Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2605697108', 'doi': 'https://doi.org/10.1074/jbc.m117.782052', 'title': 'Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma', 'display_name': 'Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma', 'publication_year': 2017, 'publication_date': '2017-04-22', 'ids': {'openalex': 'https://openalex.org/W2605697108', 'doi': 'https://doi.org/10.1074/jbc.m117.782052', 'mag': '2605697108', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28432125', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5473214'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m117.782052', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1074/jbc.m117.782052', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5031584100', 'display_name': 'James M. Dolezal', 'orcid': 'https://orcid.org/0000-0002-6788-7203'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'James M. Dolezal', 'raw_affiliation_strings': ['Divisions of Hematology/Oncology'], 'affiliations': [{'raw_affiliation_string': 'Divisions of Hematology/Oncology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087651973', 'display_name': 'Huabo Wang', 'orcid': 'https://orcid.org/0000-0003-2551-3243'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Huabo Wang', 'raw_affiliation_strings': ['Divisions of Hematology/Oncology'], 'affiliations': [{'raw_affiliation_string': 'Divisions of Hematology/Oncology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101757572', 'display_name': 'Sucheta Kulkarni', 'orcid': 'https://orcid.org/0000-0003-3574-7393'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Sucheta Kulkarni', 'raw_affiliation_strings': ['Divisions of Hematology/Oncology'], 'affiliations': [{'raw_affiliation_string': 'Divisions of Hematology/Oncology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048384848', 'display_name': 'L. Elizabeth Jackson', 'orcid': 'https://orcid.org/0000-0001-9088-576X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Laura Jackson', 'raw_affiliation_strings': ['Newborn Medicine'], 'affiliations': [{'raw_affiliation_string': 'Newborn Medicine', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103197085', 'display_name': 'Jie Lu', 'orcid': 'https://orcid.org/0000-0002-6982-2294'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jie Lu', 'raw_affiliation_strings': ['Divisions of Hematology/Oncology'], 'affiliations': [{'raw_affiliation_string': 'Divisions of Hematology/Oncology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068381719', 'display_name': 'Sarangarajan Ranganathan', 'orcid': 'https://orcid.org/0000-0001-6214-9167'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Sarangarajan Ranganathan', 'raw_affiliation_strings': ['Department of Pathology'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067775249', 'display_name': 'Eric S. Goetzman', 'orcid': 'https://orcid.org/0000-0001-9476-309X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Eric S. Goetzman', 'raw_affiliation_strings': ['Divisions of Human Genetics'], 'affiliations': [{'raw_affiliation_string': 'Divisions of Human Genetics', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091674238', 'display_name': 'Sivakama S. Bharathi', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Sivakama S. Bharathi', 'raw_affiliation_strings': ['Divisions of Human Genetics'], 'affiliations': [{'raw_affiliation_string': 'Divisions of Human Genetics', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5106231501', 'display_name': 'Kevin Beezhold', 'orcid': 'https://orcid.org/0000-0001-9305-9324'}, 'institutions': [{'id': 'https://openalex.org/I4210130600', 'display_name': "Children's Hospital of Pittsburgh", 'ror': 'https://ror.org/03763ep67', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210098814', 'https://openalex.org/I4210130600', 'https://openalex.org/I4210134769']}, {'id': 'https://openalex.org/I4210134769', 'display_name': 'University of Pittsburgh Medical Center', 'ror': 'https://ror.org/04ehecz88', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210098814', 'https://openalex.org/I4210134769']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kevin Beezhold', 'raw_affiliation_strings': ["Bone Marrow and Stem Cell Transplantation, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania 15224"], 'affiliations': [{'raw_affiliation_string': "Bone Marrow and Stem Cell Transplantation, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania 15224", 'institution_ids': ['https://openalex.org/I4210130600', 'https://openalex.org/I4210134769']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088749950', 'display_name': 'Craig A. Byersdorfer', 'orcid': 'https://orcid.org/0000-0002-0030-3699'}, 'institutions': [{'id': 'https://openalex.org/I4210130600', 'display_name': "Children's Hospital of Pittsburgh", 'ror': 'https://ror.org/03763ep67', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210098814', 'https://openalex.org/I4210130600', 'https://openalex.org/I4210134769']}, {'id': 'https://openalex.org/I4210134769', 'display_name': 'University of Pittsburgh Medical Center', 'ror': 'https://ror.org/04ehecz88', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210098814', 'https://openalex.org/I4210134769']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Craig A. Byersdorfer', 'raw_affiliation_strings': ["Bone Marrow and Stem Cell Transplantation, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania 15224"], 'affiliations': [{'raw_affiliation_string': "Bone Marrow and Stem Cell Transplantation, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania 15224", 'institution_ids': ['https://openalex.org/I4210130600', 'https://openalex.org/I4210134769']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5086726605', 'display_name': 'Edward V. Prochownik', 'orcid': 'https://orcid.org/0000-0001-9666-8205'}, 'institutions': [{'id': 'https://openalex.org/I4210128526', 'display_name': 'UPMC Hillman Cancer Center', 'ror': 'https://ror.org/03bw34a45', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I170201317', 'https://openalex.org/I4210128526']}, {'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Edward V. Prochownik', 'raw_affiliation_strings': ['Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213', 'Divisions of Hematology/Oncology', 'University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15232'], 'affiliations': [{'raw_affiliation_string': 'University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15232', 'institution_ids': ['https://openalex.org/I4210128526']}, {'raw_affiliation_string': 'Divisions of Hematology/Oncology', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213', 'institution_ids': ['https://openalex.org/I170201317']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5086726605'], 'corresponding_institution_ids': ['https://openalex.org/I4210128526', 'https://openalex.org/I170201317'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.607, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 45, 'citation_normalized_percentile': {'value': 0.88823, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '292', 'issue': '24', 'first_page': '10068', 'last_page': '10086'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11829', 'display_name': 'Mathematical Biology Tumor Growth', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2611', 'display_name': 'Modeling and Simulation'}, 'field': {'id': 'https://openalex.org/fields/26', 'display_name': 'Mathematics'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11829', 'display_name': 'Mathematical Biology Tumor Growth', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2611', 'display_name': 'Modeling and Simulation'}, 'field': {'id': 'https://openalex.org/fields/26', 'display_name': 'Mathematics'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10621', 'display_name': 'Gene Regulatory Network Analysis', 'score': 0.9907, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10482', 'display_name': 'Mathematical and Theoretical Epidemiology and Ecology Models', 'score': 0.987, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2778019345', 'wikidata': 'https://www.wikidata.org/wiki/Q1148337', 'display_name': 'Hepatocellular carcinoma', 'level': 2, 'score': 0.84442854}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.43095544}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.37774128}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.36054468}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.34845394}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.33913326}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.3282699}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3281141}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.23909631}], 'mesh': [], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m117.782052', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5473214', 'pdf_url': 'https://europepmc.org/articles/pmc5473214?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473214', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m117.782052', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01DK090242'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01CA174713'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'K08HL123631'}], 'datasets': [], 'versions': [], 'referenced_works_count': 104, 'referenced_works': ['https://openalex.org/W1496415998', 'https://openalex.org/W1528864462', 'https://openalex.org/W1572452846', 'https://openalex.org/W1584107383', 'https://openalex.org/W1599445894', 'https://openalex.org/W1640847094', 'https://openalex.org/W168063310', 'https://openalex.org/W1863069764', 'https://openalex.org/W1867428131', 'https://openalex.org/W1898560056', 'https://openalex.org/W191895441', 'https://openalex.org/W1949250268', 'https://openalex.org/W1956135695', 'https://openalex.org/W1965009601', 'https://openalex.org/W1965118614', 'https://openalex.org/W1966288604', 'https://openalex.org/W1967099167', 'https://openalex.org/W1969063927', 'https://openalex.org/W1971248187', 'https://openalex.org/W1973248503', 'https://openalex.org/W1974350437', 'https://openalex.org/W1977423644', 'https://openalex.org/W1982153609', 'https://openalex.org/W1983596157', 'https://openalex.org/W1986817171', 'https://openalex.org/W1988995126', 'https://openalex.org/W1996189137', 'https://openalex.org/W1998237137', 'https://openalex.org/W1999565461', 'https://openalex.org/W2002404925', 'https://openalex.org/W2004352153', 'https://openalex.org/W2005272351', 'https://openalex.org/W2009276462', 'https://openalex.org/W2010248689', 'https://openalex.org/W2010472544', 'https://openalex.org/W2013075901', 'https://openalex.org/W2020352533', 'https://openalex.org/W2022031287', 'https://openalex.org/W2027514832', 'https://openalex.org/W2034203463', 'https://openalex.org/W2036659083', 'https://openalex.org/W2042039461', 'https://openalex.org/W2054657650', 'https://openalex.org/W2055254495', 'https://openalex.org/W2055380862', 'https://openalex.org/W2060425936', 'https://openalex.org/W2062044716', 'https://openalex.org/W2064772366', 'https://openalex.org/W2074873270', 'https://openalex.org/W2076689851', 'https://openalex.org/W2077009876', 'https://openalex.org/W2083444354', 'https://openalex.org/W2085324493', 'https://openalex.org/W2087539641', 'https://openalex.org/W2087736884', 'https://openalex.org/W2088744527', 'https://openalex.org/W2089298112', 'https://openalex.org/W2091408887', 'https://openalex.org/W2092884146', 'https://openalex.org/W2096226098', 'https://openalex.org/W2097132273', 'https://openalex.org/W2099540110', 'https://openalex.org/W2102989013', 'https://openalex.org/W2109763969', 'https://openalex.org/W2110567472', 'https://openalex.org/W2116142842', 'https://openalex.org/W2117901133', 'https://openalex.org/W2121707384', 'https://openalex.org/W2130296076', 'https://openalex.org/W2132256680', 'https://openalex.org/W2155124667', 'https://openalex.org/W2160650707', 'https://openalex.org/W2164670057', 'https://openalex.org/W2167937185', 'https://openalex.org/W2168089202', 'https://openalex.org/W2177855681', 'https://openalex.org/W2255291773', 'https://openalex.org/W2280727461', 'https://openalex.org/W2290344215', 'https://openalex.org/W2294704562', 'https://openalex.org/W2294798900', 'https://openalex.org/W2297822018', 'https://openalex.org/W2329310651', 'https://openalex.org/W2332733221', 'https://openalex.org/W2335098315', 'https://openalex.org/W2336099035', 'https://openalex.org/W2408136561', 'https://openalex.org/W2412105346', 'https://openalex.org/W2412696100', 'https://openalex.org/W2419193153', 'https://openalex.org/W2494521861', 'https://openalex.org/W2503851771', 'https://openalex.org/W2507952693', 'https://openalex.org/W2519898902', 'https://openalex.org/W2523216894', 'https://openalex.org/W2531779082', 'https://openalex.org/W2569928878', 'https://openalex.org/W2589571072', 'https://openalex.org/W2595038369', 'https://openalex.org/W2597508040', 'https://openalex.org/W2917837889', 'https://openalex.org/W4211105405', 'https://openalex.org/W4245403358', 'https://openalex.org/W91534136'], 'related_works': ['https://openalex.org/W628600844', 'https://openalex.org/W3172842848', 'https://openalex.org/W2800415451', 'https://openalex.org/W2418745692', 'https://openalex.org/W2417822880', 'https://openalex.org/W2410885201', 'https://openalex.org/W2404951810', 'https://openalex.org/W2385390897', 'https://openalex.org/W2337719538', 'https://openalex.org/W1570838273'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2605697108', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 3}], 'updated_date': '2025-01-16T15:09:53.557540', 'created_date': '2017-04-28'}