Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2604645819', 'doi': 'https://doi.org/10.18632/oncotarget.16847', 'title': 'Migration pattern, actin cytoskeleton organization and response to PI3K-, mTOR-, and Hsp90-inhibition of glioblastoma cells with different invasive capacities', 'display_name': 'Migration pattern, actin cytoskeleton organization and response to PI3K-, mTOR-, and Hsp90-inhibition of glioblastoma cells with different invasive capacities', 'publication_year': 2017, 'publication_date': '2017-04-05', 'ids': {'openalex': 'https://openalex.org/W2604645819', 'doi': 'https://doi.org/10.18632/oncotarget.16847', 'mag': '2604645819', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28424411', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5542187'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.16847', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=16847&path%5B%5D=53905', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=16847&path%5B%5D=53905', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5031512659', 'display_name': 'Simon Memmel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210126310', 'display_name': 'Universitätsklinikum Würzburg', 'ror': 'https://ror.org/03pvr2g57', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126310']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Simon Memmel', 'raw_affiliation_strings': ['Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany', 'institution_ids': ['https://openalex.org/I4210126310']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091806326', 'display_name': 'Vladimir L. Sukhorukov', 'orcid': 'https://orcid.org/0000-0003-1459-6792'}, 'institutions': [{'id': 'https://openalex.org/I4210126310', 'display_name': 'Universitätsklinikum Würzburg', 'ror': 'https://ror.org/03pvr2g57', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126310']}, {'id': 'https://openalex.org/I25974101', 'display_name': 'University of Würzburg', 'ror': 'https://ror.org/00fbnyb24', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I25974101']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Dmitri Sisario', 'raw_affiliation_strings': ['Department of Biotechnology and Biophysics, University of Würzburg, Würzburg, Germany', 'Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany', 'institution_ids': ['https://openalex.org/I4210126310']}, {'raw_affiliation_string': 'Department of Biotechnology and Biophysics, University of Würzburg, Würzburg, Germany', 'institution_ids': ['https://openalex.org/I25974101']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072187751', 'display_name': 'Caren Zöller', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210126310', 'display_name': 'Universitätsklinikum Würzburg', 'ror': 'https://ror.org/03pvr2g57', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126310']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Caren Zöller', 'raw_affiliation_strings': ['Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany', 'institution_ids': ['https://openalex.org/I4210126310']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037108285', 'display_name': 'V. Fiedler', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210126310', 'display_name': 'Universitätsklinikum Würzburg', 'ror': 'https://ror.org/03pvr2g57', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126310']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Vanessa Fiedler', 'raw_affiliation_strings': ['Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany', 'institution_ids': ['https://openalex.org/I4210126310']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054433502', 'display_name': 'Astrid Katzer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210126310', 'display_name': 'Universitätsklinikum Würzburg', 'ror': 'https://ror.org/03pvr2g57', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126310']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Astrid Katzer', 'raw_affiliation_strings': ['Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany', 'institution_ids': ['https://openalex.org/I4210126310']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009351070', 'display_name': 'Robin Heiden', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210126310', 'display_name': 'Universitätsklinikum Würzburg', 'ror': 'https://ror.org/03pvr2g57', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126310']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Robin Heiden', 'raw_affiliation_strings': ['Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany', 'institution_ids': ['https://openalex.org/I4210126310']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086927335', 'display_name': 'Nicholas Becker', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210126310', 'display_name': 'Universitätsklinikum Würzburg', 'ror': 'https://ror.org/03pvr2g57', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126310']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Nicholas Becker', 'raw_affiliation_strings': ['Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany', 'institution_ids': ['https://openalex.org/I4210126310']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075818116', 'display_name': 'Lorenz Eing', 'orcid': 'https://orcid.org/0000-0002-1902-7428'}, 'institutions': [{'id': 'https://openalex.org/I25974101', 'display_name': 'University of Würzburg', 'ror': 'https://ror.org/00fbnyb24', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I25974101']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Lorenz Eing', 'raw_affiliation_strings': ['Department of Biotechnology and Biophysics, University of Würzburg, Würzburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biophysics, University of Würzburg, Würzburg, Germany', 'institution_ids': ['https://openalex.org/I25974101']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054191045', 'display_name': 'Fábio Luiz Rogé Ferreira', 'orcid': 'https://orcid.org/0000-0003-1672-1956'}, 'institutions': [{'id': 'https://openalex.org/I4210126310', 'display_name': 'Universitätsklinikum Würzburg', 'ror': 'https://ror.org/03pvr2g57', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126310']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Fábio L.R. Ferreira', 'raw_affiliation_strings': ['Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany', 'institution_ids': ['https://openalex.org/I4210126310']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027494826', 'display_name': 'Heiko Zimmermann', 'orcid': 'https://orcid.org/0000-0001-8595-1304'}, 'institutions': [{'id': 'https://openalex.org/I4210152467', 'display_name': 'Fraunhofer Institute for Biomedical Engineering', 'ror': 'https://ror.org/05tpsgh61', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210152467', 'https://openalex.org/I4923324']}, {'id': 'https://openalex.org/I91712215', 'display_name': 'Saarland University', 'ror': 'https://ror.org/01jdpyv68', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I91712215']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Heiko Zimmermann', 'raw_affiliation_strings': ['Fraunhofer-Institut für Biomedizinische Technik, Sulzbach, Germany', 'Molekulare und Zelluläre Biotechnologie/Nanotechnologie, Universität des Saarlandes, Saarbrücken, Germany'], 'affiliations': [{'raw_affiliation_string': 'Fraunhofer-Institut für Biomedizinische Technik, Sulzbach, Germany', 'institution_ids': ['https://openalex.org/I4210152467']}, {'raw_affiliation_string': 'Molekulare und Zelluläre Biotechnologie/Nanotechnologie, Universität des Saarlandes, Saarbrücken, Germany', 'institution_ids': ['https://openalex.org/I91712215']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006887252', 'display_name': 'Markus Sauer', 'orcid': 'https://orcid.org/0000-0002-1692-3219'}, 'institutions': [{'id': 'https://openalex.org/I25974101', 'display_name': 'University of Würzburg', 'ror': 'https://ror.org/00fbnyb24', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I25974101']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Markus Sauer', 'raw_affiliation_strings': ['Department of Biotechnology and Biophysics, University of Würzburg, Würzburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biophysics, University of Würzburg, Würzburg, Germany', 'institution_ids': ['https://openalex.org/I25974101']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046756579', 'display_name': 'Michael Flentje', 'orcid': 'https://orcid.org/0000-0002-9463-4535'}, 'institutions': [{'id': 'https://openalex.org/I4210126310', 'display_name': 'Universitätsklinikum Würzburg', 'ror': 'https://ror.org/03pvr2g57', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126310']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Michael Flentje', 'raw_affiliation_strings': ['Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany', 'institution_ids': ['https://openalex.org/I4210126310']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091806326', 'display_name': 'Vladimir L. Sukhorukov', 'orcid': 'https://orcid.org/0000-0003-1459-6792'}, 'institutions': [{'id': 'https://openalex.org/I25974101', 'display_name': 'University of Würzburg', 'ror': 'https://ror.org/00fbnyb24', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I25974101']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Vladimir L. Sukhorukov', 'raw_affiliation_strings': ['Department of Biotechnology and Biophysics, University of Würzburg, Würzburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biophysics, University of Würzburg, Würzburg, Germany', 'institution_ids': ['https://openalex.org/I25974101']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5009855159', 'display_name': 'Cholpon S. Djuzenova', 'orcid': 'https://orcid.org/0000-0002-0769-2455'}, 'institutions': [{'id': 'https://openalex.org/I4210126310', 'display_name': 'Universitätsklinikum Würzburg', 'ror': 'https://ror.org/03pvr2g57', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126310']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Cholpon S. Djuzenova', 'raw_affiliation_strings': ['Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, University Hospital of Würzburg, Würzburg, Germany', 'institution_ids': ['https://openalex.org/I4210126310']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.209, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 29, 'citation_normalized_percentile': {'value': 0.864792, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '8', 'issue': '28', 'first_page': '45298', 'last_page': '45310'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12859', 'display_name': 'Advanced Techniques in Bioimage Analysis and Microscopy', 'score': 0.9899, 'subfield': {'id': 'https://openalex.org/subfields/1304', 'display_name': 'Biophysics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12859', 'display_name': 'Advanced Techniques in Bioimage Analysis and Microscopy', 'score': 0.9899, 'subfield': {'id': 'https://openalex.org/subfields/1304', 'display_name': 'Biophysics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10782', 'display_name': 'Nanotechnology and Imaging for Cancer Therapy and Diagnosis', 'score': 0.9897, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10129', 'display_name': 'Gliomas', 'score': 0.9892, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/glioblastoma', 'display_name': 'Glioblastoma', 'score': 0.547909}, {'id': 'https://openalex.org/keywords/brain-tumor-epidemiology', 'display_name': 'Brain Tumor Epidemiology', 'score': 0.503001}], 'concepts': [{'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.66169894}, {'id': 'https://openalex.org/C2776194525', 'wikidata': 'https://www.wikidata.org/wiki/Q282142', 'display_name': 'Glioblastoma', 'level': 2, 'score': 0.5901282}, {'id': 'https://openalex.org/C2993400109', 'wikidata': 'https://www.wikidata.org/wiki/Q329638', 'display_name': 'Actin cytoskeleton', 'level': 4, 'score': 0.5620277}, {'id': 'https://openalex.org/C2777609662', 'wikidata': 'https://www.wikidata.org/wiki/Q416356', 'display_name': 'PTEN', 'level': 4, 'score': 0.46796805}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.45047766}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4374442}, {'id': 'https://openalex.org/C142669718', 'wikidata': 'https://www.wikidata.org/wiki/Q154626', 'display_name': 'Cytoskeleton', 'level': 3, 'score': 0.41146785}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.32978073}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32642826}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.31394273}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2691937}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.23163477}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.17479455}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003599', 'descriptor_name': 'Cytoskeleton', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018841', 'descriptor_name': 'HSP90 Heat-Shock Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008841', 'descriptor_name': 'Actin Cytoskeleton', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008841', 'descriptor_name': 'Actin Cytoskeleton', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003599', 'descriptor_name': 'Cytoskeleton', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005663', 'descriptor_name': 'Furans', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005663', 'descriptor_name': 'Furans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018841', 'descriptor_name': 'HSP90 Heat-Shock Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018841', 'descriptor_name': 'HSP90 Heat-Shock Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007555', 'descriptor_name': 'Isoxazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007555', 'descriptor_name': 'Isoxazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000081082', 'descriptor_name': 'Phosphoinositide-3 Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012118', 'descriptor_name': 'Resorcinols', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D012118', 'descriptor_name': 'Resorcinols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.16847', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=16847&path%5B%5D=53905', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5542187', 'pdf_url': 'https://europepmc.org/articles/pmc5542187?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542187', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-170719', 'pdf_url': 'https://opus.bibliothek.uni-wuerzburg.de/files/17071/057_Memmel_ONCOTARGET.pdf', 'source': {'id': 'https://openalex.org/S4306401635', 'display_name': 'Online Publication Service of Würzburg University (Würzburg University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I25974101', 'host_organization_name': 'University of Würzburg', 'host_organization_lineage': ['https://openalex.org/I25974101'], 'host_organization_lineage_names': ['University of Würzburg'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28424411', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.16847', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=16847&path%5B%5D=53905', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 50, 'referenced_works': ['https://openalex.org/W1487439618', 'https://openalex.org/W1731701256', 'https://openalex.org/W1853544818', 'https://openalex.org/W1970464197', 'https://openalex.org/W1973577899', 'https://openalex.org/W1976520103', 'https://openalex.org/W1978232668', 'https://openalex.org/W1979239542', 'https://openalex.org/W1994878006', 'https://openalex.org/W1995281982', 'https://openalex.org/W1996983679', 'https://openalex.org/W1999715990', 'https://openalex.org/W2005155951', 'https://openalex.org/W2012566712', 'https://openalex.org/W2019731805', 'https://openalex.org/W2020026579', 'https://openalex.org/W2020993672', 'https://openalex.org/W2021970375', 'https://openalex.org/W2023000631', 'https://openalex.org/W2025183726', 'https://openalex.org/W2028978816', 'https://openalex.org/W2037177018', 'https://openalex.org/W2040127848', 'https://openalex.org/W2040196938', 'https://openalex.org/W2041607472', 'https://openalex.org/W2045185273', 'https://openalex.org/W2049132016', 'https://openalex.org/W2050573392', 'https://openalex.org/W2061422980', 'https://openalex.org/W2076457965', 'https://openalex.org/W2076981817', 'https://openalex.org/W2084191751', 'https://openalex.org/W2087850846', 'https://openalex.org/W2096287682', 'https://openalex.org/W2106316394', 'https://openalex.org/W2114998237', 'https://openalex.org/W2115484306', 'https://openalex.org/W2122656686', 'https://openalex.org/W2126022125', 'https://openalex.org/W2130711943', 'https://openalex.org/W2133540186', 'https://openalex.org/W2134557279', 'https://openalex.org/W2135122661', 'https://openalex.org/W2138035663', 'https://openalex.org/W2144169031', 'https://openalex.org/W2153672941', 'https://openalex.org/W2159530979', 'https://openalex.org/W2315038234', 'https://openalex.org/W2395480421', 'https://openalex.org/W2517382426'], 'related_works': ['https://openalex.org/W4311957677', 'https://openalex.org/W4303449254', 'https://openalex.org/W2904912999', 'https://openalex.org/W2901611760', 'https://openalex.org/W2594707584', 'https://openalex.org/W2099875681', 'https://openalex.org/W2056665186', 'https://openalex.org/W1989836623', 'https://openalex.org/W197432475', 'https://openalex.org/W1908941310'], 'abstract_inverted_index': {'//': [0], 'Simon': [1], 'Memmel': [2], '1': [3, 12, 16, 20, 24, 28, 37, 50, 63], ',': [4, 9, 13, 17, 21, 25, 29, 33, 38, 43, 47, 51], 'Dmitri': [5], 'Sisario': [6], '1,': [7, 61], '2': [8, 32, 46, 74, 281], 'Caren': [10], 'Zöller': [11], 'Vanessa': [14], 'Fiedler': [15], 'Astrid': [18], 'Katzer': [19], 'Robin': [22], 'Heiden': [23], 'Nicholas': [26], 'Becker': [27], 'Lorenz': [30], 'Eing': [31], 'Fábio': [34], 'L.R.': [35], 'Ferreira': [36], 'Heiko': [39], 'Zimmermann': [40], '3,': [41], '4': [42, 92], 'Markus': [44], 'Sauer': [45], 'Michael': [48], 'Flentje': [49], 'Vladimir': [52, 112], 'L.': [53, 113], 'Sukhorukov': [54], '2,': [55], '*': [56, 62, 102], 'and': [57, 78, 142, 146, 166, 181, 198, 217, 226, 244, 256, 273, 354], 'Cholpon': [58, 107], 'S.': [59, 108], 'Djuzenova': [60], 'Department': [64, 75], 'of': [65, 70, 76, 81, 148, 168, 192, 212, 280, 301, 310, 323, 345, 356, 372, 390], 'Radiation': [66], 'Oncology,': [67], 'University': [68, 80], 'Hospital': [69], 'Würzburg,': [71, 72, 82, 83], 'Germany': [73, 84, 91, 101], 'Biotechnology': [77], 'Biophysics,': [79], '3': [85], 'Fraunhofer-Institut': [86], 'für': [87], 'Biomedizinische': [88], 'Technik,': [89], 'Sulzbach,': [90], 'Molekulare': [93], 'und': [94], 'Zelluläre': [95], 'Biotechnologie/Nanotechnologie,': [96], 'Universität': [97], 'des': [98], 'Saarlandes,': [99], 'Saarbrücken,': [100], 'Co-senior': [103], 'author': [104], 'Correspondence': [105], 'to:': [106], 'Djuzenova,': [109], 'email:': [110, 115], '[email protected]': [111], 'Sukhorukov,': [114], '[email protected]': [116], 'Keywords:': [117], 'single-cell': [118, 296], 'tracking,': [119], 'dSTORM,': [120], 'super-resolution': [121, 182], 'microscopy,': [122], 'PTEN': [123, 306, 315], 'p53,': [124], 'wound': [125, 284], 'healing': [126], 'Received:': [127], 'January': [128], '12,': [129], '2017': [130, 134, 138], 'Accepted:': [131], 'March': [132], '20,': [133], 'Published:': [135], 'April': [136], '05,': [137], 'ABSTRACT': [139], 'High': [140], 'invasiveness': [141], 'resistance': [143], 'to': [144, 238, 320, 367], 'chemo-': [145], 'radiotherapy': [147], 'glioblastoma': [149], 'multiforme': [150], '(GBM)': [151], 'make': [152], 'it': [153], 'the': [154, 190, 193, 202, 209, 264, 324, 357], 'most': [155], 'lethal': [156], 'brain': [157], 'tumor.': [158], 'Therefore,': [159], 'new': [160], 'treatment': [161, 389], 'strategies': [162], 'for': [163, 388], 'preventing': [164], 'migration': [165, 176, 245, 293, 300, 347], 'invasion': [167], 'GBM': [169, 222, 373], 'cells': [170, 251, 268, 317, 329], 'are': [171], 'needed.': [172], 'Using': [173], 'two': [174, 221], 'different': [175, 241], 'assays,': [177], 'Western': [178], 'blotting,': [179], 'conventional': [180], '(': [183, 303, 312], 'd': [184], 'STORM)': [185], 'fluorescence': [186], 'microscopy': [187], 'we': [188], 'examine': [189], 'effects': [191, 339], 'dual': [194], 'PI3K/mTOR-inhibitor': [195], 'PI-103': [196, 298], 'alone': [197], 'in': [199, 220, 230, 242, 258, 286, 327, 340, 370], 'combination': [200], 'with': [201, 331, 350], 'Hsp90': [203], 'inhibitor': [204], 'NVP-AUY922': [205, 335], 'and/or': [206], 'irradiation': [207], 'on': [208], 'migration,': [210], 'expression': [211], 'marker': [213], 'proteins,': [214], 'focal': [215], 'adhesions': [216], 'F-actin': [218], 'cytoskeleton': [219], 'cell': [223, 288, 342, 346, 364, 374], 'lines': [224, 235, 289], '(DK-MG': [225], 'SNB19)': [227], 'markedly': [228], 'differing': [229], 'their': [231, 292], 'invasive': [232, 249, 266], 'capacity.': [233], 'Both': [234], 'were': [236], 'found': [237], 'be': [239], 'strikingly': [240], 'morphology': [243, 255, 272], 'behavior.': [246], 'The': [247], 'less': [248], 'DK-MG': [250, 302], 'maintained': [252], 'a': [253, 259, 270, 277, 363], 'polarized': [254], 'migrated': [257, 274], 'directionally': [260], 'persistent': [261], 'manner,': [262], 'whereas': [263], 'highly': [265], 'SNB19': [267, 311, 328], 'showed': [269, 362], 'multipolar': [271], 'randomly.': [275], 'Interestingly,': [276], 'single': [278], 'dose': [279], 'Gy': [282], 'accelerated': [283], 'closure': [285], 'both': [287, 341], 'without': [290], 'affecting': [291], 'measured': [294], 'by': [295], 'tracking.': [297], 'inhibited': [299], 'p53': [304, 313], 'wt,': [305], 'wt)': [307], 'but': [308], 'not': [309], 'mut,': [314], 'mut)': [316], 'probably': [318], 'due': [319], 'aberrant': [321], 'reactivation': [322], 'PI3K': [325], 'pathway': [326], 'treated': [330], 'PI-103.': [332], 'In': [333], 'contrast,': [334], 'exerted': [336], 'strong': [337], 'anti-migratory': [338, 379], 'lines.': [343], 'Inhibition': [344], 'was': [348], 'associated': [349], 'massive': [351], 'morphological': [352], 'changes': [353], 'reorganization': [355], 'actin': [358], 'cytoskeleton.': [359], 'Our': [360], 'results': [361], 'line-specific': [365], 'response': [366], 'PI3K/mTOR': [368], 'inhibition': [369], 'terms': [371], 'motility.': [375], 'We': [376], 'conclude': [377], 'that': [378], 'agents': [380], 'warrant': [381], 'further': [382], 'preclinical': [383], 'investigation': [384], 'as': [385], 'potential': [386], 'therapeutics': [387], 'GBM.': [391]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2604645819', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 4}], 'updated_date': '2024-09-07T09:58:14.879575', 'created_date': '2017-04-14'}