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'FRCP(C)': [29], 'Yusuf': [30, 105], 'Al-Gindan,': [32], 'Facharzt/Int': [34], 'Med': [35, 3450, 3524, 3747], 'Abdelhamid': [36, 133], 'S.': [37, 134, 4191], 'Omer,': [38], 'FRCP,': [41], 'DTM&H': [42], 'Methil': [43, 161], 'K.': [44, 162], 'Kutty,': [45], 'FRCPath,': [48], 'FRCPA': [49], 'Mahmoud': [50, 189], 'B.': [51, 190, 3864], 'SaeedMB,': [53], 'BS': [54], 'El-Hassan': [57, 3531, 3602, 3641, 3944], 'Professor,': [58], 'Department': [59, 85, 113, 141, 168], 'Pathology,': [61], 'College': [62, 88, 116, 144, 171, 199], 'Medicine': [64, 90, 118, 146, 173, 201, 3906, 3960, 4056, 4129], 'Medical': [66, 92, 120, 148, 175, 194, 203, 3543, 3908], 'Sciences,': [67, 93, 121, 149, 176, 204, 3909], 'King': [68, 94, 122, 150, 177, 205, 4162], 'Faisal': [69, 95, 123, 151, 178, 206], 'University,': [70, 96, 124, 152, 179, 207], 'P.O.': [71, 97, 125, 153, 180, 208], 'Box': [72, 98, 126, 154, 181, 209], '2114,': [73, 99, 127, 155, 182, 210], 'Dammam': [74, 100, 128, 156, 183, 211], '31451,': [75, 101, 129, 157, 184, 212], 'Saudi': [76, 102, 130, 158, 185, 213, 1630, 3542, 3895, 3903, 4044, 4209], 'Arabia': [77, 103, 131, 159, 186, 214, 3896], ',': [78, 104, 132, 160, 187, 3932], 'Kubba': [80, 3600, 4068, 4095], 'Associate': [81, 108, 136], 'Professor': [82, 109, 137, 164], 'Dermatology,': [84, 4087], 'Medicine,': [87, 112, 115, 140, 143, 167, 170], 'Al-Gindan': [107, 3604, 4098], 'Internal': [111, 139, 166], 'Omer': [135, 4072], 'Kutty': [163, 3533, 3645, 4074], 'Saeed': [192, 4077, 4178], 'Resident': [193], 'Officer,': [195], 'Clinic,': [197], 'Al-Jisha,': [198], 'Published': [215], 'Online:1': [216], 'Jul': [217], '1987https://doi.org/10.5144/0256-4947.1987.212SectionsPDFCite': [218], 'ToolsAdd': [219], 'to': [220, 305, 321, 443, 465, 469, 478, 508, 515, 536, 821, 830, 850, 888, 976, 1014, 1037, 1064, 1083, 1094, 1108, 1241, 1300, 1307, 1318, 1434, 1548, 1566, 1702, 1812, 1831, 2488, 2602, 2629, 2675, 2677, 2719, 2757, 2807, 2835, 2876, 2881, 2949, 2983, 3015, 3053, 3074, 3124, 3243, 3292, 3354, 3464, 3929, 4034, 4174], 'favoritesTrack': [221], 'citations': [222], 'ShareShare': [223], 'onFacebookTwitterLinked': [224], 'InRedditEmail': [225], 'AboutABSTRACTABSTRACTT-lymphocyte': [226], 'phenotypes': [227, 481, 1721, 1732], 'human': [229, 487, 989, 1247, 3088, 3195, 3213, 3651, 3925], 'leukocyte': [230, 488], 'antigen-DR': [231, 489], 'expression': [232, 234, 3310, 3337], '(HLA-DR)': [233, 490], 'skin': [236, 411, 494, 597, 704, 712, 844, 1682, 1695, 3003, 3204, 3317], 'lesions': [237, 353, 365, 412, 705, 1505, 1537, 1545, 1870, 1931, 1944, 1961, 2026, 2150, 2160, 2422, 2437, 2794, 2833], 'draining': [239], 'lymph': [240, 498, 1250, 2237, 2279, 2494, 2921], 'nodes': [241, 499, 722, 2238], 'zoonotic': [243, 533], 'leishmaniasis': [244, 389, 437, 462, 504, 1474, 1885, 2095, 2118, 2216, 2961, 3090, 3382, 3433, 3462, 3653, 3804, 3890, 3927, 4032], 'caused': [245, 392, 2872], 'by': [246, 393, 612, 670, 799, 1018, 1129, 1135, 1258, 1304, 1357, 2531, 2565, 2700, 2898, 2924, 3068, 3117, 3129, 3273, 3300, 3305, 3311, 3338, 3343, 3676, 3884, 4157], 'Leishmania': [247, 537, 1289, 2404, 3103, 3684, 3842, 3930, 4035], 'major': [248, 324, 1334, 2709, 3135, 3161, 3685, 3931, 4036], 'were': [249, 253, 265, 296, 303, 357, 381, 526, 540, 584, 635, 700, 719, 723, 748, 781, 846, 875, 885, 1001, 1024, 1049, 1058, 1080, 1103, 1168, 1256, 1273, 1316, 1345, 1373, 1404, 1418, 1423, 1439, 1443, 1508, 1546, 1677, 1740, 1783, 1871, 2053, 2068, 2079, 2143, 2192, 2242, 2326, 2357, 2366, 2375, 2423, 2446, 2458, 2486, 2597, 2608, 2712, 2738, 2744, 2823, 2846, 2856, 2989, 2999, 3027, 3036, 3206, 3290], 'studied.': [250, 1405], 'T': [251, 294, 483, 990, 1200, 1987, 2006, 2021, 2051, 2358, 2386, 2396, 2566, 2572, 2595, 2635, 2710, 3048, 3085, 3131, 3156, 3192, 3260, 3411, 3678, 3920, 3979], 'lymphocytes': [252, 484, 991, 2007, 2022, 2052, 2142, 2174, 2374, 2387, 2397, 2573, 2596, 2711, 2737, 2743, 3119, 3145, 3164, 3193, 3365, 3679], 'dominant': [255, 273], 'cells': [256, 295, 334, 376, 978, 1139, 1164, 1201, 1213, 1224, 1229, 1272, 1280, 2067, 2078, 2110, 2131, 2167, 2186, 2260, 2272, 2356, 2365, 2482, 2515, 2636, 2652, 2660, 2805, 2852, 3035, 3049, 3064, 3086, 3128, 3201, 3233, 3370, 3412, 3923], 'lymphocytic': [259, 2103, 2583, 3325], 'preponderance': [260, 2104, 2584], 'type': [261, 1742, 1750, 1758, 1767, 1949, 2028, 2037, 2124, 2585], 'lesion.': [263, 1851, 1977, 2016], 'They': [264, 3228], 'lowest': [266, 2035, 2088, 2801, 2974], 'when': [267, 276, 355, 3171, 3420], 'parasitized': [269, 3112], 'macrophage': [270, 3708], 'was': [271, 319, 347, 610, 619, 652, 668, 691, 731, 735, 760, 797, 816, 832, 974, 1012, 1172, 1190, 1217, 1232, 1297, 1428, 1490, 1587, 1615, 1625, 1670, 1748, 1756, 1765, 1821, 1829, 1844, 1962, 1971, 1979, 2023, 2284, 2299, 2308, 2427, 2498, 2750, 2754, 3006, 3298, 3333, 4155], 'cell': [274, 1151, 1770, 2311, 3266], 'or': [275, 369, 415, 427, 678, 921, 955, 992, 1227, 1263, 1394, 1555, 2164, 2377, 2600, 3358], 'reaction': [278, 318, 667, 686, 1816, 1951, 2113, 2139, 2208, 2228, 2469, 2688, 2875, 3288], 'consisted': [279], 'an': [281, 910, 1514, 2558, 2925, 3394, 3711], 'equal': [282, 2601], 'admixture': [283], 'lymphocytes,': [285], 'macrophages': [286, 346, 2431, 2455, 2542, 2996, 3069, 3113, 3257], 'plasma': [288, 2259], 'cells.': [289, 311, 2157, 2276, 2372, 2491, 2978, 3275], 'Both': [290], 'inducer/helper': [291], 'suppressor/cytotoxic': [293, 337, 1228, 2056, 2066, 2091, 2156, 2166, 2371, 2604, 2655, 2715, 2742, 2784, 2804, 2851, 2869, 2977, 3034, 3047, 3063], 'present': [297, 3000], 'varying': [299], 'proportions.': [300], 'The': [301, 373, 410, 453, 599, 617, 663, 757, 810, 843, 944, 1009, 1046, 1056, 1078, 1101, 1196, 1243, 1477, 1681, 1772, 2017, 2102, 2195, 2324, 2425, 2436, 2463, 2561, 2606, 2615, 3058, 3096, 3262, 3276, 3341, 3349, 3437], 'latter': [302, 2562, 2607, 3402], 'thought': [304, 2487], 'be': [306, 466, 2489, 2647, 2676, 3016, 3115, 3362], 'suppressor': [307, 2632, 2659, 3410], 'rather': [308], 'than': [309, 1162, 2134, 2369], 'cytotoxic': [310, 2634, 3084, 3130, 3155, 3169, 3191], 'late': [313], 'appearance': [314, 3405], 'host': [317], 'believed': [320], 'play': [322], 'a': [323, 564, 573, 595, 604, 622, 648, 694, 738, 826, 1141, 1209, 1238, 1276, 1327, 1382, 1629, 1633, 1749, 1757, 1766, 1935, 1948, 1972, 2206, 2224, 2296, 2309, 2467, 2536, 2723, 2777, 2782, 2867, 2965, 3121, 3187, 3223, 3236, 3314, 3839, 4046, 4118, 4158], 'role': [325, 2671, 3082, 3189], 'halting': [327], 'inflammatory': [329, 1815, 2668, 2687, 2874], 'response.': [330, 2669, 2786, 3397], 'Low': [331], 'levels': [332], 'expressing': [335], 'phenotype': [338, 2716], 'continued': [341, 1817], 'presence': [342, 1601, 2257], 'antigen': [344, 629, 994, 1310, 1820, 1954, 2426, 2457, 2692, 2863, 2895, 2916, 2998, 3066, 3152, 3217, 3272, 3295, 3357, 3390, 3423, 3737], 'associated': [348, 446, 3334], 'with': [349, 416, 447, 502, 529, 750, 913, 1060, 1116, 1160, 1266, 1397, 1402, 1599, 1704, 1835, 1859, 1964, 2027, 2098, 2126, 2218, 2286, 2414, 2420, 2544, 2639, 2809, 2866, 2958, 3009, 3094, 3173, 3335, 3995], 'persistence': [350, 2861], 'even': [354, 1799], 'parasites': [356, 400, 2527, 2546, 2690, 2818, 2843, 2988], 'largely': [358, 2529, 2824], 'eliminated': [359, 2530, 2825], 'after': [360, 367, 939, 1800, 1889, 1908, 1934, 1982, 2448, 2689, 2826, 2993, 3763], 'specific': [361, 2451, 2810, 3075, 3118, 3677, 3837], 'antileishmanial': [362, 2452, 2681, 2811, 2820, 3076, 3417], 'therapy.': [363, 372, 1893, 2453, 2985], 'Such': [364, 2787], 'healed': [366], 'local': [368, 605, 707, 727, 2882, 3010], 'systemic': [370, 1911, 1983, 2884, 3012], 'steroid': [371, 1984, 2885], 'majority': [374, 1736, 2048, 2172, 2650, 3198], 'dermal': [379, 1723, 1734, 2189, 2434, 3373], 'infiltrate': [380, 495, 1825, 2012, 2190, 2312, 3205], 'positive.': [383, 1626, 2194, 3208], 'Keratinocytes': [384, 2222], 'also': [385, 593, 876, 1639, 1919, 2144, 2204, 2465, 2933], 'expressed': [386, 1207, 1274, 3149], 'antigen.INTRODUCTIONCutaneous': [388], '(cl)': [390], 'is': [391, 430, 445, 463, 553, 1411, 1464, 1651, 2535, 2555, 2563, 2621, 2626, 2698, 2771, 2896, 3014, 3078, 3091, 3347, 3403], 'different': [394, 1183, 4038], 'species': [395], 'strains': [397], 'leishmania': [399, 444, 1309, 1819, 1953, 2526], 'that': [401, 2525, 2539, 2571, 2648, 2703, 2854, 2860, 2907, 3019, 3032, 3111], 'replicate': [402], 'within': [403], 'mononuclear': [405, 2310], 'phagocytes': [406], 'skin.': [409], 'heal': [413, 2808], 'spontaneously': [414], 'treatment': [417, 516, 870, 893, 958, 1703, 1775, 1803, 2720, 2966], 'but': [418, 2473, 2740, 2844], 'some': [420, 1173], 'cases': [421, 2177, 2306], 'disease': [423, 1481, 2416, 2770], 'persists': [424], 'for': [425, 568, 697, 754, 791, 880, 917, 934, 1030, 1051, 1068, 1086, 1098, 1253, 1285, 1648, 1685, 2209, 2244, 2301, 3838, 4166, 4186, 4194, 4202], 'months': [426, 1433], 'years.': [428], 'This': [429, 1462, 2697], 'particularly': [431, 2319, 2580], 'so': [432], 'diffuse': [435], 'cutaneous': [436, 461, 503, 862, 868, 1884, 2215, 2578, 3089, 3196, 3381, 3432, 3517, 3538, 3560, 3610, 3632, 3652, 3803, 3926, 4031], '(DCL)': [438], 'where': [439], 'depressed': [440], 'cellular': [441, 1177, 3564], 'immunity': [442, 3762], 'massive': [448], 'multiplication': [449], 'parasite.1': [452], 'healing': [454, 950, 953], 'process': [455, 2552], 'usual': [458], 'form': [459], 'considered': [464, 476], 'primarily': [467], 'due': [468, 535, 3928, 4033], 'cell-mediated': [470], 'immune': [471, 2682, 2942, 3147, 3163, 3705, 3871], 'reactions.2,3': [472], 'It': [473, 1828, 2645, 2858], 'was,': [474], 'therefore,': [475], 'useful': [477], 'study': [479, 525, 589, 699, 1687, 3321], 'antigens': [491, 2950, 3210, 3247, 3360], 'patients': [501, 528, 874, 884, 1401, 1417, 1438, 1442, 1533, 1605, 1660, 1739, 1777, 2060, 2075, 2241, 2362, 2413, 2441, 2592, 2707, 2774, 2788, 2797, 3022, 3071], 'relate': [506], 'these': [507, 873, 1584], 'clinical': [510, 582, 1409, 1470, 3438], 'features,': [511], 'parasite': [512, 811, 1643, 1646, 1668, 1712, 1717, 1728, 1807, 2554, 2725, 2733, 2779, 3388, 3421, 3656], 'load,': [513], 'response': [514, 2683, 2871], 'histological': [519, 1741, 3440], 'changes.MATERIALS': [520], 'AND': [521], 'METHODSIncluded': [522], 'this': [524, 881, 1483, 1607, 1637, 1686, 1850, 2245, 2619, 2839, 3297, 3320, 3331, 3345], 'thirteen': [527], 'confirmed': [530, 798], 'diagnosis': [531, 794], 'CL': [534, 796, 1403, 2015], 'major,': [538, 609, 4000], 'who': [539, 1778, 2332, 2775, 2798, 2905], 'seen': [541, 2145, 2428, 2459, 2499], 'consecutively': [542], 'our': [544, 1473, 1693, 2792], 'Clinic': [546], 'village': [549], 'Al-Jisha': [551], 'which': [552, 835, 3344, 3413], 'located': [554], 'at': [555, 638, 657, 680, 687, 776, 1054, 1071, 1146, 1485, 1845, 2838, 2853], 'eastern': [557], 'edge': [558], 'oasis': [561], 'Al-Hassa,': [563], 'known': [565, 3093], 'endemic': [566], 'area': [567], 'CL.': [569, 1539], 'Each': [570, 650, 729], 'patient': [571, 1507, 1638, 1650, 1673, 1754, 1763, 2419], 'received': [572, 1854], 'complete': [574, 949], 'dermatological': [575], 'general': [577], 'physical': [578], 'examination,': [579], 'data': [583, 879], 'recorded': [585, 819, 1412], 'on': [586, 643, 785, 909, 1570, 2927, 2937, 3037, 3252, 3734], 'special': [587, 1679], 'computer-coded': [588], 'sheets.': [590], 'Clinical': [591, 1520, 1527, 3785, 3933, 4001], 'evaluation': [592, 1489], 'included': [594, 877, 1245, 1388, 1449, 2249], 'leishmanin': [596, 1635, 2748], 'test.': [598], 'test': [600, 618, 628, 682, 1614, 2749], 'antigen,': [601], 'prepared': [602], 'from': [603, 702, 1323, 1810, 2239, 3364, 4160], 'strain': [606], 'L.': [608, 3134], 'supplied': [611], 'Burroughs-Wellcome': [613], '(Berkhamsted,': [614], 'Hertfordshire,': [615, 928], 'England).': [616], 'performed': [620, 1257, 1298, 1684], 'using': [621, 709, 982, 3102], 'standard': [623], 'technique:': [624], '0.1': [625, 631], 'ml': [626, 632], 'control': [634, 689, 1194], 'injected': [636], 'intradermally,': [637], 'least': [639, 1157, 1846], '10': [640, 930, 1661, 1747, 2729], 'cm': [641], 'apart,': [642], 'volar': [645], 'surface': [646, 2929, 3254], 'forearm.': [649, 1573], 'site': [651, 683, 690], 'carefully': [653], 'marked': [654, 1915, 1973, 2250], 'examined': [656, 1380, 1590, 2447], '48': [658], 'hours': [659], '72': [661], 'hours.': [662], 'size': [664], 'determined': [669], "'ball": [671], 'point': [672], "technique.'4": [673], 'Induration': [674], '5': [676, 1099], 'mm': [677], 'more': [679, 1161, 2080, 2367, 2598, 2609], 'no': [685, 1689, 1946, 2165, 2842, 2987, 3166], 'regarded': [692], 'as': [693, 878, 948, 1170, 1208, 1219, 1234, 1275, 1902, 2654, 2964, 3391, 3393], 'positive': [695, 1138, 1271, 1319, 1391, 2207, 2225, 2468, 3369], 'test.Tissues': [696], 'obtained': [701, 1322], 'representative': [703, 1465], 'under': [706, 726, 3080], 'anesthesia': [708], '4-mm': [710], 'disposable': [711], 'punches.': [713], 'Ulcerated': [714, 2149], 'heavily': [716], 'encrusted': [717], 'areas': [718, 1184], 'avoided.': [720], 'surgically': [724], 'excised': [725, 1588], 'anesthesia.': [728], 'specimen': [730], 'bisected.': [732], 'One': [733, 1512, 1582, 1957, 2534, 3398], 'half': [734, 759, 2589], 'fixed': [736, 1025], 'formalin/mercuric': [739], 'chloride/acetic': [740], 'acid': [741], 'mixture,': [742], 'embedded': [743, 761], 'paraffin,': [745], 'sections': [747, 780, 806, 981, 1023, 1057, 1079, 1102, 1315, 1372, 1387, 2638], 'stained': [749, 2097, 2125, 2217], 'hematoxylin': [751], 'eosin': [753], 'light': [755], 'microscopy.': [756], 'other': [758, 1542, 2440, 2935, 3021, 3367], 'OCT': [763], '(Miles': [764], 'Laboratories,': [765], 'Naperville,': [766], 'Illinois,': [767], 'USA),': [768], 'snap': [769], 'frozen': [770, 980, 1312], 'liquid': [772], 'nitrogen,': [773], 'stored': [775], '-70°C.': [777], 'Subsequently,': [778, 1852], 'five-micron': [779], 'cut': [782], 'placed': [784], 'clean': [786], 'ungelatinized': [787], 'slides': [788, 1344], 'processed': [790], 'immunohistochemical': [792], 'studies.The': [793], 'demonstration': [800], 'amastigotes': [802, 2325], 'paraffin': [805], 'tissue.': [809], 'load': [812, 840, 1644, 1647, 1669, 1808, 2780], 'each': [814, 1166, 1649], 'section': [815, 1204], 'estimated': [817], 'according': [820, 849, 1013, 1299], 'method': [823, 973, 1254, 1302], 'Ridley;5': [825], 'scale': [827], '1+': [829], '5+': [831, 836], 'used': [833, 975, 1002, 2957], 'represented': [837, 1577], 'heaviest': [839], 'amastigotes.': [842, 1603], 'biopsies': [845], 'further': [847], 'classified': [848], 'histopathological': [852], 'features': [853, 1521, 1528, 1595, 3441], 'shown': [854, 1652, 1710, 1998, 2346, 2524, 3291], 'Table': [856, 1007, 1414, 1654, 2000, 2348], '1.6Table': [857], '1.': [858, 864, 1880, 3612, 3950], 'Histological': [859, 865, 1715, 1726], 'classification': [860, 866], 'leishmaniasis.Table': [863], 'leishmaniasis.The': [869, 3197], 'responses': [871, 2943, 2948, 3419, 3501], 'study.': [882, 2246], 'Eleven': [883], 'randomly': [886], 'allocated': [887], 'one': [889, 1456, 1459, 1833, 1941, 2278, 2330, 2418, 2511], 'two': [891, 1452, 1454, 1560, 1801, 1906, 2059, 2361, 2439, 2532, 2796, 3020], 'ongoing': [892], 'protocols;': [894], 'i.e.,': [895], 'ketoconazole': [896, 1892, 2829], '(Nizoral': [897], '–': [898, 925], 'Jenssen': [899], 'Pharmaceutica,': [900], 'Beerse,': [901], 'Belgium)': [902], '400': [903], 'mg': [904, 1857], 'single': [905], 'dose': [906], 'daily,': [907], 'given': [908, 2909], 'empty': [911], 'stomach,': [912], 'proportionally': [914], 'smaller': [915], 'doses': [916], 'children,': [918, 1419], 'until': [919], 'healed;': [920], 'sodium': [922, 1705], 'stibogluconate': [923, 1706], '(Pentostam': [924], 'Burroughs-Wellcome,': [926], 'Berkhamsted,': [927], 'England)': [929], 'mg/kg': [931], 'intramuscularly': [932], 'daily': [933], '14': [935], 'injections,': [936], 'repeated': [938], 'four': [940, 1450], 'weeks': [941, 1492, 1699, 1841, 1868, 1907, 1933, 2992], 'if': [942, 3045], 'necessary.': [943], 'results': [945, 1523, 1530, 1773, 1996, 2344, 2569], 'are': [946, 1004, 1997, 2111, 2132, 2345, 2528, 2574, 2656, 2789, 3211, 3222, 3249, 4172], 'graded': [947], '(H),': [951], 'partial': [952, 1927], '(P)': [954], 'failure': [956, 2449], '(F).T-Lymphocyte': [959], 'Subtypes': [960], 'Antigen': [963, 1290, 2405], 'Skin': [965, 1293, 1994, 2408], 'NodesA': [969], 'sensitive': [970], 'biotin': [971], 'avidin': [972, 1084], 'detect': [977, 1308], 'monoclonal': [983, 986, 1130, 1136, 2100, 2128, 2220, 2643], 'antibodies.': [984, 2644], 'Mouse': [985], 'antibodies': [987, 1048], 'against': [988], '(Becton-Dickinson': [995], 'Monoclonal': [996], 'Center,': [997], 'Mountain-view,': [998], 'California,': [999], 'USA)': [1000], 'listed': [1005], '2.': [1008, 1126, 1132, 1899], 'staining': [1010, 1189], 'procedure': [1011], 'instructions': [1016], 'provided': [1017], 'manufacturer.': [1020], 'Briefly,': [1021], 'cryostat-cut': [1022], 'cold': [1027], 'acetone': [1028], '(4°C)': [1029], 'ten': [1031, 1619, 1932, 2003, 2991], 'minutes,': [1032, 1088], 'air': [1033], 'dried': [1034], 'transferred': [1036], 'phosphate': [1038], 'buffered': [1039, 1377], 'saline': [1040, 1378], '(PBS)': [1041], '0.5': [1042], 'M,': [1043, 4019, 4021], 'pH': [1044], '7.4.': [1045], 'primary': [1047, 1261, 1392, 1568], 'applied': [1050], '15': [1052, 1069, 1087], 'minutes': [1053, 1070, 1342, 1354], '20°C.': [1055], 'rewashed': [1059], 'PBS': [1061, 1091, 1351], 'exposed': [1063, 1082, 1093, 1317], 'biotinylated': [1065], 'antimouse': [1066, 1362], 'IgG': [1067], '20°C': [1072], 'washed': [1074, 1089, 1112, 1346], 'again': [1075], 'PBS.': [1077], 'then': [1081, 2673], 'peroxidase': [1085], '3,3-diaminobenzidine-hydrogen': [1095], 'peroxide': [1096], 'mixture': [1097], 'minutes.': [1100], 'immersed': [1104], 'copper': [1106], 'sulphate': [1107], 'enhance': [1109], 'color,': [1111], 'PBS,': [1114], 'counterstained': [1115], 'hematoxylin,': [1117], 'dehydrated': [1118], 'mounted': [1120, 1374], 'distrene': [1122], 'plasticizer': [1123], 'xylene': [1124], '(DPX).Table': [1125], 'Antigens': [1127, 1133, 2339], 'detected': [1128, 1134, 1822], 'antibodies.*Table': [1131], 'antibodies.*The': [1137], 'showed': [1140, 1593, 1688, 1925, 1945, 2152, 2161, 2205, 2466, 2520, 2841, 2906], 'distinct': [1142], 'dark': [1143], 'brown': [1144, 1153], 'rim': [1145], 'periphery': [1148], 'and/or': [1152, 1249], 'cytoplasmic': [1154], 'staining.': [1155], 'At': [1156, 1866], 'five': [1158, 1353, 2074], 'infiltrates': [1159, 1181, 3561], '40': [1163, 1856], 'focus': [1167], 'counted': [1169], 'there': [1171, 1843, 1970, 2283, 2307, 2845], 'variation': [1174], 'composition': [1178], 'individual': [1180], 'section.': [1187, 1195], 'No': [1188], 'observed': [1191, 3324], 'specificity': [1193, 1255], 'total': [1197, 2005, 2736], 'number': [1198, 1503, 2728, 2814, 2975], '(Anti-Leu': [1205, 1225, 1230], '1),': [1206], 'percentage': [1210, 1221, 1239, 1277, 2019, 2089], 'all': [1212, 1279, 1864, 2305], 'infiltrate,': [1216], 'calculated': [1218, 1233], 'follows:7The': [1220], 'helper/inducer': [1223, 2077, 2364], '3a)': [1226], '2a)': [1231], 'follows:Anti-Leu-4': [1235], 'serum': [1236, 1321, 1363, 1393], 'gave': [1237], 'similar': [1240], 'Anti-Leu-1.': [1242], 'controls': [1244], 'non-neoplastic': [1246], 'tonsil': [1248], 'node.': [1251], 'Controls': [1252], 'omission': [1259, 1389], 'antibody': [1262], 'its': [1264, 1395], 'replacement': [1265, 1396], 'normal': [1267, 1398], 'BALB/C': [1268, 1324, 1399], 'mouse': [1269, 3220, 3740], 'serum.HLA-DR': [1270], 'infiltrate.Indirect': [1283], 'Immunofluorescence': [1284], 'Detection': [1287], 'NodesThis': [1296], 'recommended': [1303], 'Bray,8': [1305], 'modified': [1306], 'sections.': [1313], 'Frozen': [1314], 'antileishmania': [1320], 'mice': [1325, 3148], 'bearing': [1326], '16-week': [1328], 'growth': [1329], '1.5': [1331], 'x': [1332], '107L.': [1333], 'promastigotes': [1335], 'hind': [1338], 'footpad.': [1339], 'After': [1340, 1368], '30': [1341], 'three': [1348, 1500, 1543, 2240], 'changes': [1349], 'each,': [1355], 'followed': [1356], 'application': [1358], 'fluorescence-labeled': [1360], 'goat': [1361], '(Institut': [1364], 'Pasteur,': [1365], 'Paris,': [1366], 'France).': [1367], 'thorough': [1369], 'washing,': [1370], 'glycerine': [1376], 'Leitz': [1383], 'epifluorescence': [1384], 'microscope.': [1385], 'Control': [1386], 'serum.RESULTSThirteen': [1400], 'demographic': [1407], 'information': [1410], '3.': [1415, 1519, 1526, 2093, 2137], 'Two': [1416, 1840], 'rest': [1422], 'adults.': [1424], 'mean': [1426], 'age': [1427], '29': [1429], 'years': [1430], '(range': [1431, 1493], '4': [1432, 3024], '62': [1435], 'years).': [1436], 'Nine': [1437], 'males.': [1440], 'Three': [1441], 'native': [1444], 'Saudis,': [1445], 'others': [1448], 'Egyptians,': [1451], 'Indians,': [1453], 'Bangladeshis,': [1455], 'Thai': [1457], 'Sri': [1460], 'Lankan.': [1461], 'distribution': [1463, 3238], 'range': [1468], 'material': [1471], 'field': [1475], 'clinic.': [1476], 'average': [1478], 'duration': [1479], 'group': [1484, 1608], 'time': [1487, 2855], 'seven': [1491], '2-12': [1494], 'weeks).': [1495], 'With': [1496, 1656], 'exception': [1498, 1658], 'patients,': [1501, 1620, 2004, 2046], 'per': [1506], 'few': [1509, 2163, 3142], '(maximum': [1510], 'five).': [1511], 'patient,': [1513, 2331], 'Indian,': [1515], 'had': [1516, 1534, 1559, 1609, 1632, 1640, 1709, 1920, 2086, 2333, 2693, 2722, 2730, 2799, 2816, 2972, 3050, 3165, 3424], '53': [1517], 'lesions.Table': [1518], 'treatment.Table': [1525], 'treatment.Ten': [1532], 'classical': [1535], 'nodulo-ulcerative': [1536, 2415, 2472], 'In': [1540, 1672, 2002, 2044, 2277, 2304, 2350, 2360, 2492, 2510, 2549, 3319], 'smooth': [1547], 'irregular': [1549], 'papules': [1550], 'nodules': [1552, 1564, 1576, 1586], 'without': [1553, 1874], 'crusting': [1554], 'ulceration.': [1556], 'Patient': [1557, 1627, 1746, 1788, 2727, 2813, 2970], '2': [1558], 'discrete': [1561], 'mobile': [1562], 'subcutaneous': [1563, 1575, 1585], 'proximal': [1565], 'lesion': [1569, 1834, 1882, 1901, 2096, 2119, 3630], 'right': [1572, 1887], 'These': [1574, 2822, 3177, 3209], 'lymphatic': [1578], 'dissemination': [1579], 'CL.9': [1581], 'pathologically': [1591], 'characteristic': [1594], 'CL,': [1597], 'along': [1598, 2543], 'Four': [1604], 'painless': [1610], 'regional': [1611], 'lymphadenitis.': [1612], 'Leishmanin': [1613], 'carried': [1616], 'out': [1617, 3186], 'nine': [1623], 'it': [1624, 2625, 2753], '10,': [1628], 'infant,': [1631], 'negative': [1634, 2300], 'test;': [1636], 'highest': [1642, 2018, 2732], '(4+).The': [1645], '4.': [1655, 1714, 1725, 2001, 2116], '(see': [1662, 1826], 'above),': [1663], '11': [1664, 1755, 1789, 2083, 2443, 2815], '13,': [1666], '1+.': [1671], '11,': [1674], 'findings': [1676, 2248], 'interest.': [1680], 'biopsy': [1683, 1696], 'identifiable': [1690], 'parasites.': [1691], 'However,': [1692, 3284], 'earlier': [1694], 'done': [1697], 'several': [1698], 'previously,': [1700], 'prior': [1701, 3052], 'ketoconazole,': [1708], '3+': [1711, 1811], 'load.Table': [1713], 'type,': [1716, 1727, 2057], 'index': [1718, 1729], 'T-lymphocyte': [1720, 1731], 'infiltrate.Table': [1724], 'infiltrate.The': [1735], 'I': [1743, 2029, 3245], '(lymphocytic': [1744], 'preponderance).': [1745], 'II': [1751], '(macrophage': [1752], 'preponderance),': [1753], 'III': [1759, 2039], '(mixed': [1760], 'cellularity),': [1761], '7': [1764], 'IV': [1768, 2041], '(plasma': [1769], 'preponderance.': [1771], 'completed': [1779], 'prescribed': [1781], 'course': [1782, 1936], 'generally': [1784], 'good': [1785], '(Table': [1786], '3).': [1787], 'responded': [1790, 2717, 2879, 2981], 'differently.He': [1791], 'experienced': [1792], 'only': [1793, 1926], 'slight': [1794], 'regression': [1795, 1848, 1862, 1928, 1974], 'his': [1797, 1930, 2759], 'lesions,': [1798], 'separate': [1802], 'programs.': [1804], 'Although': [1805, 2986], 'fell': [1809], '0,': [1813], 'below).': [1827], 'decided': [1830], 'treat': [1832], 'intralesional': [1836, 1909, 1965], 'triamcinolone': [1837, 1855], '(5': [1838], 'mg/ml).': [1839], 'later': [1842, 1969, 2664], '25%': [1847], 'he': [1853], 'intramuscularly,': [1858], 'evidence': [1860], 'lesions.': [1865, 1923, 2478, 3057], 'six': [1867, 2045], 'completely': [1872, 1980, 3007], 'flat': [1873], 'induration': [1875], '(Figures': [1876], '1': [1877], '2).Figure': [1879], 'Nodular': [1881], 'involving': [1886], 'wrist': [1888], 'pentostam': [1890, 2827, 2984, 2994], 'Lesion': [1894], 'did': [1895], 'not': [1896, 2474, 2622, 2627, 2755, 2763, 3043, 3092, 3184, 3280], 'regress.Download': [1897], 'FigureFigure': [1898, 2115], 'Same': [1900], 'Figure': [1904, 2136], '1,': [1905], 'steroids.': [1912], 'Note': [1913], 'regression.Download': [1916], 'FigurePatient': [1917], '13': [1918, 2085, 2971], 'multiple': [1921], 'papulonodular': [1922], 'He': [1924, 1978, 2878, 2979, 3005], 'pentostam.': [1938], 'Rebiopsy': [1939, 2837], 'parasites,': [1947], '1a': [1950], 'macrophages.': [1956, 2849], 'nodular': [1960, 2159, 2421, 2477], 'treated': [1963], 'triamcinolone.': [1966], 'A': [1967, 3887, 3900, 3917, 3945, 3983, 4028], 'week': [1968], 'cured': [1981, 3008, 3028], 'therapy.Phenotypes': [1985], 'Lymphocytes': [1988], 'LesionsThese': [1995], 'formed': [2008], '55-85%': [2009], 'scored': [2024], 'reactions': [2030], '(Figure': [2031, 2042, 2197], '3)': [2032], 'II,': [2038], '4).': [2043], 'percentages': [2062], 'helper': [2064, 2181, 2594], 'equal,': [2069], 'remaining': [2073, 2613], 'numerous.': [2081], 'Patients': [2082, 3994], 'cells.Figure': [2092], 'Leu-1': [2099, 2127], 'antibody.': [2101, 2129, 2221], '(type': [2105], 'I)': [2106], 'reaction.': [2107, 2226], 'Majority': [2108], 'Leu-1-positive.(Immunoperoxidase': [2112], 'X400)Download': [2114, 2140, 2229], 'mixed': [2122], 'cellularity': [2123], 'Leu-1-positive': [2130], 'fewer': [2133], '(Immunoperoxidase': [2138, 2227], 'FigureT': [2141], 'epidermis.': [2148], 'regularly': [2151], 'appreciable': [2153], 'numbers': [2154, 2802, 3408], 'Nonulcerated': [2158], 'very': [2162, 3141], 'epidermis,': [2170], 'such': [2176], 'being': [2178], 'type.': [2182], 'Most': [2183], '(>80%)': [2191], 'epidermis': [2196, 3304, 3329], '5)': [2198, 2282, 3026], 'hair': [2199], 'follicles': [2200], 'vascular': [2202], 'endothelium': [2203], 'antigen.Figure': [2211], '5.': [2212, 2349, 2383, 2393], 'Epidermis': [2213], 'show': [2223, 2570], 'FigureHistological': [2230], 'Changes': [2231], 'NodesEnlarged,': [2234], 'palpable,': [2235], 'epitrochlear': [2236], 'available': [2243, 2642], 'Common': [2247], 'follicular': [2251], 'hyperplasia,': [2252], 'well-developed': [2253], 'paracortical': [2254, 2518], 'areas,': [2255], 'medullary': [2263], 'cords': [2264], 'scattered': [2266, 2430, 2480], 'small': [2267], 'granulomas': [2268], 'consisting': [2269], 'epithelioid': [2271], 'Langhans': [2274], 'giant': [2275], 'node': [2280], '(patient': [2281], 'necrosis': [2285], 'neutrophil': [2287], 'leukocytes': [2288], 'center': [2291], 'granuloma,': [2294], 'Ziehl-Neelsen': [2297], 'stain': [2298], 'acid-fast': [2302], 'bacilli.': [2303], 'capsule': [2315], 'surrounding': [2317], 'fat,': [2318], 'around': [2320], 'afferent': [2322], 'lymphatics.': [2323], 'scanty': [2327, 2376], 'except': [2328], 'moderate': [2334], 'numbers.T-lymphocyte': [2335], 'NodesThe': [2343], 'paracortex,': [2352], '78-87%': [2353], 'lymphocytes.': [2359, 2605, 3132], 'numerous': [2368, 2599, 2610], 'Suppressor/cytotoxic': [2373], 'absent': [2378], 'germinal': [2381, 2918], 'center.Table': [2382], 'Phenotype': [2384, 2394], 'paracortex': [2390, 2400], 'lymphnodes.Table': [2392], 'lymphnodes.Distribution': [2402], 'NodesThree': [2411], 'untreated': [2412], 'examined.': [2424], 'infiltrate.': [2435, 3004], '(patients': [2442, 3023], '13)': [2445], 'Many': [2454], 'containing': [2456, 2997], 'dermis.': [2462], 'keratinocytes': [2464, 3277, 3289, 3312, 3353], 'Some': [2479], 'large': [2481], 'showing': [2483], 'stronger': [2484], 'fluorescence': [2485, 2497], 'Langerhans': [2490], 'nodes,': [2495, 2922], 'strong': [2496], 'dendritic': [2502], 'cells,': [2503], 'marginal': [2506], 'sinuses': [2507], 'sinusoids.': [2509], 'case': [2512], 'interdigitating': [2514], 'zone': [2519], 'antigen.DISCUSSIONPrevious': [2521], 'studies': [2522], 'have': [2523, 2776, 2890, 2934, 2954, 3235, 3323], 'processes.6,10,11': [2533], 'necrotizing': [2537], 'mechanism': [2538, 3122, 3342], 'destroys': [2540], 'they': [2547], 'contain.': [2548], 'second': [2551], 'destroyed': [2556, 3116], 'inside': [2557], 'activated': [2559, 3259], 'macrophage.': [2560], 'mediated': [2564], 'lymphocytes.12,13': [2567], 'Our': [2568], 'usually': [2575, 2963], 'abundant': [2576], 'leishmaniasis,': [2579, 3952], 'reaction.In': [2587], 'about': [2588], 'patients.': [2614], 'exact': [2616], 'significance': [2617], 'finding': [2620], 'clear': [2623], 'since': [2624], 'possible': [2628, 2756, 3188], 'distinguish': [2630], 'between': [2631, 3231], 'presently': [2641], 'may': [2646, 2889, 3351, 3361], 'identified': [2653], 'fact': [2658, 2702, 3031], 'appearing': [2661], 'stages': [2665], 'would': [2672], 'appear': [2674], 'specifically': [2678, 3414], 'suppress': [2679, 3415], 'limit': [2685], 'already': [2694, 3425], 'been': [2695, 2956, 3426], 'eliminated.': [2696], 'supported': [2699, 2897, 4156], 'most': [2704], 'whose': [2708], 'well': [2718, 2880, 3392], 'low': [2724, 2739, 2868, 3039, 3062, 3655], 'load.': [2726, 2734], 'His': [2735, 2747, 2850], 'comparatively': [2745], 'high.': [2746], 'negative.': [2751], 'Unfortunately,': [2752], 'follow': [2758], 'progress.': [2760], 'We': [2761, 3041, 4171], 'do': [2762, 3042, 3183, 3279], 'know': [2764, 3044], 'what': [2765], 'evolution': [2767, 3627], 'like': [2772], 'high': [2778, 2783], 'lymphocyte': [2785, 2947, 3350], 'infrequent': [2790], 'area.The': [2793], 'failed': [2806, 2834], 'treatment.': [2812, 2821, 2886], 'many': [2817, 2847], 'before': [2819], 'therapy,': [2830, 2995], 'though': [2831], 'resolve.': [2836], 'stage': [2840], 'antigen-containing': [2848], 'low.': [2857], 'appears': [2859], 'coupled': [2864], 'perhaps': [2865], 'T-cell': [2870, 3568, 3833], 'continue.': [2877], 'That': [2887], 'steroids': [2888], 'actually': [2891], 'promoted': [2892], 'clearance': [2893], 'work': [2900, 3097, 4154], 'Netterheim': [2902, 3726], 'Hamous14': [2904], 'corticosteroids': [2908], 'vivo': [2911], 'reduced': [2912], 'retention': [2914, 3067, 3735], 'centers': [2919], 'possibly': [2923], 'effect': [2926, 3170], 'dentritic': [2931], 'macrophages.Steroids': [2932], 'effects': [2936], 'modulation': [2939], 'including': [2944], 'suppression': [2945], 'mitogens.15': [2952], 'Steroids': [2953], 'previously': [2955], 'benefit': [2959], 'recidivans,': [2962], 'last': [2968], 'resort.16': [2969], 'too': [2980, 3332], 'poorly': [2982, 3073], 'demonstrated': [2990], 'steroids.It': [3013], 'noted,': [3017], 'however,': [3018, 3140, 3182], 'despite': [3029], 'their': [3033, 3046, 4187], 'side.': [3040], 'increased': [3051, 3407], 'involution': [3054], 'relative': [3059], 'importance': [3060], 'responding': [3072], 'therapy': [3077], 'currently': [3079], 'investigation.The': [3081], 'certainty.': [3095], 'Bryceson': [3099, 3429, 3793], 'coworkers17': [3101], 'enriettii': [3104], 'infection': [3105, 3136], 'guinea': [3108], 'pig': [3109], 'indicated': [3110], 'might': [3114], 'through': [3120], 'akin': [3123], 'killing': [3125], 'target': [3127], 'Using': [3133], 'mouse,': [3139], 'Lyt-2': [3151], 'marker': [3153], 'lymphocytes.18': [3157], 'Furthermore,': [3158], 'mouse/L.': [3160], 'model': [3162, 3713], 'vitro': [3168, 3826], 'incubated': [3172], 'syngeneic,': [3174], 'L.-major-infected': [3175], 'macrophages.12': [3176], 'observations': [3178], 'animal': [3180], 'models,': [3181], 'rule': [3185], 'equivalent': [3214], 'la': [3216], 'product': [3224], 'HLA': [3226], 'genes.19': [3227], 'facilitate': [3229], 'communication': [3230], 'immunocompetent': [3232], 'restricted': [3237], 'body': [3241], 'compared': [3242], 'class': [3244], 'histocompatibility': [3246], 'found': [3250], 'mainly': [3251], 'B-lymphocytes,': [3256], 'lymphocytes.20': [3261], 'induction': [3263, 3706], 'T-helper': [3265], 'activation': [3267, 3709], 'requires': [3268, 3383], 'presentation': [3270], 'HLA-DR-positive': [3274], 'normally': [3278], 'express': [3281, 3293, 3355], 'antigen.': [3283], 'tuberculin': [3287], 'preceded': [3299], 'invasion': [3301], 'lymphocytes.21': [3306], 'Smolle22': [3307], 'described': [3308], 'variety': [3315], 'diseases.': [3318, 3592], 'we': [3322], 'infiltration': [3326], 'keratinocytes.': [3340], 'happens': [3346], 'unknown.': [3348], 'induce': [3352], 'adsorbed': [3363], 'epidermal': [3375], 'infiltrate.In': [3376], 'conclusion,': [3377], 'cure': [3379], 'elimination': [3385], 'appropriate': [3395], 'immunological': [3396, 3418], 'feature': [3399], 'cleared.ARTICLE': [3427], 'REFERENCES:1.': [3428], 'AD.': [3430], '"Diffuse': [3431], 'Ethiopia:': [3435], 'I.': [3436], 'disease"': [3444], '.': [3445, 3466, 3487, 3503, 3519, 3540, 3570, 3583, 3615, 3634, 3658, 3690, 3719, 3742, 3768, 3781, 3808, 3844, 3855, 3873, 3913], 'Trans': [3446, 3520], 'R': [3447, 3521, 4096], 'Soc': [3448, 3522, 3744], 'Trop': [3449, 3523], 'Hyg.': [3451, 3525], '1969;': [3452, 3471], '63:708–37.': [3453], 'Google': [3454, 3473, 3493, 3510, 3529, 3548, 3578, 3598, 3620, 3639, 3665, 3695, 3724, 3751, 3775, 3791, 3814, 3849, 3861, 3877], 'Scholar2.': [3455], 'Garnham': [3456], 'PC,': [3457], 'Humphrey': [3458], 'JH.': [3459], '"Problems': [3460], 'related': [3463], 'immunology"': [3465, 3854], 'Curr': [3467], 'Top': [3468], 'Microbiol': [3469], 'Immunol.': [3470, 3692, 3811], '48:29–42.': [3472], 'Scholar3.': [3474], 'Pearson': [3475], 'RD,': [3476], 'Wheeler': [3477], 'DA,': [3478], 'Harrison': [3479], 'LH,': [3480], 'Kay': [3481], 'HD.': [3482, 3674], '"The': [3483, 3514, 3535, 3559, 3626, 3647, 3824, 4114], 'immunobiology': [3484], 'leishmaniasis"': [3486, 3518, 3539, 3633, 3780], 'Rev': [3488], 'Infect': [3489], 'Dis.': [3490], '1983;': [3491, 3637], '5(5):907–27.': [3492], 'Scholar4.': [3494], 'Sokal': [3495], 'JE.': [3496], '"Measurement': [3497], 'delayed': [3499], 'skin-test': [3500], '[editorial]"': [3502], 'N': [3504, 3571], 'Engl': [3505, 3572], 'J': [3506, 3573, 3617, 3635, 3769], 'Med.': [3507, 3574, 3772], '1975;': [3508], '293(10):501–2.': [3509], 'Scholar5.': [3511], 'Ridley': [3512, 3622, 3624], 'DS.': [3513], 'pathogenesis': [3515], '1979;': [3526], '73(2):': [3527], '150–60.': [3528], 'Scholar6.': [3530], 'AM,': [3532, 3603, 3642], 'MK.': [3534, 3646], 'pathology': [3536], 'Eighth': [3541], 'Conference': [3544], 'Abstracts.': [3545], 'Riyadh,': [3546], '1983:214–5.': [3547], 'Scholar7.': [3549], 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