Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2606868435', 'doi': None, 'title': "Efficacy and safety of subthalamic nucleus deep brain stimulation combined with drug therapy for treating Parkinson's disease: a Meta-analysis", 'display_name': "Efficacy and safety of subthalamic nucleus deep brain stimulation combined with drug therapy for treating Parkinson's disease: a Meta-analysis", 'publication_year': 2017, 'publication_date': '2017-02-01', 'ids': {'openalex': 'https://openalex.org/W2606868435', 'mag': '2606868435'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/a1210d597a7c4389a99e6fc161beba1e', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['doaj'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5058857655', 'display_name': 'Hai jiao Wang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}, {'id': 'https://openalex.org/I4210089761', 'display_name': 'West China Hospital of Sichuan University', 'ror': 'https://ror.org/007mrxy13', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210089761']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hai jiao Wang', 'raw_affiliation_strings': ['Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China', 'institution_ids': ['https://openalex.org/I24185976', 'https://openalex.org/I4210089761']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100443253', 'display_name': 'Deng Chen', 'orcid': 'https://orcid.org/0000-0002-0969-4382'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}, {'id': 'https://openalex.org/I4210089761', 'display_name': 'West China Hospital of Sichuan University', 'ror': 'https://ror.org/007mrxy13', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210089761']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Deng Chen', 'raw_affiliation_strings': ['Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China', 'institution_ids': ['https://openalex.org/I24185976', 'https://openalex.org/I4210089761']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077978140', 'display_name': 'Li na Zhu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}, {'id': 'https://openalex.org/I4210089761', 'display_name': 'West China Hospital of Sichuan University', 'ror': 'https://ror.org/007mrxy13', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210089761']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Li na Zhu', 'raw_affiliation_strings': ['Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China', 'institution_ids': ['https://openalex.org/I24185976', 'https://openalex.org/I4210089761']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021785258', 'display_name': 'Ge Tan', 'orcid': 'https://orcid.org/0000-0003-0026-8739'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}, {'id': 'https://openalex.org/I4210089761', 'display_name': 'West China Hospital of Sichuan University', 'ror': 'https://ror.org/007mrxy13', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210089761']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ge Tan', 'raw_affiliation_strings': ['Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China', 'institution_ids': ['https://openalex.org/I24185976', 'https://openalex.org/I4210089761']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104105484', 'display_name': 'Da Xu', 'orcid': 'https://orcid.org/0000-0002-4678-1397'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}, {'id': 'https://openalex.org/I4210089761', 'display_name': 'West China Hospital of Sichuan University', 'ror': 'https://ror.org/007mrxy13', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210089761']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Da Xu', 'raw_affiliation_strings': ['Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China', 'institution_ids': ['https://openalex.org/I24185976', 'https://openalex.org/I4210089761']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5050640367', 'display_name': 'Ling Liu', 'orcid': 'https://orcid.org/0000-0001-7588-6086'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}, {'id': 'https://openalex.org/I4210089761', 'display_name': 'West China Hospital of Sichuan University', 'ror': 'https://ror.org/007mrxy13', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210089761']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ling Liu', 'raw_affiliation_strings': ['Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China', 'institution_ids': ['https://openalex.org/I24185976', 'https://openalex.org/I4210089761']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 63}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10919', 'display_name': 'Neurological disorders and treatments', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10919', 'display_name': 'Neurological disorders and treatments', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10085', 'display_name': "Parkinson's Disease Mechanisms and Treatments", 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10106', 'display_name': 'Autism Spectrum Disorder Research', 'score': 0.9783, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/subthalamic-nucleus', 'display_name': 'Subthalamic Nucleus', 'score': 0.9315796}], 'concepts': [{'id': 'https://openalex.org/C2777319143', 'wikidata': 'https://www.wikidata.org/wiki/Q2270424', 'display_name': 'Subthalamic nucleus', 'level': 5, 'score': 0.9315796}, {'id': 'https://openalex.org/C2778542668', 'wikidata': 'https://www.wikidata.org/wiki/Q618076', 'display_name': 'Deep brain stimulation', 'level': 4, 'score': 0.7717881}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6936318}, {'id': 'https://openalex.org/C2779734285', 'wikidata': 'https://www.wikidata.org/wiki/Q11085', 'display_name': "Parkinson's disease", 'level': 3, 'score': 0.68240094}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.48451895}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.473123}, {'id': 'https://openalex.org/C24998067', 'wikidata': 'https://www.wikidata.org/wiki/Q4114622', 'display_name': 'Stimulation', 'level': 2, 'score': 0.43021983}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.39588845}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3512637}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.29253867}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.21376419}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doaj.org/article/a1210d597a7c4389a99e6fc161beba1e', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.42, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4225275255', 'https://openalex.org/W3205902602', 'https://openalex.org/W2980041378', 'https://openalex.org/W2598429580', 'https://openalex.org/W2347819598', 'https://openalex.org/W2124955702', 'https://openalex.org/W2067979784', 'https://openalex.org/W2050222960', 'https://openalex.org/W1907079177', 'https://openalex.org/W1663789458'], 'abstract_inverted_index': {'Objective': [0], 'To': [2], 'evaluate': [3], 'the': [4, 136, 166, 176, 194, 246, 282, 337], 'efficacy': [5], 'and': [6, 48, 75, 88, 132, 191, 222, 265, 321, 344], 'safety': [7], 'of': [8, 67, 80, 95, 141, 168, 248, 284, 324, 326, 340], 'subthalamic': [9, 54], 'nucleus': [11, 305], 'deep': [12, 57, 306], 'brain': [13, 58, 307], 'stimulation': [14, 308], '(STN-DBS)': [15], 'combined': [16, 159, 309], 'with': [17, 51, 121, 152, 160, 311], 'drug': [18, 161, 312], 'therapy': [19, 162, 313], 'for': [20, 92, 106], 'treating': [21], "Parkinson's": [23, 170, 224], 'disease': [24], '(PD).': [25], 'Methods': [27], 'Retrieve': [29], 'relevant': [30], 'randomized': [31], 'controlled': [33], 'trials': [34], '(RCTs)': [35], 'from': [36, 117], 'online': [37], 'databases': [38], '(January': [39], '1,': [40, 42], '1980-October': [41], '2016)': [43], 'as': [45], 'PubMed,': [46], 'EBMASE/SCOPUS': [47], 'Cochrane': [49, 89], 'Library': [50], 'key': [52], 'words:': [53], 'nucleus,': [56], 'stimulation,': [59], 'DBS,': [60], 'STN,': [61], 'Parkinson': [62], 'disease,': [63], 'random.': [64], 'Selection': [65], 'studies': [68, 81, 120], 'was': [69, 82], 'performed': [70], 'according': [71], 'to': [72, 335], 'pre-designed': [73], 'inclusion': [74, 137], 'exclusion': [76], 'criteria.': [78, 138], 'Quality': [79], 'evaluated': [83], 'by': [84, 101], 'using': [85], 'Jadad': [86, 122], 'Scale': [87, 173], 'Handbook': [91], 'Systematic': [93], 'Reviews': [94], 'Interventions.': [96], 'All': [97], 'data': [98], 'were': [99, 126, 146], 'pooled': [100], 'RevMan': [102], '5.2': [104], 'software': [105], 'Meta-analysis.': [107], 'Results': [109], 'The': [111], 'research': [112], 'enrolled': [113], '3245': [115], 'articles,': [116], 'which': [118], '6': [119], 'score': [123, 228], '≥': [124], '4': [125], 'chosen': [127], 'after': [128, 346], 'excluding': [130], 'duplicates': [131], 'those': [133], 'not': [134], 'meeting': [135], 'A': [139], 'total': [140], '958': [143], 'PD': [144, 327], 'patients': [145], 'included.': [147], 'Meta-analysis': [148], 'showed': [149], 'that': [150], 'comparing': [151], 'best': [153], 'medical': [155], 'treatment': [156], '(BMT),': [157], 'STN-DBS': [158], 'significantly': [163], 'reduced': [165], 'scores': [167], 'Unified': [169], 'Disease': [171, 225], 'Rating': [172], '(UPDRS)Ⅲ': [174], 'in': [175, 193], 'on': [178], 'phase': [179, 196], '(': [180, 197, 210, 230, 252, 267, 287], 'SMD': [181, 198, 211, 231], '=-0.570,': [183], '95%CI:': [184, 201, 214, 234, 272], '-0.710—0.430;': [185], 'P': [187, 204, 217, 237, 261, 276, 296], '=': [189, 206, 219, 239, 255, 263, 270, 278, 290, 298], '0.000)': [190, 264], 'off': [195], '=-1.170,': [200], '-1.500—0.850;': [202], '0.000),': [208], 'UPDRSⅠscore': [209], '=-0.150,': [213], '-0.290—0.010;': [215], '0.030),': [221], '39-Item': [223], 'Questionnaire': [226], '(PDQ-39)': [227], '=-0.510,': [233], '-0.660—0.370;': [235], '0.000).': [240, 299], 'But': [241], 'it': [242], 'can': [243], 'increase': [245], 'occurrence': [247, 283], 'severe': [249, 341], 'adverse': [250, 342], 'events': [251, 343], 'RD': [253, 268], '0.140,': [256], '95%': [257, 292], 'CI:0.090-0.190;': [259], 'dysarthria': [266, 345], '0.070,': [271], '0.010-0.120;': [274], '0.020),': [279], 'while': [280], 'decrease': [281], 'dyskinesia': [285], 'RR': [288], '0.450,': [291], 'CI:': [293], '0.330-0.620;': [294], 'Conclusions': [302], 'Subthalamic': [304], 'could': [314], 'greatly': [315], 'improve': [316], 'motor': [317], 'function,': [318], 'mental': [319], 'status': [320], 'quality': [323], 'life': [325], 'patients,': [328], 'however,': [329], 'clinicians': [330], 'should': [331], 'pay': [332], 'more': [333], 'attention': [334], 'increased': [338], 'risk': [339], 'operation.': [347], 'DOI:': [352], '10.3969/j.issn.1672-6731.2017.02.006': [354]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2606868435', 'counts_by_year': [], 'updated_date': '2024-12-10T01:34:40.880978', 'created_date': '2017-04-28'}