Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2605770782', 'doi': 'https://doi.org/10.1371/journal.ppat.1006296', 'title': 'Interferon-inducible ribonuclease ISG20 inhibits hepatitis B virus replication through directly binding to the epsilon stem-loop structure of viral RNA', 'display_name': 'Interferon-inducible ribonuclease ISG20 inhibits hepatitis B virus replication through directly binding to the epsilon stem-loop structure of viral RNA', 'publication_year': 2017, 'publication_date': '2017-04-11', 'ids': {'openalex': 'https://openalex.org/W2605770782', 'doi': 'https://doi.org/10.1371/journal.ppat.1006296', 'mag': '2605770782', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28399146', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5388505'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.ppat.1006296', 'pdf_url': 'https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006296&type=printable', 'source': {'id': 'https://openalex.org/S2004986', 'display_name': 'PLoS Pathogens', 'issn_l': '1553-7366', 'issn': ['1553-7366', '1553-7374'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006296&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5081224801', 'display_name': 'Yuanjie Liu', 'orcid': 'https://orcid.org/0000-0002-3041-893X'}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}, {'id': 'https://openalex.org/I4394709130', 'display_name': 'Indiana University School of Medicine', 'ror': 'https://ror.org/02ets8c94', 'country_code': None, 'type': 'education', 'lineage': ['https://openalex.org/I4394709130', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Yuanjie Liu', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America', 'institution_ids': ['https://openalex.org/I55769427', 'https://openalex.org/I4394709130']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101877755', 'display_name': 'Hui Nie', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I72816309', 'display_name': 'Drexel University', 'ror': 'https://ror.org/04bdffz58', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I72816309']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Hui Nie', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America', 'institution_ids': ['https://openalex.org/I72816309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036469976', 'display_name': 'Richeng Mao', 'orcid': 'https://orcid.org/0000-0001-5534-8299'}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}, {'id': 'https://openalex.org/I4394709130', 'display_name': 'Indiana University School of Medicine', 'ror': 'https://ror.org/02ets8c94', 'country_code': None, 'type': 'education', 'lineage': ['https://openalex.org/I4394709130', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Richeng Mao', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America', 'institution_ids': ['https://openalex.org/I55769427', 'https://openalex.org/I4394709130']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039702483', 'display_name': 'Bidisha Mitra', 'orcid': 'https://orcid.org/0000-0001-6206-2723'}, 'institutions': [{'id': 'https://openalex.org/I4394709130', 'display_name': 'Indiana University School of Medicine', 'ror': 'https://ror.org/02ets8c94', 'country_code': None, 'type': 'education', 'lineage': ['https://openalex.org/I4394709130', 'https://openalex.org/I592451']}, {'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Bidisha Mitra', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America', 'institution_ids': ['https://openalex.org/I4394709130', 'https://openalex.org/I55769427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006071368', 'display_name': 'Dawei Cai', 'orcid': 'https://orcid.org/0000-0001-6650-0217'}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}, {'id': 'https://openalex.org/I4394709130', 'display_name': 'Indiana University School of Medicine', 'ror': 'https://ror.org/02ets8c94', 'country_code': None, 'type': 'education', 'lineage': ['https://openalex.org/I4394709130', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Dawei Cai', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America', 'institution_ids': ['https://openalex.org/I55769427', 'https://openalex.org/I4394709130']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077224903', 'display_name': 'Ran Yan', 'orcid': 'https://orcid.org/0000-0002-6152-9683'}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}, {'id': 'https://openalex.org/I4394709130', 'display_name': 'Indiana University School of Medicine', 'ror': 'https://ror.org/02ets8c94', 'country_code': None, 'type': 'education', 'lineage': ['https://openalex.org/I4394709130', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Ran Yan', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America', 'institution_ids': ['https://openalex.org/I55769427', 'https://openalex.org/I4394709130']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076597546', 'display_name': 'Ju‐Tao Guo', 'orcid': 'https://orcid.org/0000-0001-5335-2788'}, 'institutions': [{'id': 'https://openalex.org/I4210157427', 'display_name': 'Baruch S. Blumberg Institute', 'ror': 'https://ror.org/05evayb02', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210157427']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Ju-Tao Guo', 'raw_affiliation_strings': ['Baruch S. Blumberg Institute, Doylestown, Pennsylvania, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Baruch S. Blumberg Institute, Doylestown, Pennsylvania, United States of America', 'institution_ids': ['https://openalex.org/I4210157427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041693287', 'display_name': 'Timothy M. Block', 'orcid': 'https://orcid.org/0000-0002-0343-7668'}, 'institutions': [{'id': 'https://openalex.org/I4210157427', 'display_name': 'Baruch S. Blumberg Institute', 'ror': 'https://ror.org/05evayb02', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210157427']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Timothy M. Block', 'raw_affiliation_strings': ['Baruch S. Blumberg Institute, Doylestown, Pennsylvania, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Baruch S. Blumberg Institute, Doylestown, Pennsylvania, United States of America', 'institution_ids': ['https://openalex.org/I4210157427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113695704', 'display_name': 'Nadir Mechti', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I19894307', 'display_name': 'Université de Montpellier', 'ror': 'https://ror.org/051escj72', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I19894307']}, {'id': 'https://openalex.org/I4210098026', 'display_name': 'Laboratory of Pathogens and Host Immunity', 'ror': 'https://ror.org/00rt27171', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I19894307', 'https://openalex.org/I4210098026']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': True, 'raw_author_name': 'Nadir Mechti', 'raw_affiliation_strings': ['CNRS, UMR5235, DIMNP, University of Montpellier 2, Montpellier, France'], 'affiliations': [{'raw_affiliation_string': 'CNRS, UMR5235, DIMNP, University of Montpellier 2, Montpellier, France', 'institution_ids': ['https://openalex.org/I19894307', 'https://openalex.org/I4210098026', 'https://openalex.org/I1294671590']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5045284378', 'display_name': 'Haitao Guo', 'orcid': 'https://orcid.org/0000-0002-7146-916X'}, 'institutions': [{'id': 'https://openalex.org/I4394709130', 'display_name': 'Indiana University School of Medicine', 'ror': 'https://ror.org/02ets8c94', 'country_code': None, 'type': 'education', 'lineage': ['https://openalex.org/I4394709130', 'https://openalex.org/I592451']}, {'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Haitao Guo', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America', 'institution_ids': ['https://openalex.org/I4394709130', 'https://openalex.org/I55769427']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 7, 'corresponding_author_ids': ['https://openalex.org/A5081224801', 'https://openalex.org/A5101877755', 'https://openalex.org/A5036469976', 'https://openalex.org/A5039702483', 'https://openalex.org/A5006071368', 'https://openalex.org/A5077224903', 'https://openalex.org/A5076597546', 'https://openalex.org/A5041693287', 'https://openalex.org/A5113695704', 'https://openalex.org/A5045284378'], 'corresponding_institution_ids': ['https://openalex.org/I55769427', 'https://openalex.org/I4394709130', 'https://openalex.org/I72816309', 'https://openalex.org/I55769427', 'https://openalex.org/I4394709130', 'https://openalex.org/I4394709130', 'https://openalex.org/I55769427', 'https://openalex.org/I55769427', 'https://openalex.org/I4394709130', 'https://openalex.org/I55769427', 'https://openalex.org/I4394709130', 'https://openalex.org/I4210157427', 'https://openalex.org/I4210157427', 'https://openalex.org/I19894307', 'https://openalex.org/I4210098026', 'https://openalex.org/I1294671590', 'https://openalex.org/I4394709130', 'https://openalex.org/I55769427'], 'apc_list': {'value': 2655, 'currency': 'USD', 'value_usd': 2655, 'provenance': 'doaj'}, 'apc_paid': {'value': 2655, 'currency': 'USD', 'value_usd': 2655, 'provenance': 'doaj'}, 'fwci': 7.992, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 108, 'citation_normalized_percentile': {'value': 0.999971, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '13', 'issue': '4', 'first_page': 'e1006296', 'last_page': 'e1006296'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10340', 'display_name': 'Hepatitis B Virus Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10340', 'display_name': 'Hepatitis B Virus Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10151', 'display_name': 'Hepatitis C virus research', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12025', 'display_name': 'Hepatitis Viruses Studies and Epidemiology', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.746189}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6683408}, {'id': 'https://openalex.org/C2778976237', 'wikidata': 'https://www.wikidata.org/wiki/Q422523', 'display_name': 'Ribonuclease', 'level': 4, 'score': 0.600441}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.57541466}, {'id': 'https://openalex.org/C183978625', 'wikidata': 'https://www.wikidata.org/wiki/Q903596', 'display_name': 'Electrophoretic mobility shift assay', 'level': 4, 'score': 0.5645716}, {'id': 'https://openalex.org/C2780593183', 'wikidata': 'https://www.wikidata.org/wiki/Q6844', 'display_name': 'Hepatitis B virus', 'level': 3, 'score': 0.45146066}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.43842968}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.35025102}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.34647524}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.22034112}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.17826232}], 'mesh': [{'descriptor_ui': 'D005092', 'descriptor_name': 'Exonucleases', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D005092', 'descriptor_name': 'Exonucleases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006515', 'descriptor_name': 'Hepatitis B virus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D012260', 'descriptor_name': 'Ribonucleases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004261', 'descriptor_name': 'DNA Replication', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D004261', 'descriptor_name': 'DNA Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004261', 'descriptor_name': 'DNA Replication', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005092', 'descriptor_name': 'Exonucleases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005095', 'descriptor_name': 'Exoribonucleases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006515', 'descriptor_name': 'Hepatitis B virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006515', 'descriptor_name': 'Hepatitis B virus', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': False}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020871', 'descriptor_name': 'RNA Stability', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D020871', 'descriptor_name': 'RNA Stability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048348', 'descriptor_name': 'Reverse Transcription', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048348', 'descriptor_name': 'Reverse Transcription', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D012260', 'descriptor_name': 'Ribonucleases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}], 'locations_count': 10, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.ppat.1006296', 'pdf_url': 'https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006296&type=printable', 'source': {'id': 'https://openalex.org/S2004986', 'display_name': 'PLoS Pathogens', 'issn_l': '1553-7366', 'issn': ['1553-7366', '1553-7374'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hal.science/hal-02350891', 'pdf_url': 'https://hal.science/hal-02350891/document', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/3672ed200413436594b9c36ee86e6ccc', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5388505', 'pdf_url': 'https://europepmc.org/articles/pmc5388505?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-02350891/file/ppat.1006296.pdf', 'pdf_url': 'https://hal.archives-ouvertes.fr/hal-02350891/file/ppat.1006296.pdf', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hal.science/hal-02350891/file/ppat.1006296.pdf', 'pdf_url': 'https://hal.science/hal-02350891/file/ppat.1006296.pdf', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-02350891/document', 'pdf_url': 'https://hal.archives-ouvertes.fr/hal-02350891/document', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/1805/15507', 'pdf_url': 'https://scholarworks.iupui.edu/bitstreams/3302d663-2f47-4a85-aff7-2152a99516cd/download', 'source': {'id': 'https://openalex.org/S4306400987', 'display_name': 'IUScholarWorks (Indiana University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I592451', 'host_organization_name': 'Indiana University', 'host_organization_lineage': ['https://openalex.org/I592451'], 'host_organization_lineage_names': ['Indiana University'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388505', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28399146', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.ppat.1006296', 'pdf_url': 'https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006296&type=printable', 'source': {'id': 'https://openalex.org/S2004986', 'display_name': 'PLoS Pathogens', 'issn_l': '1553-7366', 'issn': ['1553-7366', '1553-7374'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.67, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01AI110762'}], 'datasets': [], 'versions': [], 'referenced_works_count': 62, 'referenced_works': ['https://openalex.org/W1514154332', 'https://openalex.org/W1631507265', 'https://openalex.org/W1918954877', 'https://openalex.org/W1965591672', 'https://openalex.org/W1967714111', 'https://openalex.org/W1969078573', 'https://openalex.org/W1970278586', 'https://openalex.org/W1973716190', 'https://openalex.org/W1980927876', 'https://openalex.org/W1984080351', 'https://openalex.org/W1987376967', 'https://openalex.org/W1989926440', 'https://openalex.org/W1995488467', 'https://openalex.org/W1996208605', 'https://openalex.org/W2001684550', 'https://openalex.org/W2004742914', 'https://openalex.org/W2005043758', 'https://openalex.org/W2011555137', 'https://openalex.org/W2013035173', 'https://openalex.org/W2015763479', 'https://openalex.org/W2017886632', 'https://openalex.org/W2027504182', 'https://openalex.org/W2031579836', 'https://openalex.org/W2031913105', 'https://openalex.org/W2034718801', 'https://openalex.org/W2041820736', 'https://openalex.org/W2049923099', 'https://openalex.org/W2054227142', 'https://openalex.org/W2058333731', 'https://openalex.org/W2061742276', 'https://openalex.org/W2075595885', 'https://openalex.org/W2077467499', 'https://openalex.org/W2079983771', 'https://openalex.org/W2086906135', 'https://openalex.org/W2089108066', 'https://openalex.org/W2090853473', 'https://openalex.org/W2106881036', 'https://openalex.org/W2107057287', 'https://openalex.org/W2113597524', 'https://openalex.org/W2116606690', 'https://openalex.org/W2119387393', 'https://openalex.org/W2120426460', 'https://openalex.org/W2123014574', 'https://openalex.org/W2128674168', 'https://openalex.org/W2130014003', 'https://openalex.org/W2132863459', 'https://openalex.org/W2135457568', 'https://openalex.org/W2137218964', 'https://openalex.org/W2138592666', 'https://openalex.org/W2143671051', 'https://openalex.org/W2150558072', 'https://openalex.org/W2152290170', 'https://openalex.org/W2156706324', 'https://openalex.org/W2157098396', 'https://openalex.org/W2165049207', 'https://openalex.org/W2170269111', 'https://openalex.org/W2242302594', 'https://openalex.org/W2381743533', 'https://openalex.org/W2462891611', 'https://openalex.org/W2516429582', 'https://openalex.org/W4235029171', 'https://openalex.org/W576512939'], 'related_works': ['https://openalex.org/W2741844410', 'https://openalex.org/W2557942961', 'https://openalex.org/W2404061294', 'https://openalex.org/W2345139751', 'https://openalex.org/W2073415133', 'https://openalex.org/W2069973534', 'https://openalex.org/W2063738649', 'https://openalex.org/W2062465979', 'https://openalex.org/W2033434275', 'https://openalex.org/W2010838265'], 'abstract_inverted_index': {'Hepatitis': [0], 'B': [1], 'virus': [2], '(HBV)': [3], 'replicates': [4], 'its': [5, 104], 'DNA': [6, 127], 'genome': [7], 'through': [8, 33], 'reverse': [9], 'transcription': [10], 'of': [11, 26, 35, 57, 62, 67, 77, 137, 164, 176, 195, 206, 214, 219, 228, 245, 259, 281, 289], 'a': [12, 135, 170], 'viral': [13], 'RNA': [14, 79, 82, 89, 100, 118, 173, 221, 234, 269], 'pregenome.': [15], 'We': [16], 'report': [17], 'herein': [18], 'that': [19, 225], 'the': [20, 75, 87, 108, 191, 198, 204, 211, 217, 226, 239, 257, 278, 286], 'interferon': [21], '(IFN)': [22], 'stimulated': [23], 'exoribonuclease': [24], 'gene': [25], '20': [27], 'KD': [28], '(ISG20)': [29], 'inhibits': [30], 'HBV': [31, 36, 63, 78, 88, 99, 117, 126, 159, 220, 268, 283], 'replication': [32, 64, 128], 'degradation': [34, 83, 101], 'RNA.': [37], 'ISG20': [38, 58, 154, 184, 200, 246, 290], 'expression': [39], 'was': [40, 46, 84, 113, 142, 155, 247], 'observed': [41], 'at': [42, 86], 'basal': [43], 'level': [44], 'and': [45, 54, 65, 153, 203, 236, 266, 285], 'highly': [47], 'upregulated': [48], 'upon': [49], 'IFN': [50], 'treatment': [51], 'in': [52, 60, 146, 162, 262, 291], 'hepatocytes,': [53], 'knock': [55], 'down': [56], 'resulted': [59], 'elevation': [61], 'attenuation': [66], 'IFN-mediated': [68, 282], 'antiviral': [69, 123, 287], 'effect.': [70], 'The': [71], 'sequence': [72], 'element': [73], 'conferring': [74], 'susceptibility': [76], 'to': [80, 115, 157, 185, 222, 249], 'ISG20-mediated': [81], 'mapped': [85], 'terminal': [90], 'redundant': [91], 'region': [92], 'containing': [93], 'epsilon': [94], '(ε)': [95], 'stem-loop.': [96], 'Furthermore,': [97, 238], 'ISG20-induced': [98], 'relies': [102, 231], 'on': [103, 232, 277], 'ribonuclease': [105], 'activity,': [106], 'as': [107, 256], 'enzymatic': [109], 'inactive': [110], 'form': [111], 'ISG20D94G': [112, 121], 'unable': [114], 'promote': [116], 'decay.': [119], 'Interestingly,': [120], 'retained': [122], 'activity': [124], 'against': [125], 'by': [129, 145], 'preventing': [130], 'pgRNA': [131], 'encapsidation,': [132], 'resulting': [133], 'from': [134, 210], 'consequence': [136], 'ISG20-ε': [138, 229, 264], 'interaction.': [139], 'This': [140], 'interaction': [141, 230], 'further': [143], 'characterized': [144], 'vitro': [147, 263], 'electrophoretic': [148], 'mobility': [149], 'shift': [150], 'assay': [151], '(EMSA)': [152], 'able': [156], 'bind': [158], 'ε': [160, 172, 196, 215], 'directly': [161], 'absence': [163], 'any': [165], 'other': [166], 'cellular': [167], 'proteins,': [168], 'indicating': [169], 'direct': [171], 'binding': [174, 201, 265], 'capability': [175], 'ISG20;': [177], 'however,': [178], 'cofactor(s)': [179], 'may': [180], 'be': [181, 250], 'required': [182], 'for': [183, 252], 'efficiently': [186], 'degrade': [187], 'ε.': [188], 'In': [189], 'addition,': [190], 'lower': [192], 'stem': [193], 'portion': [194, 213], 'is': [197], 'major': [199], 'site,': [202], 'removal': [205], '4': [207], 'base': [208], 'pairs': [209], 'bottom': [212], 'abrogated': [216], 'sensitivity': [218], 'ISG20,': [223], 'suggesting': [224], 'specificity': [227], 'both': [233], 'structure': [235], 'sequence.': [237], 'C-terminal': [240], 'Exonuclease': [241], 'III': [242], '(ExoIII)': [243], 'domain': [244], 'determined': [248], 'responsible': [251], 'interacting': [253], 'with': [254], 'ε,': [255], 'deletion': [258], 'ExoIII': [260], 'abolished': [261], 'intracellular': [267], 'degradation.': [270], 'Taken': [271], 'together,': [272], 'our': [273], 'study': [274], 'sheds': [275], 'light': [276], 'underlying': [279], 'mechanisms': [280], 'inhibition': [284], 'mechanism': [288], 'general.': [292]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2605770782', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 20}, {'year': 2022, 'cited_by_count': 18}, {'year': 2021, 'cited_by_count': 16}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 3}], 'updated_date': '2025-01-03T20:28:27.614773', 'created_date': '2017-04-28'}