Title: THE MECHANISM OF THE ANTI-ANDROGENIC THERAPY FOR PROSTATIC CANCER
Abstract: Serum total acid phosphatase and serum prostatic acid phosphatase activities of prostatic cancer (21 cases) and the control cases (34 cases) were determined with Bodansky's and Fischman-Lerner's Modification. Histological findings of these prostatic tissues were studied by the needle biopsy and prostatectomy. The relations between variations of serum acid phosphatase activites and the changes of histological findings of these prostatic cancer were analysed. The average value of serum total acid phosphatase activities was 3.39±0.97 B. U., and that of serum prostatic acid phosphatase activities was 2.00±2.18 B. U.. After the antiandrogenic therapy, the total acid phosphatase level decreased to 2.68±0.30 B. U., the prostatic acid phosphatase level decreased to 0.94±0.47 B. U.. In the 7 cases of prostatic cancer which including 4 cases of differentiated adenocarcinoma and 3 cases of undifferentiated carcinoma, before the anti-androgenic therapy in the 4 cases of differentiated adenocarcinoma, the abnomal high levels of total and prostatic acid phoaphatase activities were detected. After the antiandrogenic therapy, the decreasing of these acid phosphatase levels were observed. However, in the 2 cases of undifferentiated carinoma, before anti-androgenic therapy, these acid phosphatase levels were normal. There was no change of total and prostatic acid phosphatase levels by the anti-androgenic therapy. Another cases of undifferentiated carcinoma complicated with extensive metastase had a slightly high acid phosphatase level. In the above cases of differentiated adenocarcinoms, after the anti-androgenic therapy, the remission of clinical symptoms appeared with normalization of total and prostatic acid phosphatase activities and histologically hydropic degeneration of cytoplasma of cancer cells, pyknosis of nuclei, karyorrhexis, karyolysis, necrosis and disappearing of cells, straggling or proliferation of connective tissue were observed. However, in the 2 cases of undifferentiated cancer, after the anti-androgenic therapy, neither improvement of clinical symptoms nor change of acid phosphatase activity were recognized. The histological changes of tumor tissue in these undifferentiated cancer were slight and localized.