Publication Information

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[10, 85, 119, 166, 241, 275, 445, 498, 503, 567, 972, 1005, 1589, 2129, 2589, 2630, 3007, 3048, 3764], 'sporadic': [11, 167], "Alzheimer'ns": [12, 168, 314], 'disease': [13, 169, 315, 355, 1007, 1162, 1239, 1315, 1393, 3661, 3704, 3743, 3806, 3999, 4107], '(AD),': [14, 170], 'increasing': [15, 171, 541], 'up': [17, 173, 544], 'to': [18, 47, 174, 203, 326, 403, 519, 545, 577, 1431, 1458, 1706, 1911, 2124, 2221, 2239, 2260, 2411, 2890, 3116, 3301, 3312, 3547, 3584, 3770, 4173], '15-fold': [19, 175, 546], 'compared': [20, 176, 547], 'with': [21, 23, 177, 179, 345, 449, 548, 1012, 1158, 1319, 1348, 1389, 1704, 2131, 2165, 2357, 2659, 2664, 2881, 3109, 3657, 4070, 4109, 4267], 'APOE3,': [22, 178], 'APOE2': [24, 180, 554], 'decreasing': [25, 181], 'AD': [26, 35, 55, 126, 182, 191, 211, 282, 348, 405, 433, 447, 462, 529, 542, 754, 772, 857, 938, 1117, 1136, 1341, 1353, 1437, 1450, 1468, 2245, 2868, 3554, 3564, 4270], 'risk.': [27, 183], 'However,': [28, 184, 437], 'functional': [30, 186], 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'summarize': [153, 309], 'future': [154, 310], 'directions.': [155, 311], 'humans,': [313, 338], '(AD)': [316], 'progresses': [317], 'over': [318], 'decades,': [319], 'resulting': [320], 'synaptic': [322, 1192, 1216, 1246, 1748, 2073, 3862], 'dysfunction': [323, 467, 1217, 1425, 3794], 'eventually': [324], 'leading': [325], 'neuronal': [327, 1420, 1708, 2666, 2770], 'loss.': [328], 'Despite': [329], 'large': [331], 'number': [332, 439, 741], 'longitudinal': [334, 380], 'aging': [335, 381], 'studies': [336, 448, 2227], 'cognitive': [342, 569, 575, 655, 1159, 1320, 3864], 'measures': [343], 'coordinated': [344], 'results': [350], 'poorly': [353], 'understood': [354, 760], 'trajectory': [356], '(1.Erten-Lyons': [357], 'D.': [358, 639, 874, 878, 1901, 2005, 2007, 2403, 2477, 2479, 2534, 2650, 2652, 2692, 2833, 2951, 2953, 3070, 3181, 3183, 3221, 3420, 3422, 3460, 4132], 'Sherbakov': [359], 'L.O.': [360], 'Piccinin': [361], 'A.M.': [362, 1809, 1947, 1995, 2273, 2893, 2941, 3171, 3264, 3316, 3410, 3503], 'Hofer': [363], 'S.M.': [364, 1817, 1859, 1955, 2281, 2323, 2351, 2452, 2620, 2798, 2831, 2901, 3038, 3068, 3127, 3229, 3324, 3366, 3468], 'Dodge': [365], 'H.H.': [366], 'Quinn': [367], 'J.F.': [368, 924, 1623, 1660, 3601, 3889, 3926], 'Woltjer': [369], 'R.L.': [370, 2152], 'Kramer': [371], 'P.L.': [372], 'Kaye': [373], 'J.A.': [374], 'Review': [375], 'selected': [377], 'databases': [378], 'studies.Alzheimers': [382, 506], 'Dement.': [383], '2012;': [384, 1175, 1251, 1752, 3810, 4044, 4086, 4227], '8:': [385, 4118], '584-589Abstract': [386], 'Full': [387, 389, 1407, 1409, 2181, 2183, 4230, 4232], 'Text': [388, 390, 1408, 1410, 2182, 2184, 4231, 4233], 'PDF': [391, 1411, 2185, 4234], 'PubMed': [392, 512, 584, 615, 672, 729, 826, 868, 906, 952, 989, 1030, 1073, 1104, 1178, 1201, 1225, 1254, 1294, 1326, 1412, 1638, 1676, 1721, 1755, 1803, 1845, 1891, 1921, 1983, 2031, 2103, 2186, 2309, 2341, 2381, 2426, 2471, 2510, 2559, 2608, 2638, 2682, 2709, 2742, 2780, 2817, 2858, 2929, 2977, 3026, 3056, 3095, 3159, 3207, 3246, 3286, 3352, 3398, 3446, 3485, 3525, 3620, 3673, 3713, 3751, 3784, 3813, 3875, 3908, 3947, 3984, 4013, 4047, 4089, 4120, 4153, 4185, 4235, 4277], 'Scopus': [393, 513, 585, 673, 907, 1031, 1074, 1105, 1179, 1202, 1226, 1255, 1295, 1327, 1413, 1639, 1677, 1722, 1756, 1804, 1846, 1892, 1922, 1984, 2032, 2187, 2310, 2382, 2427, 2472, 2511, 2560, 2609, 2743, 2818, 2930, 2978, 3027, 3160, 3208, 3247, 3287, 3353, 3399, 3447, 3486, 3526, 3621, 3674, 3714, 3752, 3785, 3814, 3876, 3909, 3948, 3985, 4014, 4048, 4090, 4121, 4154, 4186, 4236, 4278], '(0)': [394, 908, 1032, 1414, 1678, 1723, 1923, 2473, 2561, 3753, 3786, 3910, 3986, 4015, 4091, 4122, 4155], 'Google': [395, 515, 587, 616, 675, 730, 827, 869, 909, 953, 990, 1033, 1076, 1107, 1181, 1204, 1228, 1257, 1297, 1329, 1415, 1527, 1641, 1679, 1724, 1758, 1806, 1848, 1894, 1924, 1986, 2034, 2104, 2189, 2312, 2342, 2384, 2429, 2474, 2513, 2562, 2611, 2639, 2683, 2710, 2745, 2781, 2820, 2859, 2932, 2980, 3029, 3057, 3096, 3162, 3210, 3249, 3289, 3355, 3401, 3449, 3488, 3528, 3623, 3676, 3716, 3754, 3787, 3816, 3849, 3878, 3911, 3950, 3987, 4016, 4050, 4092, 4123, 4156, 4188, 4238, 4280], 'Scholar).': [396, 516, 1108, 1330, 1416, 1925, 2190, 3097, 3290], 'Transgenic': [397], '(Tg)-mice': [398], 'are': [399, 1123, 1128, 1311, 1338, 1346, 1383, 2041, 2879, 3107], 'powerful': [401], 'tool': [402], 'track': [404], 'address': [407, 3548], 'mechanistic': [408, 749, 2223], 'hypothesis,': [409], 'assess': [411], 'activity': [413], 'potential': [415, 3663], 'therapeutics.': [416], 'An': [417], 'overall': [418], 'limitation': [419], 'all': [421, 1591], 'Tg-mouse': [422, 456], 'models': [423, 1501, 1929, 2271, 2809], 'that': [425, 453, 751, 1127, 1935, 2040, 2230, 3298, 3561], 'none': [426], 'reproduce': [427], 'full': [429, 3534], 'spectrum': [430], 'reviews': [441], 'provide': [442], 'specific': [443], 'guidelines': [444], 'consistent': [451], 'theme': [452], 'will': [458], 'incorporate': [459, 2231], 'major': [460, 527], 'factors': [464, 3664], 'demonstrate': [466], 'symptom': [471], 'interest': [473], '(2.Shineman': [474], 'D.W.': [475], 'Basi': [476], 'G.S.': [477], 'Bizon': [478], 'J.L.': [479, 647, 682, 779, 1300], 'Colton': [480], 'C.A.': [481, 962, 1260, 1372, 2579, 2997], 'Greenberg': [482, 2797], 'B.D.': [483], 'Hollister': [484], 'B.A.': [485], 'Lincecum': [486], 'J.': [487, 964, 1521, 2003, 2150, 2391, 2393, 2491, 2575, 2949, 2993, 3179, 3254, 3418, 3493, 3615, 3636, 3642, 3687, 3709, 3746, 3920, 4203, 4245], 'Leblanc': [488], 'G.G.': [489], 'Lee': [490, 2517, 2801], 'L.B.': [491, 1370], 'Luo': [492], 'F.': [493, 1761, 2495, 2644, 2725, 2788, 3215, 3454], 'et': [494, 652, 849, 891, 931, 1375, 2008, 2406, 2496, 2535, 2584, 2954, 3002, 3184, 3271, 3423, 3510, 3646, 4210], 'al.Accelerating': [495], 'drug': [496], 'discovery': [497], "Alzheimer's": [499, 607, 1006, 1086, 1219, 1238, 1288, 1314, 1839, 1977, 2022, 2303, 2375, 2421, 2599, 2923, 2968, 3017, 3198, 3346, 3437, 3606, 3660, 3703, 3742, 3805, 3902, 3998, 4041, 4083, 4106, 4147, 4179], 'disease:': [500], 'best': [501, 2114], 'practices': [502], 'animal': [505], 'Res.': [507, 1197, 3980, 4009], 'Ther.': [508], '2011;': [509, 612, 1524, 1718, 3283, 3522, 3905, 4274], '3:': [510, 1801, 3284, 3523], '28Crossref': [511], '(81)': [514], 'Thus,': [517, 2217, 3291], 'this': [520, 733, 1531, 3549], 'modeling': [521], 'inclusion': [524], 'factors.': [531], 'genotype': [534, 597, 710, 807, 1444, 1741], 'common': [550, 2167], 'APOE3': [551, 2169], 'genotype,': [552, 978], 'while': [553], 'protective': [556], '(3.Reitz': [557], 'C.': [558, 886, 930, 1366, 1510, 1609, 1646, 1690, 1735, 2148, 2319, 2487, 2616, 2719, 3034, 3223, 3270, 3462, 3509, 3992, 4057, 4128, 4255], 'Mayeux': [559, 687, 784], 'R.': [560, 688, 785, 1771, 2481, 2483, 2520, 2526, 2796, 3599, 3852, 3887, 3924, 3928, 4097, 4253], 'Use': [561], 'variation': [564], 'biomarkers': [566, 599], 'mild': [568, 574], 'impairment': [570, 576, 2456, 3734, 3996], 'progression': [572, 3531], 'dementia.J.': [578], 'Alzheimers': [579, 1522], 'Dis.': [580, 983, 1322, 1523, 1672, 1841, 1979, 2305, 2925, 3348, 3809, 3871, 3943], '2010;': [581, 3748, 3781, 4010], '19:': [582, 1919], '229-251Crossref': [583], '(41)': [586], 'Scholar,': [588, 676, 828, 870, 910, 954, 991, 1034, 1077, 1182, 1205, 1229, 1258, 1298, 1642, 1680, 1725, 1759, 1807, 1849, 1895, 1987, 2313, 2343, 2385, 2430, 2475, 2514, 2563, 2612, 2640, 2684, 2711, 2746, 2782, 2821, 2933, 2981, 3030, 3058, 3163, 3211, 3250, 3356, 3402, 3450, 3489, 3624, 3677, 3717, 3755, 3788, 3817, 3850, 3879, 3912, 3951, 3988, 4017, 4051, 4093, 4124, 4157, 4189, 4239, 4281], '4.Leoni': [589], 'V.': [590, 2583, 3001, 3679], 'effect': [592], 'apolipoprotein': [594, 708, 805, 976, 1014, 1379, 1694, 1779, 1865, 2082, 2162, 2632, 2847, 3050, 3084, 3133, 3372, 4260], 'E': [595, 709, 806, 893, 977, 2010, 2083, 2163, 2586, 2633, 2848, 2956, 3004, 3051, 3085, 3186, 3425, 4261], '(ApoE)': [596], 'amyloidogenesis,': [601], 'neurodegeneration': [605, 1286, 3773], 'disease.Clin.': [608], 'Chem.': [609, 1403, 2177, 4226], 'Lab.': [610], 'Med.': [611, 724, 821, 3282, 3521], '49:': [613], '375-383Crossref': [614], 'Scholar),': [617, 3529], 'but': [618, 2094, 2662, 2768], 'less': [619, 759], 'frequent': [620], '[estimated:': [621], 'ε2/2': [622], 'at': [623, 626, 630, 1558, 2202, 3304, 3961], '0.4%,': [624], 'ε2/3': [625], '8.8%,': [627], 'ε2/4': [629], '1.5%': [631], '(5.Shinohara': [632], 'M.': [633, 641, 872, 888, 928, 1619, 1811, 1813, 1855, 1949, 1951, 1997, 2051, 2063, 2275, 2277, 2518, 2530, 2646, 2690, 2750, 2895, 2897, 2943, 3123, 3173, 3318, 3320, 3362, 3412, 3587, 3595, 3640, 3721, 3759, 3792, 3819, 3823, 3854, 3914, 3918, 3922, 4201], 'Kanekiyo': [634, 4198], 'T.': [635, 890, 1358, 1993, 2065, 2489, 2493, 2567, 2939, 2985, 3169, 3408, 3953, 3957, 3990, 4199], 'Yang': [636, 2724], 'L.': [637, 645, 918, 1081, 1360, 1508, 2069, 2401, 3589, 3645, 3719, 3757, 3790, 4197], 'Linthicum': [638], 'Shinohara': [640], 'Fu': [642], 'Y.': [643, 1067, 1684, 1692, 1727, 2057, 2146, 2347, 2571, 2721, 2852, 2989, 3089], 'Price': [644], 'Frisch-Daiello': [646], 'Han': [648], 'X.': [649, 2448], 'Fryer': [650], 'J.D.': [651, 1851, 3119, 3358], 'al.APOE2': [653], 'eases': [654], 'decline': [656, 1160, 4140], 'during': [657], 'aging:': [658], 'clinical': [659], 'evaluations.Ann.': [662], 'Neurol.': [663, 902, 1100, 1290, 2705, 2776], '2016;': [664, 3841], '(Epub': [665, 3842], 'ahead': [666, 3843], 'print.': [668, 3845], 'March': [669], '2,': [670], 'doi:10.1002/ana.24628)Crossref': [671], '(45)': [674], '6.Farrer': [677], 'L.A.': [678, 680, 775, 777], 'Cupples': [679, 776], 'Haines': [681, 778], 'Hyman': [683, 780, 2653, 2755, 2834, 3071], 'B.': [684, 781, 880, 2001, 2059, 2827, 2947, 3064, 3177, 3416, 4165], 'Kukull': [685, 782], 'W.A.': [686, 783, 4095, 4205], 'Myers': [689, 786], 'R.H.': [690, 787], 'Pericak-Vance': [691, 788], 'M.A.': [692, 789, 2440], 'Risch': [693, 790], 'N.': [694, 791, 1066, 1682, 2156, 2851, 3088], 'van': [695, 792], 'Duijn': [696, 793], 'C.M.': [697, 794], 'Effects': [698, 795], 'age,': [700, 797, 1061, 1440], 'sex,': [701, 798, 1062], 'ethnicity': [703, 800], 'association': [706, 803], 'Alzheimer': [712, 718, 809, 815, 900, 981, 1098, 1392, 2550, 3868, 4223], 'disease.': [713, 810], 'A': [714, 811, 1826, 1964, 2290, 2541, 2762, 2838, 2889, 2910, 3075, 3333, 3583, 3694], 'meta-analysis.': [715, 812], 'APOE': [716, 745, 813, 1064, 1131, 1443, 1515, 1740, 3231, 3470], 'Disease': [719, 816, 1087], 'Meta': [720, 817], 'Analysis': [721, 818], 'Consortium.J.': [722, 819], 'Am.': [723, 820], 'Assoc.': [725, 822, 984], '1997;': [726, 823, 2178, 2556, 2679, 2777], '278:': [727, 824], '1349-1356Crossref': [728, 825], 'Scholar)].': [731, 1528], 'Although': [732], 'was': [735], 'identified': [736], '1993': [738], 'hypotheses': [743], 'propose': [744], 'genotype-specific': [746], 'functions,': [747], 'pathways': [750], 'cause': [752], 'APOE4-induced': [753, 771], 'unclear.': [757], 'Even': [758], 'link': [764], 'female': [766], '(♀)': [767], 'sex': [768, 1133, 1441], '(6.Farrer': [774], '7.Breitner': [829], 'J.C.': [830, 834, 2315, 2614, 3032, 3225, 3266, 3464, 3505], 'Wyse': [831], 'B.W.': [832, 3262, 3501], 'Anthony': [833], 'Welsh-Bohmer': [835], 'K.A.': [836], 'Steffens': [837], 'D.C.': [838], 'Norton': [839], 'M.C.': [840, 2642, 2748, 2823, 3060], 'Tschanz': [841], 'J.T.': [842], 'Plassman': [843], 'B.L.': [844, 1607, 1644], 'Meyer': [845], 'M.R.': [846], 'Skoog': [847], 'I.': [848, 1231], 'al.APOE-epsilon4': [850], 'count': [851], 'predicts': [852], 'age': [853, 1000, 2412], 'when': [854, 2876, 3104], 'prevalence': [855], 'increases,': [858], 'then': [859], 'declines:': [860], 'Cache': [862], 'County': [863], 'Study.Neurology.': [864], '1999;': [865, 949, 986, 1291, 2338, 2605, 3023], '53:': [866, 950], '321-331Crossref': [867], '8.Martinez': [871], 'Campion': [873], 'Brice': [875], 'A.': [876, 884, 920, 1079, 1302, 1656, 1688, 1899, 2325, 2395, 2399, 2446, 2622, 2688, 2786, 3040, 3638, 3955, 4055, 4130], 'Hannequin': [877], 'Dubois': [879], 'Didierjean': [881], 'O.': [882, 3827, 4061], 'Michon': [883], 'Thomas-Anterion': [885], 'Puel': [887], 'Frebourg': [889], 'al.Apolipoprotein': [892, 2009, 2585, 2955, 3003, 3185, 3424], 'epsilon4': [894], 'allele': [895, 1016, 2170], 'aggregation': [898, 4076], 'disease.Arch.': [901], '1998;': [903], '55:': [904], '810-816Crossref': [905], '9.Andersen': [911], 'K.': [912, 1270, 1853, 2055, 2516, 2522, 2528, 2713, 2752, 2754, 2829, 3066, 3121, 3360, 4163, 4249], 'Launer': [913], 'L.J.': [914, 1999, 2945, 3175, 3414], 'Dewey': [915], 'M.E.': [916, 1165], 'Letenneur': [917], 'Ott': [919], 'Copeland': [921], 'J.R.': [922, 2444], 'Dartigues': [923], 'Kragh-Sorensen': [925], 'P.': [926, 1658, 2485, 2581, 2715, 2784, 2999, 3634, 3689], 'Baldereschi': [927], 'Brayne': [929], 'al.Gender': [932], 'differences': [933], 'incidence': [936], 'vascular': [940, 1009], 'dementia:': [941], 'EURODEM': [943, 945], 'Studies.': [944], 'Incidence': [946], 'Research': [947], 'Group.Neurology.': [948], '1992-1997Crossref': [951], '10.Bretsky': [955], 'P.M.': [956, 1621, 1773, 1861, 2142, 3129, 3227, 3368, 3466], 'Buckwalter': [957], 'J.G.': [958], 'Seeman': [959], 'T.E.': [960], 'Miller': [961, 1371], 'Poirier': [963], 'Schellenberg': [965], 'G.D.': [966], 'Finch': [967], 'C.E.': [968, 2577, 2995], 'Henderson': [969, 1082], 'V.W.': [970, 1083], 'Evidence': [971], 'an': [973, 1881, 2358, 2846, 2865, 3083, 3149, 3388, 3558], 'interaction': [974], 'gender,': [979], 'disease.Alzheimer': [982], 'Disord.': [985], '13:': [987], '216-221Crossref': [988], '11.Molero': [992], 'A.E.': [993], 'Pino-Ramirez': [994], 'G.': [995, 1613, 1650, 2387, 2524, 2727, 4251], 'Maestre': [996], 'G.E.': [997], 'Modulation': [998, 2070, 2836, 3073], 'gender': [1002], 'dementia': [1010], 'associated': [1011, 2658], 'E-epsilon4': [1015], 'Latin': [1018], 'Americans:': [1019], 'findings': [1020], 'Maracaibo': [1023], 'Aging': [1024], 'Study.Neurosci.': [1025], 'Lett.': [1026], '2001;': [1027, 2706], '307:': [1028], '5-8Crossref': [1029], '12.Corder': [1035], 'E.H.': [1036], 'Ghebremedhin': [1037], 'E.': [1038, 1304, 1729, 2061, 2686, 2794, 3632, 3883, 4195, 4247], 'Taylor': [1039], 'M.G.': [1040], 'Thal': [1041], 'D.R.': [1042], 'Ohm': [1043], 'T.G.': [1044], 'Braak': [1045], 'H.': [1046, 1213, 1765, 2144, 2317, 2454, 2532, 3258, 3497, 3593, 3626], 'biphasic': [1048], 'relationship': [1049], 'regional': [1051], 'brain': [1052, 1316, 1910, 3235, 3277, 3474, 3516], 'senile': [1053], 'plaque': [1054, 1832, 1970, 2097, 2296, 2362, 2916, 3339, 3667, 4136], 'neurofibrillary': [1056, 1144], 'tangle': [1057], 'distributions:': [1058], 'modification': [1059], 'polymorphism.Ann.': [1065], 'Acad.': [1068, 1715, 2025, 2553, 2602, 2853, 2971, 3020, 3090, 3201, 3440], 'Sci.': [1069, 1716, 2026, 2554, 2603, 2854, 2972, 3021, 3091, 3202, 3441], '2004;': [1070, 1635, 2468], '1019:': [1071], '24-28Crossref': [1072], '(152)': [1075], '13.Altmann': [1078], 'Tian': [1080], 'Greicius': [1084], 'M.D.': [1085], 'Neuroimaging': [1088], 'Initiative': [1089], 'Investigators': [1090], 'Sex': [1091], 'modifies': [1092], 'APOE-related': [1094], 'developing': [1097], 'disease.Ann.': [1099, 1289], '2014;': [1101, 1222, 3981, 4150], '75:': [1102], '563-573Crossref': [1103], '(354)': [1106], 'As': [1109], 'described,': [1110], 'sequence': [1112], 'patients': [1118, 1342, 1354], 'unclear,': [1120], 'however': [1121], 'there': [1122], 'key': [1124], 'outcomes': [1126], 'modulated': [1129], 'humans.': [1135], 'diagnosed': [1138], 'extracellular': [1140], 'amyloid': [1141, 1189, 1279, 1788, 1791, 1878, 1882, 2012, 2091, 2465, 2590, 2671, 2734, 2812, 2958, 3008, 3146, 3150, 3188, 3385, 3389, 3427, 3575, 3666, 3726, 4005], 'plaques': [1142, 1792, 2415, 2735], 'tangles': [1145], '(NFTs)': [1146], 'tau.': [1148], 'addition,': [1150], 'soluble': [1151, 1378], 'oligomeric': [1152, 1386, 1670], 'conformations': [1153], '(oAβ)': [1156], 'correlate': [1157, 1318], 'severity': [1163, 1284], '(14.Larson': [1164], 'Lesne': [1166], 'S.E.': [1167], 'Soluble': [1168, 1185, 1275, 1307], 'Abeta': [1169, 1240, 1278, 1387, 1517, 1906, 2655, 4075, 4214], 'oligomer': [1170, 1309], 'production': [1171], 'toxicity.J.': [1173], 'Neurochem.': [1174], '120:': [1176], '125-139Crossref': [1177], '(208)': [1180], '15.Selkoe': [1183], 'D.J.': [1184, 2569, 2987], 'oligomers': [1186], 'beta-protein': [1190], 'impair': [1191], 'behavior.Behav.': [1195], 'Brain': [1196, 3979], '2008;': [1198], '192:': [1199], '106-113Crossref': [1200], '(831)': [1203], '16.Tu': [1206], 'S.': [1207, 1209, 1897, 2717, 2723, 3217, 3219, 3456, 3458, 3630, 3691, 3821, 3825, 3885, 4019, 4053, 4126, 4207, 4243], 'Okamoto': [1208], 'Lipton': [1210], 'S.A.': [1211], 'Xu': [1212, 1685], 'Oligomeric': [1214], 'Abeta-induced': [1215], 'disease.Mol.': [1220], 'Neurodegener.': [1221, 4116], '9:': [1223, 1843, 1981, 2307, 2927, 3350, 4151], '48Crossref': [1224], '(286)': [1227], '17.Klyubin': [1230], 'Cullen': [1232], 'W.K.': [1233], 'Hu': [1234, 2521], 'N.W.': [1235], 'Rowan': [1236], 'M.J.': [1237, 1268, 1512, 1625, 1662, 1739, 4257], 'assemblies': [1241], 'mediating': [1242], 'rapid': [1243], 'disruption': [1244], 'memory.Mol.': [1249], 'Brain.': [1250], '5:': [1252, 3782], '25Crossref': [1253], '(51)': [1256], '18.McLean': [1259], 'Cherny': [1261], 'R.A.': [1262], 'Fraser': [1263], 'F.W.': [1264], 'Fuller': [1265], 'S.J.': [1266, 2397], 'Smith': [1267], 'Beyreuther': [1269], 'Bush': [1271], 'A.I.': [1272], 'Masters': [1273], 'C.L.': [1274], 'pool': [1276], 'determinant': [1282], '46:': [1292, 2815], '860-866Crossref': [1293], '(1519)': [1296], '19.Tomic': [1299], 'Pensalfini': [1301], 'Head': [1303], 'Glabe': [1305], 'C.G.': [1306], 'fibrillar': [1308], 'levels': [1310, 1333, 3237, 3476], 'elevated': [1312], 'dysfunction.Neurobiol.': [1321], '2009;': [1323, 1918, 3243, 3482, 3872], '35:': [1324], '352-358Crossref': [1325], '(254)': [1328], 'Importantly,': [1331], 'oAβ': [1332], 'cerebrospinal': [1335], 'fluid': [1336], '(CSF)': [1337], 'increased': [1339, 1388], 'versus': [1343, 1350, 1777], 'controls;': [1344], 'greater': [1347], 'APOE4/4': [1349], 'APOE3/3': [1351], '(20.Tai': [1355], 'L.M.': [1356, 1504, 1733, 4193], 'Bilousova': [1357], 'Jungbauer': [1359, 1507, 4196], 'Roeske': [1361], 'S.K.': [1362, 3683], 'Youmans': [1363, 1505], 'K.L.': [1364, 1506, 4191, 4241], 'Yu': [1365, 1509, 1734, 2052, 4254], 'Poon': [1367], 'W.W.': [1368], 'Cornwell': [1369], 'Vinters': [1373], 'H.V.': [1374], 'al.Levels': [1376], 'E/amyloid-beta': [1380], '(Abeta)': [1381], 'complex': [1382], 'reduced': [1384, 4067], 'transgenic': [1396, 1518, 1795, 1885, 2078, 2329, 2500, 2546, 2595, 2627, 2676, 2696, 2737, 2758, 2843, 3013, 3045, 3080, 3153, 3240, 3392, 3479, 3655, 3807, 3941, 4219], 'samples.J.': [1401], 'Biol.': [1402, 2176, 4225], '2013;': [1404, 3710, 4117], '288:': [1405], '5914-5926Abstract': [1406], 'Further': [1417], 'includes': [1419], 'dysfunction,': [1421], '(CerVD).': [1426], 'Hence,': [1427], 'it': [1428, 2218], 'essential': [1430, 2588, 3006], 'study': [1432], 'interactive': [1434], 'role': [1435], 'factors:': [1439], 'development': [1447, 3309, 3571], 'using': [1452, 2264, 3557], 'models.': [1454], 'determine': [1459], 'AD-Tg': [1480], '(m)-APOE': [1489], '[for': [1490], 'complete': [1491], 'introduction': [1495], 'into': [1498, 1516, 3295], 'FAD-Tg': [1499, 2248, 2269, 2877, 3296, 3559], 'see': [1502], '(21.Tai': [1503], 'Ladu': [1511, 4256], 'Introducing': [1513], 'models.Int.': [1520], '2011:': [1525], '810981PubMed': [1526], 'Why': [1529], 'issue?': [1534], 'm-apoE': [1536, 1566, 2110], 'structurally': [1538], 'functionally': [1540], 'distinct': [1541], 'h-apoE.': [1543], 'While': [1544], 'three': [1546], 'isoforms': [1548, 3274, 3513], 'apoE': [1550, 2047, 3273, 3512], 'differ': [1551], 'single': [1554, 1571], 'amino': [1555, 1579], 'acid': [1556], 'change': [1557], 'residues': [1559], '112': [1560], '158': [1562], '(apoE2Cys,Cys,': [1563], 'apoE3Cys,Arg,': [1564], 'apoE4Arg,Arg),': [1565], 'expressed': [1568], 'isoform': [1572, 1627], 'differs': [1574], '∼100–300': [1578], 'acids.': [1580], 'Aβ': [1595, 1705, 2731, 2862, 2871, 3099], 'plasticity,': [1603], 'CerVD': [1605], '(22.Trommer': [1606], 'Shah': [1608, 1645, 3884], 'Yun': [1610, 1647], 'S.H.': [1611, 1648, 2154], 'Gamkrelidze': [1612, 1649], 'Pasternak': [1614, 1622, 1651, 1659], 'E.S.': [1615, 1652], 'Ye': [1616], 'G.L.': [1617], 'Sotak': [1618], 'Sullivan': [1620, 1657, 1772, 1860, 3128, 3226, 3367, 3465], 'LaDu': [1624, 1661, 1738], 'ApoE': [1626, 1663, 1823, 1961, 2287, 2462, 2907, 3330], 'affects': [1628], 'LTP': [1629], 'targeted': [1632], 'replacement': [1633, 2158], 'mice.Neuroreport.': [1634], '15:': [1636], '2655-2658Crossref': [1637], '(96)': [1640], '23.Trommer': [1643], 'Stine': [1653], 'W.B.': [1654], 'Manelli': [1655], 'isoform-specific': [1664], 'LTP:': [1667], 'blockade': [1668], 'amyloid-beta1–42.Neurobiol.': [1671], '2005;': [1673, 1888, 2378, 3156, 3395], '18:': [1674], '75-82Crossref': [1675], '24.Bien-Ly': [1681], 'Andrews-Zwilling': [1683], 'Q.': [1686, 2790], 'Bernardo': [1687], 'Wang': [1689], 'Huang': [1691, 2056], 'C-terminal-truncated': [1693], 'apoE4': [1695], 'inefficiently': [1696], 'clears': [1697], 'acts': [1701], 'concert': [1703], 'elicit': [1707], 'behavioral': [1710, 4139], 'deficits': [1711, 2076, 2624, 3042, 3604, 3937], 'mice.Proc.': [1713], 'Natl.': [1714, 2024, 2552, 2601, 2970, 3019, 3200, 3439], 'USA.': [1717, 2027, 2555, 2604, 2973, 3022, 3203, 3442], '108:': [1719], '4236-4241Crossref': [1720], '25.Zhu': [1726], 'Nwabuisi-Heath': [1728, 4194], 'Dumanis': [1730], 'S.B.': [1731, 2405], 'Tai': [1732, 4192], 'Rebeck': [1736, 2824, 3061, 4208], 'G.W.': [1737, 2434, 2825, 3062, 4209], 'alters': [1742, 1825, 1867, 1963, 2289, 2909, 3135, 3332, 3374, 4259], 'glial': [1743, 2194], 'activation': [1744], 'loss': [1746, 2667, 2771, 3653, 3934, 4099], 'markers': [1749], 'mice.Glia.': [1751], '60:': [1753, 2707], '559-569Crossref': [1754], '(116)': [1757], '26.Liao': [1760], 'Zhang': [1762, 4244], 'T.J.': [1763], 'Jiang': [1764, 3257, 3496], 'Lefton': [1766], 'K.B.': [1767], 'Robinson': [1768], 'G.O.': [1769], 'Vassar': [1770, 3598, 3886, 3927, 4096, 4252], 'Holtzman': [1774, 1818, 1862, 1956, 2282, 2354, 2799, 2902, 3130, 3325, 3369], 'D.M.': [1775, 1819, 1863, 1957, 1989, 2283, 2355, 2800, 2903, 2935, 3131, 3165, 3326, 3370, 3404], 'Murine': [1776], 'E4:': [1780], 'differential': [1781], 'facilitation': [1782], 'co-localization': [1785], 'cerebral': [1787, 1877, 2811, 3145, 3384], 'angiopathy': [1789, 1879, 3147, 3386], 'APP': [1794, 2842, 3079, 3803], 'models.Acta': [1797], 'Neuropathol.': [1798, 2703, 2774], 'Commun.': [1799], '2015;': [1800, 2814], '70Crossref': [1802], '(29)': [1805, 4279], '27.Fagan': [1808], 'Watson': [1810, 1948, 2274, 2894, 3317], 'Parsadanian': [1812, 1854, 1950, 1996, 2276, 2896, 2942, 3122, 3172, 3319, 3361, 3411], 'Bales': [1814, 1856, 1952, 1990, 2278, 2320, 2348, 2449, 2617, 2828, 2898, 2936, 3035, 3065, 3124, 3166, 3321, 3363, 3405], 'K.R.': [1815, 1857, 1953, 1991, 2279, 2321, 2349, 2450, 2565, 2618, 2899, 2937, 2983, 3036, 3125, 3167, 3213, 3322, 3364, 3406, 3452], 'Paul': [1816, 1858, 1954, 2280, 2322, 2350, 2451, 2619, 2830, 2900, 3037, 3067, 3126, 3228, 3323, 3365, 3467], 'Human': [1820, 1864, 1958, 2284, 2904, 3132, 3230, 3327, 3371, 3469], 'murine': [1822, 1960, 2286, 2906, 3329], 'markedly': [1824, 1962, 2288, 2908, 3331], 'beta': [1827, 1965, 2092, 2291, 2763, 2839, 2911, 3076, 3334], 'metabolism': [1828, 1966, 2292, 2912, 3335], 'before': [1829, 1967, 2293, 2913, 3336], 'after': [1831, 1969, 2295, 2915, 3338, 4300], 'formation': [1833, 1875, 1971, 2297, 2917, 3143, 3340, 3382, 4137], 'disease.Neurobiol.': [1840, 1978, 2304, 2924, 3347, 3903, 4042, 4084], '2002;': [1842, 1980, 2100, 2306, 2926, 3349], '305-318Crossref': [1844, 1982, 2308, 2928, 3351], '(207)': [1847, 1985, 2311, 2931, 3354], '28.Fryer': [1850, 3357], 'Simmons': [1852, 3120, 3359], 'E4': [1866, 3134, 3373], 'amyloid-beta': [1869, 2359, 3137, 3278, 3376, 3517, 3732], '40:42': [1870, 3138, 3377], 'ratio': [1871, 3139, 3378], 'promotes': [1873, 3141, 3380], 'precursor': [1883, 2335, 2505, 2537, 2672, 2701, 3151, 3390, 3727, 4032], 'protein': [1884, 1944, 2538, 2673, 3152, 3391], 'model.J.': [1886, 3154, 3393], 'Neurosci.': [1887, 2099, 2337, 2377, 2678, 3155, 3242, 3394, 3481, 3616, 3669, 3747, 4272], '25:': [1889, 2379, 2469, 3157, 3396], '2803-2810Crossref': [1890, 3158, 3397], '(221)': [1893, 3161, 3400], '29.Oddo': [1896], 'Caccamo': [1898], 'Cheng': [1900], 'LaFerla': [1902], 'F.M.': [1903, 2067], 'Genetically': [1904], 'altering': [1905], 'distribution': [1907], 'vasculature': [1913], 'ameliorates': [1914, 2361], 'pathology.Brain': [1916], 'Pathol.': [1917], '421-430Crossref': [1920], 'Further,': [1926], 'many': [1927], 'APOE/FAD-Tg': [1928], 'express': [1930, 2196], 'under': [1932], 'heterologous': [1933], 'promoters': [1934], 'may': [1936], 'be': [1937, 2261, 4171], 'activated': [1938], 'stressors': [1940], '[glial': [1941], 'fibrillary': [1942], 'acidic': [1943], '(GFAP)': [1945], '(27.Fagan': [1946, 2272, 2892, 3315], '30.Holtzman': [1988, 2934, 3164, 3403], 'Tenkova': [1992, 2938, 3168, 3407], 'Fagan': [1994, 2940, 3170, 3263, 3409, 3502], 'Sartorius': [1998, 2944, 3174, 3413], 'Mackey': [2000, 2946, 3176, 3415], 'Olney': [2002, 2948, 3178, 3417], 'McKeel': [2004, 2950, 3180, 3419], 'Wozniak': [2006, 2352, 2952, 3182, 3421], 'isoform-dependent': [2011, 2957, 3187, 3232, 3426, 3471], 'neuritic': [2015, 2961, 3191, 3430], 'degeneration': [2016, 2962, 3192, 3431, 4072, 4293], 'disease.Proc.': [2023, 2551, 2600, 2969, 3018, 3199, 3438], '2000;': [2028, 2423, 2635, 2855, 2974, 3053, 3092, 3204, 3443], '97:': [2029, 2975, 3205, 3444], '2892-2897Crossref': [2030, 2976, 3206, 3445], '(691)': [2033, 2979, 3209, 3448], 'Scholar)],': [2035, 2105], 'or': [2036, 2119], 'cell': [2038], 'types': [2039], 'not': [2042, 2095, 2663], 'primary': [2044], 'producers': [2045], '[neuron-specific': [2048], 'enolase': [2049], '(31.Buttini': [2050], 'G.Q.': [2053], 'Shockley': [2054], 'Jones': [2058], 'Masliah': [2060], 'Mallory': [2062, 2689], 'Yeo': [2064], 'Longo': [2066], 'Mucke': [2068], 'Alzheimer-like': [2072], 'cholinergic': [2075, 3772], 'depends': [2084, 2460], 'isoform,': [2086], 'aging,': [2087], 'overexpression': [2089], 'peptides': [2093], 'formation.J.': [2098, 3668], '22:': [2101], '10539-10548Crossref': [2102], 'endogenous': [2109, 2215], 'promoter.': [2111], 'Currently,': [2112], 'option': [2115], 'APOE-knock-in': [2118], 'targeted-replacement': [2120], '(TR)': [2121], 'mice,': [2122, 2193, 2883], 'developed': [2123], 'replace': [2125], 'coding': [2127, 2133], 'domain': [2128, 2134], 'm-APOE': [2130, 2885], 'each': [2136], '(32.Sullivan': [2141], 'Mezdour': [2143], 'Aratani': [2145], 'Knouff': [2147], 'Najib': [2149], 'Reddick': [2151], 'Quarfordt': [2153], 'Maeda': [2155], 'Targeted': [2157], 'gene': [2164, 3930], 'enhances': [2171], 'diet-induced': [2172], 'hypercholesterolemia': [2173], 'atherosclerosis.J.': [2175], '272:': [2179], '17972-17980Abstract': [2180], '(370)': [2188], 'APOE-TR': [2192], 'cells': [2195], 'native': [2200], 'conformation': [2201], 'physiologically': [2203], 'regulated': [2204], 'levels,': [2205], 'same': [2209], 'temporal': [2210, 3551], 'spatial': [2212], 'pattern': [2213], 'm-APOE.': [2216], 'conduct': [2222], 'context.': [2236], 'Operationally,': [2237], 'relative': [2238], 'm-APOE,': [2240], 'delay': [2244, 3552], 'models,': [2250], 'illustrated': [2252], 'Table': [2254], '1.': [2255], 'This': [2256], 'table': [2257], 'representation,': [2263], 'composite': [2266], 'several': [2268], '33.Dodart': [2314], 'Meziane': [2316], 'Mathis': [2318, 2615, 3033], 'Ungerer': [2324, 2621, 3039], 'Behavioral': [2326, 2623, 3041], 'disturbances': [2327], 'overexpressing': [2331, 2502, 2698], 'V717F': [2333, 2503, 2674, 2699], 'beta-amyloid': [2334, 2414, 2700, 3236, 3475, 3648], 'protein.Behav.': [2336], '113:': [2339], '982-990Crossref': [2340], '34.Hartman': [2344], 'R.E.': [2345, 2436], 'Izumi': [2346], 'D.F.': [2353], 'Treatment': [2356], 'antibody': [2360], 'load,': [2363], 'learning': [2364, 2408, 3972], 'deficits,': [2365, 2730, 4063], 'hippocampal': [2367, 3861], 'long-term': [2368], 'potentiation': [2369], 'disease.J.': [2376, 4224], '6213-6220Crossref': [2380], '(121)': [2383], '35.Chen': [2386], 'Chen': [2388], 'K.S.': [2389], 'Knox': [2390], 'Inglis': [2392], 'Bernard': [2394], 'Martin': [2396], 'Justice': [2398], 'McConlogue': [2400], 'Games': [2402, 2533, 2651, 2691], 'Freedman': [2404], 'al.A': [2407], 'deficit': [2409], 'related': [2410], 'disease.Nature.': [2422], '408:': [2424], '975-979Crossref': [2425], '(9)': [2428], '36.Nilsson': [2431], 'L.N.': [2432], 'Arendash': [2433], 'Leighty': [2435], 'Costa': [2437], 'D.A.': [2438], 'Low': [2439], 'Garcia': [2441], 'M.F.': [2442], 'Cracciolo': [2443], 'Rojiani': [2445], 'Wu': [2447, 3216, 3455], 'Potter': [2453], 'Cognitive': [2455], 'PDAPP': [2458, 3239, 3478], 'ACT-catalyzed': [2464], 'formation.Neurobiol': [2466], 'Aging.': [2467, 3904, 4043, 4085], '1153-1167Crossref': [2470], '37.Games': [2476], 'Adams': [2478], 'Alessandrini': [2480], 'Barbour': [2482, 2525], 'Berthelette': [2484], 'Blackwell': [2486], 'Carr': [2488], 'Clemens': [2490], 'Donaldson': [2492], 'Gillespie': [2494], 'al.Alzheimer-type': [2497], 'neuropathology': [2498], 'β-amyloid': [2504], 'protein.Nature.': [2506], '1995;': [2507], '373:': [2508], '523-527Crossref': [2509], '(2233)': [2512], '38.Johnson-Wood': [2515], 'Motter': [2519], 'Gordon': [2523, 2529], 'Khan': [2527], 'Tan': [2531], 'al.Amyloid': [2536], 'processing': [2539], 'beta42': [2542], '94:': [2557], '1550-1555Crossref': [2558], '39.Bales': [2564, 2982], 'Verina': [2566, 2984], 'Cummins': [2568, 2986], 'Du': [2570, 2988], 'Dodel': [2572, 2990], 'R.C.': [2573, 2991], 'Saura': [2574, 2992], 'Fishman': [2576, 2994], 'DeLong': [2578, 2996, 3222, 3461], 'Piccardo': [2580, 2998], 'Petegnief': [2582, 3000], 'APP(V717F)': [2594, 2626, 3012, 3044], '96:': [2606, 3024], '15233-15238Crossref': [2607, 3025], '(403)': [2610, 3028], '40.Dodart': [2613, 3031], 'deficient': [2629, 3047], 'gene.Neuroreport.': [2634, 3052], '11:': [2636, 3054], '603-607Crossref': [2637, 3055], '41.Irizarry': [2641], 'Soriano': [2643], 'McNamara': [2645, 2749], 'Page': [2647], 'K.J.': [2648], 'Schenk': [2649], 'B.T.': [2654, 2756, 2835, 3072], 'neuropil': [2660, 2766], 'changes,': [2661], 'overt': [2665], '(PDAPP)': [2675], 'mouse.J.': [2677], '17:': [2680], '7053-7059Crossref': [2681], '42.Masliah': [2685], 'Sisk': [2687], 'Neurofibrillary': [2693], 'protein.J.': [2702], 'Exp.': [2704, 2775], '357-368Crossref': [2708], '43.Hsiao': [2712], 'Chapman': [2714], 'Nilsen': [2716], 'Eckman': [2718], 'Harigaya': 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'171-178Crossref': [2857, 3094], 'Scholar)': [2860], 'example': [2866], 'phenotype.': [2869], 'First,': [2870], 'significantly': [2874], 'delayed': [2875, 3103], 'crossed': [2880, 3108], 'APOE-KO': [2882], 'eliminating': [2884], '(Table': [2886, 3112, 3580], '1:': [2887, 3113, 3581], 'compare': [2888, 3114, 3582], 'B)': [2891], 'Second,': [3098], 'further': [3102], 'h-APOE-Tg': [3105], 'FAD-Tg/APOE-KO': [3110], 'B': [3115], 'C)': [3117], '(28.Fryer': [3118], '47.Bales': [3212, 3451], 'Liu': [3214, 3453], 'Lin': [3218, 3457, 4022], 'Koger': [3220, 3459], 'Hansen': [3224, 3463], 'mice.J.': [3241, 3480], '29:': [3244, 3483], '6771-6779Crossref': [3245, 3484], '(189)': [3248, 3487], '48.Castellano': [3251, 3490], 'Kim': [3253, 3492, 4202], 'Stewart': [3255, 3494], 'F.R.': [3256, 3495], 'DeMattos': [3259, 3498], 'R.B.': [3260, 3499], 'Patterson': [3261, 3500], 'Morris': [3265, 3504], 'Mawuenyega': [3267, 3506], 'K.G.': [3268, 3507], 'Cruchaga': [3269, 3508], 'al.Human': [3272, 3511], 'differentially': [3275, 3514], 'regulate': [3276, 3515], 'peptide': [3279, 3518, 3696], 'clearance.Sci.': [3280, 3519], 'Transl.': [3281, 3520], '89ra57Crossref': [3285, 3524], '(713)': [3288, 3527], 'incorporation': [3292], 'normally': [3299], 'begin': [3300], '8–10': [3305], 'months': [3306, 3314, 3579], 'delays': [3307], '12–16': [3313], 'extending': [3530], 'array': [3535], 'AD-related': [3537], 'beyond': [3539], 'lifespan': [3541], 'mouse.': [3544], 'One': [3545], 'approach': [3546], 'h-APOE-induced': [3550], 'rapid-onset': [3563], '5xFAD': [3567, 4178], 'exhibit': [3569], 'accelerated': [3570], '2': [3578], 'D)': [3585], '(49.Ohno': [3586], 'Chang': [3588], 'Tseng': [3590], 'W.': [3591], 'Oakley': [3592], 'Citron': [3594, 3921], 'Klein': [3596], 'W.L.': [3597], 'Disterhoft': [3600, 3641, 3888, 3925], 'Temporal': [3602], 'models:': [3608], 'rescue': [3609, 3771], 'deletion': [3612, 3931], 'BACE1.Eur.': [3614], '2006;': [3617, 3670], '23:': [3618], '251-260Crossref': [3619], '(211)': [3622], '50.Oakley': [3625], 'S.L.': [3628, 3916], 'Logan': [3629], 'Maus': [3631, 4246], 'Shao': [3633], 'Craft': [3635], 'Guillozet-Bongaarts': [3637], 'Ohno': [3639, 3720, 3758, 3791, 3853], 'Van': [3643], 'Eldik': [3644], 'al.Intraneuronal': [3647], 'aggregates,': [3649], 'neurodegeneration,': [3650], 'neuron': [3652, 3933, 4064], 'five': [3658, 4268], 'mutations:': [3662], '26:': [3671, 3945], '10129-10140Crossref': [3672], '(1636)': [3675], '51.Shukla': [3678], 'Zheng': [3680], 'Y.L.': [3681], 'Mishra': [3682], 'Amin': [3684], 'N.D.': [3685], 'Steiner': [3686], 'Grant': [3688], 'Kesavapany': [3690], 'Pant': [3692], 'H.C.': [3693], 'truncated': [3695], 'p35,': [3698], 'Cdk5': [3700], 'activator,': [3701], 'prevents': [3702, 3932], 'phenotypes': [3705], 'mice.FASEB': [3708], '27:': [3711], '174-186Crossref': [3712], '(83)': [3715], '52.Devi': [3718], 'Genetic': [3722], 'reductions': [3723], 'beta-site': [3725], 'protein-cleaving': [3728], 'enzyme': [3729], '1': [3730], 'ameliorate': [3733], 'conditioned': [3736], 'taste': [3737], 'aversion': [3738], '5XFAD': [3741, 3778, 3838, 3867, 3939, 3977, 4079, 4102, 4143], 'mice.Eur.': [3745], '31:': [3749], '110-118Crossref': [3750], '53.Devi': [3756], 'Phospho-eIF2alpha': [3760], 'level': [3761], 'important': [3763], 'determining': [3765], 'abilities': [3766], 'BACE1': [3768, 3929], 'reduction': [3769, 4298], 'defects': [3776], 'mice.PLoS': [3779], 'One.': [3780, 4149], 'e12974Crossref': [3783], '54.Devi': [3789], 'Mitochondrial': [3793], 'accumulation': [3796, 4112, 4215], 'beta-secretase-cleaved': [3799], 'C-terminal': [3800], 'fragment': [3801], 'mice.Neurobiol.': [3808, 3942], '45:': [3811], '417-424Crossref': [3812], '(75)': [3815], '55.Hüttenrauch': [3818], 'Walter': [3820], 'Kaufmann': [3822], 'Weggen': [3824], 'Wirths': [3826, 4060], 'Limited': [3828], 'prolonged': [3831], 'environmental': [3832], 'enrichment': [3833], 'mice.Mol.': [3839], 'Neurobiol.': [3840], 'October': [3846], '12,': [3847], 'doi:10.1007/s12035-016-0167-x)PubMed': [3848], '56.Kimura': [3851], 'Impairments': [3855], 'remote': [3857], 'stabilization': [3859], 'precede': [3860], 'failures': [3865], 'model.Neurobiol.': [3870], '33:': [3873, 4045, 4087], '229-235Crossref': [3874], '(171)': [3877], '57.Kaczorowski': [3880], 'C.C.': [3881], 'Sametsky': [3882], 'Mechanisms': [3890], 'basal': [3892], 'learning-related': [3894], 'intrinsic': [3895], 'excitability': [3896], '32:': [3906], '1452-1465Crossref': [3907], '58.Ohno': [3913], 'Yasvoina': [3917], 'Zhao': [3919], 'Berry': [3923], 'APP/PS1': [3940], '2007;': [3944], '134-145Crossref': [3946], '(228)': [3949], '59.Kanno': [3952], 'Tsuchiya': [3954], 'Nishizaki': [3956], 'Hyperphos\xadphorylation': [3958], 'Tau': [3960], 'Ser396': [3962], 'occurs': [3963, 4299], 'much': [3966], 'earlier': [3967], 'stage': [3968], 'appearance': [3970], 'disorders': [3975], 'mice.Behav.': [3978], '302-306Crossref': [3983], '60.Urano': [3989], 'Tohda': [3991], 'Icariin': [3993], 'improves': [3994], '(5xFAD)': [4002], 'attenuates': [4004], 'beta-induced': [4006], 'neurite': [4007], 'atrophy.Phytother.': [4008], '24:': [4011], '1658-1663Crossref': [4012], '61.Kalinin': [4018], 'Polak': [4020], 'P.E.': [4021], 'S.X.': [4023], 'Sakharkar': [4024], 'A.J.': [4025], 'Pandey': [4026], 'S.C.': [4027], 'Feinstein': [4028], 'D.L.': [4029], 'noradrenaline': [4031], 'L-DOPS': [4033], '1651-1663Crossref': [4046], '(54)': [4049], '62.Jawhar': [4052], 'Trawicka': [4054], 'Jenneckens': [4056], 'Bayer': [4058], 'T.A.': [4059], 'Motor': [4062], 'loss,': [4065], 'anxiety': [4068], 'coinciding': [4069], 'axonal': [4071], 'intraneuronal': [4074, 4110], '196.e29-196.e40Crossref': [4088], '63.Eimer': [4094], 'Neuron': [4098], 'correlates': [4108], 'Abeta42': [4111], 'Caspase-3': [4114], 'activation.Mol.': [4115], '2Crossref': [4119], '64.Bhattacharya': [4125], 'Haertel': [4127], 'Maelicke': [4129], 'Montag': [4131], 'Galantamine': [4133], 'slows': [4134], 'down': [4135], 'disease.PLoS': [4148], 'e89454Crossref': [4152], '65.Spencer': [4158], 'N.G.': [4159], 'Lovell': [4160], 'D.P.': [4161], 'Elderfield': [4162], 'Austen': [4164], 'Howe': [4166], 'F.A.': [4167], 'Can': [4168], 'MRI': [4169], 'T1': [4170], 'used': [4172], 'detect': [4174], 'early': [4175], 'changes': [4176, 4212], 'brain?.MAGMA.': [4181], '2017;': [4182], '30:': [4183], '153-163Crossref': [4184], '(2)': [4187], '66.Youmans': [4190], 'Gan': [4200], 'Eimer': [4204], 'Estus': [4206], 'al.APOE4-specific': [4211], 'new': [4218], '287:': [4228], '41774-41786Abstract': [4229], '(154)': [4237], '67.Youmans': [4240], 'Leung': [4242], 'Baysac': [4248], 'Bu': [4250], 'Amyloid-beta42': [4258], 'solubility': [4262], 'brains': [4264], 'mutations.J.': [4271], 'Methods.': [4273], '196:': [4275], '51-59Crossref': [4276], '68.Shao': [4282], 'C.Y.': [4283], 'Mirra': [4284], 'S.S.': [4285], 'Sait': [4286], 'H.B.': [4287], 'Sacktor': [4288], 'T.C.': [4289], 'Sigurdsson': [4290], 'E.M.': [4291], 'Postsynaptic': [4292], 'revealed': [4295], 'PSD-95': [4297], 'ad': [4301]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2605159920', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}], 'updated_date': '2024-12-27T12:54:56.844502', 'created_date': '2017-04-14'}