Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2605644624', 'doi': 'https://doi.org/10.1007/978-3-319-51436-9_11', 'title': 'Primary Cilia in Cystic Kidney Disease', 'display_name': 'Primary Cilia in Cystic Kidney Disease', 'publication_year': 2017, 'publication_date': '2017-01-01', 'ids': {'openalex': 'https://openalex.org/W2605644624', 'doi': 'https://doi.org/10.1007/978-3-319-51436-9_11', 'mag': '2605644624', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28409350', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7065811'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/978-3-319-51436-9_11', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2754189475', 'display_name': 'Results and problems in cell differentiation', 'issn_l': '0080-1844', 'issn': ['0080-1844', '1861-0412'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'book series'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'book-chapter', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065811', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5027538262', 'display_name': 'Prachee Avasthi', 'orcid': 'https://orcid.org/0000-0002-1688-722X'}, 'institutions': [{'id': 'https://openalex.org/I4210128618', 'display_name': 'University of Kansas Medical Center', 'ror': 'https://ror.org/036c9yv20', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128618']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Prachee Avasthi', 'raw_affiliation_strings': ['Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA', 'institution_ids': ['https://openalex.org/I4210128618']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052313548', 'display_name': 'Robin L. Maser', 'orcid': 'https://orcid.org/0000-0003-4737-0597'}, 'institutions': [{'id': 'https://openalex.org/I4210128618', 'display_name': 'University of Kansas Medical Center', 'ror': 'https://ror.org/036c9yv20', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128618']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robin L. Maser', 'raw_affiliation_strings': ['Department of Clinical Laboratory Sciences, University of Kansas Medical Center, Kansas City, KS, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Laboratory Sciences, University of Kansas Medical Center, Kansas City, KS, USA', 'institution_ids': ['https://openalex.org/I4210128618']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5060712546', 'display_name': 'Pamela V. Tran', 'orcid': 'https://orcid.org/0000-0003-4619-4376'}, 'institutions': [{'id': 'https://openalex.org/I4210128618', 'display_name': 'University of Kansas Medical Center', 'ror': 'https://ror.org/036c9yv20', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128618']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Pamela V. Tran', 'raw_affiliation_strings': ['Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Blvd., MS #3038, Kansas City, 66160, KS, USA'], 'affiliations': [{'raw_affiliation_string': 'Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Blvd., MS #3038, Kansas City, 66160, KS, USA', 'institution_ids': ['https://openalex.org/I4210128618']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.528, 'has_fulltext': False, 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.462295, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': None, 'issue': None, 'first_page': '281', 'last_page': '321'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11412', 'display_name': 'Ciliopathies: Genetic Disorders Involving Primary Cilia', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11412', 'display_name': 'Ciliopathies: Genetic Disorders Involving Primary Cilia', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12140', 'display_name': 'Molecular Mechanisms of Kidney Development and Disease', 'score': 0.967, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling in Development and Cancer', 'score': 0.9351, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ciliogenesis', 'display_name': 'Ciliogenesis', 'score': 0.6687875}, {'id': 'https://openalex.org/keywords/cystic-kidney-disease', 'display_name': 'Cystic kidney disease', 'score': 0.6405803}, {'id': 'https://openalex.org/keywords/intraflagellar-transport', 'display_name': 'Intraflagellar transport', 'score': 0.593294}, {'id': 'https://openalex.org/keywords/autosomal-dominant-polycystic-kidney-disease', 'display_name': 'Autosomal Dominant Polycystic Kidney Disease', 'score': 0.509749}, {'id': 'https://openalex.org/keywords/nephronophthisis', 'display_name': 'Nephronophthisis', 'score': 0.50184536}, {'id': 'https://openalex.org/keywords/ciliopathies', 'display_name': 'Ciliopathies', 'score': 0.48847404}, {'id': 'https://openalex.org/keywords/ciliopathy', 'display_name': 'Ciliopathy', 'score': 0.44123703}, {'id': 'https://openalex.org/keywords/bardet–biedl-syndrome', 'display_name': 'Bardet–Biedl syndrome', 'score': 0.43875772}], 'concepts': [{'id': 'https://openalex.org/C100094513', 'wikidata': 'https://www.wikidata.org/wiki/Q180436', 'display_name': 'Cilium', 'level': 2, 'score': 0.98905873}, {'id': 'https://openalex.org/C2780145431', 'wikidata': 'https://www.wikidata.org/wiki/Q15443105', 'display_name': 'Polycystic kidney disease', 'level': 3, 'score': 0.7839305}, {'id': 'https://openalex.org/C195267511', 'wikidata': 'https://www.wikidata.org/wiki/Q5119969', 'display_name': 'Ciliogenesis', 'level': 3, 'score': 0.6687875}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6482198}, {'id': 'https://openalex.org/C2780337666', 'wikidata': 'https://www.wikidata.org/wiki/Q5201211', 'display_name': 'Cystic kidney disease', 'level': 3, 'score': 0.6405803}, {'id': 'https://openalex.org/C37590093', 'wikidata': 'https://www.wikidata.org/wiki/Q978456', 'display_name': 'Intraflagellar transport', 'level': 4, 'score': 0.593294}, {'id': 'https://openalex.org/C2778206077', 'wikidata': 'https://www.wikidata.org/wiki/Q1690779', 'display_name': 'Primary ciliary dyskinesia', 'level': 4, 'score': 0.5472722}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5465628}, {'id': 'https://openalex.org/C2778215940', 'wikidata': 'https://www.wikidata.org/wiki/Q1257011', 'display_name': 'Nephronophthisis', 'level': 4, 'score': 0.50184536}, {'id': 'https://openalex.org/C2910395002', 'wikidata': 'https://www.wikidata.org/wiki/Q203031', 'display_name': 'Ciliopathies', 'level': 4, 'score': 0.48847404}, {'id': 'https://openalex.org/C137620995', 'wikidata': 'https://www.wikidata.org/wiki/Q155769', 'display_name': 'Wnt signaling pathway', 'level': 3, 'score': 0.47914857}, {'id': 'https://openalex.org/C2780561973', 'wikidata': 'https://www.wikidata.org/wiki/Q203031', 'display_name': 'Ciliopathy', 'level': 4, 'score': 0.44123703}, {'id': 'https://openalex.org/C2781232497', 'wikidata': 'https://www.wikidata.org/wiki/Q1678281', 'display_name': 'Bardet–Biedl syndrome', 'level': 4, 'score': 0.43875772}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.35475305}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.35439622}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.32884657}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.24819466}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.21093369}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.19303283}, {'id': 'https://openalex.org/C115811362', 'wikidata': 'https://www.wikidata.org/wiki/Q189998', 'display_name': 'Flagellum', 'level': 3, 'score': 0.09605661}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.08605689}, {'id': 'https://openalex.org/C2779379686', 'wikidata': 'https://www.wikidata.org/wiki/Q32778', 'display_name': 'Bronchiectasis', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C2777714996', 'wikidata': 'https://www.wikidata.org/wiki/Q7886', 'display_name': 'Lung', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002923', 'descriptor_name': 'Cilia', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D052177', 'descriptor_name': 'Kidney Diseases, Cystic', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002923', 'descriptor_name': 'Cilia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052177', 'descriptor_name': 'Kidney Diseases, Cystic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/978-3-319-51436-9_11', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2754189475', 'display_name': 'Results and problems in cell differentiation', 'issn_l': '0080-1844', 'issn': ['0080-1844', '1861-0412'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'book series'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065811', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28409350', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065811', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.6, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 289, 'referenced_works': ['https://openalex.org/W108832634', 'https://openalex.org/W14931162', 'https://openalex.org/W1564910441', 'https://openalex.org/W1575509399', 'https://openalex.org/W1825060430', 'https://openalex.org/W1831583867', 'https://openalex.org/W1900540592', 'https://openalex.org/W190829892', 'https://openalex.org/W1940675059', 'https://openalex.org/W1945848687', 'https://openalex.org/W1959400241', 'https://openalex.org/W1963591622', 'https://openalex.org/W1965621240', 'https://openalex.org/W1965907379', 'https://openalex.org/W1968736435', 'https://openalex.org/W1968820250', 'https://openalex.org/W1970032331', 'https://openalex.org/W1971060771', 'https://openalex.org/W1971197630', 'https://openalex.org/W1971642804', 'https://openalex.org/W1973109304', 'https://openalex.org/W1973485093', 'https://openalex.org/W1974550507', 'https://openalex.org/W1974601240', 'https://openalex.org/W1975584335', 'https://openalex.org/W1976292163', 'https://openalex.org/W1976421227', 'https://openalex.org/W1976588897', 'https://openalex.org/W1976708316', 'https://openalex.org/W1977166389', 'https://openalex.org/W1977661683', 'https://openalex.org/W1978100164', 'https://openalex.org/W1978201430', 'https://openalex.org/W1979607406', 'https://openalex.org/W1980100245', 'https://openalex.org/W1981137206', 'https://openalex.org/W1981982858', 'https://openalex.org/W1982055359', 'https://openalex.org/W1983538981', 'https://openalex.org/W1984953412', 'https://openalex.org/W1985143102', 'https://openalex.org/W1985978697', 'https://openalex.org/W1986851724', 'https://openalex.org/W1991454115', 'https://openalex.org/W1992816628', 'https://openalex.org/W1993802679', 'https://openalex.org/W1993880917', 'https://openalex.org/W1995651171', 'https://openalex.org/W1996116737', 'https://openalex.org/W1997628120', 'https://openalex.org/W1998074947', 'https://openalex.org/W1998590298', 'https://openalex.org/W1998794025', 'https://openalex.org/W1999560996', 'https://openalex.org/W1999841436', 'https://openalex.org/W2000068229', 'https://openalex.org/W2000447670', 'https://openalex.org/W2000538799', 'https://openalex.org/W2000662468', 'https://openalex.org/W2000875874', 'https://openalex.org/W2001462151', 'https://openalex.org/W2001536138', 'https://openalex.org/W2001852418', 'https://openalex.org/W2002942283', 'https://openalex.org/W2005938853', 'https://openalex.org/W2011450474', 'https://openalex.org/W2012022940', 'https://openalex.org/W2012633940', 'https://openalex.org/W2012867369', 'https://openalex.org/W2013207268', 'https://openalex.org/W2013620388', 'https://openalex.org/W2018427450', 'https://openalex.org/W2018490222', 'https://openalex.org/W2019325523', 'https://openalex.org/W2019990719', 'https://openalex.org/W2020122791', 'https://openalex.org/W2022210570', 'https://openalex.org/W2023833832', 'https://openalex.org/W2024254525', 'https://openalex.org/W2024543908', 'https://openalex.org/W2028607959', 'https://openalex.org/W2028928264', 'https://openalex.org/W2029194355', 'https://openalex.org/W2030939638', 'https://openalex.org/W2032792789', 'https://openalex.org/W2033235301', 'https://openalex.org/W2033483229', 'https://openalex.org/W2033799985', 'https://openalex.org/W2034042492', 'https://openalex.org/W2035252153', 'https://openalex.org/W2035823311', 'https://openalex.org/W2038678925', 'https://openalex.org/W2040124417', 'https://openalex.org/W2040700903', 'https://openalex.org/W2041453089', 'https://openalex.org/W2041964741', 'https://openalex.org/W2042057571', 'https://openalex.org/W2043524463', 'https://openalex.org/W2045616300', 'https://openalex.org/W2047052174', 'https://openalex.org/W2049159933', 'https://openalex.org/W2049335442', 'https://openalex.org/W2049633713', 'https://openalex.org/W2052134339', 'https://openalex.org/W2052203674', 'https://openalex.org/W2052464276', 'https://openalex.org/W2053094829', 'https://openalex.org/W2053451133', 'https://openalex.org/W2055349890', 'https://openalex.org/W2057104531', 'https://openalex.org/W2060970598', 'https://openalex.org/W2062186455', 'https://openalex.org/W2063299318', 'https://openalex.org/W2064207737', 'https://openalex.org/W2064818329', 'https://openalex.org/W2065076032', 'https://openalex.org/W2066034930', 'https://openalex.org/W2066323961', 'https://openalex.org/W2066711817', 'https://openalex.org/W2069735028', 'https://openalex.org/W2070184849', 'https://openalex.org/W2071024393', 'https://openalex.org/W2071172690', 'https://openalex.org/W2071406790', 'https://openalex.org/W2072520621', 'https://openalex.org/W2073043336', 'https://openalex.org/W2078277615', 'https://openalex.org/W2078374899', 'https://openalex.org/W2079380806', 'https://openalex.org/W2080897556', 'https://openalex.org/W2081273157', 'https://openalex.org/W2081437948', 'https://openalex.org/W2082060108', 'https://openalex.org/W2083616180', 'https://openalex.org/W2083988049', 'https://openalex.org/W2085346322', 'https://openalex.org/W2085356690', 'https://openalex.org/W2085946814', 'https://openalex.org/W2090905561', 'https://openalex.org/W2091684557', 'https://openalex.org/W2092426118', 'https://openalex.org/W2093148342', 'https://openalex.org/W2093964879', 'https://openalex.org/W2094399319', 'https://openalex.org/W2095486148', 'https://openalex.org/W2095869636', 'https://openalex.org/W2096924054', 'https://openalex.org/W2097214606', 'https://openalex.org/W2097907753', 'https://openalex.org/W2099247534', 'https://openalex.org/W2100237032', 'https://openalex.org/W2100314162', 'https://openalex.org/W2100465045', 'https://openalex.org/W2100483988', 'https://openalex.org/W2100586381', 'https://openalex.org/W2100793213', 'https://openalex.org/W2101150738', 'https://openalex.org/W2101454196', 'https://openalex.org/W2101457064', 'https://openalex.org/W2101581446', 'https://openalex.org/W2101966309', 'https://openalex.org/W2102864788', 'https://openalex.org/W2103036283', 'https://openalex.org/W2103185802', 'https://openalex.org/W2103377139', 'https://openalex.org/W2103621765', 'https://openalex.org/W2103690924', 'https://openalex.org/W2104243614', 'https://openalex.org/W2105663489', 'https://openalex.org/W2107175020', 'https://openalex.org/W2108579793', 'https://openalex.org/W2108902166', 'https://openalex.org/W2109664774', 'https://openalex.org/W2109900084', 'https://openalex.org/W2109995563', 'https://openalex.org/W2109998016', 'https://openalex.org/W2110808839', 'https://openalex.org/W2111152287', 'https://openalex.org/W2111809875', 'https://openalex.org/W2112234407', 'https://openalex.org/W2112591804', 'https://openalex.org/W2112643254', 'https://openalex.org/W2113447712', 'https://openalex.org/W2114268679', 'https://openalex.org/W2114333899', 'https://openalex.org/W2115163299', 'https://openalex.org/W2115926089', 'https://openalex.org/W2116705949', 'https://openalex.org/W2117279921', 'https://openalex.org/W2117730876', 'https://openalex.org/W2118640963', 'https://openalex.org/W2118867845', 'https://openalex.org/W2119198063', 'https://openalex.org/W2119200120', 'https://openalex.org/W2119449193', 'https://openalex.org/W2119987653', 'https://openalex.org/W2120331308', 'https://openalex.org/W2121162099', 'https://openalex.org/W2121655277', 'https://openalex.org/W2122120053', 'https://openalex.org/W2123700457', 'https://openalex.org/W2124120257', 'https://openalex.org/W2124577658', 'https://openalex.org/W2124931121', 'https://openalex.org/W2124995736', 'https://openalex.org/W2125089548', 'https://openalex.org/W2126212740', 'https://openalex.org/W2127352376', 'https://openalex.org/W2127580293', 'https://openalex.org/W2128108727', 'https://openalex.org/W2129126752', 'https://openalex.org/W2129794832', 'https://openalex.org/W2130501501', 'https://openalex.org/W2130729770', 'https://openalex.org/W2131245032', 'https://openalex.org/W2132115473', 'https://openalex.org/W2133199275', 'https://openalex.org/W2134415267', 'https://openalex.org/W2134844061', 'https://openalex.org/W2135389531', 'https://openalex.org/W2135672728', 'https://openalex.org/W2136028206', 'https://openalex.org/W2136124373', 'https://openalex.org/W2136146731', 'https://openalex.org/W2137418427', 'https://openalex.org/W2138967544', 'https://openalex.org/W2139383499', 'https://openalex.org/W2140600466', 'https://openalex.org/W2140864413', 'https://openalex.org/W2141331673', 'https://openalex.org/W2141570562', 'https://openalex.org/W2142361468', 'https://openalex.org/W2142523086', 'https://openalex.org/W2144542308', 'https://openalex.org/W2145300367', 'https://openalex.org/W2145676689', 'https://openalex.org/W2150269114', 'https://openalex.org/W2150360143', 'https://openalex.org/W2151204987', 'https://openalex.org/W2151474304', 'https://openalex.org/W2152198679', 'https://openalex.org/W2152653845', 'https://openalex.org/W2153155610', 'https://openalex.org/W2153847689', 'https://openalex.org/W2154820433', 'https://openalex.org/W2155494705', 'https://openalex.org/W2157314032', 'https://openalex.org/W2158860585', 'https://openalex.org/W2159407840', 'https://openalex.org/W2159467374', 'https://openalex.org/W2160062537', 'https://openalex.org/W2160683202', 'https://openalex.org/W2164489472', 'https://openalex.org/W2165295267', 'https://openalex.org/W2165412300', 'https://openalex.org/W2165703612', 'https://openalex.org/W2166251842', 'https://openalex.org/W2167353494', 'https://openalex.org/W2167624117', 'https://openalex.org/W2168961894', 'https://openalex.org/W2171608919', 'https://openalex.org/W2173846013', 'https://openalex.org/W2177564588', 'https://openalex.org/W2178857865', 'https://openalex.org/W2188707140', 'https://openalex.org/W2191006184', 'https://openalex.org/W2233159531', 'https://openalex.org/W2239132265', 'https://openalex.org/W2259976800', 'https://openalex.org/W2268404930', 'https://openalex.org/W2281065280', 'https://openalex.org/W2282153579', 'https://openalex.org/W2283563018', 'https://openalex.org/W2290479358', 'https://openalex.org/W2311871350', 'https://openalex.org/W2312086209', 'https://openalex.org/W2320223118', 'https://openalex.org/W2321277386', 'https://openalex.org/W2324535932', 'https://openalex.org/W2330545449', 'https://openalex.org/W2331359311', 'https://openalex.org/W2399751470', 'https://openalex.org/W2418233049', 'https://openalex.org/W2595378942', 'https://openalex.org/W2985415460', 'https://openalex.org/W41955574', 'https://openalex.org/W4211143281', 'https://openalex.org/W4244085934', 'https://openalex.org/W807932216'], 'related_works': ['https://openalex.org/W4378190986', 'https://openalex.org/W4319293616', 'https://openalex.org/W4255544685', 'https://openalex.org/W4207059462', 'https://openalex.org/W2496025270', 'https://openalex.org/W2414310962', 'https://openalex.org/W2097416028', 'https://openalex.org/W2084723401', 'https://openalex.org/W2045509189', 'https://openalex.org/W2031839119'], 'abstract_inverted_index': {'Primary': [0], 'cilia': [1, 19, 46, 114, 128, 151, 181], 'are': [2, 47, 61, 70], 'small,': [3], 'antenna-like': [4], 'structures': [5], 'that': [6, 44], 'detect': [7], 'mechanical': [8, 154], 'and': [9, 12, 77, 103, 173, 182], 'chemical': [10], 'cues': [11], 'transduce': [13, 152], 'extracellular': [14], 'signals.': [15], 'While': [16], 'mammalian': [17], 'primary': [18, 45, 113, 127, 140, 150, 180], 'were': [20], 'first': [21], 'reported': [22], 'in': [23, 29, 126, 165, 184], 'the': [24, 36, 39, 53, 92, 121, 139, 145, 166, 170], 'late': [25], '1800s,': [26], 'scientific': [27], 'interest': [28], 'these': [30, 124], 'sensory': [31], 'organelles': [32], 'has': [33], 'burgeoned': [34], 'since': [35], 'beginning': [37], 'of': [38, 58, 101, 123, 136], 'twenty-first': [40], 'century': [41], 'with': [42], 'recognition': [43], 'essential': [48], 'to': [49, 112, 138, 160], 'human': [50], 'health.': [51], 'Among': [52], 'most': [54, 93], 'common': [55, 94], 'clinical': [56], 'manifestations': [57], 'ciliary': [59, 163], 'dysfunction': [60], 'renal': [62, 68, 95, 185], 'cysts.': [63], 'The': [64], 'molecular': [65, 82], 'mechanisms': [66, 147], 'underlying': [67], 'cystogenesis': [69], 'complex,': [71], 'involving': [72], 'multiple': [73], 'aberrant': [74], 'cellular': [75], 'processes': [76], 'signaling': [78, 176], 'pathways,': [79], 'while': [80], 'initiating': [81], 'events': [83], 'remain': [84], 'undefined.': [85], 'Autosomal': [86], 'Dominant': [87], 'Polycystic': [88], 'Kidney': [89], 'Disease': [90], 'is': [91], 'cystic': [96, 186], 'disease,': [97], 'caused': [98], 'by': [99, 148, 179], 'disruption': [100], 'polycystin-1': [102], 'polycystin-2': [104], 'transmembrane': [105], 'proteins,': [106], 'which': [107, 149], 'evidence': [108], 'suggests': [109], 'must': [110], 'localize': [111], 'for': [115], 'proper': [116], 'function.': [117], 'To': [118], 'understand': [119, 162], 'how': [120], 'absence': [122], 'proteins': [125], 'may': [129], 'be': [130], 'remediated,': [131], 'we': [132, 168], 'review': [133], 'intracellular': [134, 157], 'trafficking': [135], 'polycystins': [137], 'cilium.': [141], 'We': [142], 'also': [143], 'examine': [144], 'controversial': [146], 'flow-mediated': [153], 'stress': [155], 'into': [156], 'calcium.': [158], 'Further,': [159], 'better': [161], 'function': [164], 'kidney,': [167], 'highlight': [169], 'LKB1/AMPK,': [171], 'Wnt,': [172], 'Hedgehog': [174], 'developmental': [175], 'pathways': [177], 'mediated': [178], 'misregulated': [183], 'disease.': [187]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2605644624', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}], 'updated_date': '2024-08-15T14:46:44.072561', 'created_date': '2017-04-28'}