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'Chang,': [57], 'Faisal': [59, 115], 'Nabi,': [60], 'Dipan': [62, 135], 'J.': [63, 136, 138], 'Shah,': [64], 'MD': [65, 70], 'Jerry': [67, 157], 'D.': [68, 158, 160], 'Estep,': [69], 'NaguehSherif': [73], 'Nagueh': [75], 'From': [76, 98, 118, 140, 162], 'the': [77, 99, 119, 141, 163, 203, 334, 361, 367, 372, 404, 408, 424, 440, 535, 615, 641, 682, 685, 717, 750, 764, 792, 800, 810, 908, 911, 973, 977, 984, 990, 1072, 1124, 1220, 1230, 1280, 1286, 1322, 1341, 1389, 1438, 1455, 1507, 1520, 1580, 1631, 1670, 1682, 1727, 1746, 1796, 1799, 1848, 1854, 1922, 1933, 1966, 1976, 2004, 2031, 2039, 2060, 2157, 2204, 2226, 2233, 2293, 2302, 2327, 2353, 2379, 2465, 2511, 2692, 2727, 2800, 2837, 2840, 2854, 2859, 2892, 2981, 3012, 3021, 3028, 3042, 3050, 3066, 3118, 3159, 3180, 3203, 3214, 3239, 3255, 3303, 3334, 3362, 3394, 3404, 3436, 3442, 3528, 3546, 3551, 3558, 3602, 3646, 3675, 3682, 3692, 3701, 3713, 3749, 3761, 3797, 3812, 3846, 3899, 3911, 3943, 3991, 4010, 4026, 4108, 4125, 4129], 'Methodist': [78, 88, 100, 110, 120, 130, 142, 152, 164, 174], 'DeBakey': [79, 101, 121, 143, 165], 'Vascular': [82, 104, 124, 146, 168], 'Center,': [83, 105, 125, 147, 169], 'Imaging': [86, 108, 128, 150, 172, 692, 1119, 2887, 3289, 4138], 'Institute': [87, 109, 129, 151, 173], 'Hospital,': [89, 111, 131, 153, 175], 'Houston,': [90, 112, 132, 154, 176], 'TX.': [91, 113, 133, 155, 177], ',': [92, 114, 134], 'ChangSu': [95], 'Chang': [97], 'NabiFaisal': [116], 'Nabi': [117], 'ShahDipan': [137], 'Shah': [139], 'EstepJerry': [159], 'Estep': [161], 'Originally': [178], 'published11': [179], 'Apr': [180], '2017https://doi.org/10.1161/CIRCIMAGING.116.005615Circulation:': [181], 'Imaging.': [183], '2017;10:e005615Clinical': [184], 'VignetteA': [185], '60-year-old': [186], 'man': [187], 'was': [188, 282, 302, 311, 318, 328, 337, 349, 378, 418, 477, 486, 491, 1441, 1816, 1822, 2747, 2927, 2943, 2967, 3613], 'referred': [189], 'for': [190, 202, 226, 919, 932, 939, 1223, 1240, 1361, 1509, 1522, 1847, 1871, 2292, 2356, 3314, 3550, 3601, 3695, 4025, 4124, 4255], 'evaluation': [191, 680, 1934, 3773, 3798], 'of': [192, 200, 259, 267, 275, 360, 363, 391, 510, 514, 520, 572, 643, 659, 681, 684, 691, 719, 731, 794, 836, 979, 992, 1010, 1126, 1234, 1242, 1288, 1314, 1324, 1333, 1344, 1359, 1392, 1408, 1412, 1417, 1424, 1431, 1446, 1547, 1572, 1576, 1611, 1636, 1657, 1688, 1745, 1760, 1803, 1833, 1842, 1851, 1867, 1924, 1935, 1975, 2010, 2024, 2033, 2062, 2084, 2109, 2156, 2181, 2211, 2220, 2225, 2274, 2281, 2298, 2312, 2331, 2381, 2414, 2497, 2522, 2526, 2533, 2537, 2548, 2558, 2564, 2624, 2630, 2729, 2744, 2757, 2789, 2805, 2839, 2843, 2851, 2894, 2915, 2936, 2954, 2973, 2980, 3014, 3030, 3045, 3049, 3052, 3090, 3120, 3197, 3305, 3310, 3359, 3364, 3369, 3438, 3444, 3491, 3522, 3530, 3539, 3548, 3624, 3636, 3650, 3662, 3677, 3684, 3715, 3734, 3753, 3763, 3793, 3799, 3814, 3819, 3837, 3870, 3913, 3946, 3971, 3978, 3993, 4052, 4068, 4128, 4132], 'progressive': [193], 'dyspnea': [194, 3308], 'fatigue.': [196], 'He': [197, 217, 235, 245, 255, 269, 607], 'reports': [198, 264], 'shortness': [199, 2330], 'breath': [201, 2332], 'past': [204], '3': [205, 421, 3071], 'months': [206], 'now': [208], 'experiences': [209], 'this': [210, 532, 638, 860, 929, 1052, 1398, 1478, 1560, 2724, 2925, 3127, 3277, 3666], 'symptom': [211], 'while': [212], 'walking': [213], 'his': [215, 279, 290], 'house.': [216], 'prefers': [218], 'sleep': [220], 'with': [221, 340, 344, 401, 427, 507, 523, 552, 603, 628, 755, 757, 827, 853, 862, 897, 925, 1005, 1057, 1088, 1106, 1204, 1328, 1450, 1615, 1641, 1646, 1651, 1681, 1717, 1720, 1729, 1743, 1785, 1864, 1917, 1992, 2152, 2178, 2202, 2249, 2263, 2335, 2344, 2362, 2427, 2448, 2488, 2518, 2541, 2551, 2607, 2644, 2734, 2775, 2885, 3003, 3041, 3079, 3093, 3146, 3149, 3162, 3168, 3184, 3202, 3216, 3227, 3269, 3285, 3307, 3322, 3468, 3652, 3711, 3720, 3731, 3801, 3806, 3816, 3834, 3854, 3868, 3882, 3917, 3927, 4050, 4056, 4074, 4083, 4099, 4118, 4243], '2': [222, 2421, 2955, 3706], 'pillows,': [223], 'a': [224, 247, 271, 283, 355, 388, 396, 428, 524, 708, 1097, 1545, 1608, 1710, 1715, 1905, 2025, 2153, 2257, 2317, 2385, 2425, 2446, 2660, 2902, 2913, 3000, 3073, 3144, 3270, 3286, 3519, 3622, 3659, 3732], 'change': [225], 'him': [227, 232], 'that': [228, 277, 537, 632, 797, 868, 904, 1296, 1470, 1815, 1938, 2095, 2256, 2350, 2383, 2704, 3377, 3399, 3577, 3586, 3740], 'he': [229, 263, 538], 'felt': [230], 'makes': [231], 'breathe': [233], 'better.': [234], 'has': [236, 256, 270, 539, 608, 930, 1471, 1562, 1930, 2289, 2877, 3571, 3638], 'diabetes': [237, 4244], 'mellitus': [238], 'is': [240, 246, 287, 550, 707, 712, 763, 835, 916, 946, 1016, 1043, 1095, 1219, 1238, 1278, 1310, 1350, 1367, 1466, 1514, 1530, 1578, 1806, 1860, 2036, 2044, 2237, 2261, 2339, 2422, 2476, 2483, 2494, 2605, 2639, 2688, 2770, 2797, 2813, 2997, 3055, 3097, 3106, 3166, 3249, 3264, 3341, 3578, 3658, 3729, 3774, 3907, 3987, 4021, 4040, 4092, 4122], 'on': [241, 688, 961, 972, 1388, 1400, 1894, 1901, 2132, 2437, 2891, 3117, 3123, 3483, 3581, 3727, 4034, 4103], 'oral': [242], 'hypoglycemic': [243], 'medications.': [244], 'former': [248], 'smoker': [249], 'but': [250, 262, 343, 1899, 2709, 3440, 3533, 4029], 'quit': [251], '15': [252], 'years': [253], 'ago.': [254], 'no': [257, 381, 2594, 3114], 'symptoms': [258, 569, 2358], 'chest': [260, 547], 'pain,': [261], 'one': [265, 2899, 3260], 'instance': [266], 'near-syncope.': [268], 'positive': [272], 'family': [273], 'history': [274, 3883], 'HF': [276, 700, 705, 756, 1058, 2307, 2345, 2552, 2777, 2990, 3312, 3405, 3439, 3660, 3803], 'affected': [278, 1780, 1941, 2046], 'father,': [280], 'who': [281], 'nonsmoker.': [284], 'The': [285, 416, 2171, 2223, 2560, 2676, 3633], 'patient': [286, 533, 861, 1399, 1716, 1728, 1809, 2426, 2447, 2512, 2725, 2926, 3128, 3145, 3182, 3215, 3275, 4011], 'unsure': [288], 'whether': [289, 2322], 'father': [291], 'had': [292, 1810, 3280], 'coronary': [293, 3451, 3923, 4203, 4217, 4256], 'artery': [294, 661, 1244, 4257], 'disease': [295, 926, 2194, 3318, 3446, 3857, 3956, 4258], '(CAD).': [296, 4259], 'On': [297, 1853], 'physical': [298, 689], 'examination,': [299], 'heart': [300, 1202, 1718, 3147, 3596, 3897, 3936], 'rate': [301, 317, 1184, 1756, 1829, 1911, 2013, 2117, 2129], 'regular': [303], 'at': [304, 325, 371, 407, 420, 453, 459, 465, 637, 1171, 1177, 1437, 1443, 1819, 1825, 1831, 2755, 2929, 2945, 2969, 3187, 3527, 3845], '85': [305], 'per': [306, 320], 'minute': [307, 321], 'blood': [309, 456, 617, 4088], 'pressure': [310, 332, 2041, 2284, 2819, 2822, 2908, 2918, 2923, 2935, 2942, 2960, 3195, 3620], '126/80': [312], 'mm': [313, 2931, 2938, 2947, 2971, 3199], 'Hg.': [314, 2939], 'His': [315], 'respiratory': [316], '22': [319], 'pulse': [323, 2826], 'oximetry': [324], 'room': [326], 'air': [327], '93%.': [329], 'Jugular': [330], 'venous': [331, 588, 2411], 'upright': [335], 'position': [336], '14': [338], 'cm': [339], 'inspiratory': [341], 'collapse': [342], 'systolic': [345, 645, 1463, 1761, 1838, 2415, 2737, 2791, 2907, 2922, 4046, 4175, 4183, 4195, 4209, 4220], 'expansion.': [346], 'Carotid': [347], 'upstroke': [348], 'not': [350, 917, 1044, 1298, 1563, 1807, 1845, 1892, 2706, 2771, 2862, 3098, 3389, 3497, 3525, 3949, 4023], 'delayed.': [351], 'Cardiac': [352, 3925], 'examination': [353, 433, 545, 3007], 'revealed': [354, 387], 'downward': [356], 'outward': [358], 'displacement': [359], 'point': [362], 'maximum': [364, 1347, 1421, 2393], 'impulse': [365], 'sixth': [368], 'intercostal': [369, 411], 'space': [370, 412], 'anterior': [373, 3892], 'axillary': [374], 'line.': [375], 'Parasternal': [376], 'uplift': [377, 563], 'present,': [379], 'thrills': [382], 'were': [383, 446, 473, 1403, 2174, 3355, 3672], 'noted.': [384], 'Apical': [385], 'auscultation': [386], 'diminished': [389], 'intensity': [390], 'S1,': [392], 'an': [393, 679, 1027, 1045, 1060, 1304, 1311, 1467, 2519, 2992, 3299, 3575], 'S3,': [394, 580], 'grade': [397], 'III/VI': [398], 'holosystolic': [399], 'murmur': [400, 686], 'radiation': [402], 'axilla.': [405], 'Auscultation': [406], 'second': [409, 1281], 'left': [410, 525, 553, 664, 1209, 2451, 3173, 3891], 'showed': [413, 434, 450, 494, 504, 2513, 2751, 2901, 3598], 'prominent': [414], 'P2.': [415], 'liver': [417, 594], 'enlarged': [419, 1442], 'fingerbreadths': [422], 'below': [423], 'costal': [425], 'margin': [426], 'tender': [429], 'edge.': [430], 'Lower': [431], 'extremity': [432], 'bilateral': [435, 497, 583, 599], 'pitting': [436, 600], 'pretibial': [437, 601], 'edema': [438, 602], 'knee': [441], 'level.': [442, 606], 'Peripheral': [443], 'arterial': [444, 1555], 'pulses': [445], 'intact.': [447], 'Laboratory': [448], 'findings': [449, 530, 1396, 2457, 3231, 3879], 'serum': [451, 463, 621], 'sodium': [452], '131': [454], 'mEq/L,': [455], 'urea': [457, 618], 'nitrogen': [458, 619], '35': [460], 'mg/dL,': [461], 'creatinine': [464, 622], '1.5': [466], 'mg/dL.': [467], 'Alanine': [468], 'aminotransferase': [469, 472], 'aspartate': [471], 'slightly': [474], 'elevated': [475, 604, 2542, 3347, 3419, 3434, 3540, 3607, 3678], 'as': [476, 612, 789, 791, 847, 886, 894, 934, 996, 1049, 1307, 1526, 2102, 2104, 2143, 2145, 2342, 2359, 2670, 2672, 2713, 3036, 3415, 3447, 3463, 3465, 3808, 3981, 4014, 4037], 'total': [478], 'bilirubin.': [479], 'NT-proBNP': [480, 605, 3327, 3422, 3508, 3668], '(N-terminal': [481], 'pro-B-type': [482], 'natriuretic': [483], 'peptide)': [484], 'level': [485, 1440, 3529], '2400': [487], 'pg/mL.': [488], 'Chest': [489], 'x-ray': [490], 'performed': [492], 'cardiomegaly,': [495], 'small': [496], 'pleural': [498, 584], 'effusions,': [499, 585], 'hilar': [501, 581], 'congestion.': [502], 'ECG': [503, 3885], 'sinus': [505, 1335], 'rhythm': [506, 1336], 'QRS': [508, 518], 'axis': [509], '60°,': [511], 'PR': [512, 2505], 'interval': [513, 519], '180': [515], 'ms,': [516, 2528], '160': [521], 'ms': [522], 'bundle': [526, 3888], 'branch': [527, 3889], 'block': [528, 3937], 'morphology.The': [529], 'support': [534, 1677], 'conclusion': [536], 'developed': [540], 'decompensated': [541], 'congestive': [542, 1849, 2776], 'HF.': [543, 1852, 3324], 'By': [544], 'x-ray,': [548], 'there': [549, 953, 1384, 3112], 'cardiomegaly': [551], 'ventricular': [554, 673, 1697, 2452, 3344, 3939], '(LV)': [555, 2453], 'enlargement': [556, 724, 2733, 3866], '(apical': [557], 'displacement)': [558], 'pulmonary': [560, 573, 660, 1166, 1243, 2410, 2764, 2768, 2808, 2825, 2829, 2866, 2895, 2950, 3205, 3469], 'hypertension': [561, 1167, 2765], '(parasternal': [562], 'loud': [565], 'P2).': [566], 'There': [567, 624, 2493, 2655, 3826], 'are': [568, 625, 1266, 1275, 1297, 1303, 1385, 1592, 1735, 1757, 1779, 1890, 1939, 1979, 2130, 2326, 2539, 2656, 3113, 3328, 3496, 3827, 3841, 3880, 3948], 'signs': [571], 'systemic': [575, 2784, 3944], 'congestion': [576], 'including': [577, 640, 1491, 2991], 'dyspnea,': [578], 'orthopnea,': [579], 'congestion,': [582, 2785], 'increased': [586, 1683, 1925, 2323, 2612, 2752, 3172, 3725, 4199, 4213], 'jugular': [587], 'pressure,': [589, 2869, 2872], 'hepatic': [590], 'enlargement/congestion': [591], '(and': [592, 1624, 3771], 'abnormal': [593, 616, 1618, 1856], 'enzymes': [595], 'bilirubin),': [597], 'reduced': [609, 758, 1205, 1652, 1721, 1788, 1824, 1830, 1873, 2590, 2608, 3150, 3721], 'peripheral': [610], 'perfusion': [611, 3767, 4201, 4215], 'inferred': [613, 2573], 'from': [614, 1709, 1739, 2038, 2301, 2424, 2445, 3143, 3179, 3213, 4107], 'levels.': [623], 'several': [626, 1459, 1584, 3428, 3572, 3642, 3689], 'questions': [627], 'respect': [629, 854], 'diagnosis': [631, 706, 3048, 3304, 3363, 3521, 3647, 3733, 3848, 3901, 3912], 'need': [633, 1508], 'be': [635, 738, 844, 870, 884, 955, 969, 1250, 1271, 1487, 1541, 1765, 1880, 1913, 2074, 2196, 2352, 2567, 2648, 2834, 3103, 3358, 3433, 3512, 3745, 3792, 3903, 3958, 4188, 4251], 'answered': [636], 'point,': [639], 'cause': [642, 683, 1083, 3368, 3694], 'LV': [644, 651, 720, 778, 785, 795, 822, 909, 940, 1011, 1031, 1111, 1225, 1256, 1404, 1414, 1447, 1462, 1548, 1587, 1603, 1811, 1834, 1837, 1857, 1876, 1887, 1895, 1907, 1918, 1926, 1943, 1960, 2055, 2189, 2221, 2240, 2244, 2265, 2275, 2282, 2313, 2470, 2490, 2515, 2543, 2609, 2673, 2736, 3031, 3348, 3448, 3541, 3562, 3679, 3865, 3994, 4151, 4161, 4235], 'dysfunction': [646, 924, 994, 1920, 3032, 3995, 4047, 4237], 'its': [648, 1380, 1558, 2683], 'potential': [649, 1038], 'reversibility,': [650], 'volumes,': [652], 'mass': [653, 1012, 1032, 1415], 'ejection': [655, 759, 1206, 1259, 1722, 2454, 3151], 'fraction': [656, 760, 1260, 1723, 2455, 3152], '(EF),': [657], 'estimation': [658, 1241], '(PA)': [662], 'pressures,': [663], 'atrial': [665, 669, 1329, 3174, 3194], '(LA)': [666], 'right': [668, 672, 1217, 3192, 3595], '(RA)': [670], 'size,': [671, 952], '(RV)': [674], 'size': [675, 881, 1309, 1378, 2561, 2614], 'function,': [677, 857, 1602], 'noted': [687, 3426], 'examination.Role': [690], 'Characterizing': [694], 'Chamber': [695], 'Sizes': [696], 'FractionAlthough': [704], 'clinical': [709, 3124, 3278, 3703, 3918], 'diagnosis,1–4': [710], 'it': [711, 848, 915, 1513, 1539, 2050, 2812, 2876, 3809, 4091], 'still': [713, 3511], 'important': [714, 1312, 1468, 2341, 2689, 3009, 3056, 3634, 4022], 'identify': [716, 777, 3990], 'presence': [718, 793, 991, 1231, 1923, 2728, 3013, 3443, 3676, 3714, 3750, 3813, 3992], 'remodeling': [721], 'LA': [723, 824, 1308, 1346, 1363, 1420, 2394, 2546, 2917], 'assess': [727, 1253, 3561, 4000, 4095], 'LVEF': [728, 1411, 2996, 3656, 4053], 'because': [729, 1571, 2180, 2557, 3309], 'all': [730, 1736, 1883, 2536, 3390], 'these': [732, 1317, 3015, 3505, 3878, 3953], 'measurements': [733, 1805, 2219], 'predict': [734, 1321, 1475], 'outcome': [735, 1476, 2882], 'can': [737, 774, 798, 849, 905, 954, 988, 1075, 1082, 1249, 1320, 1486, 1540, 1764, 1879, 1912, 2195, 2351, 2553, 2566, 2647, 2779, 2833, 2888, 2987, 3019, 3034, 3383, 3432, 3687, 3744, 3791, 3810, 3858, 3929, 3957, 3976, 4016, 4064, 4187], 'used': [739, 1239, 1251, 3699, 3746], 'guide': [741], 'track': [743, 3616], 'response': [744, 2596, 2701, 3501, 4096], 'treatment.': [746, 3060, 4062], 'Table': [747], '1': [748], 'shows': [749], 'structural': [751, 1632, 3531], 'changes': [752, 2187, 2696, 3258, 3617], 'patients': [754, 888, 896, 920, 936, 1004, 1056, 1087, 1262, 1318, 1327, 1640, 1863, 1916, 2177, 2201, 2248, 2334, 2343, 2361, 2643, 2774, 2884, 3306, 3321, 3467, 3482, 3506, 3593, 3625, 3651, 3710, 3800, 3853, 4006, 4049, 4073, 4082, 4117, 4242], '(HFrEF).': [761], 'Echocardiography': [762], 'initial': [765, 1221], 'modality': [766], 'recommended,': [767], 'if': [769, 3921], 'needed,': [770, 3922], 'intravenous': [771, 1101], 'contrast': [772, 1102], 'injection': [773], 'help': [775], 'correctly': [776, 820], 'endocardial': [779], 'borders': [780], 'thus': [782], 'measure': [783, 821], 'accurately': [784], 'volumes': [786, 825, 963, 1257, 1302, 1348, 1364, 1549], 'EF': [788, 1465, 1775, 4059], 'well': [790, 2103, 2144, 2216, 2671, 3464], 'thrombi': [796], 'prompt': [799], 'treating': [801], 'physician': [802], 'initiate': [804], 'anticoagulant': [805], 'therapy': [806, 1068, 3092], '(Movie': [807, 1452], 'I': [808, 2436], 'Data': [811, 1456, 2466, 3067, 3240], 'Supplement).5': [812], 'Guidelines': [813], 'have': [814, 890, 1026, 1059, 1372, 1458, 1617, 1629, 1662, 1787, 1986, 2002, 2067, 2096, 2162, 2347, 2374, 2384, 2554, 2589, 3298, 3392, 3400, 3424, 3488, 3859], 'been': [815, 1472, 2290, 2375, 3401, 3425, 3639], 'published': [816], 'explaining': [817], 'how': [818], 'along': [826, 1991, 3719, 3867, 3916], 'established': [828, 3300], 'normal': [829, 1345, 1360, 1393, 1711, 1906, 2469, 2489, 2998, 3567], 'reference': [830], 'ranges.6': [831], 'When': [832, 3088, 3877], 'echocardiographic': [833, 1264, 1273, 2272, 4120], 'imaging': [834, 1884, 3018, 3517, 3570, 3637, 3686, 3833, 3906, 3986, 4247], 'suboptimal': [837, 1267, 3555, 4119], 'quality,': [838], 'cardiac': [839, 1024, 1066, 1107, 1195, 1502, 2874, 3365, 3409, 3445, 3458, 3516, 3523, 4262], 'magnetic': [840, 1196, 1299, 4263], 'resonance': [841, 1300, 4264], '(CMR)': [842], 'should': [843, 882], 'considered': [845, 938], 'next': [846], 'provide': [850, 3688, 4065], 'valuable': [851], 'information': [852], 'valvular': [856, 863, 3455], 'particularly': [858, 2340, 3697], 'lesions,': [864, 3456], 'myocardial': [866, 2063, 2193, 2742, 3754, 3955, 4069], 'texture': [867], 'cannot': [869, 1270], 'obtained': [871, 1981, 2423], 'reliably': [872, 1532, 3565], 'by': [873, 1352, 1355, 1365, 1489, 1767, 1771, 1781, 1882, 1942, 1982, 2047, 2192, 2252, 2405, 2570, 2574, 2615, 2650, 2795, 3038, 3108, 3138, 3380, 3875, 3935, 3960, 4086, 4154, 4240], 'computed': [874, 1199, 1499, 2578, 2619, 3780], 'tomographic': [875], '(CT)': [876], 'or': [877, 900, 1065, 1134, 1141, 1146, 1151, 1160, 1192, 1552, 2183, 2873, 2978, 2984, 3094, 3787, 3895], 'nuclear': [878, 1247], 'imaging.': [879, 2199, 3768, 4105], 'RV': [880, 892, 898, 902, 923, 951, 962, 1001, 1254, 1434, 2782, 2855, 3863, 4163], 'also': [883, 1096, 1373, 1900, 2640, 2710, 3534, 3828, 4030], 'determined': [885, 1533], 'some': [887], 'may': [889, 968, 3102, 3487, 3510, 3902, 4250], 'predominant': [891, 3262], 'problems': [893], 'infarction': [899, 2565], 'arrhythmogenic': [901], 'cardiomyopathy': [903, 1643, 3915], 'affect': [906], 'both': [907, 2486], 'RV.': [912], 'In': [913, 1726, 3514, 3709, 3739, 3952], 'addition,': [914, 2186], 'uncommon': [918, 1046, 2772], 'develop': [922], 'progression': [927], 'implications': [931], 'treatment': [933, 2703, 3044, 3082, 3101, 3122, 3229, 3243, 3253, 3378, 3486, 3503, 4098], 'being': [937, 1593], 'assist': [941], 'devices': [942, 1295], '(LVADs).': [943], 'Although': [944], 'echocardiography': [945, 967, 1356, 1366, 1402, 1490, 1551, 1769, 1983, 2796, 3040, 3110, 3549, 3728, 4249], 'often': [947, 2346], 'useful': [948, 2879, 3498, 3842], 'evaluating': [950, 1224], 'challenges': [956, 1077], 'reaching': [958], 'reliable': [959], 'conclusions': [960], 'although': [964, 1383, 1538, 1574, 1984, 3111, 3388, 3507], '3-dimensional': [965], '(3D)': [966], 'helpful': [970], 'based': [971], 'image': [974], 'quality': [975, 3661], 'experience': [978], 'sonographers': [980], 'physicians': [982], 'analyzing': [983], 'acquired': [985], 'scans.6': [986], 'CMR': [987, 1269, 1277, 1353, 1505, 2571, 3743, 3790, 3832, 3961, 4063, 4115], 'uncover': [989, 3811], 'segmental': [993, 1588, 1637, 1673, 2125], 'such': [995, 1525, 2255, 3121], 'akinetic,': [997], 'dyskinetic,': [998], 'aneurysmal': [1000], 'segments': [1002, 1645, 1650, 2151, 2587], 'technically': [1006], 'challenging': [1007], 'echocardiograms.': [1008], 'Assessment': [1009], 'hypertrophy': [1014, 1143], 'pattern': [1015, 2207, 2242, 2413, 2517, 3212, 3257], 'possible': [1017, 2798, 2814, 3311, 3775, 4093], 'using': [1018, 1100, 1535, 1544, 2198, 2308, 2653, 2799, 2836, 3083, 3756, 3765, 3776], 'echocardiography.': [1019], 'Three-dimensional': [1020], 'echocardiography,': [1021, 2585, 4113], 'CMR,': [1022, 4155, 4191], 'CT': [1025, 1503], 'advantage': [1028], 'obtaining': [1030], 'without': [1033, 1506, 3095], 'geometric': [1034, 1510], 'assumptions.': [1035, 1511], 'Notwithstanding': [1036], 'their': [1037, 1872, 1993, 2357], 'utility,': [1039], 'coexisting': [1040, 2363], 'renal': [1041, 1289], 'insufficiency': [1042, 1094, 1290], 'comorbid': [1047, 2348], 'condition': [1048], 'exemplified': [1050], 'case.': [1053], 'Furthermore,': [1054, 4090], 'many': [1055, 4131], 'implantable': [1061], 'cardioverter': [1062, 1293], 'defibrillator': [1063, 1294], '(ICD)': [1064], 'resynchronization': [1067], '(CRT)': [1069], 'device': [1070], 'associated': [1073, 2262, 2606], 'artifact': [1074], 'pose': [1076], 'CMR.': [1079, 1772], 'Likewise,': [1080, 3905], 'gadolinium': [1081, 3758, 3821, 3839, 3872], 'nephrogenic': [1084], 'sclerosis': [1085], 'compromised': [1089], 'glomerular': [1090], 'filteration': [1091], 'rate.': [1092, 1794], 'Renal': [1093], 'contraindication': [1098], 'agents': [1103, 4102], 'conjunction': [1105], 'CT.Table': [1108], '1.': [1109, 1695], 'Usual': [1110], 'Structure': [1112], 'Function': [1114], 'Abnormalities': [1115], 'HFrEF': [1117, 1451, 1616, 1730, 1786, 2179, 2250, 2428, 2920], 'Modalities': [1120], 'That': [1121], 'Can': [1122], 'Identify': [1123], 'Presence': [1125], 'Abnormal': [1127], 'FindingsHFrEFLV': [1128], 'end-diastolic': [1129, 1405, 1435, 2283, 2286, 2952, 3349], 'volume': [1130, 1137, 1148, 1406, 1422, 1429, 2395, 2754], '(echocardiography*,': [1131, 1138, 1144, 1149, 1158, 1164, 1173, 1179, 1181, 1185, 1188], 'MUGA†,': [1132], 'CMR‡': [1133, 1140, 1145, 1150, 1159], 'CT†)IncreasedLV': [1135, 1142], 'end-systolic': [1136, 1527], 'MUGA,': [1139, 1211], 'CT†)EccentricLA': [1147], 'CT†)IncreasedMitral': [1152], 'annular': [1153], 'early': [1154, 1908, 1948, 1954, 1972, 2019, 2126, 2164, 3163], 'diastolic': [1155, 1858, 1909, 1919, 1936, 1955, 1962, 2020, 2127, 2165, 2314, 2417, 2544, 2674, 2793, 2821, 2941, 2962, 2965, 4177, 4185, 4197, 4211, 4222, 4236], 'velocity:': [1156], "e'": [1157], 'CT†)ReducedSecondary': [1161], 'mitral': [1162, 1235, 1952, 2069, 2205, 2212, 2479, 2625, 2985, 3024, 3053, 3076, 3210, 3246, 3283, 3670], 'regurgitation': [1163, 2402, 2951, 2979, 3025, 3054, 3077, 3135, 3177, 3284], 'CMR‡)PresentSecondary': [1165], '(echocardiography*)PresentGlobal': [1168], 'longitudinal': [1169, 1605, 1665, 1705, 1813, 1961, 2028, 2166, 4232], 'strain': [1170, 1176, 1606, 1623, 1625, 1638, 1674, 1701, 1706, 1814, 1963, 2012, 2021, 2116, 2128, 2169, 4233], 'rest': [1172, 1178], 'CMR‡)ReducedGlobal': [1174], 'circumferential': [1175, 1667, 1700, 2168, 2668], 'CMR‡)ReducedTwist': [1180], 'CMR‡)ReducedPeak': [1182], 'untwisting': [1183, 1793, 1828], 'CMR‡)ReducedRV': [1186], 'function': [1187, 1228, 1762, 1839, 1859, 2315], 'RNA†,': [1189], 'CMR‡,': [1190, 4165], 'CT†)Normal': [1191], 'depressedCMR': [1193], 'indicates': [1194], 'resonance;': [1197], 'CT,': [1198], 'tomography;': [1200], 'HFrEF,': [1201, 2203, 3712], 'failure': [1203, 1719, 3148], 'fraction;': [1207], 'LV,': [1208], 'ventricular;': [1210], 'multigated': [1212], 'acquisition': [1213], 'scan;': [1214], 'RV,': [1216], 'ventricular.*Echocardiography': [1218], 'test': [1222, 1282], 'structure': [1226], 'severity': [1233, 3051, 3078, 3319], 'regurgitation.': [1236], 'It': [1237, 1485, 2646], 'pressures.†CT': [1245], 'techniques': [1248], 'where': [1263, 2995, 3261, 3831, 3985], 'images': [1265, 1274, 3556], 'utilized.‡When': [1272], 'suboptimal,': [1276], 'usually': [1279, 2588], 'consider': [1284], 'absence': [1287, 3437], 'pacemaker/implantable': [1292], 'compatible.LA': [1301], 'essential': [1305, 3908, 3988], 'measurement': [1306, 1469, 1561, 3657], 'predictor': [1313], 'events': [1315], 'success': [1323], 'cardioversion': [1325], 'fibrillation': [1330], 'likelihood': [1332, 2629], 'maintaining': [1334], 'after': [1337, 1675, 2632, 3457, 3461, 4012, 4248], 'cardioversion.7': [1338], 'Of': [1339], 'note,': [1340], 'upper': [1342, 1390], 'limit': [1343, 1358, 1391], 'index': [1349, 1407, 1416, 1423, 1430], 'larger': [1351, 1647], 'than': [1354], '(upper': [1357], 'biplane': [1362], '34': [1368], 'mL/m2).': [1369], 'Recent': [1370, 1627, 2372], 'studies': [1371, 1628, 2001, 2066, 2173, 3372, 3391], 'drawn': [1374], 'attention': [1375], 'RA': [1377, 1394, 1428, 2871, 2934], 'prognostic': [1381, 1801], 'value8': [1382], 'limited': [1386], 'data': [1387, 2658, 3115], 'volumes.The': [1395], '2D': [1401], '190': [1409], 'mL/m2,': [1410, 1426], '28%,': [1413], '140': [1418, 2527], 'g/m2,': [1419], '55': [1425], '40': [1432], 'mL/m2.': [1433], 'dimension': [1436], 'basal': [1439], '4.8': [1444], 'cm.Assessment': [1445], 'Systolic': [1448], 'FunctionPatients': [1449], 'II': [1453, 2461, 2767], 'Supplement)': [1457, 2467], 'abnormalities': [1460, 3532, 3718], 'function.': [1464, 4019], 'shown': [1473, 1630, 2003, 2068, 2291, 2458, 3219, 3232, 3356, 3393], 'population': [1479, 3406], 'other': [1482, 1523, 1758, 3429, 3979], 'cardiovascular': [1483], 'diseases.': [1484], 'measured': [1488, 1766, 1881], '3D,': [1492], 'radionuclide': [1493], 'angiography,': [1494], 'gated': [1495], 'single': [1496, 2575, 2616, 3777, 4266], 'photon': [1497, 2576, 2617, 3778], 'emission': [1498, 2577, 2582, 2618, 3779, 3785, 3966], 'tomography,': [1500, 2620, 3786], 'However,': [1512, 1886, 2049], 'load': [1515], 'dependent.': [1516], 'This': [1517, 1929, 2288, 2337, 4020, 4260], 'led': [1518, 1931], 'search': [1521], 'indices': [1524, 1759, 1978, 2273], 'elastance,': [1528], 'which': [1529, 2538, 3105, 3165, 3225, 4133], 'most': [1531, 3331], 'invasively': [1534], 'pressure–volume': [1536], 'loops': [1537], 'derived': [1542], 'noninvasively': [1543], 'combination': [1546, 3485], '(by': [1550], 'CMR)': [1553, 3998], 'pressure.9': [1556], 'Despite': [1557], 'attractiveness,': [1559], 'gained': [1564], 'acceptance': [1565], 'day-to-day': [1567], 'laboratory': [1568], 'measurements,': [1569], 'mostly': [1570], 'complexity': [1573], 'lack': [1575], 'familiarity': [1577], 'likely': [1579, 4042], 'main': [1581, 2354], 'reason': [1582], 'laboratories.': [1585], 'Instead,': [1586], 'global': [1590, 1601, 1604, 1612, 1812, 1959, 2115, 2123], 'strain10': [1591], 'increasingly': [1594], 'analyzed': [1595], 'reported': [1597], '(Figure': [1598, 3782, 3849, 3962], '1).': [1599], 'For': [1600, 2200, 2584, 2897, 3654, 3851], 'provides': [1607, 3008, 3518], 'reasonable': [1609], 'assessment': [1610, 2311], 'function.11': [1613], 'longitudinal,': [1619], 'circumferential,': [1620], 'radial': [1622], 'rate).': [1626], 'molecular': [1634, 2008], 'correlates': [1635], 'dilated': [1642, 2184, 2253], 'whereby': [1644, 2150], 'myocytes': [1648], 'mRNA': [1653, 1684], 'protein': [1655, 1686, 2107, 2141, 2296], 'expression': [1656, 1687, 2083, 2108, 2860], 'sarcoplasmic': [1658, 1689, 2110, 2133], 'reticulum': [1659, 1690, 2111, 2134], 'Ca2+ATPase': [1660, 1691, 2112, 2135], '2a': [1661, 2136], 'more': [1663, 2227, 3535], 'impaired': [1664, 1818], 'strain.12': [1668], 'Further,': [1669, 2828], 'improvement': [1671], 'LVAD': [1676], 'occurs': [1678, 3026], 'parallel': [1680], '2a.12Download': [1692], 'figureDownload': [1693, 2440, 3130], 'PowerPointFigure': [1694, 2441, 3131], 'Left': [1696], 'twist': [1698], '(top),': [1699], '(Sc,': [1702], 'middle),': [1703], '(Sl,': [1707], 'bottom)': [1708], 'subject': [1712], '(left)': [1713], '(HFrEF;': [1724], 'right).': [1725], 'twist,': [1731, 1789], 'Sc': [1732], 'Sl': [1734], 'reduced.': [1737], 'Reprinted': [1738], 'Wang': [1740], 'et': [1741], 'al10': [1742], 'permission': [1744], 'publisher.': [1747], 'Copyright': [1748], '©2008,': [1749], 'Oxford': [1750], 'University': [1751], 'Press.Twist,': [1752], 'torsion,': [1753], 'twisting': [1755, 1790], 'speckle-tracking': [1768], 'Similar': [1773], 'strain,': [1777, 2669], 'they': [1778, 1985], 'loading': [1782], 'conditions.13': [1783], 'rate,': [1791], 'At': [1795], 'present': [1797, 2641], 'time,': [1798], 'incremental': [1800], 'value': [1802, 3360, 3795], 'rotation': [1804], 'known.The': [1808], 'severely': [1817, 2449], '−8%.': [1820], 'Twist': [1821], 'likewise': [1823], '5°': [1826], '−35ο/s.Assessment': [1832], 'Diastolic': [1835], 'FunctionAbnormal': [1836], 'itself': [1843], 'does': [1844, 2861], 'account': [1846, 2865], 'state': [1850], 'contrary,': [1855], 'ubiquitous': [1861], 'HF,': [1865, 2034, 3696], 'irrespective': [1866], 'LVEF,': [1868], 'accounts': [1870], 'exercise': [1874], 'tolerance.14': [1875], 'filling': [1877, 1888, 1902, 1910, 1927, 1944, 2241, 2245, 2266, 2324, 2471, 2491, 2516, 3263, 3542, 3563, 3608, 3680, 4001], 'rates': [1878, 1889, 1964], 'modalities.': [1885], 'dependent': [1891, 2131, 3579], 'only': [1893, 2707, 3526, 3580, 4024], 'relaxation': [1896, 1968, 2016, 2056, 2120, 2665], 'stiffness': [1898, 2190, 2276], 'pressures.': [1903, 1928, 1945, 2472, 2492, 3543], 'Accordingly,': [1904, 2811], 'seen': [1914], 'parameters': [1937], 'less': [1940, 4041], 'These': [1946], 'include': [1947, 3407, 3554], 'flow': [1949, 2412, 2418, 2852], 'propagation': [1950], 'velocity,': [1951, 2627], 'annulus': [1953, 2070], 'velocity': [1956, 2072, 2214, 2404, 2482, 2532, 2842, 2848, 2953, 3186, 3248], '(e′)': [1957], 'during': [1965, 1971, 2014, 2118], 'isovolumic': [1967], 'period': [1969, 2121], 'diastole.15': [1973], 'All': [1974], 'above': [1977, 2172], 'readily': [1980], 'varying': [1987], 'feasibility': [1988, 2387], 'variability,': [1990], 'own': [1994], 'advantages': [1995, 3573], 'limitations.15': [1997], 'Animal': [1998], 'human': [2000], 'hemodynamic,': [2005], 'pathological,': [2006], 'determinants': [2009], 'e′,': [2011], 'isovolumetric': [2015, 2119], 'period,': [2017], 'rate.12,16–18': [2022], 'Because': [2023], 'delay': [2026], 'expansion': [2029], 'setting': [2032, 2061, 3029], 'e′': [2035, 2071], 'shielded': [2037], 'transmitral': [2040], 'gradient': [2042, 3196], 'minimally': [2045], 'preload.19,20': [2048], 'remains': [2051], 'strongly': [2052], 'related': [2053, 2075, 2238, 3342], 'suction': [2058], 'disease.16,17': [2064], 'Human': [2065], 'β-adrenergic': [2077], 'receptor': [2078, 2719], 'density,': [2079], 'interstitial': [2080, 2680, 2711], 'fibrosis,': [2081], 'gene': [2082, 2105, 2139, 2148, 2294], 'tumor': [2085], 'necrosis': [2086], 'factor-α': [2087], 'inducible': [2089], 'nitric': [2090], 'oxide': [2091], 'synthase': [2092], 'levels': [2093, 3382, 3423, 3490, 3495, 3509], '(cytokines': [2094], 'negative': [2097], 'inotropic': [2098], 'lusitropic': [2100], 'effects),': [2101], '2a.12,21,22': [2113], 'Likewise': [2114], 'phospholamban': [2138], 'expression,': [2142, 2149], 'titin': [2146, 2160, 2230, 2299], 'isoforms': [2147], 'higher': [2154, 2268, 3489, 3599], 'ratio': [2155, 2224, 2260, 2270, 2280, 2475, 2521, 2838, 3591], 'stiffer': [2158, 2234], 'N2B': [2159, 2235], 'isoform': [2161, 2231, 2236], 'lower': [2163, 2258, 2628], 'rate.12': [2170], 'conducted': [2175], 'CAD': [2182, 3735], 'cardiomyopathy.In': [2185], 'caused': [2191, 2251, 3934, 4085], 'identified': [2197, 2649], 'inflow': [2206, 2444, 2507, 3211, 3256, 3671], 'deceleration': [2209, 2524, 2622], 'time': [2210, 2278, 2525, 2623, 2666, 2847], 'E': [2213, 2481, 2498, 2626, 3247], 'relate': [2215], 'invasive': [2218], 'stiffness.15': [2222], 'extensible': [2228], 'N2BA': [2229], 'pressures': [2246, 2325, 2794, 3564, 3609, 4002], 'cardiomyopathy,': [2254], 'N2BA/N2B': [2259], 'restrictive': [2264, 2514], 'pattern,': [2267], 'E/e′': [2269, 2398, 3590], '(deceleration': [2277], 'volume).': [2287], 'expressions': [2297], 'isoforms.12,23Aside': [2300], 'mechanistic': [2303], 'insights': [2304], 'gleaned': [2305], 'into': [2306, 2864], 'imaging,': [2309, 4121], 'noninvasive': [2310], 'plays': [2316], 'critical': [2318], 'role': [2319, 2338, 3301, 3635], 'determining': [2321, 3317], 'reasons': [2328, 2355], 'behind': [2329], 'dyspnea.': [2336, 3370], 'conditions': [2349], 'chronic': [2364, 3323, 3473, 3855], 'obstructive': [2365], 'airway': [2366], 'disease,': [2367, 3454, 3470, 3475], 'anemia,': [2368], 'metabolic': [2370], 'acidosis.': [2371], 'guidelines': [2373, 3643], 'published15': [2376], 'recommend': [2378], 'use': [2380, 3547], 'signals': [2382], 'high': [2386], 'reproducibility': [2389], '(mitral': [2390], 'E/A': [2391, 2474, 2520], 'ratio,': [2392, 2399, 2912], 'index,': [2396], 'average': [2397], 'peak': [2400, 2480, 2530, 2841, 3185, 3245], 'tricuspid': [2401], '(TR)': [2403], 'continuous': [2406, 2801, 3139], 'wave': [2407, 2802, 3140], 'Doppler': [2408, 2509, 2803, 3039, 3142, 3603], 'ratio).': [2419], 'Figure': [2420, 3070], 'New': [2430], 'York': [2431], 'Association': [2433], 'functional': [2434, 3155, 3282], 'class': [2435], 'medical': [2438, 3081, 3091, 4061], 'therapy.Download': [2439], '2.': [2442, 4137], 'Mitral': [2443, 2473, 3134], 'depressed': [2450, 3004, 4058], '(2D': [2456, 3230], 'Movies': [2460, 3061, 3234], 'III': [2463, 3062, 3235], '<0.8,': [2477], '<50': [2484], 'cm/s,': [2485], 'consistent': [2487, 2540, 3167, 3201, 3268], 'incomplete': [2495], 'merging': [2496], 'A': [2500, 2739, 3222, 3584], 'velocities': [2501], 'due': [2502], 'prolonged': [2504], 'interval.Mitral': [2506], 'PW': [2508], '2,': [2523], 'TR': [2531, 2806, 2844], '3.2': [2534], 'm/s,': [2535], 'pressures.Assessment': [2547], 'Myocardial': [2549], 'FibrosisPatients': [2550], 'replacement': [2555, 2603], 'fibrosis': [2556, 2604, 2638, 2681, 2712, 3413], 'infraction.': [2559], 'distribution': [2563, 2743], 'directly': [2568], 'imaged': [2569], 'tomography': [2579, 3781, 3967], 'positron': [2581, 3784, 3965], 'tomography.24': [2583], 'scarred': [2586], 'wall': [2591, 3350, 3716, 3722, 4228], 'thickness': [2592, 3723], 'contractile': [2595, 2610], 'dobutamine': [2598, 3788], 'administration.': [2599], 'Extensive': [2600], 'widespread,': 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