Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2605182461', 'doi': 'https://doi.org/10.18632/oncotarget.16940', 'title': 'Potential biomarkers of DNA replication stress in cancer', 'display_name': 'Potential biomarkers of DNA replication stress in cancer', 'publication_year': 2017, 'publication_date': '2017-04-07', 'ids': {'openalex': 'https://openalex.org/W2605182461', 'doi': 'https://doi.org/10.18632/oncotarget.16940', 'mag': '2605182461', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28445142', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5514887'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.16940', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=16940&path%5B%5D=54206', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=16940&path%5B%5D=54206', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101562192', 'display_name': 'Liqun Ren', 'orcid': 'https://orcid.org/0000-0002-1132-8613'}, 'institutions': [{'id': 'https://openalex.org/I192578869', 'display_name': 'Chengde Medical University', 'ror': 'https://ror.org/02bzkv281', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I192578869']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Liqun Ren', 'raw_affiliation_strings': ['Basic Medical Research Institute, Chengde Medical University, Chengde, China'], 'affiliations': [{'raw_affiliation_string': 'Basic Medical Research Institute, Chengde Medical University, Chengde, China', 'institution_ids': ['https://openalex.org/I192578869']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100336394', 'display_name': 'Long Chen', 'orcid': 'https://orcid.org/0000-0002-2979-5033'}, 'institutions': [{'id': 'https://openalex.org/I192578869', 'display_name': 'Chengde Medical University', 'ror': 'https://ror.org/02bzkv281', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I192578869']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Long Chen', 'raw_affiliation_strings': ['Basic Medical Research Institute, Chengde Medical University, Chengde, China'], 'affiliations': [{'raw_affiliation_string': 'Basic Medical Research Institute, Chengde Medical University, Chengde, China', 'institution_ids': ['https://openalex.org/I192578869']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103143625', 'display_name': 'Wei Wu', 'orcid': 'https://orcid.org/0000-0003-3929-2090'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Wei Wu', 'raw_affiliation_strings': ['Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000065207', 'display_name': 'Lorenza Garribba', 'orcid': 'https://orcid.org/0000-0003-1840-7354'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Lorenza Garribba', 'raw_affiliation_strings': ['Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100942569', 'display_name': 'Huanna Tian', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I192578869', 'display_name': 'Chengde Medical University', 'ror': 'https://ror.org/02bzkv281', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I192578869']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Huanna Tian', 'raw_affiliation_strings': ['Basic Medical Research Institute, Chengde Medical University, Chengde, China'], 'affiliations': [{'raw_affiliation_string': 'Basic Medical Research Institute, Chengde Medical University, Chengde, China', 'institution_ids': ['https://openalex.org/I192578869']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102024320', 'display_name': 'Zihui Liu', 'orcid': 'https://orcid.org/0000-0002-6770-717X'}, 'institutions': [{'id': 'https://openalex.org/I192578869', 'display_name': 'Chengde Medical University', 'ror': 'https://ror.org/02bzkv281', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I192578869']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zihui Liu', 'raw_affiliation_strings': ['Pathology Department, Affiliated Hospital, Chengde Medical University, Chengde, China'], 'affiliations': [{'raw_affiliation_string': 'Pathology Department, Affiliated Hospital, Chengde Medical University, Chengde, China', 'institution_ids': ['https://openalex.org/I192578869']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073231346', 'display_name': 'Ivan Vogel', 'orcid': 'https://orcid.org/0000-0001-5638-3598'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Ivan Vogel', 'raw_affiliation_strings': ['Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100410474', 'display_name': 'Chunhui Li', 'orcid': 'https://orcid.org/0000-0002-3651-7736'}, 'institutions': [{'id': 'https://openalex.org/I192578869', 'display_name': 'Chengde Medical University', 'ror': 'https://ror.org/02bzkv281', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I192578869']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chunhui Li', 'raw_affiliation_strings': ['Pathology Department, Affiliated Hospital, Chengde Medical University, Chengde, China'], 'affiliations': [{'raw_affiliation_string': 'Pathology Department, Affiliated Hospital, Chengde Medical University, Chengde, China', 'institution_ids': ['https://openalex.org/I192578869']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085921889', 'display_name': 'Ian D. Hickson', 'orcid': 'https://orcid.org/0000-0002-0583-566X'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Ian D. Hickson', 'raw_affiliation_strings': ['Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark', 'Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}, {'raw_affiliation_string': 'Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5067876663', 'display_name': 'Ying Liu', 'orcid': 'https://orcid.org/0000-0003-3703-2498'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Ying Liu', 'raw_affiliation_strings': ['Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.223, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 17, 'citation_normalized_percentile': {'value': 0.999735, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '8', 'issue': '23', 'first_page': '36996', 'last_page': '37008'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10123', 'display_name': 'Molecular Mechanisms of DNA Damage Response', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10123', 'display_name': 'Molecular Mechanisms of DNA Damage Response', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10492', 'display_name': 'Regulation and Function of Microtubules in Cell Division', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/oncogene', 'display_name': 'oncogene', 'score': 0.551223}, {'id': 'https://openalex.org/keywords/chromosome-instability', 'display_name': 'Chromosome instability', 'score': 0.5326837}], 'concepts': [{'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.7845345}, {'id': 'https://openalex.org/C2781197716', 'wikidata': 'https://www.wikidata.org/wiki/Q864574', 'display_name': 'Biomarker', 'level': 2, 'score': 0.7136505}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.6976809}, {'id': 'https://openalex.org/C2781018059', 'wikidata': 'https://www.wikidata.org/wiki/Q207609', 'display_name': 'Oncogene', 'level': 4, 'score': 0.69597083}, {'id': 'https://openalex.org/C178169997', 'wikidata': 'https://www.wikidata.org/wiki/Q2892636', 'display_name': 'Genome instability', 'level': 4, 'score': 0.5664535}, {'id': 'https://openalex.org/C140752955', 'wikidata': 'https://www.wikidata.org/wiki/Q1087752', 'display_name': 'Chromosome instability', 'level': 4, 'score': 0.5326837}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.50324625}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.45199943}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.44097513}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4358279}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.42324594}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.42262053}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.3742313}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.31042975}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.26786745}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.25567058}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.21164301}, {'id': 'https://openalex.org/C30481170', 'wikidata': 'https://www.wikidata.org/wiki/Q37748', 'display_name': 'Chromosome', 'level': 3, 'score': 0.20190772}], 'mesh': [{'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D043171', 'descriptor_name': 'Chromosomal Instability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004261', 'descriptor_name': 'DNA Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D063646', 'descriptor_name': 'Carcinogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D063646', 'descriptor_name': 'Carcinogenesis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015894', 'descriptor_name': 'Genome, Human', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015894', 'descriptor_name': 'Genome, Human', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D010865', 'descriptor_name': 'Pilot Projects', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.16940', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=16940&path%5B%5D=54206', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5514887', 'pdf_url': 'https://europepmc.org/articles/pmc5514887?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514887', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://curis.ku.dk/ws/files/180367391/16940_248444_5_PB.pdf', 'pdf_url': 'https://curis.ku.dk/ws/files/180367391/16940_248444_5_PB.pdf', 'source': {'id': 'https://openalex.org/S4306401983', 'display_name': 'Research at the University of Copenhagen (University of Copenhagen)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I124055696', 'host_organization_name': 'University of Copenhagen', 'host_organization_lineage': ['https://openalex.org/I124055696'], 'host_organization_lineage_names': ['University of Copenhagen'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28445142', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.16940', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=16940&path%5B%5D=54206', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.49}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 58, 'referenced_works': ['https://openalex.org/W1608714568', 'https://openalex.org/W1628408467', 'https://openalex.org/W1815509520', 'https://openalex.org/W1964640891', 'https://openalex.org/W1964787686', 'https://openalex.org/W1965749659', 'https://openalex.org/W1967630574', 'https://openalex.org/W1967743500', 'https://openalex.org/W1970471893', 'https://openalex.org/W1978982015', 'https://openalex.org/W1981202500', 'https://openalex.org/W1981899177', 'https://openalex.org/W1984328656', 'https://openalex.org/W1984542357', 'https://openalex.org/W2005115966', 'https://openalex.org/W2013000007', 'https://openalex.org/W2013328118', 'https://openalex.org/W2014914902', 'https://openalex.org/W2015631955', 'https://openalex.org/W2017575281', 'https://openalex.org/W2019078072', 'https://openalex.org/W2022527641', 'https://openalex.org/W2027768636', 'https://openalex.org/W2042879563', 'https://openalex.org/W2048434099', 'https://openalex.org/W2049576185', 'https://openalex.org/W2057286714', 'https://openalex.org/W2058389760', 'https://openalex.org/W2061670713', 'https://openalex.org/W2067573570', 'https://openalex.org/W2072131245', 'https://openalex.org/W2080278341', 'https://openalex.org/W2080823011', 'https://openalex.org/W2083158919', 'https://openalex.org/W2084833108', 'https://openalex.org/W2087565131', 'https://openalex.org/W2094402500', 'https://openalex.org/W2098318897', 'https://openalex.org/W2101185225', 'https://openalex.org/W2102570250', 'https://openalex.org/W2113896971', 'https://openalex.org/W2116376484', 'https://openalex.org/W2119799188', 'https://openalex.org/W2122050922', 'https://openalex.org/W2124102021', 'https://openalex.org/W2126415088', 'https://openalex.org/W2131356396', 'https://openalex.org/W2138422735', 'https://openalex.org/W2157636068', 'https://openalex.org/W2162561014', 'https://openalex.org/W2187574279', 'https://openalex.org/W2290430986', 'https://openalex.org/W2418649127', 'https://openalex.org/W2419261621', 'https://openalex.org/W2532595713', 'https://openalex.org/W2533788982', 'https://openalex.org/W2563646853', 'https://openalex.org/W4238448376'], 'related_works': ['https://openalex.org/W2352719856', 'https://openalex.org/W2152859477', 'https://openalex.org/W2134683317', 'https://openalex.org/W2096764255', 'https://openalex.org/W2084475506', 'https://openalex.org/W2073596489', 'https://openalex.org/W2051467864', 'https://openalex.org/W2048694704', 'https://openalex.org/W1995981964', 'https://openalex.org/W1506578365'], 'abstract_inverted_index': {'//': [0, 98], 'Liqun': [1], 'Ren': [2], '1': [3, 7, 19, 41], ',': [4, 8, 12, 16, 20, 24, 28, 32], 'Long': [5], 'Chen': [6], 'Wei': [9], 'Wu': [10], '2': [11, 15, 27, 40, 51], 'Lorenza': [13], 'Garribba': [14], 'Huanna': [17], 'Tian': [18], 'Zihui': [21], 'Liu': [22, 39], '3': [23, 31, 67], 'Ivan': [25], 'Vogel': [26], 'Chunhui': [29], 'Li': [30], 'Ian': [33], 'D.': [34], 'Hickson': [35], '2,4': [36], 'and': [37, 59, 85, 185, 205, 222, 327], 'Ying': [38, 95], 'Basic': [42], 'Medical': [43, 47, 73], 'Research': [44], 'Institute,': [45], 'Chengde': [46, 72], 'University,': [48, 74], 'Chengde,': [49, 75], 'China': [50, 76], 'Center': [52, 78], 'for': [53, 79, 271, 339, 354], 'Chromosome': [54, 111], 'Stability,': [55], 'Department': [56, 82], 'of': [57, 63, 83, 89, 135, 141, 147, 169, 177, 230, 242, 256, 275, 293, 336, 341, 357], 'Cellular': [58, 84], 'Molecular': [60, 86], 'Medicine,': [61, 87], 'University': [62, 88], 'Copenhagen,': [64, 65, 90, 91], 'Denmark': [66, 92], 'Pathology': [68], 'Department,': [69], 'Affiliated': [70], 'Hospital,': [71], '4': [77], 'Healthy': [80], 'Aging,': [81], 'Correspondence': [93], 'to:': [94], 'Liu,': [96], 'email:': [97], 'Keywords': [99], ':': [100, 114, 119, 124], 'cancer': [101, 157, 199, 216, 257, 278], 'biomarker,': [102], 'chromosome': [103, 170], 'instability,': [104], 'common': [105, 154, 246], 'fragile': [106, 247], 'sites,': [107], 'MiDAS,': [108], 'replication': [109, 149], 'stress,': [110], 'Section': [112], 'Received': [113], 'March': [115, 120], '08,': [116], '2017': [117, 122, 127], 'Accepted': [118], '28,': [121], 'Published': [123], 'April': [125], '07,': [126], 'Abstract': [128], 'Oncogene': [129], 'activation': [130, 143], 'is': [131, 144, 162, 181, 322], 'an': [132, 304], 'established': [133], 'driver': [134], 'tumorigenesis.': [136], 'An': [137], 'apparently': [138], 'inevitable': [139], 'consequence': [140], 'oncogene': [142], 'the': [145, 167, 211, 231, 239, 262, 273, 308, 334, 361], 'generation': [146], 'DNA': [148], 'stress': [150, 267], '(RS),': [151], 'a': [152, 163, 173, 225, 253, 286, 315, 337], 'feature': [153, 176], 'to': [155, 201, 203, 238, 289, 302, 332, 351], 'most': [156], 'cells.': [158], 'RS,': [159, 243], 'in': [160, 166, 215, 252, 277, 299, 307, 343], 'turn,': [161], 'causal': [164], 'factor': [165], 'development': [168, 335], 'instability': [171], '(CIN),': [172], 'near': [174], 'universal': [175], 'solid': [178], 'tumors.': [179], 'It': [180], 'likely': [182], 'that': [183, 191, 218, 234, 261, 295, 320], 'CIN': [184], 'RS': [186, 221, 250, 276, 309, 342, 362], 'are': [187, 268, 296], 'mutually': [188], 'reinforcing': [189], 'drivers': [190], 'not': [192], 'only': [193], 'accelerate': [194, 333], 'tumorigenesis,': [195], 'but': [196], 'also': [197], 'permit': [198], 'cells': [200, 217], 'adapt': [202], 'diverse': [204], 'hostile': [206], 'environments.': [207], 'This': [208], 'article': [209], 'reviews': [210], 'genetic': [212], 'changes': [213], 'present': [214], 'influence': [219], 'oncogene-induced': [220], 'CIN,': [223], 'with': [224], 'particular': [226], 'emphasis': [227], 'on': [228], 'regions': [229], 'human': [232], 'genome': [233], 'show': [235], 'enhanced': [236], 'sensitivity': [237], 'destabilizing': [240], 'effects': [241], 'such': [244, 359], 'as': [245, 314, 360], 'sites.': [248], 'Because': [249], 'exists': [251], 'wide': [254], 'range': [255], 'types,': [258], 'we': [259, 284, 330], 'propose': [260], 'proteins': [263, 294], 'involved': [264], 'counteracting': [265], 'this': [266, 282, 321, 325], 'potential': [269], 'biomarkers': [270], 'indicating': [272], 'degree': [274], 'specimens.': [279], 'To': [280], 'test': [281], 'hypothesis,': [283], 'conducted': [285], 'pilot': [287, 328], 'study': [288], 'validate': [290], 'whether': [291], 'some': [292], 'known': [297], 'from': [298], 'vitro': [300], 'studies': [301], 'play': [303], 'essential': [305], 'role': [306], 'pathway': [310], 'could': [311, 348], 'be': [312], 'suitable': [313], 'biomarker.': [316], 'Our': [317], 'results': [318], 'indicated': [319], 'possible.': [323], 'With': [324], 'review': [326], 'study,': [329], 'aim': [331], 'biomarker': [338], 'analysis': [340], 'tumor': [344], 'biopsy': [345], 'specimens,': [346], 'which': [347], 'ultimately': [349], 'help': [350], 'stratify': [352], 'patients': [353], 'different': [355], 'forms': [356], 'therapy': [358], 'inhibitors': [363], 'already': [364], 'undergoing': [365], 'clinical': [366], 'trials.': [367]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2605182461', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-08-21T19:23:14.754868', 'created_date': '2017-04-14'}