Publication Information

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['https://openalex.org/W1974303227', 'https://openalex.org/W2159263105'], 'related_works': ['https://openalex.org/W413910907', 'https://openalex.org/W3161244899', 'https://openalex.org/W3104896408', 'https://openalex.org/W3081058191', 'https://openalex.org/W2951403334', 'https://openalex.org/W2797040186', 'https://openalex.org/W2592226915', 'https://openalex.org/W2588914123', 'https://openalex.org/W2266877340', 'https://openalex.org/W2152725356', 'https://openalex.org/W2114535987', 'https://openalex.org/W2106169706', 'https://openalex.org/W2095615927', 'https://openalex.org/W2064231828', 'https://openalex.org/W2058139403', 'https://openalex.org/W2050294137', 'https://openalex.org/W2022493303', 'https://openalex.org/W2015452592', 'https://openalex.org/W2011205686', 'https://openalex.org/W1977835632'], 'abstract_inverted_index': {'The': [0], 'liver': [1, 99], 'X': [2], 'receptors': [3], '(LXRs)': [4], 'sense': [5], 'oxysterols': [6], 'and': [7, 74], 'regulategenesinvolvedincholesterolmetabolism.SyntheticagonistsofLXRs': [8], 'are': [9], 'potent': [10], 'stimulators': [11], 'of': [12, 85, 100], 'fatty': [13, 45], 'acid': [14], 'synthesis,': [15], 'which': [16, 62], 'ismediated': [17], 'largely': [18], 'by': [19, 57], 'sterol': [20], 'regulatory': [21], 'element-binding': [22], 'pro-tein-1c': [23], '(SREBP-1c).': [24], 'Paradoxically,': [25], 'an': [26, 47, 65, 103], 'improved': [27], 'hepatic': [28], 'lipidprofilebyLXRwasobservedinmicefedaWesternhighfat(HF)diet.': [29], 'To': [30], 'explore': [31], 'the': [32, 58, 93, 98], 'underlying': [33, 92], 'mechanism,': [34], 'we': [35], 'administeredmicenormalchoworanHFdietandoverexpressedLXR': [36], 'intheliver.TheHFdietwithtail-veininjectionofadenovirusofLXRincreasedtheexpressionofLXR-targetedgenesinvolvedincho-lesterol': [37], 'reverse': [38], 'transport': [39], 'but': [40], 'not': [41], 'those': [42], 'involved': [43, 79], 'in': [44, 50, 67, 80, 97], 'acidsynthesis.Asimilareffectwasalsoobservedwiththeuseof22R-hydroxycholesterol,': [46], 'LXR': [48, 72], 'ligand,': [49], 'cultured': [51], 'hepatocytes.Consequently,': [52], 'SREBP-1c': [53], 'maturation': [54], 'was': [55], 'inhibited': [56], 'HFdiet,whichresultedfromtheinductionofInsig-2a.Importantly,increasedcholesterollevelsuppressedtheexpressionof2,3-ox-idosqualene': [59], 'cyclase': [60], '(OSC),': [61], 'led': [63], 'to': [64], 'increase': [66], 'endoge-nousLXRligand(s).Furthermore,siRNA-mediatedknockdownof': [68], 'OSC': [69, 86], 'expression': [70], 'enhanced': [71], 'activity': [73], 'selectively': [75], 'up-regulated': [76], 'LXR-targeted': [77], 'genes': [78], 'cholesterol': [81], 'reversetransport.': [82], 'Thus,': [83], 'down-regulation': [84], 'may': [87], 'account': [88], 'for': [89], 'anovel': [90], 'mechanism': [91], 'LXR-mediated': [94], 'lipid': [95], 'metabo-lism': [96], 'mice': [101], 'fed': [102], 'HF': [104], 'diet.': [105]}, 'cited_by_api_url': 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