 5218, 5236, 5243, 5263, 5421, 5427], 'Middle': [68, 217, 368, 3239], 'East.': [69], 'Rheumatic': [70, 609, 5132], 'heart': [71, 82, 111, 208, 237, 283, 300, 335, 420, 582, 610, 720, 788, 900, 912, 956, 965, 1042, 1184, 1191, 1249, 1329, 1341, 1382, 1493, 1507, 1522, 1699, 1759, 1828, 1960, 2059, 2106, 2157, 2186, 2535, 2607, 2677, 2689, 3007, 3179, 3360, 3374, 3518, 3655, 3708, 3719, 3822, 3875, 3945, 4082, 4120, 4144, 4192, 4206, 4364, 4384, 4406, 4491, 4514, 4531, 4555, 4580, 4939, 4988, 5004, 5118, 5136, 5377, 5410], 'disease': [72, 209, 238, 284, 301, 336, 417, 491, 611, 957, 966, 1192, 1276, 1342, 1616, 1643, 1681, 1700, 1829, 2060, 2107, 2126, 2312, 2536, 2678, 3033, 3126, 3361, 3375, 3876, 3998, 4021, 4083, 4145, 4581, 4940, 5011, 5119, 5297], 'is': [73, 142, 180, 198, 476, 521, 588, 612, 705, 748, 753, 774, 970, 1106, 1117, 1129, 1136, 1215, 1434, 1498, 1814, 1906, 1932, 1936, 1952, 1972, 2000, 2009, 2269, 2315, 2355, 2362, 2393, 2455, 2679, 2783, 2832, 2845, 2852, 2861, 2875, 2944, 3026, 3071, 3137, 3232, 3331, 3377, 3570, 3575, 3629, 3635, 3721, 3727, 3787, 3825, 3955, 4007, 4011, 5009], 'considered': [74, 2680], 'one': [75, 411, 479, 613, 2506, 2556, 2683, 2946, 3736, 3752], 'few,': [78], 'eminently': [79], 'fatal,': [80], 'acquired': [81, 955, 1190, 2687, 4578], 'diseases': [83, 2450, 2690, 4121], 'that': [84, 328, 646, 688, 719, 747, 1234, 1432, 1644, 1810, 1935, 2265, 2287, 2695, 2924, 2987, 3903, 4006, 5002], 'can': [85, 791, 2696, 3043, 3171, 3319, 3959], 'be': [86, 361, 433, 507, 516, 792, 927, 934, 995, 1046, 1075, 2682, 2697, 2827, 2836, 2885, 2904, 2931, 2969, 2996, 3060, 3093, 3111, 3320, 3397, 3424, 3434, 3579, 3711, 3846, 3879, 3921, 3960, 3984, 4170], 'prevented.At': [87], 'Centre,': [95], '30': [96, 373, 386, 493, 1552, 2062, 2109, 3494], 'percent': [97, 114, 151, 387, 414, 426, 457, 973, 978, 1245, 1298, 1917, 1954, 1979, 2063, 2110, 2360, 2370, 2399, 2722, 3203, 3277], '296': [99], 'pediatric': [100, 1482, 1555, 1846, 1862, 1899, 1986, 2047, 2067, 2094, 2114, 2121, 2169, 2198, 2307, 2560, 2624], 'patients': [101, 117, 485, 529, 545, 558, 725, 767, 913, 1029, 1193, 1250, 1301, 1333, 1383, 1407, 1483, 1625, 1825, 1847, 1971, 2039, 2086, 2122, 2170, 2199, 2213, 2229, 2249, 2264, 2308, 2321, 2339, 2382, 2469, 2625, 2725, 2907, 2957, 2972, 3148, 3185, 3206, 3279, 3296, 3325, 3551, 3643, 3742, 3843, 3929, 4255, 4286, 4996, 5100, 5338], 'who': [102, 121, 530, 1251, 1830, 2470, 2908, 3186, 3301, 3552], 'underwent': [103, 122, 1194, 1252, 1831, 2127, 2325, 2471, 2517], 'catheterization': [105, 1196, 1254, 1833, 2025, 2072], 'had': [106, 1035, 1208, 1267, 1286, 1302, 2216, 2485, 2728, 3284, 3309], 'advanced': [107, 1491, 3798, 3943], 'forms': [108, 1039], 'rheumatic': [110, 207, 236, 282, 299, 334, 467, 487, 513, 532, 547, 581, 586, 596, 618, 640, 678, 712, 724, 770, 787, 828, 911, 940, 964, 1033, 1041, 1172, 1183, 1209, 1226, 1248, 1289, 1381, 1492, 1611, 1628, 1638, 1698, 1827, 1959, 2005, 2041, 2058, 2088, 2105, 2124, 2172, 2201, 2310, 2566, 2628, 2644, 2714, 2724, 2870, 3006, 3107, 3142, 3178, 3287, 3295, 3359, 3373, 3453, 3627, 3871, 3874, 3978, 4078, 4081, 4104, 4119, 4143, 4168, 4191, 4205, 4220, 4236, 4257, 4289, 4375, 4383, 4487, 4490, 4607, 4674, 4692, 4722, 4776, 4858, 4876, 4938, 4969, 5003, 5040, 5098, 5117, 5135, 5175, 5201, 5294, 5340, 5376], 'disease.': [112, 789, 2620, 3008, 4989, 5137, 5378], 'Forty-three': [113], '58': [116, 2320, 2338], 'all': [119, 484, 2283, 2323, 2955, 3556], 'ages': [120, 315, 2324], 'surgery': [123, 1745, 2129, 2158, 2187, 2219, 2326, 2499, 3076, 3806, 3858, 4060, 5216], 'open': [125, 2156, 2185, 2590], 'commissurotomy': [126, 2329, 2472], 'were': [127, 1258, 1845, 1879, 2340, 3302, 3553], '20': [128, 384, 544, 977, 2341, 2386, 3161, 3492], 'years': [129, 1263, 1282, 1707, 2342, 2387, 2483, 2511, 3152, 3162, 3221, 3411, 4999], 'age': [131, 137, 1854, 1900, 2344, 2350, 2430, 2480, 2490, 3154, 3441, 3908, 5001], 'or': [132, 798, 1059, 1096, 1354, 1426, 1591, 1871, 1890, 1991, 2238, 2345, 2454, 2730, 2791, 2898, 3085, 3386, 3456, 3463, 3507, 3515, 3527, 3647, 3831], 'younger': [133, 2429, 3907], 'mean': [136, 1853, 2349], '15': [139, 1903, 2352, 3276, 3535], 'years.': [140, 320, 2353, 2492], 'This': [141, 1044, 1529, 1905, 2008, 2354, 2390, 2596, 2782, 3733, 3917, 3947], 'strikingly': [144], 'high': [145, 1909, 2261, 2294, 2364, 3868, 3951], 'incidence': [146, 234, 259, 475, 1219, 1885, 1918, 1927, 1940, 1947, 2295, 2357, 2666, 2938, 3869], 'when': [147, 2365, 3568], 'compared': [148, 560, 1630, 1911, 2366], '1.3': [150, 251, 2369], '1000': [153, 225, 245, 253, 264, 270, 280, 2372], 'commissurotomies': [154, 2373, 2402], 'reported': [155, 327, 921, 1220, 2374, 2403, 2922], '1956': [157, 2376], 'United': [160, 309, 345, 380, 428, 1922, 2379], 'States.1In': [161], 'article,': [163], 'review': [165], 'subject,': [168], 'short': [171, 1067], 'discussion': [172], 'our': [174, 1481, 1898, 1969, 2306, 2558, 2623], 'experience': [175], 'disabling': [178], 'disease,': [179, 549, 1058, 1211, 1454, 1513, 2174, 2203, 2275, 3180, 3705, 3899, 3918, 3948, 5005], 'presented': [181, 2584, 2626], 'giving': [182], 'special': [183], 'emphasis': [184], 'treatment': [186, 1120, 1362, 1464, 2704, 2806, 2849, 2860, 2934, 3404, 3448, 3693, 3782, 3968, 3976, 5043], 'long-term': [188, 1393, 1421, 2280, 2599, 3115, 3812, 3991], 'prophylaxis.PREVALENCE,': [189], 'MORBIDITY,': [190], 'AND': [191], 'MORTALITYRheumatic': [192], 'fever,': [193, 1315, 3108, 3454], 'manifestations,': [197], 'world-wide': [200], 'problem.': [202], 'The': [203, 357, 481, 734, 755, 902, 960, 1071, 1788, 1884, 1926, 1962, 2293, 2422, 2663, 3088, 3592, 4030, 4671], 'prevalence': [204, 1079], 'rates': [205, 962], 'South': [211], 'America,': [212], 'Africa,': [213], 'Asia,': [214], 'East': [218], 'are': [219, 565, 656, 846, 1484, 1655, 2288, 2447, 2800, 2909, 3326, 3611, 3657, 3669, 3675, 3681, 3743, 3760, 4043], 'about': [220, 525, 764, 971, 1449, 2945, 3275], '22': [221], '33': [223], 'per': [224, 244, 252, 263, 269, 279, 351, 2947, 3475, 3523, 3525], 'urban': [227], 'slum': [228], 'school': [229, 247, 311, 389, 430, 3774], 'children.': [230], 'In': [231, 256, 273, 321, 445, 1559, 1860, 1944, 1981, 3193, 3264, 3391, 3496, 3565, 3888], '1974,': [232], 'Japan': [240], 'was': [241, 288, 302, 541, 552, 1235, 1565, 1589, 1820, 1902, 2054, 2061, 2101, 2108, 2476, 2500, 2553], 'approximately': [242, 492], '0.1': [243], 'children,': [248, 2505], 'dropping': [249], 'from': [250, 261, 338, 383, 1197, 1377, 1834, 2026, 2073, 2330, 3214, 3412, 3789, 4045, 4152, 4331, 4374, 4991, 5420], '1962.2': [255], 'Sweden,': [257], 'dropped': [260], '0.25': [262], '1930': [266], '0.025': [268], '1964.3': [272], 'India,': [274], 'between': [275, 313, 573, 595, 1637, 2133, 4401, 4461, 4506], '1.5': [276], '39': [278], 'suffered': [281], '1976;': [286], 'attributed': [289, 1076], 'low,': [291], 'socioeconomic': [292, 1089, 3262], 'overcrowding': [293], 'poor': [295, 2610], 'sanitary': [296], 'conditions.In': [297], '1940,': [298], 'leading': [304], 'cause': [305, 929, 3050], 'death': [307], 'States': [310, 429, 1923, 2380], 'children': [312, 390, 403, 431, 1259, 2417, 4774], '5': [317], '19': [319, 1978], '1971,': [322], 'World': [324, 4792], 'Health': [325], 'Organization': [326], 'crude': [330], 'mortality': [331, 2694], 'rate': [332, 1671, 3813], 'varied': [337], '1.6': [339], 'Switzerland,': [341], '8.0': [342], 'States,': [346, 381], '27.5': [348], 'Egypt,': [350], '100,000': [352], 'general': [355, 447, 1371], 'population.2': [356], 'higher': [358], 'figures': [359], 'might': [360], 'applicable': [362, 1657], 'populations': [365], 'most': [367, 776, 1026, 1114, 1881, 1957, 1964, 2002, 3894], 'Eastern': [369, 2435, 3240], 'countries.EPIDEMIOLOGYFor': [370], 'past': [372, 606], 'years,': [374], 'during': [375, 450, 707, 1002, 1351, 2050, 2097, 2130, 2564, 4856], 'any': [376, 3508], 'winter': [377], 'cultures': [382, 439], 'severe': [392, 1038, 1054, 1805, 2605, 3505, 3895], 'sore': [393, 1306], 'throat': [394, 438, 500, 538, 1307, 2707, 2732, 2771, 2895], 'would': [395, 418, 465, 515, 2439, 2995], 'grow': [396], 'beta': [397], 'hemolytic': [398, 441, 4087], 'streptococcus.': [399], 'However,': [400, 469, 1661, 2744, 2838], 'those': [402, 557, 1207], 'positive': [405, 437, 1303, 2801], 'group': [406, 443, 461, 636, 944, 1093, 1654, 1901, 2431, 3909, 4332, 4574, 5404], 'A': [407, 462, 637, 2514, 2854, 4333, 4423, 4610, 4878, 5319], 'streptococcus': [408, 638, 4507], '(GrAS),': [409], 'only': [410, 455, 2368, 2634], 'three': [413, 456, 795, 1281, 1397, 1916, 3484, 3550, 3557, 3585, 3766, 3777], 'contracting': [415], 'develop': [419, 531, 622, 3942], 'involvement.3,5': [421], 'Thus,': [422], '8': [423], '32': [425, 1212], 'could': [432, 506, 661, 802, 820, 870, 994, 1045, 1074, 3920], 'carriers': [434], 'have': [436, 534, 631, 1159, 1374, 1682, 2646, 2672, 2727, 2769, 3144, 3548, 3690, 3859, 3937], 'strep': [442, 453, 2915, 2936, 4307], 'A.2': [444], 'population,': [448], 'epidemics': [451], 'infection,': [454], 'individuals': [459], 'streptococcal': [463, 499, 504, 741, 4261, 4402, 4424, 4439, 4462, 4482, 4602, 4658, 4771, 5045, 5078], 'pharyngitis': [464, 869, 969, 3971], 'contract': [466], 'fever.': [468, 641, 3288, 3979, 4675], 'an': [471, 1520, 1907, 2356, 4992], 'endemic': [472], 'situation,': [473, 3567], 'less': [477, 1260, 1937, 2346, 2384, 2395], 'than': [478, 1105, 1261, 1938, 2385, 2396, 3242], 'percent.6': [480], 'majority': [482, 1479, 3927], 'developed': [489, 3190], 'days': [494, 2815, 3216, 3308], 'date': [497], 'infection': [501, 505, 2708, 2760, 4483], 'onset.': [502], 'If': [503, 2794, 2829], 'recognized': [508, 603], 'early': [511, 2701, 3640, 3973], 'stage,': [512], 'virtually': [517], 'eliminated.': [518], 'Unfortunately,': [519, 2718], 'very': [522, 1082, 2788, 3797], 'difficult': [523, 3636], 'because': [524, 2603, 3139], 'half': [526], 'histories': [535, 1268, 1304, 1379], 'asymptomatic': [537, 2731], 'infection.HLA': [539], 'antigen': [540, 856], 'studied': [542], 'valvular': [548, 2641, 4579, 4987], 'but': [550, 3181, 3460, 3650, 3863], 'there': [551, 1819, 2446], 'no': [553, 2914, 3461, 3820, 3910], 'difference': [555], 'as': [559, 744, 814, 840, 877, 879, 1367, 1369, 1466, 1468, 2443, 2528, 2552, 2650, 2762, 3155, 3157, 3321, 3323, 3499, 3606, 3667, 4039], 'controls.7': [562], 'Further': [563], 'studies': [564, 4362], 'needed': [566], 'see': [568], 'if': [569, 1127, 2913], 'correlation': [571], 'exists': [572], 'HLA': [575], 'inheritance': [576], 'occurrence': [579, 2423], 'disease.7PATHOGENESISThe': [583], 'pathogenesis': [584, 784], 'not': [589, 657, 1335, 1656, 2862, 2930, 3332, 3433, 3682, 3931], 'well': [590, 602, 878, 1368, 1413, 1467, 2648, 3156], 'understood;': [591], 'however,': [592, 2392], 'association': [594, 1873, 1892, 1993, 2614, 3599], 'GrAS': [599, 627, 850, 868, 891, 932, 968, 1084, 2706, 2977, 3970, 4004], 'has': [600, 643, 682, 715, 726, 914, 1645, 2410, 2748, 2920, 3013, 3468, 3807], 'been': [601, 632, 644, 683, 716, 727, 915, 1646, 1683, 2412, 2647, 2674, 2921, 3014, 3145, 3469, 3691, 3860], '100': [607], 'years.8': [608], 'manifestations': [616, 2750], 'which': [620, 650, 696, 993, 1214, 1535, 2361, 2632, 2734, 3634, 4022], 'cannot': [621], 'without': [623, 2239, 2754, 2893, 3457, 3516, 3648, 3697, 3783, 3832, 4625], 'being': [624, 3224], 'preceded': [625], 'pharyngitis.': [628], 'Several': [629], 'hypotheses': [630], 'proposed': [633], 'relate': [635], 'It': [642, 714, 790, 2542, 3070, 3250], 'speculated': [645], 'L-forms': [648], 'strep,': [649], 'lack': [651], 'cell': [653, 666, 2652, 4963], 'wall': [654, 851, 4748], 'susceptible': [658], 'penicillin,': [660, 1425, 2912, 3201, 3226], 'perhaps': [662], 'remain': [663], 'within': [664, 1065, 1277, 2523], 'then,': [667, 2522], 'later,': [668], 'revert': [669], 'pathogen': [672], 'development': [675, 953, 1169, 4000], 'acute': [677, 709, 769, 786, 939, 1032, 1171, 1627, 1675, 2565, 3208, 3452, 3458, 3626, 4103, 4260, 4288, 4721, 4857, 4875, 4900, 5375], 'fever.9': [679], 'Another': [680, 2621], 'hypothesis': [681, 735, 781], 'based': [684], 'on': [685, 2165, 2194, 2290, 2502, 2954, 3113, 3402, 3712, 3837, 4279, 4606, 5073, 5235], 'observation': [687], 'serum': [690, 909, 3488, 4253], 'level': [691, 3490], 'antistreptolysin': [694, 757, 1662], 'S,': [695, 4708, 4868, 5332], 'inhibits': [697], 'activity': [699], 'toxic': [701, 749, 800, 3731], 'streptolysin': [702, 731, 745, 4249, 4277], 'S': [703, 732, 4233, 4250, 4278], 'substance,': [704], 'decreased': [706], 'attacks': [710, 1064, 1273, 1704, 3175], 'fever.10-12': [713], 'assumed,': [717], 'therefore,': [718, 3919], 'damage': [721, 3129], 'seen': [722, 1107, 1313, 1919, 2432, 2464, 2554, 3297, 3912], 'result': [729, 2530], 'accumulation.': [733], 'hypersensitivity': [738], 'reaction': [739], 'antigens,': [742], 'such': [743, 837, 2761, 3498, 3605], 'O,': [746, 758], 'myocardium,': [752], 'another.': [754], 'antibody,': [756], 'shows': [759], 'increase': [762, 1573], 'three-quarters': [765], 'attack.': [771, 1005, 1310], 'Autoimmune': [772], 'mechanism': [773], 'recent,': [777], 'attractive,': [778], 'acceptable': [780, 3235], 'divided': [793], 'into': [794, 2655], 'categories.The': [796], 'streptococcus,': [797], 'products,': [801], 'injure': [803], 'myocardial': [805, 824, 858, 2611], 'cells;': [806], 'injured': [808], 'cells,': [809, 2658], 'turn,': [811], 'may': [812, 1008, 2537, 2543, 2726, 2961, 2968, 2988, 3734, 3771, 4023], 'act': [813], 'foreign': [816], 'antigen.': [817], 'Its': [818], 'antibody': [819, 888, 4432, 4768], 'then': [821], 'attack': [822, 2740, 2868], 'fibers': [825], 'causing': [826, 1718, 2548, 4899], 'involvement.A': [830], 'limited': [831, 3659], 'number,': [832], '11': [833], '70,': [835], 'M-protein': [838, 2462], 'serotypes': [839], 'C51,': [841], '27,': [842], 'M11,': [843], 'M6': [845], 'present': [847, 2538], 'share': [853], 'common': [855, 2414, 5270], 'sarcolemma': [859], 'smooth': [861, 881], 'muscle': [862, 882, 4960], 'blood': [865, 885, 3254], 'vessels.13–16': [866], 'Therefore,': [867], 'produce': [871], 'cross-reactive': [872, 4426], 'antibodies': [873, 906, 4485], 'against': [874, 890, 2985, 4167], 'myocardium': [876, 3132], 'vessels.17–19Goldstein': [886], 'demonstrated': [887, 1550], 'cross-reactivity': [889], 'structural': [893, 4511], 'glycoprotein': [894], 'human': [897, 4405], 'oxen': [899], 'valves.': [901, 2247, 3134], 'presence': [903], 'these': [905, 1300, 1332], 'documented.20G.': [916], 'E.': [917, 3020], 'Burch,': [918], 'et': [919, 4184, 4230, 4272, 4322, 4396, 4502, 4571, 4644, 4709, 4738, 4764, 4808, 4844, 4895, 5066, 5169, 5196, 5290, 5313, 5333, 5356], 'al.': [920], 'coxsackie': [923], 'B-4': [924], 'virus': [925, 4576], 'conditioning': [936], 'agent': [937], 'development.21,22': [942], 'Other': [943, 1311, 2574], 'B': [945, 4575], 'viruses': [946, 4550], 'also': [947, 1599, 2673, 3072, 3845], 'play': [948], 'role': [950, 4548], 'children.23': [959], 'recurrence': [961, 1013, 1073, 3123], 'after': [967, 1401, 3173, 3222, 3587, 3779, 3840], '50': [972, 2721], 'C51': [975], 'serotype': [980, 2463], '17.24': [981], 'Risk': [982], 'further': [984, 3128], 'increases': [987], 'number': [990, 2045, 2092, 2262], 'attacks,': [992], 'due': [996, 1047], 'subclinical': [999, 2729, 3177], 'first': [1004, 1403, 2867, 3223], 'become': [1009, 2989, 4024], 'obvious': [1010], 'disease.25EXPERIENCEAt': [1016], '(KFSH),': [1025], 'admitted': [1030, 1500], 'moderate': [1036, 3503], 'involvement.': [1043, 3946], 'late': [1050], 'referral': [1051], 'specialist,': [1053], 'form': [1055, 3896], 'frequent': [1061, 1072, 1702, 1882], 'recurrent': [1063, 1703, 2974, 3174], 'period': [1068, 1293, 2053, 2100, 2132, 2812, 3479, 3541], 'time.': [1070, 2781], 'virulent': [1083, 2461], 'country,': [1087], 'status': [1090], 'people,': [1095], 'social': [1099], 'custom': [1100], 'gathering': [1102], 'frequently': [1104, 1965, 2003], 'Western': [1110, 2420, 3915], 'world.': [1111, 2421, 3916], 'Perhaps': [1112], 'likely': [1115], 'reason': [1116], 'inappropriate': [1119], 'inadequate': [1122], 'use': [1123, 1394], 'penicillin': [1125, 1365, 2776, 2805, 2825, 2834, 2883, 2943, 2950, 2982, 3116, 3312, 3344, 3347, 3353, 3356, 3367, 3370, 3838, 3992, 5070], 'prophylaxis,': [1126], 'it': [1128, 2456, 2844, 3431], 'used': [1130, 1230, 1600, 2932], 'at': [1131, 1154, 1203, 1255, 1409, 2032, 2079, 2143, 2473, 2478, 2489, 2778, 2887, 2958, 3298, 3428, 3491, 4041, 4984, 5006, 5431], 'all.ResearchA': [1132], 'collaborative': [1133], 'research': [1134], 'project': [1135], 'progress': [1138], 'involving': [1139], 'Hospital,': [1141, 2960, 3446], 'University': [1143, 1156], 'Tennessee,': [1145], 'Riyadh': [1146], 'University,': [1147], "Children's": [1149], 'Riyadh.': [1152], 'Scientists': [1153], 'Tennessee': [1158], 'succeeded': [1160], 'purifying': [1162], 'M': [1163, 4328, 4347, 4463, 4659], 'protein': [1164, 1666, 4329, 4464], 'making': [1166], 'possible': [1167, 1177], 'vaccine': [1168], 'prevention': [1174, 2736, 3001, 3995, 4015], 'thus,': [1176], 'eradication': [1178, 3004, 4018], 'new': [1180, 2956], 'cases': [1181, 3497], "disease.13'26Two": [1185], 'hundred': [1186], 'ninety-six': [1187], 'congenital': [1188], 'August': [1198], '1976': [1199, 1836, 2028, 2075], 'through': [1200, 1837, 2029, 2076, 2177, 2206, 2333], 'December': [1201, 1838, 2030, 2077], '1979': [1202], 'KFSH.': [1204, 1387], 'Seventy-eight': [1205], 'valve': [1210, 1615, 1642, 1748, 1895, 1996, 2006, 2042, 2089, 2125, 2160, 2173, 2189, 2202, 2218, 2226, 2235, 2256, 2267, 2298, 2311, 2497, 2519, 2619, 3032, 3512, 3704, 3823, 3833, 3857, 4694, 4713, 4780, 5296, 5406, 5408], 'percent,': [1213, 1934], 'similar': [1216], 'India.4As': [1222], 'guideline': [1224], 'diagnosis,': [1228, 2891], 'we': [1229, 3891], 'Jones': [1232, 4669], 'criteria': [1233], 'modified': [1236], 'American': [1239, 3101, 4031], 'Heart': [1240, 3102, 4032, 4108, 4210, 4817, 4832, 4883, 4927, 5146, 5185, 5423], 'Association': [1241, 4033], '1955.27': [1243], 'Thirty': [1244], '16': [1262, 1851], 'age.': [1265, 1709, 2513], 'Most': [1266], 'two': [1270, 1914, 2448, 2503, 3290, 3521, 3695, 3738, 3754, 3764, 3775], 'six': [1272, 1278, 1399, 3481, 3545, 3582], 'months': [1279, 1400, 3586], 'before': [1283, 3436], 'admission;': [1284], 'some': [1285, 2711], 'apparent,': [1287], 'continuous': [1288], 'activities': [1290, 3619, 3661, 3687, 3746, 3759], 'over': [1291, 3539, 4997], 'months.': [1295], 'Only': [1296, 3289], '40': [1297, 2719, 3528], 'prior': [1308], 'symptoms': [1312], 'included': [1314], 'migratory': [1316], 'joint': [1317, 3672], 'pain': [1318, 1322], 'swelling,': [1320], 'chest': [1321, 1751], 'usually': [1323], 'followed': [1324, 1408, 2010, 4961], 'dyspnea,': [1326], 'congestive': [1328, 1506, 2606, 3517, 3654, 3707, 3718], 'failure.': [1330], 'Generally,': [1331], 'do': [1334, 1347, 3930], 'seek': [1336, 1348, 3932], 'medical': [1337, 3781, 3933], 'help': [1338, 3934], 'until': [1339, 2850, 3688, 3716, 3935], 'becomes': [1343], 'incapacitating.': [1344], 'When': [1345], 'they': [1346, 1357, 3668, 3674, 3689, 3936], 'help,': [1349], 'often': [1350, 3327, 3382], 'second': [1353, 1963], 'third': [1355], 'attack,': [1356], 'fail': [1358], 'comply': [1360, 1412], 'regimen': [1363, 3118], 'prophylaxis': [1366, 1396, 3054, 3117, 3136, 3189, 3314, 3422, 3839, 3993, 4166], 'instructions.': [1372], 'We': [1373, 1430, 1598, 3547], 'noted': [1375, 3146], 'initially': [1384], 'treated': [1385], 'outside': [1386], 'They': [1388, 3680], 'tend': [1389], 'drop': [1391], 'attack.Most': [1404], 'full': [1416, 3686], 'course': [1417, 5076], 'treatment,': [1419], 'IM': [1422, 2820, 2879, 3197, 3228], 'injections': [1423, 3198, 3283, 3305, 3345, 3354, 3368], 'other': [1427, 1894, 1995, 2246], 'prophylactic': [1428, 3389], 'measures.': [1429], 'feel': [1431], 'directly': [1435], 'related': [1436, 2457], 'time': [1439, 2889, 3414, 5240], 'taken': [1440], 'instruct,': [1442], 'properly,': [1443], 'patient': [1445, 1497, 1783, 1789, 2516, 2597, 2747, 3030, 3105, 3384, 3438, 3597, 3726, 3770, 4719], 'family': [1448], 'gravity': [1451], 'improved': [1456, 3601], 'prognosis': [1457, 5096], 'following': [1458, 3163, 3195], 'strict': [1459, 3713], 'adherence': [1460], 'established': [1463], 'regimen,': [1465], 'interest': [1470], 'showed': [1471, 1753], 'him': [1473, 3401], 'entire': [1476], 'staff.The': [1478], 'chronically': [1485], 'ill': [1486, 1624, 4718], 'emaciated': [1488], 'significantly': [1490, 2363], 'damage.': [1494], 'Such': [1495], 'generally': [1499], 'severe,': [1502, 2532], 'sometimes': [1504, 1530], 'intractable,': [1505], 'failure,': [1508, 3519, 3656], 'respiratory': [1509, 2759, 4604], 'difficulties,': [1510], 'chronic': [1511, 2688], 'liver': [1512], 'failure': [1515, 2608, 3709, 3720], 'thrive.': [1517], 'X-rays': [1518], 'show': [1519], 'enlarged': [1521, 1537], 'cardio-thoracic': [1524], 'ratio': [1525], 'exceeding': [1526], '65': [1527], 'percent.': [1528, 1904], 'indicates': [1531], 'situation': [1533], 'left': [1538, 1579, 1586, 1619, 1716, 1722, 1764, 1800, 4746], 'atrium': [1539, 1717], 'compresses': [1540], 'right,': [1542, 1547], 'main-stem': [1543, 1563, 1723, 1733, 1771], 'bronchus': [1544, 1564, 1724, 1734], 'producing': [1545], 'partial': [1546, 1728, 1736], 'middle-lobe': [1548], 'collapse,': [1549], '78': [1554, 1844, 2119, 2168, 2197, 2559, 3292], 'patients.': [1556], 'Figure': [1557], '1.': [1558, 1686, 1841, 2023, 2070], 'addition,': [1560, 3194], 'left,': [1562], 'displaced': [1566], 'posteriorly': [1567], 'upwardly': [1569], 'tremendous': [1572], 'size': [1576, 1760], 'atrial': [1580, 1587, 1765, 1801], 'cavity.': [1581], 'On': [1582], 'M-mode': [1583, 1603], 'echocardiogram,': [1584], 'diameter': [1588, 1594], 'twice,': [1590], 'more,': [1592], 'aorta.': [1597], 'cross-sectional': [1601, 4688], 'echocardiography': [1604], 'evaluating': [1606, 1618], 'severity': [1608], 'mitral': [1612, 1641, 1747, 1808, 1865, 1887, 1942, 1949, 1974, 1988, 2013, 2255, 2297, 2408, 2425, 2494, 2518, 2616, 3166, 3169, 3191, 3209, 3466, 3506, 4062, 4693, 4779, 4790, 5014, 5219, 5237, 5264, 5275, 5341], 'aortic': [1614, 1812, 1875, 1929, 2019, 2253, 2496, 2618, 3511, 5176, 5202], 'ventricular': [1620, 1777, 4747], 'performance': [1621], 'critically': [1623, 4717], 'carditis': [1629, 2629, 3459, 3500, 3649, 4898], 'normal': [1632, 1769, 4283, 4751], 'subjects.28–30': [1633], 'Serologic': [1634], 'tests': [1635, 1673], 'differentiating': [1636], 'non-rheumatic': [1640, 4778], 'described': [1647, 2649], 'S.': [1649, 5310], 'T.': [1650], 'Shulman': [1651, 4758], 'his': [1653, 3024], 'Hospital.31': [1660], 'titer': [1663], '(ASO),': [1664], 'C-reactive': [1665], '(CRP),': [1667], 'erythrocyte': [1669], 'sedimentation': [1670], '(ESR)': [1672], 'follow-up': [1677], 'states': [1678], 'helpful': [1684, 2970, 3612], 'measures.Figure': [1685], 'A.': [1687, 1775], 'Chest': [1688, 4754], 'x-ray': [1689, 1752], 'nine-year-old': [1692], 'child': [1693], 'history': [1696, 5173], 'since': [1705], 'four': [1706, 3215, 3543], 'Note': [1710, 1767], 'marked': [1712], 'cardiomegaly': [1713, 3462, 3652], 'huge': [1715], 'shelfing': [1719], 'elevation': [1726], 'compression': [1729], 'right': [1732, 1740, 1770], 'atelectasis': [1737], 'middle': [1741], 'lobe.': [1742], 'B.': [1743, 1787], 'Following': [1744], 'replacement,': [1749, 3834], 'decrease': [1755, 2962], 'total': [1758, 1822, 2066, 2113, 2811], 'size.': [1766], 'bronchus.Download': [1772], 'FigureFigure': [1773], '2.': [1774, 2151, 2180], 'Left': [1776], '(LV)': [1778], 'cineangiogram': [1779], 'same': [1782, 2052, 2099, 2780], 'systole': [1785], '(LVS).': [1786], 'diastole': [1791], '(LVd).': [1792], 'These': [1793, 3842], 'demonstrate': [1794], 'degree': [1797, 1806, 3509], '(LA)': [1802], 'enlargement': [1803], 'regurgitation.Note': [1809], 'route': [1813], 'faintly': [1815], 'delineated.Download': [1816], 'FigureAt': [1817], 'KFSH,': [1818], '281': [1824, 2038, 2085], 'February': [1835, 2027, 2074], '1979.': [1839], 'Table': [1840, 2149, 3336], 'Of': [1842], 'those,': [1843], '(range': [1848], '6': [1849], 'years;': [1852], '12': [1855, 2221], 'years)': [1856], '203': [1858], 'adults.': [1859], 'patients,': [1863, 1987, 2561, 3829], 'regurgitation': [1866, 1876, 1930, 1975, 2014, 2020, 3210, 5177], 'lesion': [1867, 1951, 1967, 1976, 2415], 'alone': [1868, 1889, 1990], '(33': [1869], 'percent)': [1870, 1878, 1999, 2016, 2215, 2223, 2231, 2251, 3294], '(14': [1877], 'lesions.': [1883], 'stenosis': [1888, 1950, 1989, 2409, 2426, 3170], 'lesions': [1896, 1931, 1997], 'extremely': [1908], 'figure': [1910], 'Norway.32': [1925], 'ten': [1933, 2510, 2814], 'stenosis.': [1943, 4791], 'adults,': [1945], '26': [1953], 'constituting': [1955], 'prevalent': [1958], 'lesion.': [1961, 2007], 'occurring': [1966, 2004], 'adult': [1970, 1984], 'incidence.': [1980], '282': [1983], '(32': [1998], 'isolated': [2012, 2018], '(23': [2015], '(15': [2021], 'percent).Table': [2022], '1978': [2031, 2078, 2135, 2176, 2205, 2332, 5158], 'diseases.': [2043, 2090], 'Total': [2044, 2091], 'catheterizations': [2049, 2096], '296.': [2055, 2102], '(Incidence': [2056, 2103], 'catheterized': [2068, 2115, 2120], 'patients.)Table': [2069], 'patients.)Sixty-one': [2116], 'open-heart': [2128, 2328], 'May': [2134, 2175, 2204, 2331], '(when': [2136], 'Baylor': [2138, 5422], 'Open-Heart': [2139, 5428], 'Surgery': [2140, 5429], 'Program': [2141, 5430], 'began': [2142], 'Hospital)': [2145], 'January': [2147, 2178, 2207, 2334], '1980.': [2148, 2335], '2.Table': [2150], 'anuloplasty,': [2161, 2190], 'commissurotomy,': [2162, 2191], 'replacement': [2164, 2193, 2236, 2257, 2268, 2498, 2527, 4714, 5199, 5261, 5359, 5373], '61': [2166, 2195, 2211, 2302], '1980Table': [2179], '1980Forty-nine': [2208], 'surgical': [2212, 3828, 5260], '(80': [2214], 'single': [2217, 2234, 2819, 2878], 'whereas': [2220], '(20': [2222], 'required': [2224, 2232, 2252, 2266, 2598, 3558], 'multiple': [2225], 'surgery.': [2227, 3087, 3841], 'Thirty-seven': [2228], '(60': [2230], 'prosthetic': [2233, 2259], 'need': [2241, 3850], 'repair': [2243, 2520], 'Three': [2248], '(5': [2250], 'valves.The': [2260], 'discouraging,': [2270], 'potentially': [2273], 'preventable': [2274], 'considering': [2276], 'short-': [2278, 3810], 'complications': [2281, 3902], 'artificial': [2285], 'valves': [2286], 'available': [2289, 2990, 4025, 4044], 'market.': [2292], 'stenosis,': [2299], '13': [2300], '(21': [2303], 'percent),': [2304], 'requiring': [2313], 'commissurotomies,': [2314], 'striking.': [2316], 'At': [2317], 'Twenty-five': [2336], '43': [2359], 'age.1': [2389], 'figure,': [2391], 'even': [2394, 2892], '34': [2398], '373': [2401], 'Southern': [2405], 'India.33': [2406], 'Tight': [2407], 'never': [2411], 'tropical': [2437], 'pose': [2440], 'question': [2442], 'whether': [2445], 'different': [2449, 2452], 'etiologies,': [2453], 'here?One': [2465], 'youngest': [2468], 'diagnosed': [2477], 'eight': [2482, 3218], 'procedure': [2487], 'done': [2488, 3015], 'nine': [2491, 2507], 'Double': [2493], 'performed': [2501, 2953], 'young': [2504, 4813, 5337], 'another': [2509, 3751, 3763, 4012], 'seven-year-old': [2515, 2582], 'few': [2525, 2686, 2855], 'days,': [2526, 3231, 3536], 'postoperative': [2533], 'hemolysis.PATHOLOGYRheumatic': [2534], 'unusual': [2540], 'ways.': [2541], 'involve': [2544], 'conduction': [2546], 'pathway': [2547], 'complete': [2549, 4850], 'A-V': [2550, 4851], 'block,': [2551], 'Wolff-Parkinson-White': [2562], 'syndrome': [2563, 4855], 'carditis,': [2567], 'sinus': [2568], 'node': [2569, 4872], 'suppression,': [2570], 'trifascicular': [2572, 4901], 'block.': [2573], 'possibilities': [2575], 'include': [2576], 'constrictive': [2577, 4920], 'pericarditis': [2578], 'endomyocardial': [2580], 'fibrosis.35–39A': [2581], 'boy': [2583], 'us': [2586], 'pericardial': [2588, 2591], 'tamponade;': [2589], 'drainage': [2592], 'revealed': [2593], 'old': [2594], 'blood.': [2595], 'intensive': [2600, 4009], 'care': [2601], 'measures': [2602], 'function': [2612], 'pneumonitis': [2631], 'responded': [2633], 'corticosteroid': [2636], 'treatment.The': [2637], 'pathologic,': [2638], 'myocardial,': [2639], 'changes': [2642], 'having': [2651], 'degeneration,': [2653], 'transformation': [2654], 'variety': [2656], 'regeneration,': [2659], 'subsequently,': [2661], 'fibrosis.40': [2662], 'description': [2664], 'Aschoff': [2668], 'cells': [2669], 'bodies': [2671, 4983], 'widely': [2675, 3864], 'reviewed.40–42PREVENTIONRheumatic': [2676], 'morbidity': [2692, 3815, 3952], 'prevented.': [2698], 'Proper': [2699], 'diagnosis': [2702, 2851, 3974, 4672], 'can,': [2709], 'extent,': [2712], 'prevent': [2713, 3056, 3122], 'carditis.': [2717, 3802, 4877], 'infections': [2733, 4605], 'make': [2735], 'initial': [2739, 3165], 'much': [2741], 'difficult.': [2743], 'once': [2745], 'clinical': [2749, 3593, 4626, 5320], 'exudative': [2752], 'pharyngitis,': [2753], 'evidence': [2755, 3698, 3784, 4627], 'viral': [2757], 'upper': [2758, 4603], 'hoarseness,': [2763], 'conjunctivitis,': [2764], 'cough,': [2766], 'he': [2767, 3109], 'should': [2768, 2807, 2826, 2835, 2884, 2903, 2929, 3059, 3092, 3110, 3396, 3423, 3432, 3578, 3710, 3835, 3844, 3983, 4165], 'cultured': [2772], 'begin': [2774], 'oral': [2775, 2804, 3036, 3311], 'therapy': [2777], 'important': [2785], 'sick,': [2789], 'walk-in,': [2790], 'unreliable': [2792], 'patient.34': [2793], 'results': [2796, 4058], 'culture': [2799, 2831], 'GrAS,': [2803, 2986], 'continue': [2808, 3836, 3877], 'or,': [2816], 'preferably,': [2817], 'injection': [2821, 2880, 3245], 'long-acting': [2823], 'benzathine': [2824, 2882, 3200, 3343, 5104], 'given.': [2828], 'negative,': [2833], 'stopped.': [2837], 'compliant,': [2841], 'reliable': [2842], 'patient,': [2843], 'safer': [2846], 'delay': [2848, 2857], 'confirmed.': [2853], "days'": [2856], 'starting': [2859], 'harmful': [2863], 'preventing': [2865], 'fever.43If': [2871], 'dependable': [2873], 'laboratory': [2874], 'unavailable,': [2876], 'given': [2886, 2905, 3061, 3094, 3227, 3580], 'culture.': [2896], 'Erythromycin': [2897], 'lincomycin,': [2899], 'appropriate': [2901], 'dosages,': [2902], 'allergic': [2910], 'resistance': [2916], 'drugs': [2919], 'area.34': [2925], 'Sulfonamides': [2926], 'tetracyclines': [2928], 'pharyngitis.44The': [2937], 'anaphylactic': [2940], 'shock': [2941], '50,000.': [2948], 'Routine': [2949], 'skin': [2951], 'tests,': [2952], 'already': [2964], 'low': [2965, 3261], 'occurrence.Tonsillectomy': [2966], 'occasionally': [2967], 'tonsillitis': [2975, 5079], 'origin,': [2978], 'spite': [2980], 'prophylaxis.': [2983], 'Vaccination': [2984], 'near': [2993, 4028], 'future,': [2994], 'another,': [2997], 'effective': [2998], 'means': [2999, 3613, 4013], 'probable': [3003, 4017], 'Extensive': [3009], 'exciting': [3011], 'work': [3012], 'field': [3018], 'H.': [3021], 'Beachey': [3022, 4300, 4316, 4638], 'associates.13,14,26It': [3025], 'essential': [3027], 'maintain': [3035], 'hygiene': [3037], 'adequate': [3039, 3253], 'dental': [3040, 3064], 'care.': [3041], 'Bacteremia': [3042], 'easily': [3044], 'originate': [3045], 'mouth': [3048], 'subacute': [3051, 3057, 3852], 'endocarditis.': [3052], 'Antibiotic': [3053], 'endocarditis': [3058, 3853], 'routine': [3063, 3757], 'procedures,': [3065], 'bronchoscopy,': [3066], 'tonsillectomy,': [3067], 'adenoidectomy.': [3069], 'advisable': [3073], 'minor': [3075], 'infected': [3078], 'tissues,': [3079, 4365], 'genitourinary': [3080], 'tract': [3081], 'gastrointestinal': [3083], 'manipulation,': [3084], 'major': [3086], 'dosages': [3089, 3341, 3351, 3365, 4036], 'schedule': [3091, 3236, 4038], 'according': [3095], 'recommendations': [3098, 4034], 'Association.*TREATMENTMedicalOnce': [3103], 'contracts': [3106], 'started': [3112], 'order': [3120], 'Life-long': [3135], 'recommended': [3138, 3246, 3340], 'episodes': [3140], 'up': [3149, 3159], '36': [3151], 'recurrences': [3158, 3285, 3939], 'lesion.4': [3167], 'Also,': [3168], 'occur': [3172, 3904], 'none': [3182], 'received': [3187], 'stenosis.45': [3192], 'regular': [3196, 5102], '70': [3202], 'lost': [3211], 'their': [3212], 'murmurs': [3213], 'one-half': [3220], 'heard.45Benzathine': [3225], 'every': [3229, 3306, 3394], '21': [3230, 3307, 3443], 'monthly': [3244, 3282], 'West.': [3249], 'better': [3251], 'maintains': [3252], 'levels': [3255], 'prevents': [3257], 'reinfection': [3258], 'crowded,': [3260], 'surroundings.46': [3263], 'unpublished': [3265], 'data': [3266], 'collected': [3267], 'while': [3271], 'practicing': [3272], 'Lebanon,': [3274], 'receiving': [3280, 3303, 5101], '(three': [3293], 'recurrences.Although': [3310], 'V': [3313], '(250': [3315], 'mg': [3316], 'twice': [3317], 'daily)': [3318], 'affective': [3322], 'injections,': [3324], 'noncompliant': [3328], 'so': [3329], 'preferred': [3334], 'therapy.': [3335, 3390], '3': [3337], 'gives': [3338], 'alternatives.Table': [3348], '3.': [3349, 3363], 'Recommended': [3350, 3364], 'alternatives': [3357, 3371], 'prophylaxis.Table': [3362], 'prophylaxis.Compliance': [3376], 'real': [3379], 'refuses': [3385], 'discontinues': [3387], 'permanent': [3388], 'case,': [3393], 'effort': [3395], 'made': [3398], 'keep': [3400], 'plan': [3405], 'minimum': [3408], 'five': [3410], 'murmur': [3416], 'disappeared.': [3417], 'For': [3418], 'maximum': [3419], 'benefit,': [3420], 'continued': [3425], 'indefinitely': [3426], 'but,': [3427], 'minimum,': [3430], 'discontinued': [3435], 'reaches': [3439], 'years.At': [3444], 'choice': [3450], 'mild': [3465], 'regurgitation,': [3467], 'salicylates,': [3470], '60': [3471, 3530], '120': [3473], 'mg/kg': [3474], 'day': [3476], 'weeks': [3482, 3583, 3696, 3767, 3778], 'months,': [3485], 'keeping': [3486], 'salicylate': [3489], 'mg%.': [3495], 'cardiomegaly,': [3502, 3703], 'prednisone': [3520, 3562, 3569], 'milligrams': [3522], 'kilogram': [3524], 'day,': [3526], 'mg/m2': [3531], '7': [3533], 'tapering': [3537], 'off': [3538, 3572, 3692], 'weeks.': [3546, 3739, 3755], 'encountered': [3549], 'prednisone-dependent,': [3554], 'combination': [3560], 'aspirin.': [3564], 'tapered': [3571], 'aspirin': [3574, 3577], 'started,': [3576], 'discontinuation': [3589], 'prednisone.': [3591], 'response': [3594, 4648, 4769], 'serology': [3602], 'test': [3603], 'results,': [3604], 'ESR,': [3607], 'CRP,': [3608], 'ASO,': [3610], 'assess': [3615], 'index': [3617], 'disease.Bed': [3622], 'RestBed': [3623], 'rest': [3624, 3715], 'still': [3630, 3956], 'controversial': [3632, 3862], 'issue': [3633], 'accomplish': [3638], 'childhood.': [3641], 'Our': [3642], 'polyarthritis,': [3645], 'neither': [3651], 'nor': [3653], 'allowed': [3658, 3676, 3683, 3744, 3761], 'bedroom': [3660, 3745], 'bathroom': [3663, 3748], 'privileges.': [3664], 'As': [3665], 'soon': [3666], 'free': [3670], 'symptoms,': [3673], 'routine,': [3677], 'indoor': [3678, 3758], 'activities.': [3679], 'resume': [3685], 'rebound.Patients': [3700], 'bed': [3714], 'under': [3722, 4008], 'control': [3723], 'out': [3728], 'state.': [3732], 'take': [3735], 'Then,': [3740], 'privileges': [3749], 'Finally,': [3756], 'return': [3772], 'successful': [3780], 'rebound.SurgicalSurgery': [3786], 'far': [3788], 'optimum': [3791], 'providing': [3793], 'definite': [3794], 'relief': [3795], 'disabling,': [3800], 'end-stage': [3801], 'Under': [3803], 'certain': [3804, 4379], 'conditions,': [3805], 'considerable': [3809], 'mortality.': [3817], 'To': [3818], 'date,': [3819], 'ideal': [3821], 'prosthesis': [3824], 'available.': [3826], 'All': [3827], 'instructed': [3847, 3986], 'prophylaxis.Surgical': [3854], 'indications': [3855, 5180], 'reviewed': [3865], 'issue.': [3866], '48–55SUMMARYThe': [3867], 'serious': [3881], 'countries.': [3887], 'Saudi': [3889, 5443], 'Arabia,': [3890], 'observe': [3892], 'longer': [3911], 'called': [3922], 'juvenile': [3924], '“malignant”': [3925], 'form.The': [3926], 'several': [3938], 'subsequently': [3941], 'stage': [3944], 'mortality,': [3954], 'preventable.': [3957], 'Prevention': [3958], 'achieved': [3961], 'emphasizing': [3963], 'importance': [3965, 3989], 'proper': [3967], 'Patients': [3980], 'families': [3982], 'properly': [3985], 'concerning': [3987], 'complications.Polyvalent': [4003], 'vaccine,': [4005], 'investigation,': [4010], 'future.*': [4029], 'applied': [4040], 'KFSH': [4042], 'upon': [4048], 'request.ARTICLE': [4049], 'REFERENCES:1.': [4050], 'Bailey': [4051], 'CP,': [4052], 'Bolton': [4053], 'HE:': [4054, 4956], '"Criteria': [4055], 'stenosis"': [4063, 5317, 5342], '.': [4064, 4089, 4106, 4125, 4154, 4194, 4208, 4222, 4238, 4263, 4291, 4349, 4386, 4408, 4441, 4468, 4493, 4516, 4536, 4557, 4584, 4609, 4630, 4661, 4696, 4724, 4753, 4782, 4815, 4830, 4881, 4903, 4922, 4943, 4971, 5016, 5027, 5052, 5082, 5106, 5123, 5183, 5206, 5221, 5245, 5277, 5300, 5318, 5343, 5362, 5380], 'NY': [4065], 'State': [4066], 'J': [4067, 4092, 4109, 4126, 4197, 4211, 4264, 4350, 4387, 4442, 4496, 4539, 4559, 4585, 4613, 4632, 4662, 4699, 4818, 4833, 4863, 4884, 4928, 5084, 5186, 5223, 5247, 5279, 5301], 'Med': [4068, 4128, 4352, 4389, 4444, 4586, 4664, 4906, 4948, 5056, 5085], '56:8251956.': [4069], 'Google': [4070, 4095, 4111, 4132, 4159, 4176, 4199, 4214, 4226, 4241, 4268, 4298, 4314, 4355, 4392, 4412, 4447, 4475, 4498, 4520, 4541, 4562, 4591, 4617, 4636, 4667, 4678, 4701, 4730, 4756, 4785, 4800, 4820, 4836, 4865, 4887, 4909, 4931, 4951, 4976, 5019, 5030, 5058, 5087, 5110, 5128, 5161, 5188, 5210, 5226, 5250, 5282, 5305, 5325, 5348, 5368, 5385], 'Scholar2.': [4071], 'Shiokawa': [4072], 'Y,': [4073], 'Yamada': [4074], 'T:': [4075], '"Epidemiology': [4076], 'surveillance': [4085], 'streptococcus"': [4088], 'Jpn': [4090, 4195, 4494, 4697, 4861, 4926], 'Cir': [4091, 4196, 4495, 4698, 4862], '41(2):': [4093], '167–731977.': [4094], 'Scholar3.': [4096], 'Sievers': [4097], 'J,': [4098, 4570], 'Hall': [4099], 'P:': [4100, 4139], '"Incidence': [4101], 'fever"': [4105, 4221, 4237, 4290, 4970], 'Br': [4107, 4816, 5184], '33(6):833–361971.': [4110], 'Scholar4.': [4112], 'Bhattacherjee': [4113], 'TD,': [4114, 4525], 'Kundu': [4115], 'SC:': [4116], '"Profile': [4117], 'India': [4123], '(editorial)"': [4124], 'Indian': [4127, 4882], 'Assoc': [4129, 4587], '67(3):': [4130], '78–801976.': [4131], 'Scholar5.': [4133], 'Gharagozloo': [4134], 'RA,': [4135], 'Daneshpajooh': [4136], 'M,': [4137, 4452], 'Ghavamian': [4138], '"Rheumatic': [4140, 4479, 4623, 4826, 4897, 4917, 5114, 5315], 'among': [4146], '56,800': [4147], 'inhabitants': [4148], 'southeast': [4150], 'Teheran': [4151], '1972-1974"': [4153], 'Acta': [4155, 5322], 'Trop': [4156, 4947], '(Basel)': [4157], '33(3):215–221976.': [4158], 'Scholar6.': [4160], 'Ayoub': [4161, 4760], 'EM:': [4162], '"How': [4163], 'long': [4164], 'continued?"': [4171], 'Clin': [4172, 4223, 4265, 4614], 'Pediat': [4173], '9:': [4174], '503–041970.': [4175], 'Scholar7.': [4177], 'Matsumori': [4178], 'A,': [4179, 4183, 5287, 5308], 'Hirose': [4180], 'K,': [4181, 4271, 4683, 4841], 'Walabayashi': [4182], 'al.:': [4185, 4231, 4273, 4323, 4397, 4503, 4572, 4645, 4710, 4739, 4765, 4809, 4845, 4896, 5067, 5170, 5197, 5291, 5314, 5334, 5357], '"HLA': [4186], 'hypertrophic': [4188], 'cardiomyopathy': [4189], 'disease"': [4193, 4207, 4385, 4492, 4556, 4695, 4781], '43:445–491979.': [4198], 'Scholar8.': [4200], 'Fleming': [4201], 'PR:': [4202], '"Recognition': [4203], 'Br.': [4209], '39(10):': [4212], '1045–501977.': [4213], 'Scholar9.': [4215], 'Joorabchi': [4216], 'B:': [4217], '"Pathogenesis': [4218, 4528], 'Ped': [4224], '8:4051969.': [4225], 'Scholar10.': [4227], 'Todd': [4228], 'EW,': [4229], '"Anti-streptolysin': [4232], 'titers': [4234], 'Lancet': [4239], '2:12131939.': [4240], 'Scholar11.': [4242], 'Stollerman': [4243, 4302, 4318, 4640], 'GH,': [4244, 4303, 4319, 4641], 'Bernheimer': [4245], 'AW:': [4246, 5371], '"Inhibition': [4247], 'pharyngitis"': [4262, 5081], 'Invest': [4266, 4615], '29:11471950.': [4267], 'Scholar12.': [4269], 'Hirschhorn': [4270], '"The': [4274, 4547, 5171], 'action': [4275], 'peripheral': [4280], 'lymphocytes': [4281], 'subjects': [4284], 'Proc': [4292, 4410, 4469], 'Natl': [4293, 4470], 'Acad': [4294, 4471], 'Sci': [4295, 4472], 'USA': [4296, 4473], '52:11511964.': [4297], 'Scholar13.': [4299], 'EH,': [4301, 4317, 4639], 'Bisno': [4304], 'AL:': [4305], '"A': [4306, 4846], 'vaccine:': [4308], 'how': [4309], 'close?"': [4310], 'Hosp': [4311], 'Pract': [4312], '14(11):49–571979.': [4313], 'Scholar14.': [4315], 'Chiang': [4320], 'EY,': [4321], '"Purification': [4324], 'properties': [4326], 'extracted': [4330], 'Streptococci': [4334], 'pepsin:': [4336], 'covalent': [4337], 'structure': [4338], 'amino': [4341], 'terminal': [4342], 'region': [4343], 'type': [4345], '24': [4346], 'antigen"': [4348, 4440], 'Exp': [4351, 4388, 4443, 4663, 4972], '145(6):': [4353], '1469–831977.': [4354], 'Scholar15.': [4356], 'Kaplan': [4357], 'MH,': [4358], 'Dallenbach': [4359], 'FD:': [4360], '"Immunologic': [4361], 'III.': [4366], 'Occurrence': [4367], 'bound': [4369], 'gamma-globulin': [4370], 'auricular': [4372], 'appendage': [4373], 'hearts;': [4376], 'relationship': [4377, 4400, 4505], 'histopathologic': [4380], 'features': [4381], '113:': [4390], '11961.': [4391], 'Scholar16.': [4393], 'Zabriskie': [4394], 'JB,': [4395, 4419], '"An': [4398], 'immunological': [4399], 'membranes': [4403], 'tissue"': [4407], 'Fed': [4409], '23:3421964.': [4411], 'Scholar17.': [4413], 'Van': [4414, 5230, 5254], 'de': [4415], 'Rijn': [4416], 'I,': [4417, 4501, 4912], 'Zabriski': [4418], 'McCarey': [4420], 'M:': [4421], '"Group': [4422], 'antigens': [4425, 4772], 'myocardium.': [4428], 'Purification': [4429], 'heart-reactive': [4431], 'isolation': [4434], 'characterization': [4436], '146(2):': [4445], '579–991977.': [4446], 'Scholar18.': [4448], 'Hosein': [4449], 'B,': [4450, 4565, 5092], 'McCarty': [4451], 'Fischetti': [4453], 'VA:': [4454], '"Amino': [4455], 'acid': [4456], 'sequence': [4457], 'physico-chemical': [4459], 'similarities': [4460], 'mammalian': [4466], 'tropomyosin"': [4467], '76(8):3765–681979.': [4474], 'Scholar19.': [4476], 'Kumagai': [4477], 'N:': [4478], 'anti-streptococcal': [4484], '39:167–681975.': [4497], 'Scholar20.': [4499], 'Goldstein': [4500], '"Immunological': [4504], 'polysaccharide': [4508], 'glycoproteins': [4512], 'valve"': [4515, 5015, 5220], 'Nature': [4517], '(London)': [4518, 4796], '213:441967.': [4519], 'Scholar21.': [4521], 'Burch': [4522, 4543], 'GE,': [4523, 4544], 'Giles': [4524, 4545], 'Colcolough': [4526], 'HL:': [4527], '"rheumatic"': [4530], 'disease:': [4532], 'critique': [4533], 'theory"': [4535], 'Amer': [4537, 4631], 'Hear': [4538], '80:556–611970.': [4540], 'Scholar22.': [4542], 'TD:': [4546, 4670], 'production': [4553], 'Am': [4558, 4831, 5083, 5222, 5246, 5278], 'Cardiol': [4560, 5224, 5248, 5323], '29:231–401972.': [4561], 'Scholar23.': [4563], 'Pongpanich': [4564], 'Na': [4566], 'Ayuthya': [4567], 'PS,': [4568], 'Jayavasu': [4569], '"Coxsackie': [4573], 'children"': [4583, 4608, 4829, 5299, 5361], 'Thai': [4588], '59(10):': [4589], '452–561976.': [4590], 'Scholar24.': [4592], 'Kuttner': [4593], 'AG,': [4594], 'Krumweide': [4595], 'E:': [4596], '"Observations': [4597], 'effect': [4600], 'three-year': [4611], 'study.': [4612], '20:273–871941.': [4616], 'Scholar25.': [4618], 'Leonard': [4619], 'R,': [4620], 'Wenger': [4621], 'NK:': [4622], 'carditis"': [4629, 4723, 4859], 'Dis': [4633], 'Child': [4634], '111:5331966.': [4635], 'Scholar26.': [4637], 'Johnson': [4642, 4891], 'RH,': [4643], '"Human': [4646], 'immune': [4647], 'immunization': [4650], 'structurally': [4653], 'defined': [4654], 'polypeptide': [4655], 'fragment': [4656], 'protein"': [4660], '150(4):': [4665], '862–771979.': [4666], 'Scholar27.': [4668], 'JAMA': [4676], '126:4811944.': [4677], 'Scholar28.': [4679], 'Umeda': [4680], 'T,': [4681, 4839], 'Kuwako': [4682], 'Machii': [4684], 'K:': [4685, 4788], '"M-mode': [4686], 'echocardiographic': [4689], 'evaluation': [4690], '43:297–3041979.': [4700], 'Scholar29.': [4702], 'Lewis': [4703], 'BS,': [4704], 'Geft': [4705], 'IL,': [4706], 'Milo': [4707], '"Echocardiography': [4711, 4740], 'Ann': [4725, 5344], 'Thorac': [4726, 5345], 'Surg': [4727, 5303], '27(6):': [4728], '529–351979.': [4729], 'Scholar30.': [4731], 'Conetta': [4732], 'DA,': [4733], 'Christie': [4734], 'LG,': [4735], 'Wise': [4736], 'DE,': [4737], 'analysis': [4741, 4993], 'systolic': [4743], 'diastolic': [4745], 'motion': [4749], 'man"': [4752], '76(1):76–821979.': [4755], 'Scholar31.': [4757], 'ST,': [4759], 'EM,': [4761], 'Victorica': [4762], 'BE,': [4763], '"Differences': [4766], 'Circulation': [4783, 5017, 5028, 5107, 5363], '50:1244–511974.': [4784], 'Scholar32.': [4786], 'Chartikavanij': [4787], 'Juvenile': [4789], 'Congress': [4793], 'Cardio': [4795, 5280], '1970': [4797], 'p': [4798], '27.': [4799], 'Scholar33.': [4801], 'Cherian': [4802], 'G,': [4803, 4823, 5285], 'Vytlingam': [4804], 'KI,': [4805], 'Sukumar': [4806], 'IP,': [4807], '"Mitral': [4810], 'valvotomy': [4811], 'patients"': [4814], '26:1571964.': [4819], 'Scholar34.': [4821], 'DiSciascio': [4822], 'Taranta': [4824], 'A:': [4825], '99(5):': [4834], '635–581980.': [4835], 'Scholar35.': [4837], 'Kamiya': [4838], 'Nishioka': [4840], 'Nakano': [4842], 'H,': [4843, 5328, 5353], 'case': [4847, 4879], 'transient': [4849], 'block': [4852], 'WPW': [4854], '.,': [4860], '41:1821977.': [4864], 'Scholar36.': [4866], 'Singhi': [4867], 'Shrivastava': [4869], 'S:': [4870, 5113], '"Sinus': [4871], 'suppression': [4873], 'report"': [4880], '31(5):': [4885], '305–81979.': [4886], 'Scholar37.': [4888], 'Altieri': [4889], 'PI,': [4890], 'C,': [4892, 5330], 'Crenshaw': [4893], 'RP,': [4894], 'block"': [4902], 'Bol': [4904], 'Asoc': [4905], 'PR': [4907], '63(12):323–261971.': [4908], 'Scholar38.': [4910], 'Aryanpur': [4911], 'Raafat': [4913], 'F,': [4914], 'Zangeneh': [4915], 'F:': [4916, 4934], 'valvulitis': [4918], 'pericarditis"': [4921], 'Report': [4923], 'case.': [4925], '16(6):': [4929], '749–551975.': [4930], 'Scholar39.': [4932], 'Bijlsma': [4933], '"Endomyocardial': [4935], 'fibrosis': [4936], 'Mozambique"': [4942], 'Trans': [4944], 'R': [4945], 'Soc': [4946], 'Hyg': [4949], '73(6):661–621979.': [4950], 'Scholar40.': [4952], 'McDonald': [4953], 'HG,': [4954], 'Calkins': [4955], '"Degeneration': [4957], 'transformation,': [4964], 'regeneration': [4965], 'fibrogenesis': [4967], 'Path': [4973], 'Bd': [4974], '15:185–951978.': [4975], 'Scholar41.': [4977], 'Roberts': [4978], 'WC,': [4979], 'Virmani': [4980], 'R:': [4981, 5037], '"Aschoff': [4982], 'necropsy': [4985], 'Evidence': [4990], '543': [4995], '14': [4998], 'least': [5007], 'anatomically,': [5008], '57(4):803–071978.': [5018], 'Scholar42.': [5020], 'Soloff': [5021], 'LA:': [5022], '"Letter': [5023], 'editor"': [5026], '56(3):499–5001977.': [5029], 'Scholar43.': [5031], 'Catanzaro': [5032], 'FJ,': [5033], 'Rammelkamp': [5034, 5062], 'CH,': [5035, 5063], 'Chamovitz': [5036], '"Prevention': [5038], 'infections.': [5046], 'II.': [5047], 'Factors': [5048], 'responsible': [5049], 'failures"': [5051], 'N': [5053], 'Engl': [5054], 'J.': [5055], '259:511958.': [5057], 'Scholar44.': [5059], 'Brink': [5060], 'WR,': [5061], 'Denny': [5064], 'FW,': [5065], '"Effect': [5068], 'aureomycin': [5072], 'natural': [5075, 5172], '10:3001951.': [5086], 'Scholar45.': [5088], 'Tompkins': [5089], 'DG,': [5090], 'Boxerbaum': [5091], 'Liebman': [5093], 'J:': [5094], '"Long-term': [5095], 'intramuscular': [5103], 'penicillin"': [5105], '45(3):': [5108], '543–511972.': [5109], 'Scholar46.': [5111], 'Padmavati': [5112], 'countries"': [5122], 'Bull': [5124], 'WHO': [5125], '56(4):': [5126], '543–501978.': [5127], 'Scholar47.': [5129], 'Keith': [5130, 5139], 'JD:': [5131], 'In:': [5138], 'JD,': [5140], 'Rowe': [5141], 'RD,': [5142], 'Vlad': [5143], 'P,': [5144], 'eds:': [5145], 'Disease': [5147], 'Infancy': [5149], 'Childhood.': [5151], 'New': [5152], 'York,': [5153], 'Macmillan': [5154], 'Publishing': [5155], 'Co.': [5156], 'Inc.,': [5157], 'pp': [5159], '203–31.': [5160], 'Scholar48.': [5162], 'Smith': [5163, 5194], 'HJ,': [5164], 'Neutze': [5165], 'JM,': [5166], 'Roche': [5167], 'AHG,': [5168], 'surgery"': [5182], '38:147–541976.': [5187], 'Scholar49.': [5189], 'Weir': [5190], 'EK,': [5191], 'Matisonn': [5192], 'RE,': [5193], 'AS,': [5195], '"Value': [5198], 'incompetence': [5203], 'adolescents"': [5205], 'Thorax': [5207], '33:': [5208], '608–111978.': [5209], 'Scholar50.': [5211], 'Bonchek': [5212], 'LI:': [5213], '"Indications': [5214, 5258], '46:155–581980.': [5225], 'Scholar51.': [5227], 'Fowler': [5228, 5252], 'NO,': [5229, 5253], 'Der': [5231, 5255], 'Bel-Kahn': [5232], 'JM:': [5233, 5257], '"Operations': [5234], 'valve:': [5238], 'weighing': [5242], 'issues"': [5244], '46:159–621980.': [5249], 'Scholar52.': [5251], 'Bel-Khan': [5256], 'valve.': [5265], 'With': [5266], 'particular': [5267], 'reference': [5268], 'uncommon': [5272], 'causes': [5273], 'regurgitation"': [5276], '44:148–571979.': [5281], 'Scholar53.': [5283], 'Merin': [5284], 'Simcha': [5286], 'Gotsman': [5288], ',': [5289], '"Surgery': [5292], 'tricuspid': [5295, 5316], 'Cardiovasc': [5302], '17:306–131976.': [5304], 'Scholar54.': [5306], 'Sheikhzadeh': [5307], 'Tarbiat': [5309], 'Paydar': [5311], 'D,': [5312], 'overview': [5321], '33(6):431–421978.': [5324], 'Scholar55.': [5326], 'Manabe': [5327], 'Oyama': [5329], 'Kitamura': [5331], '"Valvotomy': [5335], 'Swrg': [5346], '23(3):245–481977.': [5347], 'Scholar56.': [5349], 'Chen': [5350], 'SC,': [5351], 'Laks': [5352], 'Fagan': [5354], 'L,': [5355], '"Valve': [5358, 5372], '(Suppl': [5364], '2)': [5365], '56(3):': [5366], '117–211977.': [5367], 'Scholar57.': [5369], 'Strauss': [5370], '(Editorial.)"': [5379], '/': [5381], 'Pediatr': [5382], '84(5):': [5383], '786–871974.': [5384], 'Scholar': [5386], 'Previous': [5387], 'article': [5388, 5390], 'Next': [5389], 'FiguresReferencesRelatedDetails': [5391], 'Volume': [5392], '1,': [5393], 'Issue': [5394], '2October': [5395], '1981': [5396, 5402], 'Metrics': [5397], 'History': [5398], 'online1': [5400], 'October': [5401], 'KeywordsStreptococcus': [5403], 'AMitral': [5405], 'insufficiencyAortic': [5407], 'insufficiencyRheumatic': [5409], 'diseaseRheumatic': [5411], 'feverBenzathine': [5412], 'penicillinACKNOWLEDGEMENTSThe': [5413], 'wishes': [5415], 'acknowledge': [5417], 'information': [5418], 'obtained': [5419], 'Team': [5424], 'participating': [5425], 'Centre.InformationCopyright': [5438], '©': [5439], '1981,': [5440], 'Annals': [5441], 'MedicinePDF': [5444], 'download': [5445]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2608647103', 'counts_by_year': [{'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-11T09:46:32.513255', 'created_date': '2017-05-05'}