Publication Information

{'id': 'https://openalex.org/W2605879069', 'doi': 'https://doi.org/10.1016/j.eplepsyres.2017.04.011', 'title': 'Ivabradine attenuates the anticonvulsant potency of lamotrigine, but not that of lacosamide, pregabalin and topiramate in the tonic-clonic seizure model in mice', 'display_name': 'Ivabradine attenuates the anticonvulsant potency of lamotrigine, but not that of lacosamide, pregabalin and topiramate in the tonic-clonic seizure model in mice', 'publication_year': 2017, 'publication_date': '2017-04-21', 'ids': {'openalex': 'https://openalex.org/W2605879069', 'doi': 'https://doi.org/10.1016/j.eplepsyres.2017.04.011', 'mag': '2605879069', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28458102'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.eplepsyres.2017.04.011', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S144140688', 'display_name': 'Epilepsy Research', 'issn_l': '0920-1211', 'issn': ['0920-1211', '1872-6844'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5072488610', 'display_name': 'Katarzyna Sawicka', 'orcid': 'https://orcid.org/0000-0002-3915-1899'}, 'institutions': [{'id': 'https://openalex.org/I121032520', 'display_name': 'Medical University of Lublin', 'ror': 'https://ror.org/016f61126', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I121032520']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Katarzyna M. Sawicka', 'raw_affiliation_strings': ['Department of Internal Medicine in Nursing, Medical University of Lublin, Lublin, Poland', 'Department of Pathophysiology, Medical University of Lublin, Lublin, Poland'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathophysiology, Medical University of Lublin, Lublin, Poland', 'institution_ids': ['https://openalex.org/I121032520']}, {'raw_affiliation_string': 'Department of Internal Medicine in Nursing, Medical University of Lublin, Lublin, Poland', 'institution_ids': ['https://openalex.org/I121032520']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026681156', 'display_name': 'Katarzyna Załuska-Ogryzek', 'orcid': 'https://orcid.org/0000-0001-5358-8889'}, 'institutions': [{'id': 'https://openalex.org/I121032520', 'display_name': 'Medical University of Lublin', 'ror': 'https://ror.org/016f61126', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I121032520']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Katarzyna Załuska', 'raw_affiliation_strings': ['Department of Pathophysiology, Medical University of Lublin, Lublin, Poland'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathophysiology, Medical University of Lublin, Lublin, Poland', 'institution_ids': ['https://openalex.org/I121032520']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056017217', 'display_name': 'Agnieszka Wawryniuk', 'orcid': 'https://orcid.org/0000-0002-1582-6628'}, 'institutions': [{'id': 'https://openalex.org/I121032520', 'display_name': 'Medical University of Lublin', 'ror': 'https://ror.org/016f61126', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I121032520']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Agnieszka Wawryniuk', 'raw_affiliation_strings': ['Department of Internal Medicine in Nursing, Medical University of Lublin, Lublin, Poland'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine in Nursing, Medical University of Lublin, Lublin, Poland', 'institution_ids': ['https://openalex.org/I121032520']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066259999', 'display_name': 'Karolina Załuska-Patel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I121032520', 'display_name': 'Medical University of Lublin', 'ror': 'https://ror.org/016f61126', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I121032520']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Karolina Załuska-Patel', 'raw_affiliation_strings': ['Department of Pathophysiology, Medical University of Lublin, Lublin, Poland'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathophysiology, Medical University of Lublin, Lublin, Poland', 'institution_ids': ['https://openalex.org/I121032520']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047020134', 'display_name': 'Michał Szczyrek', 'orcid': 'https://orcid.org/0000-0002-1271-2254'}, 'institutions': [{'id': 'https://openalex.org/I121032520', 'display_name': 'Medical University of Lublin', 'ror': 'https://ror.org/016f61126', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I121032520']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Michał Szczyrek', 'raw_affiliation_strings': ['Department of Internal Medicine in Nursing, Medical University of Lublin, Lublin, Poland'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine in Nursing, Medical University of Lublin, Lublin, Poland', 'institution_ids': ['https://openalex.org/I121032520']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081158348', 'display_name': 'Bartłomiej Drop', 'orcid': 'https://orcid.org/0000-0001-7044-3657'}, 'institutions': [{'id': 'https://openalex.org/I121032520', 'display_name': 'Medical University of Lublin', 'ror': 'https://ror.org/016f61126', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I121032520']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Bartłomiej Drop', 'raw_affiliation_strings': ['Department of Pathophysiology, Medical University of Lublin, Lublin, Poland'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathophysiology, Medical University of Lublin, Lublin, Poland', 'institution_ids': ['https://openalex.org/I121032520']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026961650', 'display_name': 'Jadwiga Daniluk', 'orcid': 'https://orcid.org/0000-0002-0635-2221'}, 'institutions': [{'id': 'https://openalex.org/I121032520', 'display_name': 'Medical University of Lublin', 'ror': 'https://ror.org/016f61126', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I121032520']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Jadwiga Daniluk', 'raw_affiliation_strings': ['Department of Internal Medicine in Nursing, Medical University of Lublin, Lublin, Poland'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine in Nursing, Medical University of Lublin, Lublin, Poland', 'institution_ids': ['https://openalex.org/I121032520']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007344816', 'display_name': 'Monika Szpringer', 'orcid': 'https://orcid.org/0000-0002-6510-5714'}, 'institutions': [{'id': 'https://openalex.org/I169495764', 'display_name': 'Jan Kochanowski University', 'ror': 'https://ror.org/00krbh354', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I169495764']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Monika Szpringer', 'raw_affiliation_strings': ['Faculty of Medicine and Health Sciences, The Jan Kochanowski University in Kielce, Kielce, Poland'], 'affiliations': [{'raw_affiliation_string': 'Faculty of Medicine and Health Sciences, The Jan Kochanowski University in Kielce, Kielce, Poland', 'institution_ids': ['https://openalex.org/I169495764']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087490307', 'display_name': 'Dorota Żółkowska', 'orcid': 'https://orcid.org/0000-0003-1988-0119'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dorota Żółkowska', 'raw_affiliation_strings': ['Department of Neurology, School of Medicine, University of California–Davis, Sacramento, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, School of Medicine, University of California–Davis, Sacramento, CA, USA', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5009737999', 'display_name': 'Jarogniew J. Łuszczki', 'orcid': 'https://orcid.org/0000-0002-3059-0393'}, 'institutions': [{'id': 'https://openalex.org/I121032520', 'display_name': 'Medical University of Lublin', 'ror': 'https://ror.org/016f61126', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I121032520']}], 'countries': ['PL'], 'is_corresponding': True, 'raw_author_name': 'Jarogniew J. Łuszczki', 'raw_affiliation_strings': ['Department of Pathophysiology, Medical University of Lublin, Lublin, Poland'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathophysiology, Medical University of Lublin, Lublin, Poland', 'institution_ids': ['https://openalex.org/I121032520']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5009737999'], 'corresponding_institution_ids': ['https://openalex.org/I121032520'], 'apc_list': {'value': 2940, 'currency': 'USD', 'value_usd': 2940, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.708, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 15, 'citation_normalized_percentile': {'value': 0.806157, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '133', 'issue': None, 'first_page': '67', 'last_page': '70'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10094', 'display_name': 'Epilepsy and Seizures', 'score': 0.9944, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10094', 'display_name': 'Epilepsy and Seizures', 'score': 0.9944, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10429', 'display_name': 'Brain-Computer Interfaces in Neuroscience and Medicine', 'score': 0.986, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10217', 'display_name': 'Molecular Mechanisms of Cardiac Arrhythmias', 'score': 0.9825, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lacosamide', 'display_name': 'Lacosamide', 'score': 0.95545805}, {'id': 'https://openalex.org/keywords/pregabalin', 'display_name': 'Pregabalin', 'score': 0.7336178}, {'id': 'https://openalex.org/keywords/antiepileptic-drugs', 'display_name': 'Antiepileptic Drugs', 'score': 0.542501}, {'id': 'https://openalex.org/keywords/pharmacodynamics', 'display_name': 'Pharmacodynamics', 'score': 0.48529026}, {'id': 'https://openalex.org/keywords/ivabradine', 'display_name': 'Ivabradine', 'score': 0.4576837}, {'id': 'https://openalex.org/keywords/seizure-threshold', 'display_name': 'Seizure threshold', 'score': 0.43208492}, {'id': 'https://openalex.org/keywords/levetiracetam', 'display_name': 'Levetiracetam', 'score': 0.41876608}], 'concepts': [{'id': 'https://openalex.org/C2778802184', 'wikidata': 'https://www.wikidata.org/wiki/Q410346', 'display_name': 'Lamotrigine', 'level': 3, 'score': 0.9641874}, {'id': 'https://openalex.org/C2778139780', 'wikidata': 'https://www.wikidata.org/wiki/Q420077', 'display_name': 'Lacosamide', 'level': 3, 'score': 0.95545805}, {'id': 'https://openalex.org/C2775858608', 'wikidata': 'https://www.wikidata.org/wiki/Q576618', 'display_name': 'Anticonvulsant', 'level': 3, 'score': 0.8987483}, {'id': 'https://openalex.org/C2777683783', 'wikidata': 'https://www.wikidata.org/wiki/Q221174', 'display_name': 'Topiramate', 'level': 3, 'score': 0.8102497}, {'id': 'https://openalex.org/C2776468701', 'wikidata': 'https://www.wikidata.org/wiki/Q412174', 'display_name': 'Pregabalin', 'level': 2, 'score': 0.7336178}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.70743805}, {'id': 'https://openalex.org/C2778186239', 'wikidata': 'https://www.wikidata.org/wiki/Q41571', 'display_name': 'Epilepsy', 'level': 2, 'score': 0.53142476}, {'id': 'https://openalex.org/C111113717', 'wikidata': 'https://www.wikidata.org/wiki/Q725307', 'display_name': 'Pharmacodynamics', 'level': 3, 'score': 0.48529026}, {'id': 'https://openalex.org/C2779167562', 'wikidata': 'https://www.wikidata.org/wiki/Q425729', 'display_name': 'Ivabradine', 'level': 4, 'score': 0.4576837}, {'id': 'https://openalex.org/C2778460930', 'wikidata': 'https://www.wikidata.org/wiki/Q7447053', 'display_name': 'Seizure threshold', 'level': 4, 'score': 0.43208492}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.42433184}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.42021665}, {'id': 'https://openalex.org/C2777332695', 'wikidata': 'https://www.wikidata.org/wiki/Q417227', 'display_name': 'Levetiracetam', 'level': 3, 'score': 0.41876608}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.39882985}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.22608417}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.21420002}, {'id': 'https://openalex.org/C2777953023', 'wikidata': 'https://www.wikidata.org/wiki/Q1073121', 'display_name': 'Heart rate', 'level': 3, 'score': 0.11174017}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.08150482}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000927', 'descriptor_name': 'Anticonvulsants', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001552', 'descriptor_name': 'Benzazepines', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D002317', 'descriptor_name': 'Cardiovascular Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D004830', 'descriptor_name': 'Epilepsy, Tonic-Clonic', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000081', 'descriptor_name': 'Acetamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000081', 'descriptor_name': 'Acetamides', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000927', 'descriptor_name': 'Anticonvulsants', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000927', 'descriptor_name': 'Anticonvulsants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001552', 'descriptor_name': 'Benzazepines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002317', 'descriptor_name': 'Cardiovascular Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004347', 'descriptor_name': 'Drug Interactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004597', 'descriptor_name': 'Electroshock', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D004597', 'descriptor_name': 'Electroshock', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004830', 'descriptor_name': 'Epilepsy, Tonic-Clonic', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D004830', 'descriptor_name': 'Epilepsy, Tonic-Clonic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005632', 'descriptor_name': 'Fructose', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D005632', 'descriptor_name': 'Fructose', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D005632', 'descriptor_name': 'Fructose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077550', 'descriptor_name': 'Ivabradine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000078334', 'descriptor_name': 'Lacosamide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077213', 'descriptor_name': 'Lamotrigine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069583', 'descriptor_name': 'Pregabalin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069583', 'descriptor_name': 'Pregabalin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000077236', 'descriptor_name': 'Topiramate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014227', 'descriptor_name': 'Triazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014227', 'descriptor_name': 'Triazines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.eplepsyres.2017.04.011', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S144140688', 'display_name': 'Epilepsy Research', 'issn_l': '0920-1211', 'issn': ['0920-1211', '1872-6844'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28458102', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 23, 'referenced_works': ['https://openalex.org/W1593555249', 'https://openalex.org/W1605881505', 'https://openalex.org/W1974809694', 'https://openalex.org/W1978551870', 'https://openalex.org/W2005320342', 'https://openalex.org/W2010680811', 'https://openalex.org/W2017480595', 'https://openalex.org/W2018390256', 'https://openalex.org/W2024545193', 'https://openalex.org/W2029462182', 'https://openalex.org/W2047168771', 'https://openalex.org/W2057406931', 'https://openalex.org/W2073940547', 'https://openalex.org/W2097861145', 'https://openalex.org/W2113938049', 'https://openalex.org/W2161628727', 'https://openalex.org/W2262262884', 'https://openalex.org/W2395752786', 'https://openalex.org/W2401188729', 'https://openalex.org/W2482105278', 'https://openalex.org/W2529776038', 'https://openalex.org/W2578975773', 'https://openalex.org/W2588512793'], 'related_works': ['https://openalex.org/W4309878877', 'https://openalex.org/W2945766942', 'https://openalex.org/W2381773918', 'https://openalex.org/W2159544592', 'https://openalex.org/W2128031693', 'https://openalex.org/W2041350175', 'https://openalex.org/W2025203805', 'https://openalex.org/W2022927468', 'https://openalex.org/W2018390256', 'https://openalex.org/W1982732353'], 'abstract_inverted_index': {'Hyperpolarization-activated': [0], 'cyclic': [1], 'nucleotide-gated': [2], '(HCN)': [3], 'channels': [4], 'are': [5], 'involved': [6], 'not': [7, 122], 'only': [8], 'in': [9, 20, 48, 111, 133, 152, 164], 'synaptic': [10], 'transmission': [11], 'and': [12, 46, 188, 194], 'neuronal': [13], 'excitability': [14], 'under': [15], 'physiological': [16], 'conditions,': [17], 'but': [18], 'also': [19], 'seizure': [21, 53], 'activity.': [22], 'To': [23], 'determine': [24], 'the': [25, 34, 49, 90, 97, 101, 112, 125, 134, 149, 169, 174, 178], 'influence': [26], 'of': [27, 37, 68, 77, 93, 100, 128, 147, 173, 177, 183], 'ivabradine': [28, 118, 139, 161, 184], '(an': [29], 'HCN': [30], 'channel': [31], 'inhibitor)': [32], 'on': [33, 143], 'anticonvulsant': [35, 91, 126, 175], 'potency': [36, 92, 127], 'four': [38], 'novel': [39], 'antiepileptic': [40], 'drugs': [41], '(AEDs:': [42], 'lacosamide,': [43, 129, 186], 'lamotrigine,': [44], 'pregabalin': [45, 130, 187], 'topiramate)': [47], 'mouse': [50, 113, 135], 'maximal': [51, 64], 'electroshock-induced': [52], '(MES)': [54], 'model.': [55, 115, 137], 'Adult': [56], 'male': [57], 'albino': [58], 'Swiss': [59], 'mice': [60], 'were': [61, 79], 'challenged': [62], 'with': [63, 81, 162, 185], 'electroconvulsions': [65], '(electric': [66], 'current': [67], '25mA': [69], 'delivered': [70], 'via': [71], 'auricular': [72], 'electrodes).': [73], 'Total': [74], 'brain': [75, 145], 'concentrations': [76, 146], 'AEDs': [78, 151], 'measured': [80], 'high-pressure': [82], 'liquid': [83], 'chromatography.': [84], 'Ivabradine': [85], '(10mg/kg,': [86, 119], 'i.p.)': [87, 120], 'significantly': [88, 123], 'reduced': [89], 'lamotrigine': [94, 163], 'by': [95], 'elevating': [96], 'ED50': [98], 'value': [99], 'AED': [102], 'from': [103, 196], '7.48': [104], '(6.15-9.11)': [105], 'to': [106, 168, 191], '10.07': [107], '(8.85-11.45)': [108], 'mg/kg': [109], '(P<0.05)': [110], 'MES': [114, 136], 'In': [116], 'contrast,': [117], 'did': [121], 'affect': [124], 'or': [131], 'topiramate': [132, 189], 'Additionally,': [138], 'had': [140], 'no': [141], 'impact': [142], 'total': [144], 'all': [148], 'studied': [150], 'mice.': [153], 'A': [154], 'special': [155], 'caution': [156], 'is': [157], 'advised': [158], 'when': [159], 'combining': [160], 'epilepsy': [165], 'patients': [166], 'due': [167], 'possible': [170], 'pharmacodynamic': [171, 193], 'reduction': [172], 'action': [176], 'later': [179], 'drug.': [180], 'The': [181], 'combinations': [182], 'seem': [190], 'be': [192], 'neutral': [195], 'a': [197], 'preclinical': [198], 'viewpoint.': [199]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2605879069', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}], 'updated_date': '2024-09-26T04:50:14.347472', 'created_date': '2017-04-28'}