Publication Information

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1089, 1131, 1173, 1215, 1257, 1299, 1341, 1383, 1546, 1552, 1563, 1586, 1643, 1670, 1676, 1687, 1770, 1850, 1856, 1867], 'Ministry': [31, 73, 115, 157, 199, 241, 283, 325, 367, 409, 451, 493, 535, 738, 795, 880, 922, 964, 1006, 1048, 1090, 1132, 1174, 1216, 1258, 1300, 1342, 1384, 1587, 1644, 1771], 'Education,': [33, 75, 117, 159, 201, 243, 285, 327, 369, 411, 453, 495, 537, 740, 797, 882, 924, 966, 1008, 1050, 1092, 1134, 1176, 1218, 1260, 1302, 1344, 1386, 1589, 1646, 1773], 'Department': [34, 76, 118, 160, 202, 244, 286, 328, 370, 412, 454, 496, 538, 568, 591, 741, 760, 798, 883, 925, 967, 1009, 1051, 1093, 1135, 1177, 1219, 1261, 1303, 1345, 1387, 1417, 1440, 1590, 1609, 1647, 1774], 'Immunology': [36, 78, 120, 162, 204, 246, 288, 330, 372, 414, 456, 498, 540, 669, 743, 800, 885, 927, 969, 1011, 1053, 1095, 1137, 1179, 1221, 1263, 1305, 1347, 1389, 1518, 1592, 1649, 1776, 1833], 'Microbiology,': [38, 80, 122, 164, 206, 248, 290, 332, 374, 416, 458, 500, 542, 745, 802, 887, 929, 971, 1013, 1055, 1097, 1139, 1181, 1223, 1265, 1307, 1349, 1391, 1594, 1651, 1778], 'Shanghai': [39, 43, 81, 85, 123, 127, 165, 169, 207, 211, 249, 253, 291, 295, 333, 337, 375, 379, 417, 421, 459, 463, 501, 505, 543, 547, 620, 648, 746, 750, 803, 807, 842, 850, 888, 892, 930, 934, 972, 976, 1014, 1018, 1056, 1060, 1098, 1102, 1140, 1144, 1182, 1186, 1224, 1228, 1266, 1270, 1308, 1312, 1350, 1354, 1392, 1396, 1469, 1497, 1595, 1599, 1652, 1656, 1691, 1699, 1779, 1783, 1823, 1879], 'Institute': [40, 82, 124, 166, 208, 250, 292, 334, 376, 418, 460, 502, 544, 747, 804, 889, 931, 973, 1015, 1057, 1099, 1141, 1183, 1225, 1267, 1309, 1351, 1393, 1596, 1653, 1780], 'Immunology,': [42, 84, 126, 168, 210, 252, 294, 336, 378, 420, 462, 504, 546, 749, 806, 891, 933, 975, 1017, 1059, 1101, 1143, 1185, 1227, 1269, 1311, 1353, 1395, 1598, 1655, 1782], 'Jiao': [44, 86, 128, 170, 212, 254, 296, 338, 380, 422, 464, 506, 548, 621, 649, 751, 808, 851, 893, 935, 977, 1019, 1061, 1103, 1145, 1187, 1229, 1271, 1313, 1355, 1397, 1470, 1498, 1600, 1657, 1700, 1784, 1824, 1880], 'Tong': [45, 87, 129, 171, 213, 255, 297, 339, 381, 423, 465, 507, 549, 622, 650, 752, 809, 852, 894, 936, 978, 1020, 1062, 1104, 1146, 1188, 1230, 1272, 1314, 1356, 1398, 1471, 1499, 1601, 1658, 1701, 1785, 1825, 1881], 'University': [46, 88, 130, 172, 214, 256, 298, 340, 382, 424, 466, 508, 550, 623, 651, 712, 753, 810, 836, 853, 895, 937, 979, 1021, 1063, 1105, 1147, 1189, 1231, 1273, 1315, 1357, 1399, 1472, 1500, 1561, 1602, 1659, 1685, 1702, 1786, 1826, 1865, 1882], 'School': [47, 89, 131, 173, 215, 257, 299, 341, 383, 425, 467, 509, 551, 624, 652, 709, 754, 811, 833, 854, 896, 938, 980, 1022, 1064, 1106, 1148, 1190, 1232, 1274, 1316, 1358, 1400, 1473, 1501, 1558, 1603, 1660, 1682, 1703, 1787, 1827, 1862, 1883], 'Medicine': [49, 91, 133, 175, 217, 259, 301, 343, 385, 427, 469, 511, 553, 616, 644, 756, 813, 856, 898, 940, 982, 1024, 1066, 1108, 1150, 1192, 1234, 1276, 1318, 1360, 1402, 1465, 1493, 1605, 1662, 1705, 1789, 1819, 1885], '(SJTU-SM),': [50, 92, 134, 176, 218, 260, 302, 344, 386, 428, 470, 512, 554, 757, 814, 857, 899, 941, 983, 1025, 1067, 1109, 1151, 1193, 1235, 1277, 1319, 1361, 1403, 1606, 1663, 1706, 1790, 1886], 'Shanghai,': [51, 93, 135, 177, 219, 261, 303, 345, 387, 429, 471, 513, 555, 627, 655, 758, 815, 858, 900, 942, 984, 1026, 1068, 1110, 1152, 1194, 1236, 1278, 1320, 1362, 1404, 1476, 1504, 1607, 1664, 1707, 1791, 1830, 1887], 'China': [52, 94, 136, 178, 220, 262, 304, 346, 388, 430, 472, 514, 556, 579, 600, 628, 656, 717, 759, 769, 816, 841, 859, 901, 943, 985, 1027, 1069, 1111, 1153, 1195, 1237, 1279, 1321, 1363, 1405, 1428, 1449, 1477, 1505, 1566, 1608, 1618, 1665, 1690, 1708, 1792, 1804, 1814, 1831, 1870, 1888], 'Search': [53, 95, 137, 179, 221, 263, 305, 347, 389, 431, 473, 515, 557, 580, 601, 629, 657, 682, 718, 770, 860, 902, 944, 986, 1028, 1070, 1112, 1154, 1196, 1238, 1280, 1322, 1364, 1406, 1429, 1450, 1478, 1506, 1531, 1567, 1619, 1709], 'for': [54, 96, 138, 180, 222, 264, 306, 348, 390, 432, 474, 516, 558, 581, 602, 614, 630, 642, 658, 673, 683, 719, 771, 845, 861, 903, 945, 987, 1029, 1071, 1113, 1155, 1197, 1239, 1281, 1323, 1365, 1407, 1430, 1451, 1463, 1479, 1491, 1507, 1522, 1532, 1568, 1620, 1694, 1710, 1817, 1837, 1874, 2032, 2570, 2622, 2630, 3144, 3149, 3303, 3362, 3424, 3658, 3815], 'more': [55, 97, 139, 181, 223, 265, 307, 349, 391, 433, 475, 517, 559, 582, 603, 631, 659, 684, 720, 772, 862, 904, 946, 988, 1030, 1072, 1114, 1156, 1198, 1240, 1282, 1324, 1366, 1408, 1431, 1452, 1480, 1508, 1533, 1569, 1621, 1711], 'papers': [56, 98, 140, 182, 224, 266, 308, 350, 392, 434, 476, 518, 560, 583, 604, 632, 660, 685, 721, 773, 863, 905, 947, 989, 1031, 1073, 1115, 1157, 1199, 1241, 1283, 1325, 1367, 1409, 1432, 1453, 1481, 1509, 1534, 1570, 1622, 1712], 'by': [57, 99, 141, 183, 225, 267, 309, 351, 393, 435, 477, 519, 561, 584, 605, 633, 661, 686, 722, 774, 864, 906, 948, 990, 1032, 1074, 1116, 1158, 1200, 1242, 1284, 1326, 1368, 1410, 1433, 1454, 1482, 1510, 1535, 1571, 1623, 1713, 1986, 2267, 2286, 2304, 2316, 2425, 2511, 2794, 2858, 3355, 3772, 4061, 4091], 'this': [58, 100, 142, 184, 226, 268, 310, 352, 394, 436, 478, 520, 562, 585, 606, 634, 662, 687, 723, 775, 865, 907, 949, 991, 1033, 1075, 1117, 1159, 1201, 1243, 1285, 1327, 1369, 1411, 1434, 1455, 1483, 1511, 1536, 1572, 1624, 1714, 3145, 3384], 'author': [59, 101, 143, 185, 227, 269, 311, 353, 395, 437, 479, 521, 563, 586, 607, 635, 663, 688, 724, 776, 866, 908, 950, 992, 1034, 1076, 1118, 1160, 1202, 1244, 1286, 1328, 1370, 1412, 1435, 1456, 1484, 1512, 1537, 1573, 1625, 1715, 1932], 'Fangzhou': [60, 62, 909, 911, 1720], 'Lou': [61, 63, 910, 912], 'Qianqian': [102, 104, 951, 953, 1722], 'Yin': [103, 105, 952, 954], 'Yuanyuan': [144, 146, 993, 995, 1724], 'Gao': [145, 147, 994, 996], 'Yang': [186, 188, 1035, 1037, 1726], 'Sun': [187, 189, 1036, 1038], 'Jing': [228, 230, 1077, 1079, 1728], 'Bai': [229, 231, 1078, 1080], 'Zhenyao': [270, 272, 1119, 1121, 1730], 'Xu': [271, 273, 1120, 1122], 'Zhaoyuan': [312, 314, 1161, 1163, 1732], 'Liu': [313, 315, 1162, 1164], 'Wei': [354, 356, 1203, 1205, 1734], 'Cai': [355, 357, 1204, 1206], 'Fang': [396, 398, 1245, 1247, 1736], 'Ke': [397, 399, 1246, 1248], 'Lingyun': [438, 440, 1287, 1289, 1738], 'Zhang': [439, 441, 609, 611, 1288, 1290, 1458, 1460], 'Hong': [480, 482, 522, 524, 1329, 1331, 1371, 1373, 1740, 1742], 'Zhou': [481, 483, 1330, 1332], 'Wang': [523, 525, 565, 567, 637, 639, 778, 782, 1372, 1374, 1414, 1416, 1486, 1488, 1627, 1631, 1760], 'Gang': [564, 566, 1413, 1415, 1744], 'Dermatology,': [570, 593, 762, 1419, 1442, 1611, 1795, 1807], 'Xijing': [571, 1420, 1796], 'Hospital,': [572, 595, 619, 647, 764, 1421, 1444, 1468, 1496, 1613, 1797, 1809, 1822], 'The': [573, 706, 830, 1422, 1555, 1679, 1798, 1859, 2507, 2807, 2909, 3157, 3433, 3824], 'Fourth': [574, 1423, 1799], 'Military': [575, 1424, 1800], 'Medical': [576, 704, 828, 1425, 1553, 1677, 1801, 1857], 'University,': [577, 598, 767, 1426, 1447, 1616, 1802, 1812], "Xi'an,": [578, 1427, 1803], 'Xiang': [587, 589, 1436, 1438, 1746], 'Chen': [588, 590, 1437, 1439], 'Xiangya': [594, 763, 1443, 1612, 1808], 'Central': [596, 765, 1445, 1614, 1810], 'South': [597, 766, 1446, 1615, 1811], 'Changsha,': [599, 768, 1448, 1617, 1813], 'Hongxin': [608, 610, 1457, 1459, 1748], 'Centre': [613, 641, 1462, 1490, 1816], 'Experimental': [615, 643, 1464, 1492, 1818], 'Rujin': [618, 646, 1467, 1495, 1821], 'Medicine,': [626, 654, 698, 715, 822, 839, 1475, 1503, 1547, 1564, 1671, 1688, 1829, 1851, 1868], 'Zhugang': [636, 638, 1485, 1487, 1750], 'Florent': [664, 666, 1513, 1515, 1752], 'Ginhoux': [665, 667, 1514, 1516], 'Singapore': [668, 679, 681, 1517, 1528, 1530, 1843, 1845], 'Network': [670, 1519, 1834], '(SIgN),': [671, 1520, 1835], 'Agency': [672, 1521, 1836], 'Science,': [674, 1523, 1838], 'Technology': [675, 1524, 1839], '(A*STAR),': [678, 1527, 1842], 'City,': [680, 1529, 1844], 'Chuanjian': [689, 691, 1538, 1540, 1754], 'Lu': [690, 692, 1539, 1541], 'Guangdong': [693, 699, 817, 823, 1542, 1548, 1666, 1672, 1852], 'Provincial': [694, 700, 818, 824, 1543, 1549, 1667, 1673, 1847, 1853], 'Hospital': [695, 819, 1544, 1668, 1848], 'Academy': [701, 825, 1550, 1674, 1854], 'Sciences,': [705, 829, 1554, 1678, 1858], 'Second': [707, 831, 1556, 1680, 1860], 'Clinical': [708, 832, 1557, 1681, 1861], 'Guangzhou': [711, 835, 1560, 1684, 1864], 'Guangzhou,': [716, 840, 1565, 1689, 1869], 'Bing': [725, 727, 1574, 1576, 1756], 'Su': [726, 728, 1575, 1577], 'Honglin': [777, 781, 1626, 1630, 1759], 'Corresponding': [779, 1628], 'Author': [780, 1629, 1716], '[email': [783, 1632, 1902], 'protected]': [784, 1633, 1903], 'orcid.org/0000-0001-6302-6927': [785, 1634], 'Tumor': [846, 1695, 1875], 'Microenvironment': [847, 1696, 1876], 'Inflammation,': [849, 1698, 1878], 'Information': [1717], 'Zhu1,': [1719], 'Lou1,': [1721], 'Yin1,': [1723], 'Gao1,': [1725], 'Sun1,': [1727], 'Bai1,': [1729], 'Xu1,': [1731], 'Liu1,': [1733], 'Cai1,': [1735], 'Ke1,': [1737], 'Zhang1,': [1739], 'Zhou1,': [1741], 'Wang1,': [1743], 'Wang2,': [1745], 'Chen3,': [1747], 'Zhang4,': [1749], 'Wang4,': [1751], 'Ginhoux5,': [1753], 'Lu6,': [1755], 'Su1,3': [1757], '*,1,6,7': [1761], '1Key': [1762], '2Department': [1793], '3Department': [1805], '4Research': [1815], '5Singapore': [1832], '6Guangdong': [1846], '7Shanghai': [1871], '*Corresponding': [1889], 'author.': [1890], 'Tel:': [1891], '+86': [1892, 1898], '21': [1893, 1899], '63846590': [1894], 'ext.': [1895], '776727;': [1896], 'Fax:': [1897], '64660996;': [1900], 'E-mail:': [1901], 'EMBO': [1904], 'Mol': [1905], 'Med': [1906], '(2017)9:589-604https://doi.org/10.15252/emmm.201607027': [1907], 'PDFDownload': [1908], 'PDF': [1909], 'article': [1911], 'text': [1912], 'main': [1914], 'figures.': [1915], 'Peer': [1916], 'ReviewDownload': [1917], 'a': [1918, 1973, 2017, 2033, 2191, 2218, 2238, 2263, 2313, 2353, 2373, 2382, 2389, 2426, 2554, 2571, 2681, 2751, 2866, 3169, 3249, 3283, 3711, 3788], 'summary': [1919], 'the': [1921, 1956, 1965, 1982, 1993, 2009, 2054, 2079, 2082, 2089, 2096, 2101, 2144, 2182, 2186, 2197, 2202, 2234, 2243, 2269, 2281, 2298, 2332, 2346, 2386, 2395, 2402, 2405, 2463, 2470, 2475, 2491, 2515, 2520, 2544, 2594, 2616, 2623, 2627, 2631, 2642, 2645, 2652, 2659, 2688, 2699, 2708, 2723, 2743, 2768, 2779, 2787, 2799, 2812, 2822, 2827, 2830, 2833, 2837, 2853, 2882, 2890, 2934, 2963, 2981, 3165, 3191, 3198, 3202, 3209, 3219, 3224, 3259, 3263, 3274, 3352, 3356, 3366, 3401, 3442, 3469, 3616, 3631, 3641, 3648, 3665, 3675, 3684, 3687, 3708, 3732, 3738, 3744, 3766, 3803, 3835, 3865, 3993, 4000, 4004, 4017, 4042, 4062, 4074, 4087, 4097, 4292], 'editorial': [1922, 1926], 'decision': [1923, 1927], 'including': [1925, 2394, 2432, 2826, 3338], 'letters,': [1928], 'reviewer': [1929], 'comments': [1930], 'responses': [1933, 2085, 2393, 2648], 'to': [1934, 1937, 2008, 2012, 2053, 2137, 2142, 2175, 2279, 2312, 2338, 2411, 2458, 2543, 2549, 2593, 2672, 2698, 2714, 2767, 2817, 2880, 2938, 3162, 3190, 3382, 3447, 3840, 3890, 3999, 4133, 4184, 4296, 4299], 'feedback.': [1935], 'ToolsAdd': [1936], 'favoritesDownload': [1938], 'CitationsTrack': [1939], 'CitationsPermissions': [1940], 'ShareFacebookTwitterLinked': [1941], 'InMendeleyWechatReddit': [1942], 'Figures': [1943], '&': [1944, 2416, 2849, 3177], 'Info': [1945], 'Abstract': [1946], 'Retinoic': [1947], 'acid': [1948], 'inducible-gene': [1949], 'I': [1950, 2399], '(RIG-I)': [1951], 'functions': [1952], 'as': [1953, 1972, 2217, 2352, 2365, 2372, 2865, 2966, 2984, 3097, 3472, 3831, 3868, 4059, 4291, 4304], 'one': [1954], 'major': [1957, 2383, 3170], 'sensors': [1958, 2843], 'RNA': [1960], 'viruses.': [1961], 'DDX58,': [1962, 2859], 'which': [1963, 2370, 2860, 3167], 'encodes': [1964], 'protein,': [1967], 'has': [1968, 2214, 2349, 2861], 'been': [1969, 2215, 2350, 2862], 'newly': [1970, 2863], 'identified': [1971, 2864], 'susceptibility': [1974, 2355, 2867], 'gene': [1975, 2356, 2868], 'in': [1976, 2002, 2022, 2039, 2069, 2081, 2100, 2119, 2124, 2128, 2158, 2167, 2189, 2199, 2242, 2246, 2257, 2331, 2385, 2440, 2469, 2490, 2529, 2559, 2577, 2606, 2626, 2638, 2644, 2663, 2677, 2687, 2718, 2725, 2754, 2765, 2778, 2798, 2869, 2886, 2889, 2915, 2921, 2967, 2985, 3038, 3066, 3098, 3112, 3174, 3197, 3228, 3233, 3258, 3273, 3287, 3309, 3318, 3374, 3394, 3473, 3514, 3540, 3579, 3622, 3714, 3718, 3737, 3743, 3797, 3832, 3869, 3913, 3933, 3958, 3985, 4016, 4041, 4073, 4096, 4114, 4129, 4156, 4178, 4208, 4239, 4255], 'psoriasis.': [1977, 2104, 2138, 2535, 2664, 2895, 3379, 4107], 'Here,': [1978, 2447], 'we': [1979, 2456, 2482, 2583, 2692, 2875, 3239, 3313, 3626, 3662, 3729, 3977, 4054], 'show': [1980, 2483, 3764], 'that': [1981, 2078, 2222, 2276, 2484, 2531, 2538, 2585, 2615, 2641, 2707, 2742, 2786, 3188, 3213, 3241, 3323, 3351, 3664, 3731, 3765, 3979, 4056, 4086], 'activation': [1983, 2387, 2403, 2508, 2516, 3163, 3225, 3369, 3767], '5′ppp-dsRNA,': [1987, 3668, 3787], 'its': [1988, 3773], 'synthetic': [1989, 3775, 3789], 'ligand,': [1990], 'directly': [1991, 2513], 'causes': [1992, 2514], 'IL-23': [1996, 2007, 2014, 2048, 2118, 2152, 2163, 2170, 2213, 2260, 2300, 2329, 2473, 2524, 2542, 2551, 2588, 2624, 2670, 2697, 2712, 2749, 2795, 3214, 3247, 3253, 3264, 3281, 3300, 3316, 3372, 3417, 3525, 4245], 'triggers': [1998, 2111, 2151, 2328, 2438, 2526, 3609, 3793], 'mice.': [2003, 2027, 2704, 3320], 'Repeated': [2004], 'injections': [2005, 2540, 2695, 3243, 3317], 'ears': [2010, 2545, 2678, 2700, 2746, 2964, 2982, 3200, 3245, 3402, 3470, 3649, 3746, 3804, 3866, 3888, 4240, 4256], 'failed': [2011, 2713], 'induce': [2013, 2550, 2715], 'full': [2018, 2034, 2555, 2572, 2719], 'phenotype,': [2021, 2558], 'either': [2023], 'germ-free': [2024, 2560, 2702, 2922], 'or': [2025, 2423, 2920, 2928, 3016, 3050, 3636, 4216, 4244, 4258], 'RIG-I-deficient': [2026], 'is': [2029, 2172, 2261, 2301, 2341, 2467, 2487, 2567, 2590, 2620, 2811, 2856, 3168, 3215, 3282, 3301, 3360, 3392, 3778, 4093, 4112], 'also': [2030, 2262, 2568, 3696, 4039], 'critical': [2031, 2569], 'development': [2035, 2476, 2573, 3304], 'inflammation': [2038, 2528, 2576, 2637, 2662, 2676, 2907, 3308, 3332, 3709, 3796], 'imiquimod': [2040, 2451], '(IMQ)-induced': [2041, 2452], 'mouse': [2043, 2159, 2454, 2505, 2580, 2745, 2892, 3311, 3376, 3745, 3963, 4048, 4104, 4119], 'model.': [2044, 2506, 2581], 'Furthermore,': [2045, 2582, 2764, 4033], 'RIG-I-mediated': [2046, 2169, 2464, 2586, 2617, 3158, 3619], 'endogenous': [2047, 2587, 3297, 3371], 'was': [2050, 2362, 2796, 3982, 3997, 4013, 4067], 'mainly': [2051, 2173, 2302, 2591], 'confined': [2052, 2174, 2592, 3998], 'CD11c+': [2055, 2120, 2595], 'dendritic': [2056, 2308, 2596], 'cells': [2057, 2275, 2309, 2597, 2774, 3007, 3065, 3539, 3932, 4007, 4177], '(DCs)': [2058, 2598], 'via': [2059, 2599, 2821], 'nuclear': [2060, 2406], 'factor-kappa': [2061, 2407], 'B': [2062, 2408], '(NF-κB)': [2063, 2409], 'signaling,': [2064, 2115, 2601], 'stimulated': [2066], 'expression': [2068, 2166, 2171, 2486, 2605, 3094, 3187, 3220, 3272, 3733, 3957, 3981, 4012, 4111, 4128, 4207, 4238, 4254, 4268], 'an': [2070, 2366, 2607, 2716], 'auto-regulatory': [2071, 2608], 'feedback': [2072, 2609], 'loop.': [2073, 2610], 'Thus,': [2074], 'our': [2075, 2612, 3348], 'data': [2076, 2613, 3140, 3349, 3762, 4084], 'suggest': [2077, 3350, 4085], 'dysregulation': [2080, 2643], 'immune': [2084, 2368, 2647, 2809, 3358], 'hosts': [2087, 2650], 'through': [2088, 2651], 'innate': [2090, 2367, 2653, 2685, 2808, 3357], 'pattern': [2091, 2654, 2823], 'recognition': [2092, 2655, 2824], 'receptors': [2093, 2656, 2825], 'may': [2094, 2657], 'trigger': [2095], 'inflammatory': [2098, 2193, 2759, 4006], 'conditions': [2099, 2727, 2733, 2919, 2924], 'pathophysiology': [2102], 'Synopsis': [2105], 'In': [2106, 2297], 'predisposed': [2107, 2337, 2442], 'individuals,': [2108], 'virus': [2109], 'infection': [2110], 'TLR-7/8': [2112], 'and/or': [2113, 2306], 'subsequently': [2116], 'induces': [2117], 'DCs': [2121, 2628], 'mutations': [2123], 'certain': [2125], 'genes': [2126], 'resulting': [2127], 'impaired': [2129], 'regulation': [2130], 'NF-κB': [2132, 2518, 2600, 3227, 3368], 'proinflammatory': [2133, 2413, 3171, 3285], 'activity,': [2134], 'thereby': [2135], 'leading': [2136], 'Germ-free': [2139, 2666, 2898], 'mice': [2140, 2530, 2667, 2724, 2781, 2899, 2914, 3012, 3046, 3204, 3235, 3276, 3325, 3396, 3405, 3410, 3440, 3490, 3522, 3548, 3653, 3720, 3798, 3829, 4212], 'fail': [2141, 2671], 'develop': [2143, 2339, 2673], 'IL-23-induced': [2145, 2891, 2904, 3310, 3375, 3388, 4021], 'phenotype.': [2147], 'response': [2150, 2619, 3160], 'production.': [2153], 'Development': [2154], 'phenotype': [2157], 'models': [2160, 3964, 4105], 'requires': [2161], 'RIG-I.': [2162], 'stimulates': [2164, 2603], 'DCs.': [2168, 2176], 'Introduction': [2177], 'Recent': [2178], 'studies': [2179], 'have': [2180], 'highlighted': [2181], 'pathogenic': [2183], 'role': [2184, 2384, 2683, 2883], 'IL-23/Th17': [2187], 'axis': [2188], 'psoriasis,': [2190, 2691, 3991], 'chronic': [2192, 2660], 'disorder': [2195], 'affecting': [2196], '1–3%': [2200], 'general': [2203], 'population': [2204, 2443], '(Nestle': [2205], 'et': [2206, 2210, 2249, 2253, 2290, 2294, 2319, 2323, 2358, 2845, 2872, 3291], 'al,': [2207, 2211, 2250, 2254, 2291, 2295, 2320, 2324, 2359, 2846, 2873, 3292], '2009;': [2208, 2847], 'Lowes': [2209], '2013).': [2212, 2296], 'demonstrated': [2216, 3663], 'key': [2219], 'master': [2220], 'cytokine': [2221], 'promotes': [2223], 'T': [2224], 'helper': [2225], '17': [2226], '(Th17)': [2227], 'cell': [2228, 3716], 'survival': [2229, 2270], 'proliferation,': [2231], 'targeting': [2233], 'IL-23p19': [2235, 3105, 3572], 'subunit': [2236], 'with': [2237, 2669, 2729, 2748, 2783, 2926, 3014, 3048, 3206, 3246, 3334, 3416, 3492, 3524, 3550, 3630, 3640, 3693, 3700, 3722, 3748, 3752, 3808, 3990, 4070, 4162, 4214, 4242, 4260], 'monoclonal': [2239], 'antibody': [2240], 'results': [2241], 'clinical': [2244], 'improvement': [2245], 'psoriasis': [2247, 2340, 2354, 2439, 2496, 2870, 3175, 3288, 3962, 4118], '(Zheng': [2248], '2007;': [2251], 'Kopp': [2252], '2015).': [2255, 3293], 'However,': [2256], 'psoriatic': [2258, 2287, 2887, 4076, 4130, 4159, 4181, 4273], 'lesions,': [2259], 'potent': [2264], 'factor': [2266, 3286], 'promoting': [2268], 'proliferation': [2272, 2789], 'Th17': [2274], 'release': [2277], 'IL-29': [2278], 'simulate': [2280], 'secretion': [2282], 'proteins': [2285], 'keratinocytes': [2288, 2317, 2792, 4002], '(Lowes': [2289], '2013;': [2292], 'Wolk': [2293], 'skin,': [2299], 'produced': [2303], 'tissue-resident': [2305], 'recruited': [2307], '(DCs),': [2310], 'lesser': [2314], 'extent,': [2315], '(Lee': [2318], '2004;': [2321], 'Piskin': [2322], '2006).': [2325], 'Yet': [2326], 'what': [2327, 2436], 'individuals': [2335], 'genetically': [2336, 2441], 'still': [2342], 'unclear.': [2343], 'DDX58': [2344], 'encoding': [2345], 'protein': [2348, 2379, 2855, 3110, 3256, 3577, 4027, 4036], 'suggested': [2351], '(Nair': [2357, 2871], '2009).': [2360], 'initially': [2363], 'reported': [2364], 'receptor,': [2369], 'acts': [2371], 'cytoplasmic': [2374], 'sensor': [2375], 'viral': [2377], 'RNA-binding': [2378], 'plays': [2381], 'cascade': [2390], 'induction': [2396], 'type': [2398], 'interferons': [2400], 'produce': [2412], 'cytokines': [2414], '(Loo': [2415, 3176], 'Gale,': [2417, 3178], '2011).': [2418, 3179], 'Psoriasis': [2419], 'can': [2420], 'be': [2421], 'exacerbated': [2422], 'provoked': [2424], 'variety': [2427], 'different': [2429], 'environmental': [2430], 'factors,': [2431], 'infections.': [2433], 'So': [2434], 'far,': [2435], 'infection(s)': [2437], 'remains': [2444], 'poorly': [2445], 'understood.': [2446], 'using': [2448], 'IL-23-': [2449, 2501, 2632], 'model,': [2455, 3312], 'sought': [2457], 'investigate': [2459, 3295, 3615], 'whether': [2460, 3296], 'how': [2462], 'involved': [2468, 3173], 'lesions.': [2480], 'Here': [2481], 'markedly': [2488, 3184, 3673, 4014], 'increased': [2489, 3674, 3698, 3742, 3984, 4034, 4113], 'affected': [2492, 4018], 'derived': [2494, 3041, 3118, 3517, 3543, 3585, 3915], 'from': [2495, 2499, 2903, 3042, 3119, 3518, 3544, 3586, 3916], 'patients': [2497, 3966, 3989, 4101, 4122], 'both': [2500, 4024], 'IMQ-induced': [2503, 2578, 2634, 4046], '5′ppp-dsRNA': [2512, 3608, 3628, 3637, 3694, 3749, 3777], 'subsequent': [2521, 3367], 'cutaneous': [2527], 'closely': [2532, 4068], 'resembles': [2533], 'human': [2534, 4075], 'We': [2536, 2705, 3321], 'demonstrate': [2537], 'repeated': [2539, 2694, 3242, 3315], 'are': [2546, 2900, 2931, 2943, 2989, 3020, 3071, 3124, 3141, 3452, 3496, 3554, 3591, 3845, 3895, 3938, 4138, 4189, 4220, 4281], 'not': [2547, 3232, 3270, 3670], 'able': [2548], 'knockout': [2563], 'mice,': [2564, 2639, 2770, 3211, 3230, 3261, 3337], 'identify': [2584], 'Therefore,': [2611], 'indicate': [2614], 'pivotal': [2621], 'highlighting': [2640], 'initiate': [2658], 'Results': [2665], 'injected': [2668, 3627, 3692], 'To': [2679, 3294, 3613], 'study': [2680, 2881], 'potential': [2682], 'immunity': [2686], 'etiology': [2689], 'performed': [2693, 3314], '(GF)': [2703, 2923], 'found': [2706, 3240, 3322, 4040], 'intradermal': [2709, 3414, 3806], 'injection': [2710, 3265, 3415, 3666, 3807], 'increase': [2717, 3251, 3713], 'ear': [2720, 2910, 3067, 3115, 3339, 3434, 3515, 3541, 3582, 3690, 3825, 3934, 4209], 'thickness': [2721, 2911, 3340, 3435, 3685, 3826], 'GF': [2726, 2744, 2780, 3011, 3045, 3203, 3234, 3275], 'compared': [2728, 3205, 3333, 3699, 3721, 3751, 4132, 4161, 4183], 'specific': [2730, 2916, 3774], 'pathogen-free': [2731, 2917], '(SPF)': [2732, 2918], '(Fig': [2734, 2762, 2803, 3236, 3277, 3345, 3681, 3703, 3726, 3756, 4008, 4029, 4050, 4078], '1A).': [2735], 'Hematoxylin': [2736], 'eosin': [2738], '(H&E)': [2739], 'staining': [2740, 2961, 3467, 3863], 'confirmed': [2741], 'administrated': [2747], 'showed': [2750], 'robust': [2752], 'decrease': [2753], 'epidermal': [2755, 4001], 'acanthosis': [2756, 3688, 4072, 4270], 'dermal': [2758, 3005, 3715, 3884, 4005], 'cellular': [2760, 3885], 'infiltration': [2761, 3717], '1B–D).': [2763], 'contrast': [2766], 'SPF': [2769, 3009, 3043, 3210, 3229, 3260], 'numbers': [2771], 'Ki67+': [2773, 3064, 3538, 3931], 'were': [2775, 3695, 3740, 4038], 'significantly': [2776, 3697, 3741, 3983], 'decreased': [2777, 3185], 'treated': [2782, 2925, 2965, 2983, 3013, 3047, 3471, 3491, 3523, 3549, 3747, 3830, 3867, 4213, 4241, 4259], 'IL-23,': [2784, 3051, 3268], 'indicating': [2785], 'excessive': [2788], 'basal': [2791], 'induced': [2793, 3248], 'reduced': [2797], 'absence': [2800], 'microbiota': [2802, 3353], '1E': [2804], 'F).': [2806], 'system': [2810, 3359], 'first': [2813], 'line': [2814], 'defense': [2816], 'combat': [2818], 'invading': [2819], 'microbes': [2820], 'Toll-like': [2828], 'receptors,': [2829, 2832, 2836, 2839], 'NOD-like': [2831], 'C-type': [2834], 'lectin': [2835], 'RIG-I-like': [2838], 'cytosolic': [2841], 'DNA': [2842], '(Hornung': [2844], 'Takeuchi': [2848], 'Akira,': [2850], '2010).': [2851], 'Because': [2852], 'encoded': [2857], '2009),': [2874], 'here': [2876, 3381], 'set': [2877], 'up': [2878], 'experiments': [2879], 'pathology': [2888], 'model': [2893, 3377, 4022, 4049, 4120], 'Figure': [2896, 3150, 3386, 3785, 4108], '1.': [2897], 'almost': [2901], 'protected': [2902], 'A.': [2908, 3397, 3799], 'WT': [2913, 3404, 3437, 3487, 3519, 3545, 3828], 'PBS': [2927, 3015, 3049, 4215, 4243], 'IL-23.': [2929, 3017, 3493, 3551, 4217], 'Data': [2930, 3148, 4286], 'presented': [2932, 3445], 'on': [2933, 3420, 3441, 3654, 3811, 3834], 'indicated': [2935, 3120, 3443, 3587, 3809, 3836, 3891, 3917, 4060, 4303], 'day': [2936, 2939, 3423, 3444, 3448, 3657, 3814, 3837, 3841], 'relative': [2937, 3446, 3839, 4298], '0.': [2940, 3449, 3842], 'Significant': [2941, 2987, 3018, 3069, 3122, 3450, 3494, 3552, 3589, 3843, 3893, 3936, 4136, 4187, 4218, 4279], 'differences': [2942, 2988, 3019, 3070, 3123, 3451, 3495, 3553, 3590, 3844, 3894, 3937, 4137, 4188, 4219, 4280], 'indicated:': [2944, 2990, 3021, 3072, 3125, 3453, 3497, 3555, 3592, 3846, 3896, 3939, 4139, 4190, 4221, 4282], 'P': [2945, 3847], '<': [2946, 3848], '0.0001,': [2947, 3849], 'one-way': [2948, 3454, 3850], 'ANOVA,': [2949, 3455, 3851], 'n': [2950, 2969, 2994, 3025, 3052, 3076, 3129, 3427, 3456, 3475, 3501, 3526, 3559, 3596, 3818, 3852, 3871, 3900, 3919, 3943, 4143, 4165, 4194, 4225], '=': [2951, 2970, 2995, 3026, 3053, 3077, 3130, 3428, 3457, 3476, 3502, 3527, 3560, 3597, 3819, 3853, 3872, 3901, 3920, 3944, 4144, 4166, 4195, 4226, 4247, 4263, 4277], '6–9': [2952, 2971, 2996, 3027, 3054, 3078], 'per': [2953, 2972, 2997, 3028, 3055, 3079, 3132, 3430, 3459, 3478, 3504, 3529, 3562, 3599, 3821, 3855, 3874, 3903, 3922, 3946, 4146, 4168, 4197, 4228], 'group': [2954, 2998, 3029, 3080, 3133, 3460, 3505, 3563, 3600, 3856, 3904, 3947, 4147, 4198, 4229], '(mean': [2955, 2999, 3030, 3081, 3134, 3461, 3506, 3564, 3601, 3857, 3905, 3948, 4148, 4199, 4230], '±': [2956, 3000, 3031, 3082, 3135, 3462, 3507, 3565, 3602, 3858, 3906, 3949, 4149, 4200, 4231], 'SEM).': [2957, 3001, 3032, 3083, 3463, 3508, 3566, 3603, 3859, 3907, 3950, 4150, 4201, 4232], 'B.': [2958, 3432, 3823], 'Representative': [2959, 3034, 3398, 3465, 3510, 3800, 3861, 3909, 4151], 'H&E': [2960, 3466, 3862], '(A),': [2968, 3474, 3870], 'group.': [2973, 3056, 3431, 3479, 3530, 3822, 3875, 3923, 4169], 'Scale': [2974, 3057, 3480, 3531, 3876, 3924, 4170], 'bar:': [2975, 3058, 3481, 3532, 3877, 3925, 4171], '50': [2976, 3059, 3482, 3533, 3878], 'μm.': [2977, 3060, 3483, 3534, 3879, 3927, 4173], 'C.': [2978, 3464, 3860], 'Acanthosis': [2979, 3485, 3882], '(A).': [2986, 3099], 'two-tailed': [2991, 3022, 3073, 3126, 3498, 3556, 3593, 3897, 3940, 4140, 4191, 4222], "Student's": [2992, 3023, 3074, 3127, 3499, 3557, 3594, 3898, 3941, 4141, 4192, 4223], 't-test,': [2993, 3024, 3075, 3128, 3500, 3558, 3595, 3899, 3942, 4142, 4193, 4224], 'D.': [3002, 3484], 'Numbers': [3003], 'infiltrating': [3006], 'E.': [3033, 3509, 3881], 'immunostaining': [3035, 3511, 3910], 'Ki67': [3037, 3513, 3736, 3912], 'lesional': [3039, 3959, 3986, 4043, 4115], 'F.': [3061, 3535, 3908], 'Quantitation': [3062, 3536, 3929, 4174], 'skin.': [3068, 3935, 4186], 'G.': [3084, 3928], 'Western': [3085, 3180, 4233, 4249], 'blot': [3086, 3181, 4234, 4250], 'analysis': [3087, 3103, 3182, 3706, 4124, 4203, 4235, 4251], 'phosphorylated': [3091, 3195], 'IκBα': [3092, 3196], '(p-IκBα)': [3093], 'after': [3095, 3413, 3805], 'treatment': [3096, 3755], 'H,': [3100], 'I.': [3101], 'ELISA': [3102, 3569], '(H)': [3106, 3576], 'IL-17': [3108, 3255, 3271, 3575], '(I)': [3109], 'levels': [3111, 3193, 3257, 3578, 3734, 4028, 4037], 'supernatants': [3113, 3580], 'homogenates': [3117, 3584], 'groups.': [3121, 3588], '3–8': [3131], 'SEM),': [3136], 'U.D.,': [3137], 'undetected.': [3138], 'available': [3142], 'online': [3143], 'figure.': [3146, 3385], '1': [3151], '[emmm201607027-sup-0004-SDataFig1.pdf]': [3152], 'Download': [3153, 3155, 3604, 3606, 3951, 3953], 'figure': [3154, 3605, 3952], 'PowerPoint': [3156, 3607, 3954], 'leads': [3161], 'NF-κB,': [3166], 'pathway': [3172], 'revealed': [3183, 3710], 'corresponded': [3189], 'diminished': [3192], 'IL-23-treated': [3199], 'those': [3207], 'suggesting': [3212], 'capable': [3216, 3779], 'triggering': [3218, 3781], 'but': [3231, 3269, 3669], '1G).': [3237], 'Moreover,': [3238, 3728], 'profound': [3250], 'whereas': [3262], 'slightly': [3266], 'triggered': [3267], '1H': [3278], 'I).': [3280], 'crucial': [3284], 'pathogenesis': [3289], '(Kopp': [3290], 'essential': [3302], 'IL-23−/−': [3319, 3324, 3395, 3409, 3439, 3489, 3521, 3547], 'exhibited': [3326], 'less': [3327], 'severity': [3328], 'wild-type': [3335, 3651], '(WT)': [3336, 3652], 'other': [3342, 3422, 3813], 'features': [3344], 'EV1).': [3346, 4082], 'Together,': [3347, 3760], 'recognized': [3354], 'required': [3361], 'expression,': [3364, 4058], 'Click': [3380], 'expand': [3383], 'EV1.': [3387], 'ameliorated': [3393], 'photographs': [3399, 3801], '(left': [3406], 'panel)': [3407, 3412], '(right': [3411], '(500': [3418], 'ng)': [3419], 'every': [3421, 3655, 3812], '8': [3425], 'times,': [3426, 3817], '6': [3429, 3458, 3477, 3503, 3528, 3561], 'G,': [3567], 'H.': [3568], 'detection': [3570, 4153], '(G)': [3573], '3–5': [3598], 'specifically': [3614], 'contribution': [3617], 'inflammation,': [3625], '(complexed': [3629, 3639], 'cationic': [3632, 3642], 'lipid': [3633, 3643], 'LyoVec™,': [3634, 3644], '5′ppp-dsRNA)': [3635], 'control': [3638, 4300], 'dsRNA': [3645, 3671, 3701, 3723, 3753], 'Ctr)': [3646], 'into': [3647], 'second': [3656], '2': [3659], 'weeks.': [3660], 'Strikingly,': [3661], 'Ctr,': [3672], 'formation': [3676], 'demarcated': [3678], 'erythematous': [3679], 'plaques': [3680], '2A).': [3682], 'Correspondingly,': [3683], 'Ctr': [3702, 3754], '2B–D).': [3704], 'Histological': [3705], 'significant': [3712], '5′ppp-dsRNA-treated': [3719], 'Ctr-treated': [3724], 'controls': [3725], '2E).': [3727], 'detected': [3730, 3978], 'epidermis': [3739], 'when': [3750], '2F': [3757], 'G).': [3759], 'these': [3761], 'clearly': [3763], 'ligand': [3776, 3790], 'inflammation.': [3784], '2.': [3786], 'RIG-I,': [3792], 'administration': [3810], 'eight': [3816], '4–5': [3820, 3854, 3873, 3902, 3921, 3945], '(A)': [3833], 'expressed': [3838, 4290], 'D,': [3880], 'infiltrates': [3886], 'subjected': [3889], 'administration.': [3892], 'groups,': [3918], '20': [3926, 4172], 'Increased': [3955], 'By': [3967], 'quantitative': [3968], 'real-time': [3969], 'polymerase': [3970], 'chain': [3971], 'reaction': [3972], '(qPCR)': [3973], 'immunohistochemistry': [3975], 'analysis,': [3976], 'up-regulation': [3994], '3A–C).': [4009], 'Consistently,': [4010], 'enhanced': [4015], 'at': [4023], 'mRNA': [4025, 4127, 4206, 4295], '3D': [4030], 'E).': [4032], '3F).': [4051], 'More': [4052], 'importantly,': [4053], 'observed': [4055], 'histological': [4063], 'score': [4064], '(H': [4065], 'score),': [4066], 'correlated': [4069], 'lesions': [4077, 4099, 4131, 4160], '3G': [4079], 'Table': [4081], 'These': [4083], 'mediated': [4090], 'highly': [4094], 'activated': [4095], 'two': [4103], '3.': [4109], 'qPCR': [4123, 4202, 4288], 'healthy': [4134, 4163, 4185], 'samples.': [4135], '10–13': [4145], 'immunohistochemical': [4152], 'samples,': [4164, 4301], '5': [4167, 4196], 'RIG-I+': [4176], 'dermis': [4179], '11': [4227], '(n': [4246, 4262], '3).': [4248], 'untreated': [4257], 'IMQ': [4261], '4).': [4264], 'Correlation': [4265], 'between': [4266], '84': [4272], 'samples': [4275], '(r2': [4276], '0.3577).': [4278], 'Pearson': [4283], 'test,': [4284], 'two-tailed.': [4285], 'information:': [4287], 'values': [4289], 'ratio': [4293], 'β-actin,': [4297], 'fold': [4305], 'ch': [4306]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2604840810', 'counts_by_year': [{'year': 2024, 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