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'At': [259, 340], 'time,': [261, 343], 'higher': [264, 437], 'referred': [267], '“diastolic': [270], 'HF,”': [271], 'implicit': [273], 'term': [276, 293], 'much': [279], 'debated': [280], 'concept': [281], 'abnormalities': [283], 'diastolic': [285], 'function': [286, 1213, 1258], 'were': [287, 348, 429], 'responsible': [288], 'disorder.': [291], '“preserved”': [294], 'coined': [297], 'characterize': [299], '>40%': [306], 'CHARM': [309], 'program': [310], '(Candesartan': [311], 'Assessment': [315], 'Reduction': [317], 'Mortality': [319], 'Morbidity),': [321], 'whom': [323], 'no': [324, 1059], 'specific': [325], 'therapy': [326], 'had': [327], 'been': [328, 696, 966], 'identified,': [329], 'component': [332], 'trial': [333, 644], 'consisting': [334], 'CHARM-Preserved.': [339], 'same': [342, 1004], 'purists': [344], 'field': [347], 'arguing': [349], 'cutoff': [353, 684, 688], 'HFpEF': [355, 402, 699, 835, 858], '≥45%': [360, 663], 'or': [361, 421, 436, 576, 615, 702, 985, 1075, 1444, 1564], 'even': [362], '50%,': [363, 628], 'acknowledging': [364], 'EFs': [366], 'are': [373, 528, 936, 1000, 1068, 1513], 'clearly': [374, 610, 616], 'not': [375, 407, 529, 1069], 'normal': [376, 617], 'these': [379, 764, 786], 'patients,': [380], 'many': [382], 'ways,': [383], 'resembled': [384], 'their': [385, 471], 'lower': [386, 435, 917], 'siblings.': [388], 'growing': [390, 477], 'chasm': [391], 'inevitably': [392], 'left': [393, 519, 547, 1255, 1517, 1839, 2130], 'gap': [396], 'between': [397, 745, 803, 1581], 'accepted': [399], 'cutoffs.The': [403], 'term,': [404], '“HFmrEF”': [405], 'did': [406], 'arise': [408], 'discovery': [411], 'new': [414], 'phenotype': [415], 'mysteriously': [417], 'appeared': [418], '2016': [420], 'biologically': [430], 'distinct': [431], 'those': [433, 883, 1071], 'EFs.': [438], 'Our': [439], 'intention': [440], 'simply': [442], 'acknowledge': [444], 'gap,': [447], 'rather': [448, 930], 'than': [449, 931, 1516], 'leave': [450], 'it': [451, 791, 923], 'undefined,': [452], 'highlight': [455], 'lack': [457], 'knowledge': [459], 'about': [460], 'well': [466], 'encourage': [468], 'investigation': [469], 'phenotypic': [472], 'biological': [474], 'characteristics.': [475], 'appreciation': [478], 'there': [480], 'can': [481, 954], 'prognostic': [483, 1679], 'differences': [484], 'different': [486], 'responses': [487], 'therapeutic': [489], 'interventions': [490], 'throughout': [491], 'spectrum2,3': [494], 'reinforced': [495], 'need': [497], 'understand': [499, 956], 'middle': [501, 940, 1108, 1931], 'range.The': [502], 'perils': [503], 'overly': [506, 987], 'pedantic': [507], 'lie': [510], 'imprecise': [513], 'methods': [514], 'by': [515, 666, 829, 838, 1009, 1259, 1371], 'which': [516, 656], 'measure': [518], 'ventricular': [520, 548, 1256, 1518, 1840, 2131], 'fact': [524], 'measurements': [527, 668, 673], 'static': [530], 'over': [531, 812, 831, 840, 983], 'time': [532, 813], 'single': [535], 'patient.': [536], 'A': [537, 1324, 1466, 1561, 2186, 2239], 'systematic': [538, 1262, 1594, 2398], 'analysis': [539], 'reliability': [542], 'echocardiographic': [544, 1225], 'determination': [545], 'EF—the': [549], 'technique': [550], 'commonly': [552], 'used': [553], 'clinically—by': [554], 'Simpson’s': [555], 'rule': [556], 'interobserver': [559], 'variability': [560, 568], '8%': [562], '21%': [564], 'intraobserver': [567], '6%': [570], '13%.4': [572], 'Compared': [573], 'radionuclide': [575], 'ventriculography,': [578], 'Bland-Altman': [580], 'limits': [581], 'ranged': [584], 'LVEF': [586], '±7%': [587], '±25%': [589], '(median': [590], '±18%).': [591], 'authors': [593], 'remarked': [594], 'level': [597], 'accuracy': [599], 'may': [600, 741, 766, 775, 797, 897], 'adequate': [602], 'establishing': [604], 'whether': [605], 'is': [607, 638, 792, 924, 1007, 1081], 'abnormal': [611], '<30%': [614], '>50%;': [620], 'however,': [621], '30%': [626], 'evidence': [630], 'indicated': [631], 'echocardiography': [633, 713], 'imprecise.4': [635], 'imprecision': [637], 'further': [639], 'illustrated': [640], 'TOPCAT': [643, 1154, 1208], '(Treatment': [645], 'Preserved': [647, 1231, 1419, 2058], 'Cardiac': [648, 1210, 1232, 1792, 2192, 2424], 'Function': [649, 1233], 'Aldosterone': [654, 1238], 'Antagonist),2': [655], 'enrolled': [657], 'determined': [665], 'at': [669, 681, 751, 1083, 1584], 'sites.': [670], 'Comparing': [671], 'site': [672], 'core': [675], 'laboratory': [676], 'measurements,': [677], 'found': [679], '(upper': [687], 'HFmrEF),': [690], '19%': [691], 'would': [694], 'reclassified': [697], 'vice': [703], 'versa': [704], '(S.': [705], 'unpublished': [708], 'data,': [709], '2017).': [710], 'Moreover,': [711, 867], 'laboratories': [714], 'report': [715], 'semiquantitatively': [717], 'both': [719, 889], 'work': [721], 'trials,': [725], 'majority': [728], 'measures': [731], 'multiples': [733], '5.': [735], 'Indeed,': [736, 807], 'really': [742], 'mean': [743], 'anything': [744], '45%': [746], '55%,': [748], 'making': [749], 'cutoffs': [750, 787], 'likely': [756], 'increase': [758], 'risk': [760, 2446], 'misclassification.': [762], 'Collectively,': [763], 'problems': [765], 'unnecessarily': [767], 'complicate': [768], 'our': [769, 990], 'future': [770, 784], 'and,': [773], 'worse,': [774], 'impede': [776], 'care': [778, 1330, 1897], 'if': [779], 'guideline': [780], 'groups': [781], 'apply': [785], 'therapies.Beyond': [789], 'misclassification,': [790], 'increasingly': [793], 'recognized': [794], 'represent': [798], 'transition': [802], 'HFpEF.': [806], 'change': [809], 'among': [814], 'quantified': [819], 'Olmsted': [822], 'County,': [823], 'Minnesota,': [824], 'cohort,': [825], 'where': [826], 'decreased': [828], '≈6%': [830], '5': [832, 841, 1095], 'years': [833, 842], 'increased': [837], '≈7%': [839], 'HFrEF,': [844, 885, 912], 'representing': [845], 'crossing': [847], 'threshold': [851], '38.5%': [853], 'transitioning': [856], '38.8%': [862], 'HFpEF.5': [866], 'recent': [868], 'data': [869], 'TOPCAT2': [871], 'CHARM-Preserved3': [873], 'shown': [875], 'behave': [880], 'similarly': [881, 902], 'terms': [887], 'prognosis': [890], 'response': [892], 'therapy.': [894], 'attributable': [899], 'high': [903], 'burden': [904, 918], 'coronary': [906], 'artery': [907], 'disease': [908], 'HFpEF,': [920], 'suggesting': [921], 'etiology': [927], 'matters,': [929], 'per': [934], 'se.We': [935], 'delighted': [937], 'finally': [946], 'received': [947, 1023], 'some': [948], 'attention.': [949], 'By': [950, 1312], 'doing': [951], 'so,': [952], 'better': [955], 'substantial': [958, 971], 'proportion': [959], 'who': [964], 'yet': [969], 'morbidity': [972], 'mortality.': [974], 'Nevertheless,': [975], 'resist': [978], 'temptation': [980], 'fuss': [982], 'names': [984], 'become': [986], 'rigid': [988], 'partitioning.': [991], 'After': [992], 'all,': [993], 'all': [994], 'children': [999], 'part': [1001], 'family.DISCLOSURESDr': [1005], 'supported': [1008], 'Clinician': [1011], 'Scientist': [1012], 'Award': [1013], 'Medical': [1017], 'Research': [1018, 1046], 'Council': [1019], 'Singapore;': [1021], 'support': [1025], 'Boston': [1027], 'Scientific,': [1028], 'Bayer,': [1029, 1039], 'Thermofisher,': [1030], 'Medtronic,': [1031], 'Vifor': [1033], 'Pharma;': [1034], 'consulted': [1037], 'Novartis,': [1040], 'Takeda,': [1041], 'Merck,': [1042], 'Astra': [1043], 'Zeneca,': [1044], 'Janssen': [1045], '&': [1047, 2453], 'Development,': [1048], 'LLC,': [1049], 'Menarini,': [1050], 'Boehringer': [1051], 'Ingelheim,': [1052], 'Abbott': [1054], 'Diagnostics.': [1055], 'Dr': [1056], 'reports': [1058], 'conflicts': [1060], 'interest.FootnotesThe': [1062], 'opinions': [1063], 'expressed': [1064], 'article': [1067], 'necessarily': [1070], 'editors': [1074], 'American': [1078, 2518], 'Association.Circulation': [1080], 'available': [1082], 'http://circ.ahajournals.org.Correspondence': [1084], 'to:': [1085], 'PhD,': [1090], 'Centre': [1093], 'Singapore,': [1094], 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1777], 'stratification': [1645, 2447], 'mild': [1650], 'Preventive': [1657], '10.1177/2047487320951104,': [1659], '27:2_suppl,': [1660], '(59-64),': [1661], 'Alkhalil': [1666], 'Kearney': [1668], 'MacElhatton': [1670], 'Fergie': [1672], 'R': [1673], 'Dixon': [1675], 'role': [1680], 'ST-segment': [1686], 'elevation': [1687], 'myocardial': [1688, 2449], 'infarction,': [1689, 2450], 'International': [1690, 2224], '10.1016/j.ijcard.2020.07.001,': [1694], '321,': [1695], '(12-17),': [1696], 'MAGRÌ': [1701], 'PIEPOLI': [1703], 'CORRÀ': [1705], 'U,': [1706], 'GALLO': [1707], 'MARUOTTI': [1709], 'VIGNATI': [1711], 'C,': [1712, 1739, 1741, 1867, 1871, 1916, 1989, 2110, 2284, 2296, 2318], 'SALVIONI': [1713], 'MAPELLI': [1715], 'PAOLILLO': [1717], 'PERRONE': [1719], 'FILARDI': [1720], 'GIROLA': [1722], 'METRA': [1724], 'SCARDOVI': [1726], 'LAGIOIA': [1728], 'LIMONGELLI': [1730], 'SENNI': [1732], 'SCRUTINIO': [1734], 'EMDIN': [1736], 'PASSINO': [1738], 'LOMBARDI': [1740], 'CATTADORI': [1742], 'PARATI': [1744], 'CICOIRA': [1746], 'CORREALE': [1748], 'FRIGERIO': [1750], 'CLEMENZA': [1752], 'F,': [1753, 1993, 2008, 2310, 2372], 'BUSSOTTI': [1754], 'GUAZZI': [1756], 'BADAGLIACCA': [1758], 'SCIOMER': [1760], 'DI': [1762], 'LENARDA': [1763], 'MAGGIONI': [1765], 'SINAGRA': [1767], 'VOLPE': [1769], 'AGOSTONI': [1772], 'P': [1773, 2202, 2236], 'Death': [1776], 'Recovered': [1779, 2244], 'Failure:': [1784, 2185], 'Insights': [1785], 'Cardiopulmonary': [1787], 'Exercise': [1788], 'Test,': [1789], '10.1016/j.cardfail.2020.04.021,': [1794], '26:11,': [1795], '(932-943),': [1796], '1-Nov-2020.': [1800], 'Yoshikawa': [1801], 'Tamaki': [1803], 'Morimoto': [1805], 'Yaku': [1807], 'Yamamoto': [1809], 'Inuzuka': [1811], 'Ozasa': [1813], 'Kitai': [1815], 'Nagao': [1817], 'K,': [1818, 1828, 2302], 'Sato': [1819], 'Kondo': [1821], 'Tamura': [1823], 'Nakagawa': [1825], 'Kuwahara': [1827], 'Kato': [1829], 'Kimura': [1831], 'Lionetti': [1834], 'Impact': [1837], 'effect': [1845], 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