Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2605489512', 'doi': 'https://doi.org/10.1681/asn.2016111208', 'title': 'Janus Kinase 2 Regulates Transcription Factor EB Expression and Autophagy Completion in Glomerular Podocytes', 'display_name': 'Janus Kinase 2 Regulates Transcription Factor EB Expression and Autophagy Completion in Glomerular Podocytes', 'publication_year': 2017, 'publication_date': '2017-04-19', 'ids': {'openalex': 'https://openalex.org/W2605489512', 'doi': 'https://doi.org/10.1681/asn.2016111208', 'mag': '2605489512', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28424277', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5576936'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1681/asn.2016111208', 'pdf_url': 'https://jasn.asnjournals.org/content/jnephrol/28/9/2641.full.pdf', 'source': {'id': 'https://openalex.org/S115693375', 'display_name': 'Journal of the American Society of Nephrology', 'issn_l': '1046-6673', 'issn': ['1046-6673', '1533-3450'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315620', 'host_organization_name': 'American Society of Nephrology', 'host_organization_lineage': ['https://openalex.org/P4310315620'], 'host_organization_lineage_names': ['American Society of Nephrology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://jasn.asnjournals.org/content/jnephrol/28/9/2641.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5078228690', 'display_name': 'Tamadher A. Alghamdi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1297363086', 'display_name': "St. Michael's Hospital", 'ror': 'https://ror.org/04skqfp25', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1297363086', 'https://openalex.org/I4399598460']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'Tamadher A. Alghamdi', 'raw_affiliation_strings': ['Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada;'], 'affiliations': [{'raw_affiliation_string': 'Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada;', 'institution_ids': ['https://openalex.org/I1297363086']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029931153', 'display_name': 'Syamantak Majumder', 'orcid': 'https://orcid.org/0000-0001-8957-9810'}, 'institutions': [{'id': 'https://openalex.org/I1297363086', 'display_name': "St. Michael's Hospital", 'ror': 'https://ror.org/04skqfp25', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1297363086', 'https://openalex.org/I4399598460']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'Syamantak Majumder', 'raw_affiliation_strings': ['Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada;'], 'affiliations': [{'raw_affiliation_string': 'Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada;', 'institution_ids': ['https://openalex.org/I1297363086']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023802335', 'display_name': 'Karina Thieme', 'orcid': 'https://orcid.org/0000-0003-2896-4445'}, 'institutions': [{'id': 'https://openalex.org/I1297363086', 'display_name': "St. Michael's Hospital", 'ror': 'https://ror.org/04skqfp25', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1297363086', 'https://openalex.org/I4399598460']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'Karina Thieme', 'raw_affiliation_strings': ['Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada;'], 'affiliations': [{'raw_affiliation_string': 'Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada;', 'institution_ids': ['https://openalex.org/I1297363086']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013048733', 'display_name': 'Sri Nagarjun Batchu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1297363086', 'display_name': "St. Michael's Hospital", 'ror': 'https://ror.org/04skqfp25', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1297363086', 'https://openalex.org/I4399598460']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'Sri N. Batchu', 'raw_affiliation_strings': ['Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada;'], 'affiliations': [{'raw_affiliation_string': 'Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada;', 'institution_ids': ['https://openalex.org/I1297363086']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046154325', 'display_name': 'Kathryn White', 'orcid': 'https://orcid.org/0000-0003-2163-3547'}, 'institutions': [{'id': 'https://openalex.org/I84884186', 'display_name': 'Newcastle University', 'ror': 'https://ror.org/01kj2bm70', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I84884186']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Kathryn E. White', 'raw_affiliation_strings': ['Electron Microscopy Research Services, Newcastle University, Newcastle upon Tyne, United Kingdom; and'], 'affiliations': [{'raw_affiliation_string': 'Electron Microscopy Research Services, Newcastle University, Newcastle upon Tyne, United Kingdom; and', 'institution_ids': ['https://openalex.org/I84884186']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008151032', 'display_name': 'Youan Liu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1297363086', 'display_name': "St. Michael's Hospital", 'ror': 'https://ror.org/04skqfp25', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1297363086', 'https://openalex.org/I4399598460']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'Youan Liu', 'raw_affiliation_strings': ['Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada;'], 'affiliations': [{'raw_affiliation_string': 'Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada;', 'institution_ids': ['https://openalex.org/I1297363086']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013602662', 'display_name': 'Angela S. Brijmohan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1297363086', 'display_name': "St. Michael's Hospital", 'ror': 'https://ror.org/04skqfp25', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1297363086', 'https://openalex.org/I4399598460']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'Angela S. Brijmohan', 'raw_affiliation_strings': ['Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada;'], 'affiliations': [{'raw_affiliation_string': 'Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada;', 'institution_ids': ['https://openalex.org/I1297363086']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023244342', 'display_name': 'Bridgit B. Bowskill', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1297363086', 'display_name': "St. Michael's Hospital", 'ror': 'https://ror.org/04skqfp25', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1297363086', 'https://openalex.org/I4399598460']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'Bridgit B. Bowskill', 'raw_affiliation_strings': ['Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada;'], 'affiliations': [{'raw_affiliation_string': 'Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada;', 'institution_ids': ['https://openalex.org/I1297363086']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080593288', 'display_name': 'Suzanne L. Advani', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1297363086', 'display_name': "St. Michael's Hospital", 'ror': 'https://ror.org/04skqfp25', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1297363086', 'https://openalex.org/I4399598460']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'Suzanne L. Advani', 'raw_affiliation_strings': ['Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada;'], 'affiliations': [{'raw_affiliation_string': 'Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada;', 'institution_ids': ['https://openalex.org/I1297363086']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054259257', 'display_name': 'Minna Woo', 'orcid': 'https://orcid.org/0000-0002-5163-0112'}, 'institutions': [{'id': 'https://openalex.org/I1325899441', 'display_name': 'University Health Network', 'ror': 'https://ror.org/042xt5161', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441']}, {'id': 'https://openalex.org/I2801845744', 'display_name': 'Toronto General Hospital', 'ror': 'https://ror.org/026pg9j08', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2801845744']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Minna Woo', 'raw_affiliation_strings': ['Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada', 'institution_ids': ['https://openalex.org/I1325899441', 'https://openalex.org/I2801845744']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5061450499', 'display_name': 'Andrew Advani', 'orcid': 'https://orcid.org/0000-0003-0497-645X'}, 'institutions': [{'id': 'https://openalex.org/I1297363086', 'display_name': "St. Michael's Hospital", 'ror': 'https://ror.org/04skqfp25', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1297363086', 'https://openalex.org/I4399598460']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'Andrew Advani', 'raw_affiliation_strings': ['Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada;'], 'affiliations': [{'raw_affiliation_string': 'Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada;', 'institution_ids': ['https://openalex.org/I1297363086']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5078228690', 'https://openalex.org/A5029931153', 'https://openalex.org/A5023802335', 'https://openalex.org/A5013048733', 'https://openalex.org/A5008151032', 'https://openalex.org/A5013602662', 'https://openalex.org/A5023244342', 'https://openalex.org/A5080593288', 'https://openalex.org/A5061450499'], 'corresponding_institution_ids': ['https://openalex.org/I1297363086', 'https://openalex.org/I1297363086', 'https://openalex.org/I1297363086', 'https://openalex.org/I1297363086', 'https://openalex.org/I1297363086', 'https://openalex.org/I1297363086', 'https://openalex.org/I1297363086', 'https://openalex.org/I1297363086', 'https://openalex.org/I1297363086'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.851, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 22, 'citation_normalized_percentile': {'value': 0.85764, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '28', 'issue': '9', 'first_page': '2641', 'last_page': '2653'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11029', 'display_name': 'Renal Diseases and Glomerulopathies', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2727', 'display_name': 'Nephrology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11029', 'display_name': 'Renal Diseases and Glomerulopathies', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2727', 'display_name': 'Nephrology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11412', 'display_name': 'Genetic and Kidney Cyst Diseases', 'score': 0.9828, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11616', 'display_name': 'Autoimmune and Inflammatory Disorders Research', 'score': 0.9823, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tfeb', 'display_name': 'TFEB', 'score': 0.958846}, {'id': 'https://openalex.org/keywords/autophagosome', 'display_name': 'Autophagosome', 'score': 0.44985047}, {'id': 'https://openalex.org/keywords/sphingosine-kinase-1', 'display_name': 'Sphingosine kinase 1', 'score': 0.41460693}], 'concepts': [{'id': 'https://openalex.org/C132647116', 'wikidata': 'https://www.wikidata.org/wiki/Q18032677', 'display_name': 'TFEB', 'level': 4, 'score': 0.958846}, {'id': 'https://openalex.org/C2777146197', 'wikidata': 'https://www.wikidata.org/wiki/Q138912', 'display_name': 'Podocyte', 'level': 4, 'score': 0.8308723}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.6893078}, {'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.6819928}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.68055755}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5749153}, {'id': 'https://openalex.org/C2780216420', 'wikidata': 'https://www.wikidata.org/wiki/Q83330', 'display_name': 'Lysosome', 'level': 3, 'score': 0.53222096}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.5006807}, {'id': 'https://openalex.org/C168296220', 'wikidata': 'https://www.wikidata.org/wiki/Q14882441', 'display_name': 'Autophagosome', 'level': 4, 'score': 0.44985047}, {'id': 'https://openalex.org/C2777550365', 'wikidata': 'https://www.wikidata.org/wiki/Q14913834', 'display_name': 'Sphingosine kinase 1', 'level': 5, 'score': 0.41460693}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.32892108}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.1763306}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.15323952}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.09957099}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.091151774}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C2778703144', 'wikidata': 'https://www.wikidata.org/wiki/Q46298', 'display_name': 'Sphingosine', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C2776596873', 'wikidata': 'https://www.wikidata.org/wiki/Q418267', 'display_name': 'Sphingosine-1-phosphate', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C2779561371', 'wikidata': 'https://www.wikidata.org/wiki/Q570197', 'display_name': 'Proteinuria', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1681/asn.2016111208', 'pdf_url': 'https://jasn.asnjournals.org/content/jnephrol/28/9/2641.full.pdf', 'source': {'id': 'https://openalex.org/S115693375', 'display_name': 'Journal of the American Society of Nephrology', 'issn_l': '1046-6673', 'issn': ['1046-6673', '1533-3450'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315620', 'host_organization_name': 'American Society of Nephrology', 'host_organization_lineage': ['https://openalex.org/P4310315620'], 'host_organization_lineage_names': ['American Society of Nephrology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5576936', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576936', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1681/asn.2016111208', 'pdf_url': 'https://jasn.asnjournals.org/content/jnephrol/28/9/2641.full.pdf', 'source': {'id': 'https://openalex.org/S115693375', 'display_name': 'Journal of the American Society of Nephrology', 'issn_l': '1046-6673', 'issn': ['1046-6673', '1533-3450'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315620', 'host_organization_name': 'American Society of Nephrology', 'host_organization_lineage': ['https://openalex.org/P4310315620'], 'host_organization_lineage_names': ['American Society of Nephrology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.77}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1487257968', 'https://openalex.org/W1768274470', 'https://openalex.org/W1853148353', 'https://openalex.org/W1869269119', 'https://openalex.org/W1947637767', 'https://openalex.org/W1975200363', 'https://openalex.org/W1977767269', 'https://openalex.org/W1979036772', 'https://openalex.org/W1980568348', 'https://openalex.org/W1982397114', 'https://openalex.org/W1990488096', 'https://openalex.org/W1990586782', 'https://openalex.org/W1991692801', 'https://openalex.org/W1998399313', 'https://openalex.org/W2012421877', 'https://openalex.org/W2014914589', 'https://openalex.org/W2018567511', 'https://openalex.org/W2021188790', 'https://openalex.org/W2027033552', 'https://openalex.org/W2066126648', 'https://openalex.org/W2073294340', 'https://openalex.org/W2077499130', 'https://openalex.org/W2080207036', 'https://openalex.org/W2085574022', 'https://openalex.org/W2086445650', 'https://openalex.org/W2104040600', 'https://openalex.org/W2107661284', 'https://openalex.org/W2112231282', 'https://openalex.org/W2116505693', 'https://openalex.org/W2128999719', 'https://openalex.org/W2131349854', 'https://openalex.org/W2131660144', 'https://openalex.org/W2136458558', 'https://openalex.org/W2139948451', 'https://openalex.org/W2146124002', 'https://openalex.org/W2147360810', 'https://openalex.org/W2148659064', 'https://openalex.org/W2155357669', 'https://openalex.org/W2155876350', 'https://openalex.org/W2161143063', 'https://openalex.org/W2163087340', 'https://openalex.org/W2165765668', 'https://openalex.org/W2179291431', 'https://openalex.org/W2276198961', 'https://openalex.org/W2321540293', 'https://openalex.org/W2469870615'], 'related_works': ['https://openalex.org/W4385191034', 'https://openalex.org/W4306971719', 'https://openalex.org/W4304091936', 'https://openalex.org/W4243180838', 'https://openalex.org/W4237382727', 'https://openalex.org/W3173564820', 'https://openalex.org/W3114379697', 'https://openalex.org/W2809738004', 'https://openalex.org/W2525423931', 'https://openalex.org/W2153188271'], 'abstract_inverted_index': {'The': [0], 'nonreceptor': [1], 'kinase': [2, 4], 'Janus': [3], '2': [5], '(JAK2)': [6], 'has': [7, 115], 'garnered': [8], 'attention': [9], 'as': [10, 118], 'a': [11, 119], 'promising': [12], 'therapeutic': [13], 'target': [14], 'for': [15, 34], 'the': [16, 25, 41, 96, 105, 126, 131, 168, 177, 198, 206, 220], 'treatment': [17], 'of': [18, 44, 78, 86, 98, 104, 122, 128, 130, 171, 182, 201, 208], 'CKD.': [19], 'However,': [20], 'being': [21], 'ubiquitously': [22], 'expressed': [23], 'in': [24, 48, 59, 95, 184, 203, 213, 231], 'adult,': [26], 'JAK2': [27, 45, 50, 87, 135, 149, 172, 202], 'is': [28, 141], 'also': [29, 218], 'likely': [30], 'to': [31, 93, 176, 210], 'be': [32], 'necessary': [33], 'normal': [35], 'organ': [36], 'function.': [37], 'Here,': [38], 'we': [39, 137], 'investigated': [40], 'phenotypic': [42], 'effects': [43], 'deficiency.': [46], 'Mice': [47], 'which': [49, 75], 'had': [51], 'been': [52], 'deleted': [53], 'from': [54], 'podocytes': [55, 186, 204], 'exhibited': [56], 'an': [57], 'elevation': [58], 'urine': [60], 'albumin': [61, 192], 'excretion': [62], 'that': [63, 167, 222], 'was': [64], 'accompanied': [65], 'by': [66, 134, 143], 'increased': [67], 'podocyte': [68, 229], 'autophagosome': [69], 'fractional': [70], 'volume': [71], 'and': [72, 91, 101, 156, 162, 190, 205], 'p62': [73], 'aggregation,': [74], 'are': [76], 'indicative': [77], 'impaired': [79, 89], 'autophagy': [80, 90], 'completion.': [81], 'In': [82, 145, 159], 'cultured': [83], 'podocytes,': [84, 148], 'knockdown': [85, 150], 'similarly': [88], 'led': [92], 'downregulation': [94], 'expression': [97, 127], 'lysosomal': [99, 106, 188], 'genes': [100, 132], 'decreased': [102, 151], 'activity': [103, 226], 'enzyme,': [107], 'cathepsin': [108], 'D.': [109], 'Because': [110], 'transcription': [111], 'factor': [112], 'EB': [113], '(TFEB)': [114], 'recently': [116], 'emerged': [117], 'master': [120], 'regulator': [121], 'autophagosome-lysosome': [123, 211], 'function,': [124], 'controlling': [125], 'several': [129], 'downregulated': [133], 'knockdown,': [136], 'questioned': [138], 'whether': [139], 'TFEB': [140, 152, 178, 183, 209, 225], 'regulated': [142], 'JAK2.': [144], 'immortalized': [146], 'mouse': [147], 'promoter': [153], 'activity,': [154], 'expression,': [155], 'nuclear': [157], 'localization.': [158], 'silico': [160], 'analysis': [161], 'chromatin': [163], 'immunoprecipitation': [164], 'assays': [165], 'revealed': [166], 'downstream': [169], 'mediator': [170], 'signaling': [173], 'STAT1': [174], 'binds': [175], 'promoter.': [179], 'Finally,': [180], 'overexpression': [181], 'JAK2-deficient': [185], 'reversed': [187], 'dysfunction': [189], 'restored': [191], 'permselectivity.': [193], 'Collectively,': [194], 'these': [195, 214], 'observations': [196], 'highlight': [197], 'homeostatic': [199], 'actions': [200], 'importance': [207], 'function': [212], 'cells.': [215], 'These': [216], 'results': [217], 'raise': [219], 'possibility': [221], 'therapeutically': [223], 'modulating': [224], 'may': [227], 'improve': [228], 'health': [230], 'glomerular': [232], 'disease.': [233]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2605489512', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}], 'updated_date': '2025-01-10T14:21:03.594779', 'created_date': '2017-04-28'}