Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2604987403', 'doi': 'https://doi.org/10.18632/oncotarget.16789', 'title': 'TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT', 'display_name': 'TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT', 'publication_year': 2017, 'publication_date': '2017-04-03', 'ids': {'openalex': 'https://openalex.org/W2604987403', 'doi': 'https://doi.org/10.18632/oncotarget.16789', 'mag': '2604987403', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31741718', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6849646'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.16789', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=16789&path%5B%5D=53711', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=16789&path%5B%5D=53711', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101733710', 'display_name': 'Xinxing Li', 'orcid': 'https://orcid.org/0000-0003-1129-0085'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xinxing Li', 'raw_affiliation_strings': ['Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102005064', 'display_name': 'Shifeng Teng', 'orcid': 'https://orcid.org/0000-0002-6297-9205'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shifeng Teng', 'raw_affiliation_strings': ['Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100389082', 'display_name': 'Yanyan Zhang', 'orcid': 'https://orcid.org/0000-0001-8297-720X'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yanyan Zhang', 'raw_affiliation_strings': ['Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014774434', 'display_name': 'Weigang Zhang', 'orcid': 'https://orcid.org/0000-0003-0042-7074'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Weigang Zhang', 'raw_affiliation_strings': ['Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101742243', 'display_name': 'Qian Zhang', 'orcid': 'https://orcid.org/0000-0002-8421-2419'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xianwen Zhang', 'raw_affiliation_strings': ['Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017591338', 'display_name': 'Kai Xu', 'orcid': 'https://orcid.org/0000-0003-2036-3469'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Kai Xu', 'raw_affiliation_strings': ['Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024857104', 'display_name': 'Houshan Yao', 'orcid': 'https://orcid.org/0000-0002-8966-3411'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Houshan Yao', 'raw_affiliation_strings': ['Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056169325', 'display_name': 'Jun Yao', 'orcid': 'https://orcid.org/0000-0003-0781-5694'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jun Yao', 'raw_affiliation_strings': ['Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100659861', 'display_name': 'Haolu Wang', 'orcid': 'https://orcid.org/0000-0003-4935-1103'}, 'institutions': [{'id': 'https://openalex.org/I2801814493', 'display_name': 'Princess Alexandra Hospital', 'ror': 'https://ror.org/04mqb0968', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801814493']}, {'id': 'https://openalex.org/I165143802', 'display_name': 'University of Queensland', 'ror': 'https://ror.org/00rqy9422', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165143802']}, {'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['AU', 'CN'], 'is_corresponding': False, 'raw_author_name': 'Haolu Wang', 'raw_affiliation_strings': ['Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China', 'Therapeutics Research Centre, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Woolloongabba QLD 4102, Australia'], 'affiliations': [{'raw_affiliation_string': 'Therapeutics Research Centre, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Woolloongabba QLD 4102, Australia', 'institution_ids': ['https://openalex.org/I2801814493', 'https://openalex.org/I165143802']}, {'raw_affiliation_string': 'Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004678145', 'display_name': 'Xiaowen Liang', 'orcid': 'https://orcid.org/0000-0001-7811-5148'}, 'institutions': [{'id': 'https://openalex.org/I2801814493', 'display_name': 'Princess Alexandra Hospital', 'ror': 'https://ror.org/04mqb0968', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801814493']}, {'id': 'https://openalex.org/I165143802', 'display_name': 'University of Queensland', 'ror': 'https://ror.org/00rqy9422', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165143802']}], 'countries': ['AU'], 'is_corresponding': True, 'raw_author_name': 'Xiaowen Liang', 'raw_affiliation_strings': ['Therapeutics Research Centre, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Woolloongabba QLD 4102, Australia'], 'affiliations': [{'raw_affiliation_string': 'Therapeutics Research Centre, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Woolloongabba QLD 4102, Australia', 'institution_ids': ['https://openalex.org/I2801814493', 'https://openalex.org/I165143802']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5040423679', 'display_name': 'Zhiqian Hu', 'orcid': 'https://orcid.org/0000-0002-3973-6280'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhiqian Hu', 'raw_affiliation_strings': ['Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5004678145'], 'corresponding_institution_ids': ['https://openalex.org/I2801814493', 'https://openalex.org/I165143802'], 'apc_list': None, 'apc_paid': None, 'fwci': 9.632, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 81, 'citation_normalized_percentile': {'value': 0.999982, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '8', 'issue': '29', 'first_page': '47052', 'last_page': '47063'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11364', 'display_name': 'Cholangiocarcinoma', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11364', 'display_name': 'Cholangiocarcinoma', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13779', 'display_name': 'Role of Pim Oncogenes in Tumorigenesis', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10966', 'display_name': 'Mechanisms and Treatment of Liver Fibrosis', 'score': 0.9888, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gallbladder-cancer', 'display_name': 'Gallbladder Cancer', 'score': 0.543026}, {'id': 'https://openalex.org/keywords/cancer-progression', 'display_name': 'Cancer Progression', 'score': 0.51702}, {'id': 'https://openalex.org/keywords/nude-mouse', 'display_name': 'Nude mouse', 'score': 0.4623429}], 'concepts': [{'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.8101921}, {'id': 'https://openalex.org/C2777609662', 'wikidata': 'https://www.wikidata.org/wiki/Q416356', 'display_name': 'PTEN', 'level': 4, 'score': 0.7309686}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.712965}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6830385}, {'id': 'https://openalex.org/C2776534502', 'wikidata': 'https://www.wikidata.org/wiki/Q977787', 'display_name': 'Gallbladder cancer', 'level': 3, 'score': 0.65029895}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6223396}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.61135316}, {'id': 'https://openalex.org/C147447768', 'wikidata': 'https://www.wikidata.org/wiki/Q411624', 'display_name': 'Vimentin', 'level': 3, 'score': 0.56888646}, {'id': 'https://openalex.org/C76419328', 'wikidata': 'https://www.wikidata.org/wiki/Q74419', 'display_name': 'Epithelial–mesenchymal transition', 'level': 4, 'score': 0.5590401}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.5541583}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.50800234}, {'id': 'https://openalex.org/C2780278673', 'wikidata': 'https://www.wikidata.org/wiki/Q476743', 'display_name': 'Nude mouse', 'level': 3, 'score': 0.4623429}, {'id': 'https://openalex.org/C137738243', 'wikidata': 'https://www.wikidata.org/wiki/Q189092', 'display_name': 'Cell migration', 'level': 3, 'score': 0.43186006}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.3142764}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.2893803}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.2547276}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.24722224}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.23323905}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23289284}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.13062477}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.08623722}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000951', 'descriptor_name': 'Antigens, Neoplasm', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015815', 'descriptor_name': 'Cell Adhesion Molecules', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D058750', 'descriptor_name': 'Epithelial-Mesenchymal Transition', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D005706', 'descriptor_name': 'Gallbladder Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005706', 'descriptor_name': 'Gallbladder Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000951', 'descriptor_name': 'Antigens, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000951', 'descriptor_name': 'Antigens, Neoplasm', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015815', 'descriptor_name': 'Cell Adhesion Molecules', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015815', 'descriptor_name': 'Cell Adhesion Molecules', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058750', 'descriptor_name': 'Epithelial-Mesenchymal Transition', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005706', 'descriptor_name': 'Gallbladder Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005706', 'descriptor_name': 'Gallbladder Neoplasms', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D005706', 'descriptor_name': 'Gallbladder Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D064593', 'descriptor_name': 'Heterografts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060787', 'descriptor_name': 'Neoplasm Grading', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009362', 'descriptor_name': 'Neoplasm Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009367', 'descriptor_name': 'Neoplasm Staging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047368', 'descriptor_name': 'Tumor Burden', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.16789', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=16789&path%5B%5D=53711', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5564543', 'pdf_url': 'https://europepmc.org/articles/pmc5564543?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564543', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28423362', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.16789', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=16789&path%5B%5D=53711', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/1', 'score': 0.41, 'display_name': 'No poverty'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1823362496', 'https://openalex.org/W1975074702', 'https://openalex.org/W1976123200', 'https://openalex.org/W1979988883', 'https://openalex.org/W1993127658', 'https://openalex.org/W2005370955', 'https://openalex.org/W2008749520', 'https://openalex.org/W2016267087', 'https://openalex.org/W2037158090', 'https://openalex.org/W2038553774', 'https://openalex.org/W2041969134', 'https://openalex.org/W2045306661', 'https://openalex.org/W2046005712', 'https://openalex.org/W2046178435', 'https://openalex.org/W2050370100', 'https://openalex.org/W2054318449', 'https://openalex.org/W2054492655', 'https://openalex.org/W2083083084', 'https://openalex.org/W2095432971', 'https://openalex.org/W2095774850', 'https://openalex.org/W2098482544', 'https://openalex.org/W2102353246', 'https://openalex.org/W2104134360', 'https://openalex.org/W2109650221', 'https://openalex.org/W2113922475', 'https://openalex.org/W2141091746', 'https://openalex.org/W2143306529', 'https://openalex.org/W2144763569', 'https://openalex.org/W2155860096', 'https://openalex.org/W2168563465', 'https://openalex.org/W2188271125', 'https://openalex.org/W2238400138', 'https://openalex.org/W2240888538', 'https://openalex.org/W2289198644', 'https://openalex.org/W2402880145', 'https://openalex.org/W2415615858', 'https://openalex.org/W2493388059', 'https://openalex.org/W4211140559'], 'related_works': ['https://openalex.org/W4255321854', 'https://openalex.org/W3042521424', 'https://openalex.org/W3032018168', 'https://openalex.org/W2991110581', 'https://openalex.org/W2784579557', 'https://openalex.org/W2556217098', 'https://openalex.org/W2099293728', 'https://openalex.org/W2092051801', 'https://openalex.org/W2076842104', 'https://openalex.org/W1513049384'], 'abstract_inverted_index': {'//': [0], 'Xinxing': [1, 91], 'Li': [2], '1,': [3, 8, 13], '*': [4, 9, 14, 80], ',': [5, 10, 15, 19, 23, 27, 31, 35, 39, 189], 'Shifeng': [6], 'Teng': [7], 'Yanyan': [11], 'Zhang': [12, 17, 21], 'Weigang': [16], '1': [18, 22, 26, 30, 34, 46, 47], 'Xianwen': [20], 'Kai': [24], 'Xu': [25], 'Houshan': [28], 'Yao': [29, 33], 'Jun': [32], 'Haolu': [36], 'Wang': [37], '2': [38, 42, 62, 128], 'Xiaowen': [40, 95], 'Liang': [41], 'and': [43, 141, 185, 208, 221, 257, 277, 287, 298], 'Zhiqian': [44, 99], 'Hu': [45], 'Department': [48], 'of': [49, 67, 71, 143, 162, 170, 199, 204, 260, 279, 305], 'General': [50], 'Surgery,': [51], 'Changzheng': [52], 'Hospital,': [53, 75], 'The': [54, 69, 122], 'Second': [55], 'Military': [56], 'Medical': [57], 'University,': [58], 'Shanghai': [59], '200003,': [60], 'China': [61], 'Therapeutics': [63], 'Research': [64], 'Centre,': [65], 'School': [66], 'Medicine,': [68], 'University': [70], 'Queensland,': [72], 'Princess': [73], 'Alexandra': [74], 'Woolloongabba': [76], 'QLD': [77], '4102,': [78], 'Australia': [79], 'These': [81], 'authors': [82], 'have': [83], 'contributed': [84], 'equally': [85], 'to': [86], 'this': [87, 149], 'work': [88], 'Correspondence': [89], 'to:': [90], 'Li,': [92], 'email:': [93, 97, 101], '[email protected]': [94], 'Liang,': [96], '[email protected]': [98], 'Hu,': [100], '[email protected]': [102], 'Keywords:': [103], 'gallbladder': [104, 144, 159, 173, 230, 261, 280, 306], 'cancer,': [105], 'TROP2,': [106], 'AKT,': [107], 'EMT': [108, 259], 'Received:': [109], 'September': [110], '30,': [111], '2016    ': [112], 'Accepted:': [113], 'March': [114], '21,': [115], '2017    ': [116], 'Published:': [117], 'April': [118], '03,': [119], '2017': [120], 'ABSTRACT': [121], 'human': [123], 'trophoblast': [124], 'cell': [125, 175, 180], 'surface': [126], 'antigen': [127], '(TROP2)': [129], 'is': [130], 'overexpressed': [131], 'in': [132, 158, 172, 187, 240, 246, 264], 'many': [133], 'cancers.': [134], 'However,': [135], 'its': [136], 'effect': [137], 'on': [138], 'proliferation,': [139, 181, 275], 'migration': [140, 186, 276], 'metastasis': [142, 278], 'cancer': [145, 174, 231, 262, 281], 'remains': [146], 'unclear.': [147], 'In': [148, 196, 243, 267], 'study,': [150], 'we': [151, 269], 'found': [152], 'that': [153, 271], 'TROP2': [154, 163, 171, 191, 200, 216, 234, 249, 272, 290], 'was': [155, 164], 'highly': [156], 'expressed': [157], 'cancer.': [160, 307], 'Overexpression': [161], 'associated': [165], 'with': [166, 233, 245], 'poor': [167], 'prognosis.': [168], 'Knockdown': [169], 'lines': [176], 'strongly': [177], 'inhibited': [178, 219], 'the': [179, 202, 274, 302], 'clone': [182], 'formation,': [183], 'invasion': [184], 'vitro': [188, 247], 'while': [190], 'overexpression': [192], 'had': [193], 'opposite': [194], 'effects.': [195], 'addition,': [197], 'knockdown': [198, 235], 'increased': [201, 222, 254], 'expression': [203, 224, 256], 'total': [205], 'PTEN,': [206], 'p-PTEN': [207], 'PDK-1': [209], 'but': [210], 'reduced': [211], 'p-AKT': [212], 'via': [213], 'PI3K/AKT': [214, 285], 'pathway.': [215], 'downregulation': [217], 'also': [218], 'vimentin': [220], 'E-cadherin': [223], 'during': [225], 'epithelial-mesenchymal': [226], 'transition': [227], '(EMT).': [228], 'Moreover,': [229], 'cells': [232, 263, 282], 'formed': [236], 'smaller': [237], 'xenografted': [238], 'tumors': [239], 'vivo': [241, 265], '.': [242, 266], 'consistent': [244], 'results,': [248], 'inhibition': [250], 'decreased': [251], 'Akt': [252], 'phosphorylation,': [253], 'PTEN': [255], 'postponed': [258], 'conclusion,': [268], 'revealed': [270], 'promoted': [273], 'by': [283], 'regulating': [284], 'pathway': [286], 'inducing': [288], 'EMT.': [289], 'could': [291], 'serve': [292], 'as': [293], 'a': [294], 'potential': [295], 'prognostic': [296], 'biomarker': [297], 'therapeutic': [299], 'target': [300], 'for': [301], 'clinical': [303], 'management': [304]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2604987403', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 16}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 15}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 3}], 'updated_date': '2024-09-19T09:36:30.986456', 'created_date': '2017-04-14'}