Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies

Name: Work Video:
Duration: 3 min 30 s
Mitsuru Shinohara; Masaya Tachibana; Takahisa Kanekiyo; Guojun Bu
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2681, 2690, 2697, 2725, 2778, 2824, 2840, 2851, 2905, 2931, 2950, 2985, 3081, 3125, 3261, 3264, 3272, 3308, 3332, 3347, 3391, 3467, 3484, 3489, 3565, 3570, 3594, 3603, 3638, 3677, 3714, 3729, 3819, 3878, 4134, 4152, 4181, 4225, 4282, 4298, 4310], 'LDL': [2, 195, 387, 1078, 1245, 1346, 1412, 1463, 1997, 2633, 2739, 2765, 4135, 4226, 4252], 'receptor': [3, 196, 388, 410, 413, 417, 1069, 2033, 2107, 2433, 2557, 2872, 3175, 3311], '(LDLR)': [4, 197, 389], 'family': [5, 198, 390, 516, 598, 656, 1091], 'members,': [6, 199, 657], 'roles': [8, 201, 662, 2242, 2677], 'of': [9, 16, 68, 83, 101, 108, 146, 202, 209, 261, 276, 294, 301, 339, 459, 467, 489, 514, 629, 646, 663, 697, 705, 751, 776, 825, 857, 884, 912, 1003, 1025, 1030, 1068, 1077, 1130, 1230, 1270, 1283, 1298, 1345, 1372, 1433, 1538, 1572, 1644, 1653, 1808, 1839, 1846, 1867, 1881, 1967, 2103, 2145, 2155, 2243, 2295, 2322, 2331, 2360, 2461, 2496, 2524, 2604, 2660, 2678, 2685, 2692, 2699, 2704, 2727, 2770, 2801, 2811, 2826, 2848, 2853, 2900, 2933, 2957, 2984, 3080, 3124, 3172, 3200, 3208, 3236, 3263, 3274, 3343, 3539, 3573, 3593, 3637, 3668, 3679, 3734, 3757, 3786, 3814, 3822, 4125, 4172, 4216, 4251, 4279, 4293, 4301], 'LDLR-related': [10, 203, 404], 'protein': [11, 204, 405, 439, 567, 781, 811, 865, 920, 949, 1036, 1247, 1278, 1303, 1308, 1402, 1407, 1453, 1458, 1640, 1711, 1950, 1999, 2010, 2148, 2159, 2198, 2284, 2299, 2340, 2423, 2467, 2474, 2635, 2741, 2989, 3086, 3177, 3951, 4047, 4137, 4228, 4254], '(LRP)1': [12, 205], 'in': [13, 72, 90, 103, 148, 206, 265, 283, 296, 341, 434, 464, 542, 572, 649, 665, 707, 714, 736, 868, 891, 923, 955, 958, 1000, 1096, 1121, 1224, 1232, 1286, 1309, 1363, 1386, 1431, 1600, 1607, 1648, 1650, 1890, 1962, 2068, 2239, 2382, 2391, 2594, 2608, 2662, 2671, 2680, 2772, 2803, 2805, 2839, 2850, 2865, 2949, 2961, 3077, 3105, 3178, 3196, 3271, 3346, 3376, 3404, 3443, 3446, 3483, 3494, 3602, 3649, 3728, 3763, 3818, 3869, 3877, 3890, 3900, 3952, 3973, 3977, 3985, 3996, 4048, 4078, 4151, 4157, 4177, 4180, 4191, 4259, 4263, 4281, 4309], 'pathogenesis': [15, 150, 169, 208, 343, 362, 466, 546, 604, 667, 1894, 3716], "Alzheimer's": [17, 210, 468, 543, 573, 1511, 1850, 1891, 2392, 2867, 2998, 3023, 3056, 3092, 3179, 3245, 3314, 3377, 3444, 3541, 3764, 3953, 4049, 4079, 4130, 4221], 'disease': [18, 211, 469, 1851, 2710, 3315, 3378, 3445, 3601, 4131, 4222, 4261], '(AD),': [19, 212, 470], 'especially': [20, 213, 3269, 3482], 'late-onset': [21, 214, 2962, 2997, 3022, 3055], 'AD,': [22, 215, 630], 'have': [23, 96, 216, 289, 424, 521, 1093, 2674, 2718, 2926, 3704], 'been': [24, 217, 2719, 2927], 'most': [26, 219], 'studied': [27, 220], 'by': [28, 175, 190, 221, 368, 383, 525, 668, 746, 888, 953, 1253, 1306, 1611, 1875, 1921, 2007, 2123, 2471, 2526, 2688, 2747, 3138, 3330, 4133, 4166, 4224], 'genetic,': [29, 222], 'neuropathological,': [30, 223], 'and': [31, 38, 75, 172, 179, 224, 231, 268, 365, 372, 398, 420, 447, 474, 509, 539, 547, 569, 636, 676, 710, 741, 771, 833, 957, 980, 989, 1022, 1071, 1219, 1343, 1408, 1459, 1481, 1592, 1706, 1844, 1878, 1887, 1895, 1964, 2013, 2029, 2061, 2101, 2245, 2256, 2290, 2378, 2388, 2428, 2475, 2564, 2600, 2637, 2641, 2683, 2715, 2722, 2775, 2828, 2834, 2871, 3054, 3111, 3142, 3170, 3212, 3307, 3439, 3471, 3507, 3596, 3641, 3684, 3732, 3761, 3788, 3794, 3875, 3905, 3914, 3949, 4001, 4010, 4045, 4075, 4085, 4129, 4220, 4262, 4295], 'biomarker': [32, 225], 'analyses': [33, 226], '(clinical': [34, 227], 'studies)': [35, 43, 228, 236], 'or': [36, 229, 427, 592, 609, 620, 729, 1770, 1918, 1928, 2221, 2666, 3144, 3569, 3737, 3979], 'cellular': [37, 230, 445, 479, 591, 619], 'animal': [39, 232, 593, 621], 'model': [40, 233, 1652], 'systems': [41, 234], '(preclinical': [42, 235], 'over': [44, 237, 532], 'last': [46, 239], '25': [47, 240], 'years.': [48, 241], 'Although': [49, 242], 'there': [50, 243, 614, 3806], 'are': [51, 244, 392, 615, 841, 886, 991, 1484, 2723, 2898, 3689, 3711, 3726], 'some': [52, 245, 458], 'conflicting': [53, 246, 3041, 3809], 'reports,': [54, 247], 'accumulating': [55, 248], 'evidence': [56, 121, 249, 314, 586], 'from': [57, 122, 141, 250, 315, 334, 587, 738, 1378, 1515, 2568, 2820, 2842, 3114], 'preclinical': [58, 94, 142, 180, 251, 287, 335, 373, 588, 671, 3571], 'studies': [59, 95, 124, 252, 288, 317, 589, 594, 635, 638, 672, 678, 2822, 2925, 3117, 3553, 3664, 3688, 3698], 'indicates': [60, 253, 595], 'that': [61, 254, 485, 596, 623, 1589, 2945, 3260, 3555, 3666, 3722, 3968, 4148], 'LRP1': [62, 102, 131, 147, 166, 255, 295, 324, 340, 359, 664, 690, 698, 706, 726, 732, 803, 885, 1148, 1271, 1362, 1373, 1430, 1441, 1490, 1673, 1779, 1870, 1913, 2055, 2094, 2118, 2237, 2323, 2497, 2590, 2606, 2661, 2679, 2705, 2802, 2827, 2849, 2934, 2958, 3126, 3265, 3312, 3392, 3468, 3558, 3562, 3597, 3639, 3669, 3694, 3709, 3723, 3815, 3840, 3866, 3880, 3898, 3969, 3994, 4149, 4173, 4189, 4192, 4280, 4302], 'not': [63, 126, 256, 319, 1184, 1605, 3136, 3556], 'only': [64, 257, 3557], 'regulates': [65, 258, 1965, 2002, 2424, 2565], 'metabolism': [67, 260, 2430, 2502, 2691], 'amyloid-β': [69, 262, 475, 570], 'peptides': [70, 263, 476, 1647], '(Aβs)': [71, 264, 477], 'brain': [74, 80, 267, 273, 708, 1570, 1806, 2425, 3348, 3374, 3702], 'periphery,': [76, 269], 'but': [77, 270, 1183, 3397, 3560, 3975], 'also': [78, 97, 183, 271, 290, 376, 720, 1774, 2120, 3561, 4175], 'maintains': [79, 272], 'homeostasis,': [81, 274, 709], 'impairment': [82, 275, 3648], 'which': [84, 277, 401, 840, 1100, 2615, 2717, 3339], 'likely': [85, 278, 430, 2707], 'contributes': [86, 132, 279, 325], 'to': [87, 128, 133, 152, 280, 321, 326, 345, 432, 437, 518, 602, 641, 699, 727, 784, 898, 1154, 1272, 1486, 1535, 1869, 1872, 1909, 2337, 2611, 2709, 2777, 2815, 2929, 3119, 3693, 3910, 3982, 4006], 'AD': [88, 134, 149, 168, 189, 281, 327, 342, 361, 382, 501, 519, 603, 650, 666, 693, 715, 2843, 2938, 2963, 3109, 3130, 3139, 3210, 3405, 3495, 3502, 3568, 3574, 3671, 3715, 3735, 3795, 3823, 3891, 3986, 4158], 'development': [89, 282, 520, 2682], 'Aβ-independent': [91, 284], 'manners.': [92, 285], 'Several': [93, 286], 'demonstrated': [98, 291, 1588, 4147], 'an': [99, 292, 834, 1404, 1455, 1649, 2846, 2901, 2992, 4187], 'involvement': [100, 293, 2847], 'regulating': [104, 297, 2689], 'pathogenic': [106, 299], 'role': [107, 145, 300, 338, 645, 704, 790, 2144], 'apoE,': [109, 302, 1480], 'whose': [110, 303], 'gene': [111, 304, 492, 1255, 2607, 2749, 2935, 2990, 3018, 3053, 3087, 3640, 3695], 'is': [112, 125, 305, 318, 494, 639, 804, 951, 1124, 1304, 1403, 1425, 1454, 1529, 1773, 2062, 2095, 2200, 2291, 2591, 2616, 2642, 3088, 3435, 3807, 3867], 'strongest': [114, 307, 496], 'genetic': [115, 308, 497, 2924, 3663], 'risk': [116, 309, 498, 3566, 3672], 'factor': [117, 310, 499, 1935, 1960], 'for': [118, 188, 311, 381, 478, 500, 531, 748, 774, 996, 1105, 1126, 1195, 1411, 1429, 1462, 1489, 1716, 1778, 2064, 2097, 2161, 2301, 2644, 3244, 3567], 'AD.': [119, 312, 731, 2816], 'Nonetheless,': [120, 313, 3256], 'clinical': [123, 178, 316, 371, 677], 'sufficient': [127, 320], 'conclude': [129, 322], 'how': [130, 165, 323, 358, 3708], 'development.': [135, 328], 'Thus,': [136, 329, 2702], 'despite': [137, 330], 'very': [138, 331, 806], 'promising': [139, 332], 'results': [140, 333, 1603, 3039, 3134], 'studies,': [143, 336], 'remains': [151, 344], 'be': [153, 346, 1487, 1873, 2121, 3883], 'further': [154, 347, 3687], 'clarified.': [155, 348], 'In': [156, 349, 1907, 3328, 3691], 'this': [157, 350, 2728, 2919], 'review,': [158, 351], 'we': [159, 352, 658, 718], 'discuss': [160, 184, 353, 377, 660, 721], 'potential': [162, 185, 355, 378, 512, 722], 'mechanisms': [163, 356, 2387], 'underlying': [164, 357], 'affects': [167, 360], 'through': [170, 363, 605, 1107, 1680, 1754, 2357, 2431, 3349, 3844], 'Aβ-dependent': [171, 364], '-independent': [173, 366], 'pathways': [174, 367, 713, 1715, 1917], 'reviewing': [176, 369, 669], 'both': [177, 370, 670], 'studies.': [181, 374], 'We': [182, 375, 682], 'therapeutic': [186, 379, 723], 'strategies': [187, 380, 724], 'targeting': [191, 384, 725], 'LRP1.': [192, 385], 'The': [386, 563, 881, 946, 967, 1020, 1180, 1267, 1635, 1996, 2143, 2193, 2318, 2458, 3075, 3132], 'members': [391, 517, 599, 1092], 'cell': [393, 900, 1274, 1755, 1842, 1925, 3487, 3888], 'surface': [394, 901, 1275, 1756, 1926, 2099], 'receptors': [395, 423, 453, 541, 1889, 1927, 2380], 'sharing': [396], 'structural': [397], 'functional': [399, 1075, 1919], 'similarities,': [400], 'include': [402], 'LDLR,': [403], '(LRP)1,': [406], 'LRP1B,': [407], 'megalin/LRP2,': [408], 'VLDL': [409], '(VLDLR),': [411], 'apoE': [412, 473, 1868, 1882, 2833], '2': [414], '(apoER2),': [415], 'sortilin-related': [416], '(SorLA/LR11),': [418], 'LRP5,': [419], 'LRP6.': [421], 'These': [422], 'distinct': [425, 3535], 'physiological': [426, 789], 'pathophysiolgical': [428], 'roles,': [429], 'due': [431], 'differences': [433], 'their': [435, 1097], 'affinity': [436, 773], 'ligands,': [438, 457, 2693, 2831], 'stability,': [440], 'endocytosis': [441, 1106, 1161, 1193], 'rate,': [442], 'signaling': [443, 482, 1916, 1955, 2005, 2018, 2700], 'potency,': [444], 'localization,': [446], 'tissue': [448, 2687], 'expression': [449, 691, 1297, 2330, 3817, 3843, 3899, 3995], 'pattern.': [450], 'While': [451], 'these': [452, 1536, 3662], 'bind': [454, 1594], 'diverse': [455, 2595, 2894, 3870], 'extracellular': [456, 831, 968, 1226, 4299], 'them': [460], 'recognize': [461], 'key': [462], 'molecules': [463], 'such': [471, 1602, 1686, 1930, 2712], 'as': [472, 613, 791, 1102, 1190, 1687, 1931, 2151, 2325, 2587, 2694, 2696, 2713], 'trafficking': [480, 1845], 'and/or': [481], 'pathways.': [483, 2701], 'Given': [484], 'ε4': [487], 'allele': [488], 'APOE': [491, 3536, 3915, 4011], '(APOE4)': [493], 'among': [502, 653], 'three': [504], 'human': [505, 637, 680, 742, 2240, 3700], 'alleles': [506], '(ε2,': [507], 'ε3,': [508], 'ε4),': [510], 'contributions': [513], 'LDLR': [515, 597, 655, 756, 814, 1090, 2624], 'attracted': [522], 'great': [523], 'interest': [524], 'many': [526, 3697], 'laboratories': [527], 'around': [528, 3479], 'world': [530], 'two': [533, 882, 1186], 'decades': [534], '(1Bu': [535, 1883], 'G.': [536, 562, 1014, 1066, 1179, 1392, 1443, 1630, 1702, 1746, 1884, 2236, 2420, 3362], 'Apolipoprotein': [537, 1747, 1885, 2863], 'E': [538, 1748, 1886, 2427, 2864, 2903, 2994, 3310, 4084], 'its': [540, 1888, 2566, 2829, 4305], 'disease:': [544, 1892, 2868, 4080], 'pathways,': [545, 1893], 'therapy.Nat.': [548, 1896], 'Rev.': [549, 1258, 1897, 2752], 'Neurosci.': [550, 576, 1720, 1898], '2009;': [551, 1899, 2248, 3320, 3653], '10:': [552, 1900], '333-344Crossref': [553, 1901], 'PubMed': [554, 580, 798, 876, 931, 964, 1050, 1086, 1144, 1211, 1262, 1318, 1354, 1419, 1470, 1522, 1583, 1668, 1724, 1764, 1819, 1858, 1902, 1981, 2024, 2075, 2113, 2167, 2216, 2251, 2313, 2366, 2398, 2443, 2487, 2534, 2582, 2653, 2756, 2791, 2880, 2915, 3003, 3033, 3066, 3098, 3185, 3251, 3323, 3386, 3453, 3547, 3615, 3656, 3770, 3860, 3921, 3959, 4017, 4055, 4096, 4144, 4235, 4271], 'Scopus': [555, 581, 799, 877, 932, 1051, 1212, 1263, 1355, 1420, 1471, 1523, 1584, 1669, 1725, 1765, 1820, 1859, 1903, 1982, 2025, 2076, 2114, 2168, 2217, 2252, 2314, 2367, 2399, 2444, 2488, 2535, 2583, 2654, 2757, 2792, 2881, 3034, 3099, 3186, 3252, 3324, 3387, 3454, 3548, 3616, 3657, 3771, 3801, 3861, 3922, 3960, 4018, 4056, 4097, 4272], '(733)': [556, 1904], 'Google': [557, 583, 801, 879, 934, 965, 1053, 1087, 1145, 1214, 1265, 1319, 1357, 1422, 1473, 1525, 1586, 1671, 1727, 1767, 1822, 1861, 1905, 1984, 2027, 2078, 2116, 2170, 2219, 2254, 2316, 2369, 2401, 2446, 2490, 2537, 2585, 2656, 2759, 2794, 2883, 2916, 3004, 3036, 3067, 3101, 3188, 3254, 3326, 3389, 3456, 3550, 3618, 3659, 3773, 3803, 3863, 3924, 3962, 4020, 4058, 4099, 4145, 4236, 4274], 'Scholar,': [558, 935, 1054, 1320, 1728, 1823, 1985, 2079, 2171, 2370, 2402, 2447, 2538, 2760, 2884, 3005, 3068, 3619, 3774, 3925, 4021, 4059], '2Kanekiyo': [559], 'T.': [560, 1618, 1692, 1744, 1833, 2451, 2522, 2967, 3167, 3414, 3741], 'Bu': [561, 1065, 1178, 1629, 1701, 1745, 2235, 2419], 'low-density': [564, 1708, 2146, 2986, 3173], 'lipoprotein': [565, 792, 863, 918, 1034, 1134, 1198, 1301, 1502, 1638, 1709, 1749, 1948, 2196, 2282, 2432, 2465, 2528, 2556, 2987, 3084, 3174], 'receptor-related': [566, 864, 919, 948, 1035, 1079, 1199, 1246, 1302, 1347, 1413, 1464, 1503, 1639, 1710, 1949, 1998, 2147, 2197, 2283, 2466, 2634, 2740, 2766, 2909, 2988, 3085, 4136, 4227, 4253], '1': [568, 1641, 1712, 1951, 2000, 2149, 2289], 'clearance': [571, 1507, 2567, 4128, 4219], 'disease.Front.': [574, 2393], 'Aging': [575], '2014;': [577, 1855, 2783, 3450], '6:': [578], '93Crossref': [579], '(120)': [582, 3772], 'Scholar).': [584, 802, 880, 966, 1088, 1146, 1215, 1266, 1358, 1423, 1474, 1526, 1672, 1768, 1862, 1906, 2117, 2317, 2657, 2795, 2917, 3102, 3189, 3255, 3327, 3457, 3551, 3660, 3864, 3963, 4100, 4237], 'Cumulative': [585], 'using': [590, 673, 3699], 'can': [600, 624, 1914, 2119, 2499], 'contribute': [601, 2708], 'modulating': [606, 2014], 'Aβ': [607, 700, 1532, 1676, 1772, 2501, 2854, 3344, 3477, 3680], 'accumulation': [608, 2852, 3345], 'neurodegenerative': [610, 2812], 'processes.': [611], 'However,': [612, 1527, 4238], 'currently': [616], 'no': [617, 3191], 'complete': [618], 'models': [622, 2673, 2807], 'recapitulate': [625], 'all': [626, 998, 1436], 'pathological': [627], 'features': [628, 2810], 'parallel': [631], 'understanding': [632, 3707], 'between': [633, 3305, 3466], 'cellular/animal': [634, 674], 'necessary': [640], 'define': [642], 'specific': [644], 'any': [647], 'molecule': [648], 'pathogenesis.': [651, 716], 'Herein,': [652], 'comprehensively': [659], 'models,': [675], 'analyzing': [679], 'samples/cohorts.': [681], 'will': [683, 719], 'specifically': [684], 'review': [685, 2729], 'current': [686], 'knowledge': [687], 'regarding:': [688], '1)': [689], 'during': [692, 3713], 'progression,': [694], '2)': [695], 'contribution': [696], 'metabolism,': [701, 1912], '3)': [702], '4)': [711], 'apoE-LRP1': [712], 'Finally,': [717], 'prevent': [728], 'treat': [730], 'was': [733, 2823, 3395, 3491, 3966, 4174], 'first': [734], 'identified': [735], '1988': [737], 'mouse': [739, 2570, 2672, 2806], 'lymphocyte': [740], 'liver': [743, 779], 'cDNA': [744], 'libraries': [745], 'screening': [747], 'homologous': [749], 'sequences': [750], 'apoE-binding': [753], 'domain': [754, 969, 1223, 2321, 2460, 4300, 4307], 'within': [755], '(3Herz': [757], 'J.': [758, 794, 848, 872, 903, 927, 945, 960, 1295, 1326, 1334, 1350, 1415, 1466, 1551, 1694, 1732, 1787, 1835, 1987, 2226, 2347, 2408, 2416, 2628, 2781, 3074, 3150, 3298, 3300, 3526, 3778], 'Hamann': [759], 'U.': [760, 2049, 2091, 3070, 3165], 'Rogne': [761], 'S.': [762, 1554, 1790, 2085, 2089, 2190, 2234, 2374, 3372, 3422, 3897, 3993], 'Myklebost': [763], 'O.': [764, 3302, 3416, 3832], 'Gausepohl': [765], 'H.': [766, 1016, 1060, 1328, 1740, 2139, 2228, 3157, 3356, 3430, 3521, 3623, 3627, 3745, 3749], 'Stanley': [767], 'K.K.': [768], 'Surface': [769], 'location': [770], 'high': [772], 'calcium': [775, 1004], 'a': [777, 788, 805, 819, 826, 869, 924, 1103, 1117, 1150, 1220, 1280, 1336, 1426, 1505, 1608, 1775, 1954, 2152, 2201, 2292, 2326, 2617, 2768, 2946, 3121, 3197, 3459, 3463, 3534, 3808, 3847, 4289], '500-kd': [778], 'membrane': [780, 2384], 'closely': [782], 'related': [783, 3176], 'LDL-receptor': [786], 'suggest': [787, 3665], 'receptor.EMBO': [793], '1988;': [795], '7:': [796], '4119-4127Crossref': [797], '(719)': [800], 'large': [807, 827], 'type': [808], 'I': [809], 'transmembrane': [810, 838], 'compared': [812, 2621, 3500, 4160], 'with': [813, 844, 976, 1074, 1163, 1361, 1374, 1440, 1595, 1682, 1923, 1957, 2058, 2287, 2622, 2937, 2996, 3020, 3091, 3379, 3400, 3437, 3501, 3504, 3599, 3644, 3792, 3846, 4082, 4086, 4161], '(Fig.': [815], '1).': [816, 3718], 'It': [817], 'encodes': [818], '4,525': [820], 'amino': [821], 'acid': [822], 'protein,': [823, 3849], 'composed': [824], '515': [828], 'kDa': [829, 836, 1285, 1400, 1451], 'N-terminal': [830], 'subunit': [832], '85': [835], 'C-terminal': [837, 4306], 'subunit,': [839], 'noncovalently': [842], 'associated': [843, 3090, 3399, 3436], 'one': [845], 'another': [846, 3257], '(4Herz': [847, 902], 'Kowal': [849, 904], 'R.C.': [850, 905], 'Goldstein': [851, 906, 1112], 'J.L.': [852, 907, 1113, 2047, 3288], 'Brown': [853, 908, 1114], 'M.S.': [854, 909, 1115], 'Proteolytic': [855, 910], 'processing': [856, 911, 2359, 2390], '600': [859, 914], 'kd': [860, 915], 'low': [861, 916, 1032, 1132, 1196, 1299, 1636, 2194, 2463, 3082], 'density': [862, 917, 1033, 1133, 1197, 1300, 1637, 1947, 2195, 2281, 2464, 3083], '(LRP)': [866, 921, 950, 2199, 2285], 'occurs': [867, 922, 1380], 'trans-Golgi': [870, 893, 925], 'compartment.EMBO': [871, 926], '1990;': [873, 928, 1138], '9:': [874, 929, 1856], '1769-1776Crossref': [875, 930], '(202)': [878, 933], 'subunits': [883], 'generated': [887], 'furin': [889, 954], 'cleavage': [890], 'complex': [894, 1956], 'before': [895], 'being': [896], 'transported': [897], '5Willnow': [936], 'T.E.': [937, 1289, 1322], 'Moehring': [938, 942], 'J.M.': [939, 1632], 'Inocencio': [940], 'N.M.': [941], 'T.J.': [943], 'Herz': [944, 1294, 1333, 2346, 2415], 'low-density-lipoprotein': [947], 'processed': [952], 'vivo': [956], 'vitro.Biochem.': [959], '1996;': [961, 1351], '313:': [962], '71-76Crossref': [963], 'has': [970, 1149], 'four': [971, 3201], 'ligand': [972, 1428, 1438, 1777, 1911, 4257], 'binding': [973, 994, 1371, 1866, 2008], 'domains': [974, 987, 1537, 1590], '(I–IV)': [975], '2,': [977], '8,': [978], '10,': [979], '11': [981, 3240], 'cysteine-rich': [982, 1028], 'complement-type': [983], 'repeats,': [984], 'respectively,': [985], 'where': [986, 3476], 'II': [988, 1591], 'IV': [990, 1593, 2559], 'major': [993, 1714], 'regions': [995], 'almost': [997], 'ligands': [999, 1231, 1488, 2899], 'presence': [1002, 3273], '(6Neels': [1005], 'J.G.': [1006], 'van': [1007, 1017, 1173], 'Den': [1008], 'Berg': [1009], 'B.M.': [1010, 2184], 'Lookene': [1011], 'A.': [1012, 1324, 1549, 1785, 2037, 2087, 2176, 2260, 2449, 2504, 2516, 2544, 3148, 3163, 3296, 3358, 3424, 3432, 3513, 3776, 4063], 'Olivecrona': [1013], 'Pannekoek': [1015], 'Zonneveld': [1018], 'A.J.': [1019], 'second': [1021, 1156], 'fourth': [1023], 'cluster': [1024, 2558], 'class': [1026], 'A': [1027, 2555, 3103], 'repeats': [1029, 1218], 'share': [1037], 'ligand-binding': [1038, 1072], 'properties.J.': [1039], 'Biol.': [1040, 1136, 1201, 1658, 1971, 2071, 2206, 2303, 2477, 2572], 'Chem.': [1041, 1137, 1202, 1659, 1972, 2207, 2304, 2478, 2573], '1999;': [1042, 3095], '274:': [1043], '31305-31311Abstract': [1044], 'Full': [1045, 1047, 1141, 1206, 1208, 1578, 1580, 1663, 1665, 1814, 1816, 1976, 1978, 2211, 2213, 2308, 2310, 2438, 2440, 2482, 2484, 2577, 2579, 2650, 2786, 2788, 2877, 3028, 3030, 3061, 3063, 3610, 3612, 3855, 3857], 'Text': [1046, 1048, 1142, 1207, 1209, 1579, 1581, 1664, 1666, 1815, 1817, 1977, 1979, 2212, 2214, 2309, 2311, 2439, 2441, 2483, 2485, 2578, 2580, 2651, 2787, 2789, 2878, 3029, 3031, 3062, 3064, 3611, 3613, 3856, 3858], 'PDF': [1049, 1143, 1210, 1582, 1667, 1818, 1980, 2215, 2312, 2442, 2486, 2581, 2652, 2790, 2879, 3032, 3065, 3614, 3859], '(119)': [1052], '7Obermoeller-McCormick': [1055], 'L.M.': [1056], 'Li': [1057], 'Y.': [1058, 1169, 1622, 1730, 1734, 1825, 2550, 2971, 3360, 3582, 3586, 3826], 'Osaka': [1059], 'FitzGerald': [1061], 'D.J.': [1062], 'Schwartz': [1063, 1397, 1448], 'A.L.': [1064, 1398, 1449, 3228], 'Dissection': [1067], 'folding': [1070], 'property': [1073], 'minireceptors': [1076], 'protein.J.': [1080, 1200], 'Cell': [1081], 'Sci.': [1082, 1313], '2001;': [1083, 4268], '114:': [1084], '899-908Crossref': [1085], 'Most': [1089], 'NPXY': [1094, 1157, 1187], 'motif(s)': [1095], 'cytoplasmic': [1098, 1122], 'tails,': [1099, 1123], 'serve': [1101], 'signal': [1104, 1194], 'clathrin-coated': [1108], 'pits': [1109], '(8Chen': [1110], 'W.J.': [1111], 'NPXY,': [1116], 'sequence': [1118], 'often': [1119], 'found': [1120], 'required': [1125, 2063], 'coated': [1127], 'pit-mediated': [1128], 'internalization': [1129, 2102], 'receptor.J.': [1135], '265:': [1139], '3116-3123Abstract': [1140], 'Moreover,': [1147], 'YXXL': [1151, 1181], 'motif': [1152, 1167], 'adjacent': [1153], 'motif,': [1158, 1182], 'enabling': [1159], 'rapid': [1160], 'together': [1162], 'proximal': [1165], 'di-leucine': [1166], '(9Li': [1168], 'Paz': [1170], 'Marzolo': [1171], 'M.': [1172, 1560, 1624, 1742, 1796, 1943, 1993, 2083, 2137, 3366, 3743, 3830, 3834], 'Kerkhof': [1174], 'P.': [1175, 2035, 2135, 2351, 3012, 3292, 3428, 3780], 'Strous': [1176, 1395, 1446], 'G.J.': [1177, 1396, 1447], 'motifs,': [1188], 'serves': [1189, 2324], 'dominant': [1192], '2000;': [1203, 4141, 4232], '275:': [1204], '17187-17194Abstract': [1205], '(183)': [1213], 'Cysteine-rich': [1216], 'EGF': [1217], 'YWTD': [1221], 'β-propeller': [1222], 'portion': [1227], 'facilitate': [1228, 1675], 'dissociation': [1229], 'endocytic': [1234, 1348], 'vesicles': [1235], '(10Lillis': [1236, 2730], 'A.P.': [1237, 1496, 2540, 2731], 'Van': [1238, 2732], 'Duyn': [1239, 2733], 'L.B.': [1240, 2734], 'Murphy-Ullrich': [1241, 2735], 'J.E.': [1242, 2736, 3927, 4023], 'Strickland': [1243, 1625, 1944, 1994, 2272, 2454, 2737, 2859, 2889, 4070, 4244], 'D.K.': [1244, 1626, 1945, 1995, 2273, 2455, 2738, 2860, 2890, 4071, 4245], '1:': [1248, 2364, 2742], 'unique': [1249, 1427, 2743], 'tissue-specific': [1250, 2744], 'functions': [1251, 2706, 2745], 'revealed': [1252, 2746], 'selective': [1254, 2748], 'knockout': [1256, 2625, 2750], 'studies.Physiol.': [1257, 2751], '2008;': [1259, 1660, 2363, 2753], '88:': [1260, 2754], '887-918Crossref': [1261, 2755], '(448)': [1264, 2758], 'efficient': [1268], 'delivery': [1269], 'requires': [1276], 'receptor-associated': [1277, 1307, 1401, 1452], '(RAP),': [1279], 'molecular': [1281, 1409, 1460], 'chaperone': [1282, 1410, 1461], '39': [1284, 1399, 1450], 'size': [1287], '(11Willnow': [1288], 'Armstrong': [1290], 'S.A.': [1291], 'Hammer': [1292, 1331, 2631], 'R.E.': [1293, 1332, 2632, 3519], 'Functional': [1296], 'controlled': [1305], 'vivo.Proc.': [1310], 'Natl.': [1311], 'Acad.': [1312], 'USA.': [1314], '1995;': [1315, 1416, 1467, 2912], '92:': [1316], '4537-4541Crossref': [1317], '12Willnow': [1321], 'Rohlmann': [1323, 2036], 'Horton': [1325], 'Otani': [1327], 'Braun': [1329], 'J.R.': [1330], 'RAP,': [1335], 'specialized': [1337], 'chaperone,': [1338], 'prevents': [1339], 'ligand-induced': [1340], 'ER': [1341, 1405, 1456], 'retention': [1342], 'degradation': [1344], 'receptors.EMBO': [1349], '15:': [1352], '2632-2639Crossref': [1353], '(236)': [1356], 'RAP': [1359, 1379, 1424], 'associates': [1360, 2057], 'early': [1365, 2612], 'secretary': [1366], 'pathway,': [1367], 'thereby': [1368], 'preventing': [1369], 'premature': [1370], 'other': [1375, 1683, 1924], 'ligands.': [1376], 'Dissociation': [1377], 'at': [1381, 2953, 3016], 'lower': [1383, 4156], 'pH': [1384], 'encountered': [1385], 'late': [1388], 'secretory': [1389], 'pathway': [1390, 2006, 3759], '(13Bu': [1391, 1442], 'Geuze': [1393, 1444], 'H.J.': [1394, 1445], 'resident': [1406, 1457], 'protein.EMBO': [1414, 1465], '14:': [1417, 1468], '2269-2280Crossref': [1418, 1469], '(270)': [1421, 1472], 'terms': [1432], 'universally': [1434], 'inhibiting': [1435], 'known': [1437], 'interactions': [1439, 4258], 'Over': [1475], '40': [1476], 'proteins,': [1477, 1685, 1929], 'including': [1478, 2334, 2597, 2832, 3872], 'Aβ,': [1479], 'activated': [1482, 4087], 'α2-macroglobulin,': [1483], 'reported': [1485, 3721, 3967, 4186], '(14Zlokovic': [1491], 'B.V.': [1492, 2554], 'Deane': [1493, 1541, 2505], 'R.': [1494, 1545, 1781, 1829, 1837, 2186, 2506, 2514, 2981, 3043, 3224, 3940, 4036, 4123, 4214], 'Sagare': [1495, 1548, 1784], 'Bell': [1497, 2507, 2541], 'R.D.': [1498, 2508, 2542], 'Winkler': [1499], 'E.A.': [1500], 'Low-density': [1501], 'protein-1:': [1504, 2767], 'serial': [1506], 'homeostatic': [1508], 'mechanism': [1509], 'controlling': [1510, 1910], 'amyloid': [1512, 1645, 2157, 2297, 2338, 2472, 3333, 3375, 3402, 3441, 3473, 3531, 3912, 3983, 4008, 4126, 4217], 'beta-peptide': [1513, 1566, 1802], 'elimination': [1514], 'brain.J.': [1517, 2571], 'Neurochem.': [1518], '2010;': [1519, 1973, 2164, 3544], '115:': [1520], '1077-1089Crossref': [1521], '(162)': [1524], 'it': [1528, 3965], 'controversial': [1530], 'whether': [1531], 'directly': [1533], 'binds': [1534, 2562], 'LRP1;': [1539], 'though': [1540, 4286], 'et': [1542, 1613, 4102, 4240], 'al.': [1543, 1614, 4103, 4241], '(15Deane': [1544, 1780], 'Wu': [1546, 1782, 2519, 3943, 4039], 'Z.': [1547, 1783, 2520, 4243], 'Davis': [1550, 1786], 'Du': [1552, 1788], 'Yan': [1553, 1789], 'Hamm': [1555, 1791, 2511], 'K.': [1556, 1616, 1792, 2041, 2232, 2343, 2512, 3524, 3747, 4061], 'Xu': [1557, 1793], 'F.': [1558, 1794, 2131, 3010, 3629], 'Parisi': [1559, 1795], 'LaRue': [1561, 1797], 'B.': [1562, 1798, 2127, 2412, 2510, 3234], 'Hu': [1563, 1799], 'H.W.': [1564, 1800], 'LRP/amyloid': [1565, 1801], 'interaction': [1567, 1803, 3304, 3845], 'mediates': [1568, 1642, 1804], 'differential': [1569, 1805], 'efflux': [1571, 1807], 'Abeta': [1573, 1809], 'isoforms.Neuron.': [1574, 1810], '2004;': [1575, 1811, 2072, 3383], '43:': [1576, 1812], '333-344Abstract': [1577, 1813], '(613)': [1585, 1821], 'Scholar)': [1587, 2028, 2220, 2255, 2586, 3804, 4146, 4275], 'Aβs': [1596], '(especially': [1597], 'monomeric': [1598, 1847], 'Aβ40)': [1599], 'vitro,': [1601], 'were': [1604, 2944, 2959, 3040, 3135, 3194, 3268, 3971, 4155], 'confirmed': [1606], 'similar': [1609, 2336], 'assay': [1610], 'Yamada': [1612], '(16Yamada': [1615], 'Hashimoto': [1617], 'Yabuki': [1619], 'C.': [1620, 1941, 2345, 2372, 2376, 3072, 3226, 3426, 3836], 'Nagae': [1621], 'Tachikawa': [1623], 'Liu': [1627, 1695, 1697, 1737, 1834], 'Q.': [1628, 1696, 2224, 2404, 3944, 4040], 'Basak': [1631], 'Holtzman': [1633], 'D.M.': [1634], 'uptake': [1643, 1677, 1753, 1843], 'beta': [1646], 'vitro': [1651], 'blood-brain': [1655], 'barrier': [1656], 'cells.J.': [1657], '283:': [1661], '34554-34562Abstract': [1662], '(0)': [1670, 2489, 3035, 3100, 3617, 3802, 4098], 'might': [1674], 'into': [1678], 'cells': [1679, 2670], 'cooperating': [1681], 'Aβ-binding': [1684], 'heparan': [1688, 1757], 'sulfate': [1689], 'proteoglycan': [1690, 1705], '(17Kanekiyo': [1691], 'Zhang': [1693, 1699, 1836, 2225, 2407, 3624], 'C.C.': [1698, 1738], 'L.': [1700, 2182, 2267, 2418, 3576, 3590, 4109, 4200], 'Heparan': [1703], 'sulphate': [1704, 1758], 'constitute': [1713], 'neuronal': [1717], 'amyloid-beta': [1718, 1752, 1852, 2525, 2563, 3950, 4046], 'uptake.J.': [1719], '2011;': [1721], '31:': [1722], '1644-1651Crossref': [1723], '(121)': [1726], '18Fu': [1729], 'Zhao': [1731], 'Atagi': [1733], 'Nielsen': [1735], 'H.M.': [1736], 'Zheng': [1739], 'Shinohara': [1741], 'Kanekiyo': [1743], 'particles': [1750], 'inhibit': [1751], 'proteoglycan.Mol.': [1759], 'Neurodegener.': [1760, 2109, 2247], '2016;': [1761], '11:': [1762, 2875, 3853], '37Crossref': [1763], '(26)': [1766, 1860, 2584], 'Oligomeric': [1769], 'aggregated': [1771], 'poor': [1776], '19Li': [1824], 'Cheng': [1826, 1828], 'D.': [1827, 2129, 3155, 3220], 'Zhu': [1830], 'X.': [1831, 2969], 'Wan': [1832], 'Mechanisms': [1838], 'U87': [1840], 'astrocytoma': [1841], 'versus': [1848], 'protofibril': [1849], 'proteins.PLoS': [1853], 'One.': [1854, 2020], 'e99939Crossref': [1857], 'Of': [1863], 'note,': [1864], 'appears': [1871], 'affected': [1874, 3137], 'conformational': [1877], 'lipidation': [1879], 'status': [1880, 3146, 3678], 'addition': [1908, 3692], 'regulate': [1915], 'activations': [1920], 'coupling': [1922], 'platelet-derived': [1933, 1958], 'growth': [1934, 1959], '(20Muratoglu': [1936], 'S.C.': [1937], 'Mikhailenko': [1938, 1988], 'I.': [1939, 1989, 2548, 3290, 3368], 'Newton': [1940], 'Migliorini': [1942, 1992], 'Low': [1946, 2280], '(LRP1)': [1952, 2001, 2150], 'forms': [1953, 2495], 'receptor-beta': [1961], 'endosomes': [1963], 'activation': [1966], 'MAPK': [1969], 'pathway.J.': [1970, 4138, 4229], '285:': [1974], '14308-14317Abstract': [1975], '(59)': [1983, 3549], '21Craig': [1986], 'Noyes': [1990], 'N.': [1991, 2552, 4111, 4202], 'PDGF': [2004, 2017], 'phosphatase': [2011], 'SHP-2': [2012], 'SHP-2-': [2015], 'mediated': [2016, 2470], 'events.PLoS': [2019], '2013;': [2021, 2110, 2574, 3248], '8:': [2022, 2111], 'e70432Crossref': [2023], '(10)': [2026], 'N-methyl-D-aspartate': [2031], '(NMDA)': [2032], '(22May': [2034], 'Bock': [2038, 2348], 'H.H.': [2039, 2349], 'Zurhove': [2040], 'Marth': [2042], 'J.D.': [2043, 2051, 2546, 3578], 'Schomburg': [2044], 'E.D.': [2045], 'Noebels': [2046], 'Beffert': [2048], 'Sweatt': [2050], 'Weeber': [2052], 'E.J.': [2053], 'Neuronal': [2054], 'functionally': [2056], 'postsynaptic': [2059], 'proteins': [2060, 2897, 3762], 'normal': [2065, 4178], 'motor': [2066], 'function': [2067, 2381], 'mice.Mol.': [2069], 'Cell.': [2070], '24:': [2073], '8872-8883Crossref': [2074], '(153)': [2077], '23Maier': [2080], 'W.': [2081, 3584, 3942, 4038], 'Bednorz': [2082], 'Meister': [2084], 'Roebroek': [2086], 'Weggen': [2088], 'Schmitt': [2090], 'Pietrzik': [2092, 2278, 4106, 4197], 'C.U.': [2093, 2279, 4107, 4198], 'critical': [2096, 2676], 'distribution': [2100], 'NR2B': [2105], 'NMDA': [2106], 'subtype.Mol.': [2108], '25Crossref': [2112], '(33)': [2115], 'cleaved': [2122], 'β-secretase': [2124], '(24von': [2125], 'Einem': [2126], 'Schwanzar': [2128], 'Rehn': [2130], 'Beyer': [2132], 'A.S.': [2133], 'Weber': [2134], 'Wagner': [2136, 4116, 4207], 'Schneckenburger': [2138], 'von': [2140, 2263], 'Arnim': [2141, 2173, 2264], 'C.A.': [2142, 2174, 2265, 3218], 'competitive': [2153, 2293], 'substrate': [2154, 2294], 'precursor': [2158, 2298, 2339, 2422, 2473], '(APP)': [2160, 2300, 2341], 'BACE1.Exp.': [2162], 'Neurol.': [2163, 2911, 3382, 4267], '225:': [2165], '85-93Crossref': [2166], '(22)': [2169], '25von': [2172], 'Kinoshita': [2175, 4062], 'Peltan': [2177, 2270], 'I.D.': [2178, 2271], 'Tangredi': [2179, 2268, 2452], 'M.M.': [2180, 2230, 2269, 2453], 'Herl': [2181, 2266], 'Lee': [2183], 'Spoelgen': [2185], 'Hshieh': [2187], 'T.T.': [2188], 'Ranganathan': [2189], 'Battey': [2191], 'F.D.': [2192], 'novel': [2202], 'beta-secretase': [2203], '(BACE1)': [2204], 'substrate.J.': [2205], '2005;': [2208, 2305, 3182, 3607], '280:': [2209, 2306], '17777-17785Abstract': [2210], '(215)': [2218], 'α-secretase': [2222], '(26Liu': [2223], 'Tran': [2227], 'Verbeek': [2229], 'Reiss': [2231], 'Estus': [2233], 'shedding': [2238], 'brain:': [2241], 'ADAM10': [2244], 'ADAM17.Mol.': [2246], '4:': [2249, 3451], '17Crossref': [2250], '(66)': [2253], 'then': [2257], 'γ-secretase': [2258], '(27Lleó': [2259], 'Waldron': [2261], 'E.': [2262, 2973, 3294, 3528, 3946, 4042], 'Koo': [2274], 'E.H.': [2275], 'Hyman': [2276, 2456, 2861, 2891, 3754, 4072, 4246], 'B.T.': [2277, 2457, 2862, 2892, 3755, 4073, 4247], 'interacts': [2286], 'presenilin': [2288], 'gamma-secretase.J.': [2302], '27303-27309Abstract': [2307], '(58)': [2315], 'resulting': [2319], 'intracellular': [2320, 2459], 'transcription': [2327], 'regulator,': [2328], 'affecting': [2329], 'several': [2332, 2809, 2923], 'genes,': [2333], 'interferon-γ,': [2335], '(28Zurhove': [2342], 'Nakajima': [2344], 'May': [2350], 'Gamma-secretase': [2352], 'limits': [2353], 'inflammatory': [2355], 'response': [2356], 'LRP1.Sci.': [2361], 'Signal.': [2362], 'ra15Crossref': [2365], '(90)': [2368], '29Spuch': [2371], 'Ortolano': [2373], 'Navarro': [2375], 'LRP-1': [2377, 3433], 'LRP-2': [2379], 'neuron.': [2385], 'Trafficking': [2386], 'proteolytic': [2389], 'Physiol.': [2394], '2012;': [2395, 3798, 3918, 4014], '3:': [2396], '269Crossref': [2397], '(49)': [2400], '30Liu': [2403], 'Zerbinatti': [2405], 'C.V.': [2406], 'Hoe': [2409], 'H.S.': [2410], 'Wang': [2411, 3359], 'Cole': [2413], 'S.L.': [2414, 2762, 3929, 4025, 4117, 4208], 'Muglia': [2417], 'Amyloid': [2421], 'apolipoprotein': [2426, 2902, 2993, 3309, 4083], 'cholesterol': [2429], 'LRP1.Neuron.': [2434], '2007;': [2435, 2531, 3767], '56:': [2436], '66-78Abstract': [2437], '(264)': [2445], '31Kinoshita': [2448], 'Shah': [2450], 'modulates': [2468], 'transactivation': [2469], 'Fe65.J.': [2476], '2003;': [2479], '278:': [2480], '41182-41188Abstract': [2481], 'Scholar),': [2491, 3037, 3390], 'while': [2492], 'secreted': [2493], 'soluble': [2494], '(sLRP1)': [2498], 'affect': [2500], '(32Sagare': [2503], 'Johnson': [2509], 'Pendu': [2513], 'Marky': [2515], 'Lenting': [2517], 'P.J.': [2518], 'Zarcone': [2521], 'Clearance': [2523], 'circulating': [2527], 'receptors.Nat.': [2529], 'Med.': [2530], '13:': [2532], '1029-1031Crossref': [2533], '(319)': [2536], '33Sagare': [2539], 'Srivastava': [2543], 'Sengillo': [2545], 'Singh': [2547], 'Nishida': [2549], 'Chow': [2551], 'Zlokovic': [2553], 'mutant': [2560], 'preferentially': [2561], '288:': [2575], '15154-15166Abstract': [2576], 'discussed': [2588], 'later.': [2589], 'abundantly': [2592], 'expressed': [2593, 3868], 'tissues,': [2596], 'liver,': [2598], 'brain,': [2599, 3879], 'vasculatures.': [2601], 'Conventional': [2602], 'deletion': [2603, 2800], 'mice': [2609, 2626], 'led': [2610], 'embryonic': [2613], 'lethality,': [2614], 'remarkable': [2618], 'difference': [2619], 'when': [2620, 4164], 'nonlethal': [2623], '(34Herz': [2627], 'Clouthier': [2629], 'D.E.': [2630, 2965, 4105, 4113, 4196, 4204], 'internalizes': [2636], 'degrades': [2638], 'uPA-PAI-1': [2639], 'complexes': [2640], 'essential': [2643], 'embryo': [2645], 'implantation.Cell.': [2646], '1992;': [2647], '71:': [2648], '411-421Abstract': [2649], '(483)': [2655], 'Conditional': [2658], 'knockouts': [2659], 'hepatocytes,': [2663], 'macrophages,': [2664], 'adipocytes,': [2665], 'vascular': [2667], 'smooth': [2668, 3485], 'muscle': [2669, 3486], 'supported': [2675], 'homeostasis': [2684], 'each': [2686], 'well': [2695], 'strength': [2698], 'disturbances': [2703], 'development,': [2711], 'atherosclerosis': [2714], 'cancer,': [2716, 2774], 'reviewed': [2720], 'elsewhere': [2721], 'beyond': [2724], 'aim': [2726], '35Gonias': [2761], 'Campana': [2763], 'W.M.': [2764], 'regulator': [2769], 'inflammation': [2771], 'atherosclerosis,': [2773], 'injury': [2776], 'nervous': [2779], 'system.Am.': [2780], 'Pathol.': [2782], '184:': [2784], '18-27Abstract': [2785], '(93)': [2793], 'As': [2796], 'described': [2797], 'later,': [2798], 'conditional': [2799], 'neurons': [2804], 'showed': [2808, 3259, 3554], 'diseases': [2813], 'relevant': [2814], 'An': [2817, 4169], 'initial': [2818, 2941], 'finding': [2819], 'neuropathological': [2821, 2921, 3460], 'detection': [2825, 3342], 'multiple': [2830], 'α2-macroglubulin,': [2835], 'on': [2836, 3129, 3670, 3676, 3706, 3887], 'senile': [2837, 2895, 4076], 'plaques': [2838, 3984, 4077], 'brains': [2841, 3987], 'patients,': [2844], 'suggesting': [2845], '(36Rebeck': [2855], 'G.W.': [2856, 2886, 3232, 4069, 4249], 'Reiter': [2857], 'J.S.': [2858], 'sporadic': [2866, 3021, 3540], 'allelic': [2869], 'variation': [2870], 'interactions.Neuron.': [2873], '1993;': [2874], '575-580Abstract': [2876], '(922)': [2882], '37Rebeck': [2885], 'Harr': [2887], 'S.D.': [2888], 'Multiple,': [2893], 'plaque-associated': [2896], 'receptor,': [2904, 2995], 'alpha': [2906], '2-macroglobulin': [2907], 'receptor/low-density-lipoprotein': [2908], 'protein.Ann.': [2910], '37:': [2913], '211-217Crossref': [2914], 'Following': [2918], 'leading': [2920], 'finding,': [2922], 'performed': [2928], 'address': [2930], 'association': [2932, 2983, 3203, 3465], 'variants': [2936], 'risk.': [2939, 3131], 'Though': [2940], 'intriguing': [2942], 'observations': [2943], 'silent': [2947], 'polymorphism': [2948, 3076, 3128, 3267, 3279, 3394, 3434, 3470, 3490], 'exon': [2951, 3078], '3': [2952, 3079], 'codon': [2954], '766': [2955], '(C766T)': [2956], 'under-represented': [2960], '(38Kang': [2964], 'Saitoh': [2966], 'Chen': [2968], 'Xia': [2970], 'Masliah': [2972], 'Hansen': [2974], 'L.A.': [2975], 'Thomas': [2976], 'R.G.': [2977], 'Thal': [2978], 'L.J.': [2979], 'Katzman': [2980, 4122, 4213], 'Genetic': [2982, 3303], '(LRP),': [2991], 'disease.Neurology.': [2999], '1997;': [3000], '49:': [3001], '56-61Crossref': [3002], '39Lambert': [3006], 'J.C.': [3007, 3159, 3216, 3230, 4119, 4210], 'Wavrant-De': [3008], 'Vrieze': [3009], 'Amouyel': [3011], 'Chartier-Harlin': [3013, 3160], 'M.C.': [3014, 3161, 3753, 3938, 4034, 4067], 'Association': [3015, 3168, 3591, 3636, 3785], 'LRP': [3017, 3052, 3789, 4074], 'locus': [3019], 'disease.Lancet.': [3024, 3057], '1998;': [3025, 3058], '351:': [3026], '1787-1788Abstract': [3027], 'following': [3038], '(40Woodward': [3042], 'Singleton': [3044], 'A.B.': [3045], 'Gibson': [3046], 'A.M.': [3047], 'Edwardson': [3048], 'J.A.': [3049, 3934, 4030], 'Morris': [3050], 'C.M.': [3051, 4065], '352:': [3059], '239-240Abstract': [3060], '41Beffert': [3069], 'Arguin': [3071], 'Poirier': [3073], 'weakly': [3089], 'disease.Neurosci.': [3093, 3180], 'Lett.': [3094, 3181, 3917, 4013], '259:': [3096], '29-32Crossref': [3097], 'meta-analysis': [3104, 3171, 3199], '2005': [3106], 'combining': [3107], '4,668': [3108], 'patients': [3110, 3406, 3496, 3736, 3824, 4159], '4,473': [3112], 'controls': [3113, 3214, 3839, 4163], '18': [3115], 'case-control': [3116], 'failed': [3118], 'detect': [3120], 'significant': [3122, 3192, 3464], 'effect': [3123], 'C766T': [3127, 3266, 3469], 'obtained': [3133], 'onset': [3140], '(early-': [3141], 'late-onset)': [3143], 'APOE4': [3145], '(42Pritchard': [3147], 'Harris': [3149], 'Pritchard': [3151], 'C.W.': [3152], 'St': [3153], 'Clair': [3154], 'Lemmon': [3156], 'Lambert': [3158], 'Hayes': [3162], 'Thaker': [3164], 'Iwatsubo': [3166], 'study': [3169, 3204, 3258, 3461, 3592], '382:': [3183], '221-226Crossref': [3184], '(27)': [3187], 'Also,': [3190, 3458], 'effects': [3193, 3262], 'observed': [3195, 3462, 4276], 'recent': [3198], 'genome-wide': [3202], 'data': [3205], 'sets': [3206], 'consisting': [3207], '17,008': [3209], 'cases': [3211, 3503], '37,154': [3213], '(43Lambert': [3215], 'Ibrahim-Verbaas': [3217], 'Harold': [3219], 'Naj': [3221], 'A.C.': [3222], 'Sims': [3223], 'Bellenguez': [3225], 'DeStefano': [3227], 'Bis': [3229], 'Beecham': [3231], 'Grenier-Boley': [3233], 'Meta-analysis': [3235], '74,046': [3237], 'individuals': [3238, 3509, 3739, 4179], 'identifies': [3239, 3533], 'new': [3241], 'susceptibility': [3242, 4132, 4223], 'loci': [3243], 'disease.Nat.': [3246], 'Genet.': [3247], '45:': [3249], '1452-1458Crossref': [3250], '(2068)': [3253], 'obvious': [3270], 'tau': [3275, 3306], 'intron': [3276], '9': [3277], 'rs2471738': [3278], '(odds': [3280], 'ratio': [3281], '=': [3282, 3285, 3408, 3411], '6.20,': [3283], 'P': [3284, 3410], '0.005)': [3286], '(44Vázquez-Higuera': [3287], 'Mateo': [3289], 'Sánchez-Juan': [3291], 'Rodríguez-Rodríguez': [3293], 'Pozueta': [3295], 'Infante': [3297], 'Berciano': [3299], 'Combarros': [3301], 'increases': [3313], 'risk.Dement.': [3316], 'Geriatr.': [3317], 'Cogn.': [3318], 'Disord.': [3319], '28:': [3321], '116-120Crossref': [3322], '(15)': [3325], 'addition,': [3329], 'introducing': [3331], 'imaging': [3334], '11C-Pittsburgh': [3335], 'compound': [3336], 'B': [3337], 'technique,': [3338], 'enables': [3340], 'antemortem': [3341], 'positron': [3350], 'emission': [3351], 'tomography': [3352], '(45Klunk': [3353], 'W.E.': [3354], 'Engler': [3355], 'Nordberg': [3357], 'Blomqvist': [3361], 'Holt': [3363], 'D.P.': [3364], 'Bergstrom': [3365], 'Savitcheva': [3367], 'Huang': [3369], 'G.F.': [3370], 'Estrada': [3371], 'Imaging': [3373], 'Pittsburgh': [3380], 'Compound-B.Ann.': [3381], '55:': [3384], '306-319Crossref': [3385], '(3207)': [3388], 'C667T': [3393, 3559, 4193], 'moderately,': [3396], 'significantly,': [3398], 'global': [3401, 3438], 'deposition': [3403], '(n': [3407], '72,': [3409], '0.046)': [3412], '(46Grimmer': [3413], 'Goldhardt': [3415], 'Guo': [3417, 3579], 'L.H.': [3418], 'Yousefi': [3419], 'B.H.': [3420], 'Forster': [3421], 'Drzezga': [3423], 'Sorg': [3425], 'Alexopoulos': [3427], 'Forstl': [3429], 'Kurz': [3431], 'regional': [3440], 'load': [3442], 'humans': [3447], 'in-vivo.Neuroimage': [3448], 'Clin.': [3449, 4139, 4230], '411-416Crossref': [3452], '(13)': [3455], 'cerebral': [3472, 3530, 3901, 3911, 3997, 4007], 'angiopathy': [3474, 3532, 3913, 4009], '(CAA),': [3475], 'accumulates': [3478], 'blood': [3480, 3907, 4003], 'vessels,': [3481], 'layers;': [3488], 'more': [3492], 'frequent': [3493], 'without': [3497], 'capillary': [3498, 3505], 'CAA,': [3499], 'CAA': [3506, 3682], 'control': [3508], '(47Thal': [3510], 'D.R.': [3511], 'Papassotiropoulos': [3512], 'Saido': [3514], 'T.C.': [3515], 'Griffin': [3516], 'W.S.': [3517], 'Mrak': [3518], 'Kolsch': [3520], 'Del': [3522], 'Tredici': [3523], 'Attems': [3525], 'Ghebremedhin': [3527], 'Capillary': [3529], 'epsilon4-associated': [3537], 'subtype': [3538], 'disease.Acta': [3542, 3954, 4050], 'Neuropathol.': [3543, 3955, 4051, 4265], '120:': [3545], '169-183Crossref': [3546], 'Other': [3552], 'haplotypes': [3563], 'influence': [3564], 'stage': [3572], '(48Bian': [3575], 'Yang': [3577, 3941, 4037], 'T.W.': [3580], 'Duan': [3581], 'Qin': [3583], 'Sun': [3585], 'Feng': [3587], 'G.Y.': [3588], 'He': [3589], 'A2M': [3595], 'Genes': [3598], 'Alzheimer': [3600, 4260], 'Han': [3604], 'Chinese.Biol.': [3605], 'Psychiatry.': [3606], '58:': [3608], '731-737Abstract': [3609], '49Shi': [3620], 'Y.M.': [3621], 'Zhou': [3622], 'Z.J.': [3625], 'Yu': [3626], 'Bai': [3628], 'Yuan': [3630], 'Y.G.': [3631], 'Deng': [3632], 'L.L.': [3633], 'Jia': [3634], 'J.P.': [3635], 'cognitive': [3642, 3647], 'performance': [3643], 'amnestic': [3645], 'mild': [3646], 'elderly': [3650], 'Chinese.Int.': [3651], 'Psychogeriatr.': [3652], '21:': [3654], '1072-1080Crossref': [3655], '(5)': [3658], 'Together,': [3661], 'influences': [3667], 'may': [3673, 3882], 'differ': [3674], 'depending': [3675, 3886], 'pathology,': [3681], 'formation,': [3683], 'tauopathy,': [3685], 'although': [3686, 3805], 'needed.': [3690], 'polymorphisms,': [3696], 'postmortem': [3701], 'samples': [3703], 'focused': [3705], 'levels': [3710, 3725, 3791, 3813, 3881, 3970, 4150, 4255, 4278], 'modulated': [3712], '(Table': [3717], 'Some': [3719], 'groups': [3720], 'mRNA': [3724, 3790, 3816], 'increased': [3727, 3976, 4188, 4277], 'temporal': [3730], 'cortex': [3731, 3821, 4154], 'hippocampus': [3733], 'demented': [3738], '(50Matsui': [3740], 'Ingelsson': [3742], 'Fukumoto': [3744], 'Ramasamy': [3746], 'Kowa': [3748], 'Frosch': [3750], 'M.P.': [3751], 'Irizarry': [3752, 4066], 'Expression': [3756], 'APP': [3758], 'mRNAs': [3760], 'disease.Brain': [3765], 'Res.': [3766, 4089, 4092], '1161:': [3768], '116-123Crossref': [3769], '51Akram': [3775], 'Schmeidler': [3777], 'Katsel': [3779], 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[3904, 4000], 'meningeal': [3906, 4002], 'vessels:': [3908, 4004], 'relationship': [3909, 4005], 'status.Neurosci.': [3916, 4012], '525:': [3919, 4015], '123-128Crossref': [3920, 4016], '(11)': [3923, 4019], '54Donahue': [3926, 4022], 'Flaherty': [3928, 4024], 'Johanson': [3930, 4026], 'C.E.': [3931, 4027], 'Duncan': [3932, 4028], 'III,': [3933, 4029], 'Silverberg': [3935, 4031], 'G.D.': [3936, 4032], 'Miller': [3937, 4033], 'Tavares': [3939, 4035], 'Sabo': [3945, 4041], 'RAGE,': [3947, 4043], 'LRP-1,': [3948, 4044], '2006;': [3956, 4052], '112:': [3957, 4053], '405-415Crossref': [3958, 4054], '(341)': [3961, 4057], 'Indeed,': [3964], 'astrocytes': [3980], 'proximate': [3981], '55Arélin': [4060], 'Whelan': [4064], 'Rebeck': [4068, 4248], 'colocalization': [4081], 'astrocytes.Brain': [4088], 'Mol.': [4090], 'Brain': [4091], '2002;': [4093], '104:': [4094], '38-46Crossref': [4095], 'Kang': [4101], '(56Kang': [4104, 4195], 'Baum': [4108, 4199], 'Chevallier': [4110, 4201], 'Merriam': 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