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3515, 3670, 3694, 3711, 3738, 3808, 3844, 4034, 4118], 'number': [566, 879, 3516], 'function': [568, 881, 2077, 2833, 4035], 'is': [569, 882, 971, 1153, 1169, 1467, 2588, 2670, 2782, 2880, 3122, 3284, 3497, 3675, 3722], 'important': [570, 883, 915, 1468, 3490, 3644], 'ensure': [572, 885], 'clearance': [574, 887, 1288, 2721, 2925, 2937, 3907], 'protection': [576, 889], 'from': [577, 619, 890, 1714, 1803, 1827, 2064, 2082, 2481, 2568], 'infection-associated': [578, 2593, 3482], 'immunopathologies.': [579, 893], 'Recent': [580], 'advances': [581, 620], 'understanding': [583], 'influence': [586, 945, 1439, 1784, 3370], 'on': [587, 993, 1085, 1309, 1428, 1465, 1638, 1642, 1796, 1813, 1974, 2133, 2150, 2166, 2967, 3065, 4045, 4097], 'outcome': [589, 1441, 1473, 4085], 'infection': [591, 871, 891, 1152, 1206, 1509, 1854, 2005, 2202, 2224, 2476, 2553, 2676, 2885, 2944, 2960, 2971, 3169, 3549, 3668, 3686], 'opened': [592], 'new': [593], 'them.': [597, 849], 'Various': [598, 1302, 1760], 'small': [599, 3439, 4127], 'molecules,': [600, 1058, 1060], 'pharmacological': [601], 'inhibitors,': [602], 'monoclonal': [603, 3761], 'antibodies': [604], 'that': [605, 790, 931, 1006, 1147, 1211, 1248, 1261, 1458, 1632, 2206, 2388, 2625, 2703, 2718, 2741, 2766, 2783, 2876, 2893, 3118, 3227, 3317, 3396, 3492, 3576, 4004, 4062, 4091], 'provided': [608], 'proof': [609], 'concept': [611], 'experimental': [613, 3126, 3804], 'models.': [614], 'field': [616, 3725], 'benefits': [618, 3504], 'other': [622, 990, 1351, 1747, 3192, 3683, 3969], 'subjects,': [623], 'particularly': [624], 'oncology': [625], 'autoimmunity,': [627, 3717], 'where': [628], 'Treg-targeted': [629], 'therapies': [630], 'exploited': [632], 'clinic': [635], 'greater': [638], 'extent.': [639], 'future': [641], 'research': [642], 'should': [643], 'aim': [644], 'at': [645, 1202, 1505, 2317, 2508, 2801, 3536, 4076, 4099], 'translating': [646], 'preclinical': [648], 'success': [649, 1880], 'human': [651, 1658, 2022, 2768, 3089, 3752], 'application.': [652], '1': [653, 788, 4224], 'IMMUNE': [654, 1183, 3558], 'RESPONSE': [655, 3559], 'TO': [656, 3560], 'PATHOGENS': [657], 'As': [658, 1987, 2558, 2641, 3217, 3255, 3632], 'part': [660], 'first': [662, 2304], 'line': [663, 4133], 'defence,': [665], 'professional': [666], 'antigen-presenting': [667, 1059], '(APCs)': [669], 'recognise': [670], 'via': [672, 1078, 1088, 1511, 2161, 3079], 'pathogen-associated': [673], 'molecular': [674], 'pattern': [675], '(PAMP)': [676], 'pattern-recognition': [678], 'receptor': [679, 2824], '(PRR)': [680], 'interaction.': [681], 'PRR–PAMP': [682], 'interaction': [683, 2162], 'signals': [684], 'phagocytosis': [685], 'antigens': [687, 710, 957, 4082, 4149], 'their': [689, 1068, 2534], 'processing': [690], 'endosomes': [692], 'lysosomes': [694], 'presentation': [697, 717], 'major': [699, 2313, 3369, 3840], 'histocompatibility': [700], 'complex': [701, 3166], '(MHC)': [702], 'class': [703, 1636, 1651], 'II': [704, 1637, 1652], 'CD4+': [706, 756, 1014, 1267, 1829, 3212, 3934], 'cells.': [708, 724, 1540], 'Endogenous': [709], 'processed': [712], 'proteasomes': [714], 'MHC': [719, 1635, 1650], 'I': [720], 'CD8+': [722, 807, 1016, 1269, 1489, 1716, 2154, 2167, 3878, 3901, 3925], 'Signalling': [725], 'PRR': [727], 'leads': [729, 1400, 3850], 'APCs': [733, 1028, 1157, 1639], 'characterised': [734, 2775], 'enhanced': [736, 1482, 1603, 2050, 2413, 2860, 3852, 3929, 3963, 4140, 4218], 'expression': [737, 1055, 2052, 2094], 'costimulatory': [739, 1057], 'molecules': [740, 1132, 2111, 3829], 'T-cell': [743, 757, 1072, 1689, 2155, 2247, 2356, 3583, 3741, 3825, 3902, 4202, 4220], 'activation,': [744], 'chemokines': [745], 'guide': [747], 'migration': [748, 1504, 4122], 'cytokines': [753, 947, 1041, 1063], 'mediate': [755, 2905], 'polarization': [758], 'into': [759, 2484, 3438], 'effector': [760, 1043, 1101, 1266, 1331, 1947, 3742, 3818, 3964], 'Th1,': [761, 2579], 'Th2,': [762, 2580], 'Th17': [764, 2582, 2642, 2650, 2917, 2933, 3101, 3305, 3325], 'various': [767, 2802], 'suppressor': [769, 808, 841, 2414], 'including': [771, 1013, 1749, 4150], '(Tregs).': [776], 'Suppressor': [777], 'diverse.': [781], 'In': [782, 926, 980, 1092, 1163, 1378, 1494, 2174, 2259, 2372, 2474, 2501, 2574, 2715, 2807, 2869, 2949, 2978, 3530, 3810, 3914, 3975, 4132], 'addition': [783, 927, 1495], 'classical': [785], 'Tregs,': [786, 1499, 3262], 'type': [787, 4223], 'express': [791, 984, 1845, 3215, 4049], 'LAG3': [792], 'CD49b': [794], 'secrete': [796, 4063], 'interleukin': [797], '(IL)-10,': [798], 'transforming': [799], 'growth': [800, 1234], 'factor': [801, 3303], '(TGF)': [802], 'β-producing': [803], 'Th3': [804], 'identified.': [813], 'Among': [814], 'them,': [815], 'most': [818, 1010], 'studied': [819], 'population': [820], 'focus': [824], 'review.': [827], 'Pathogens': [828], 'deploy': [829], 'several': [830, 1189, 1546, 1967, 3727], 'mechanisms': [831, 842, 1146, 2332, 3063], 'evade': [833], 'responses,': [836, 3640], 'enhancement': [838], 'represents': [846, 3775], 'one': [847, 3499], 'Although': [850, 3383], 'support': [857, 3094], 'infection,': [859, 1251, 2577, 2995, 3049, 3071], 'they': [860, 3641], 'critical': [863], '(Figure': [872], '1).': [873], 'caused': [892], 'Figure': [894, 1241, 1297, 1920, 2370], '1Open': [895], 'figure': [897, 1300], 'viewerPowerPoint': [898, 1301], '2': [910, 2825], 'CD4+CD25+FOXP3+': [911], 'TREGS': [912, 1176, 1666, 2291, 2752, 3556, 3628], '(Sakaguchi,': [920], 'Yamaguchi,': [921], 'Nomura,': [922], '&': [923, 1221, 1282, 1366, 1371, 1434, 1528, 1579, 1586, 1646, 1701, 1799, 1954, 1984, 2235, 2256, 2287, 2337, 2400, 2498, 2606, 2612, 2617, 3205, 3430, 3485, 3552, 3599, 3621, 3755, 4038, 4159], 'Ono,': [924], '2008).': [925, 1141, 1956, 2105, 2237, 2451, 2540, 2557, 3913], 'thymus-derived': [929, 962, 965, 3242, 3282], 'mostly': [933, 2790], 'self-antigen': [934], 'specific,': [935], 'can': [937, 1008, 1501, 1783, 1851, 2035, 2827, 2973, 3016, 3257, 3397, 3500, 3713, 3814, 3822, 4021], 'be': [938, 1964, 2013, 3258, 3495, 3652, 3989, 4002, 4022, 4246], 'induced': [939, 3231, 3261, 3280], 'periphery': [942], 'under': [943], 'APCs.': [949], 'Induced': [950], 'generally': [953], 'specific': [954, 3394], 'foreign': [956], 'phenotypically': [959], 'similar': [960], 'Tregs.': [963, 2043, 3731], 'functionally': [968], 'stable.': [969], 'FoxP3': [970, 4028], 'master': [973], 'regulator': [974], 'development': [977, 3023], 'functions.': [979, 3518], 'addition,': [981, 1093, 1164, 3531, 3811], 'constituently': [983], 'CTLA-4': [985, 4026], 'CD127low.': [988], 'markers': [991, 3336], 'described': [992, 2305], 'LAG-3,': [997, 1134], 'ICOS,': [998], 'GITR,': [999, 3341], 'CCR4,': [1000], 'neuropilin-1.': [1002], 'Current': [1003], 'evidence': [1004], 'suggest': [1005, 2455, 2892, 3226, 3605], 'natural': [1021], 'killer': [1022], '(NK)': [1023], 'NKT': [1025], '(DCs),': [1033], 'monocytes,': [1034], 'macrophages.': [1036], 'inhibit': [1038, 1053, 3563, 3655], 'proliferation': [1039, 3267], 'promote': [1046, 1105, 1933, 2042, 2099], 'B-cell': [1047], 'anergy': [1048], 'impede': [1050], 'antibody': [1051, 3762], 'production,': [1052], 'inflammatory': [1062, 2668, 2987], 'APCs,': [1065], 'reduce': [1067, 2883, 3823], 'ability': [1069], 'stimulate': [1071, 1542], 'responses.': [1073, 3700, 3826], 'tryptophan': [1076], 'catabolism': [1077], 'IDO': [1079, 2051, 2076, 2093, 3098], 'pathway': [1080, 3837, 3849, 3891, 3961, 4020], 'induce': [1082, 3398, 3419], 'cytotoxic': [1083, 3824], 'effects': [1084, 1303, 2352, 3792, 4116], 'perforin': [1089], 'granzymes.': [1091], 'consuming': [1095], 'IL-2,': [1096, 2384, 2930], 'hamper': [1098], 'apoptosis.': [1106], 'Thus,': [1107, 2965], 'affect': [1109], 'all': [1110], 'stages': [1111], 'response.': [1114, 2977, 2990, 4071], 'Treg-mediated': [1115, 2793, 3112], 'suppression': [1116, 2141, 3074, 3113, 3611, 4068], 'implicates': [1120], 'soluble': [1122], 'factors': [1123], '(TGF-β,': [1124], 'IL-10,': [1125, 2385], 'IL-35,': [1126], 'perforins,': [1127], 'granzymes)': [1129], 'cell-associated': [1131], '(CTLA-4,': [1133], 'CD39,': [1135], 'neuropilin-1;': [1137], 'Sakaguchi': [1138], 'al.,': [1140, 1226, 1239, 1291, 1295, 1376, 1392, 1396, 1476, 1522, 1566, 1570, 1574, 1608, 1612, 1616, 1620, 1663, 1695, 1730, 1775, 1779, 1819, 1840, 1857, 1886, 1890, 1894, 1914, 1918, 2008, 2031, 2058, 2087, 2104, 2126, 2147, 2172, 2198, 2364, 2368, 2405, 2427, 2450, 2519, 2539, 2556, 2639, 2683, 2747, 2838, 2854, 2888, 2947, 2963, 3085, 3110, 3135, 3139, 3156, 3180, 3202, 3236, 3253, 3288, 3309, 3331, 3359, 3427, 3459, 3463, 3595, 3772, 3862, 3866, 3870, 3885, 3912, 3956, 3973, 4164, 4168, 4172, 4212, 4233], 'One': [1142], 'main': [1145, 2780], 'underlie': [1148], 'expansion': [1150, 1252, 1414, 1497, 1544, 1553, 1599, 1628, 1656, 1982, 1995, 2011, 2101, 2116, 2139, 2831, 3159, 3931], 'upon': [1151, 1249, 4227], 'direct': [1154, 1165], 'modulation': [1155], 'its': [1161], 'PAMPs.': [1162, 1174], 'stimulation': [1166], 'reported': [1171, 1762, 1908, 1924, 1998, 2026, 2672, 4217], 'certain': [1173], '3': [1175], 'IN': [1177, 1667, 1672, 3629], 'BACTERIAL': [1178], 'INFECTIONS:': [1179, 2755], 'INHIBITION': [1180], 'OF': [1181], 'PROTECTIVE': [1182], 'RESPONSES': [1184], 'expanded': [1187], 'chronic': [1190, 1352, 1402, 1960, 2000, 2177, 2311, 2551, 2913, 3685, 3783, 4242], 'bacterial': [1191, 1353, 1398, 1443, 3388], 'infections': [1192, 1354, 1962, 2186, 3132, 3478, 3512, 3659, 4243], 'tuberculosis.': [1195], 'Tuberculosis': [1196], 'patients': [1197, 1772, 1808, 1834, 1911, 2048, 2068], 'increased': [1199, 1707, 1763, 3873, 3920, 3949], 'site': [1204, 1507, 2222, 2319], 'circulation': [1210], 'compromise': [1212], 'interferon': [1214], '(IFN)-γ': [1215], '(Guyot-Revol,': [1217], 'Innes,': [1218], 'Hackforth,': [1219], 'Hinks,': [1220], 'Lalvani,': [1222], '2006;': [1223, 1393, 1776, 2608, 3136], 'Hougardy': [1224], '2007)': [1227, 1820], 'interfere': [1229], 'stasis': [1231], 'mycobacterial': [1233], 'macrophages': [1236], '(Semple': [1237], '2013;': [1240, 1581, 1613, 3460, 3867], '2).': [1242, 1921, 2371], 'Detailed': [1243], 'exploration': [1244], 'mice': [1246, 1680, 2204, 2483, 2487, 2532, 2545, 2702, 2717, 2851, 2858, 2875, 3909], 'indicated': [1247], 'aerosol': [1250], 'occurs': [1255, 3031], 'draining': [1258], 'lymph': [1259], 'nodes': [1260], 'defer': [1262], 'influx': [1264, 2212], 'lungs': [1274, 3153], 'during': [1275, 2900, 2909, 2940, 2956, 3167, 3264], 'early': [1276, 2229, 2910, 3046], 'tuberculosis': [1277, 3859], '(Shafiani,': [1278], 'Tucker-Heard,': [1279], 'Kariyone,': [1280], 'Takatsu,': [1281], 'Urdahl,': [1283], '2010)': [1284, 1648], 'prevent': [1286], 'bacilli': [1287], '(Kursar': [1289], '2007;': [1292], 'Scott-Browne': [1293], '2007).': [1296, 2059], '2Open': [1298], 'response': [1319, 1385, 1690, 1745, 1905, 1949, 2144, 2231, 2248, 2326, 2357, 2392, 2583, 2651, 2862, 2918, 3078, 3117, 3374, 3614, 3663, 3781, 3854, 3903, 4105, 4110, 4145, 4186, 4240], 'pathogens.': [1321], 'DC': [1322], '=': [1323, 1327, 1330, 1335, 1340], 'cells;': [1325, 1333], 'MΦ': [1326], 'macrophage;': [1328], 'Teff': [1329], 'cell;': [1338], 'lymphocytes.': [1342], 'role': [1346, 1683, 1736, 2107, 2182, 2458, 2731, 2908, 2922, 3096, 3671, 3841, 4011], 'Mycobacterium': [1357, 1550], 'leprae,': [1358], 'Streptococcus': [1359], 'pneumonia,': [1360], 'Salmonella': [1362, 1423, 1455], '(Johanns,': [1363], 'Ertelt,': [1364, 1431], 'Rowe,': [1365], 'Way,': [1367, 1435], '2010;': [1368], 'Saini,': [1369], 'Ramesh,': [1370], 'Nath,': [1372], '2014;': [1373, 1523, 4161], 'Zhang': [1374], '2011).': [1377, 1436, 1664, 2009, 2948, 2964, 3237, 3554, 4040], 'case': [1379, 1990, 2561, 3240], 'Helicobacter': [1381], 'pylori,': [1382], 'adequate': [1383], 'although': [1386, 3635], 'prevents': [1387], 'peptic': [1388], 'ulcer': [1389], '(Rad': [1390], 'Robinson': [1394], '2008),': [1397], 'inflammation': [1403, 2193, 2570, 3001, 3177, 3715], 'tumour': [1405], 'induction.': [1406], 'susceptibility': [1409, 2445, 2820], 'prenatal': [1411], 'wherein': [1413, 2916], 'maternal': [1416], 'predisposes': [1418], 'Listeria': [1420], 'monocytogenes': [1421], 'enterica': [1424], 'was': [1426, 1923, 2303, 2416, 2623, 2628], 'dependent': [1427], 'IL-10': [1429, 1934, 1942, 2845, 3080], '(Rowe,': [1430], 'Aguilera,': [1432], 'Farrar,': [1433], 'clinical': [1440, 3768], 'disease': [1444, 1472, 2470, 2493, 2515], 'due': [1445, 1965, 2015], 'altered': [1447, 4177], 'distribution': [1449], 'properties.': [1450], 'Human': [1451, 3602, 4047], 'challenge': [1452, 2513], 'studies': [1453, 1678, 1761, 2454, 3225, 3391, 3603], 'typhi': [1456], 'showed': [1457, 2205], 'pathogen-specific': [1459], 'upregulation': [1460], 'gut-homing': [1462], 'integrin': [1463, 1794], 'α4β7': [1464, 1795], 'determinator': [1469], 'typhoid': [1471], '(McArthur': [1474], '2015).': [1477, 2032, 2173, 3289, 3310, 3886], 'Importantly,': [1478, 2060, 2541, 3333], 'depletion': [1479, 1824, 2505, 3712, 3721], 'S.': [1483], 'typhi-specific': [1484], 'cytokine': [1485], 'production': [1486, 1935, 2846, 3172], 'effector-memory': [1488], 'vitro.': [1493], 'bacteria': [1500, 3395, 3450], 'chemokine': [1512, 4043], 'axis': [1513, 1519, 1558, 4007], 'CCL17/CCL22-CCR4': [1516], 'CCL20-CCR6': [1518], '(Cook': [1520], 'Wang,': [1524, 3620], 'Sjolinder,': [1525, 1529], 'Gao,': [1526], 'Wan,': [1527], '2016)': [1530], 'thus': [1532], 'increasing': [1533], 'contact': [1535, 4053], 'between': [1536, 3032, 4054], 'Bacteria': [1541], 'mutually': [1547], 'nonexclusive': [1548], 'mechanisms.': [1549, 1968], 'tuberculosis-mediated': [1551], 'humans': [1555], 'implicate': [1556], 'PD-1-PD-L1/PD-L2': [1557, 3836], 'COX-2-catalysed': [1560], 'Prostaglandin': [1561], 'E2': [1562], '(PGE2)': [1563], '(Garg': [1564], '2008;': [1567, 2614, 4165], 'Holla': [1568], '2016;': [1571], 'Periasamy': [1572], '2011;': [1575, 1609, 1887, 1891, 3203, 3428, 3863], 'Singh,': [1576], 'Mohan,': [1577], 'Dey,': [1578], 'Mitra,': [1580], 'Trinath,': [1582], 'Maddur,': [1583], 'Kaveri,': [1584], 'Balaji,': [1585], '2012).': [1588, 2199, 3623, 3757], 'Blockade': [1589], 'these': [1591, 2453, 3218, 3318, 4179], 'pathways': [1592, 1623], 'vitro': [1594, 1823, 3856], 'not': [1595, 3651, 4176, 4189], 'only': [1596], 'abrogated': [1597], 'but': [1600], 'reciprocally': [1602, 2646], 'IFN-γ': [1604, 1712, 3853], '(Periasamy': [1606, 3860], 'Singh': [1610, 3864], '2015;': [1617, 4169], '2016).': [1621, 1858, 3157, 3181, 3332, 3360, 4234], 'Additional': [1622], 'include': [1624, 3523], 'bacteria-derived': [1630], 'superantigens': [1631], 'directly': [1633, 2828], 'TCR': [1641], '(Taylor': [1645], 'Llewelyn,': [1647], 'PGE2-dependent': [1654], 'colonic': [1659, 3211], 'myofibroblasts': [1660], '(Pinchuk': [1661], '4': [1665], 'VIRAL': [1668], 'INFECTION:': [1669, 2294], 'DISTINCT': [1670], 'ROLES': [1671], 'ACUTE': [1673], 'VERSUS': [1674], 'CHRONIC': [1675], 'INFECTION': [1676, 3189], 'Initial': [1677], 'ascribed': [1681], 'attenuating': [1687], 'CD8': [1688, 2246], 'virus': [1692, 1708, 1726, 1753, 1758, 2003, 2130, 2252, 3923, 3947, 4222], '(Dittmer': [1693], '2004;': [1696, 1915, 2365], 'Suvas,': [1697, 3598], 'Kumaraguru,': [1698], 'Pack,': [1699], 'Lee,': [1700], 'Rouse,': [1702, 3600], '2003).': [1703, 1731], 'account': [1705], 'load': [1709], 'restraining': [1711], 'virus-specific': [1715, 2267, 3933], 'mouse': [1721, 2308, 2809], 'model': [1722, 2160, 2309, 2677, 2810, 4215], 'herpes': [1724], 'simplex': [1725], '(HSV)': [1727], '(Suvas': [1728], 'Subsequent': [1732], 'reports': [1733], 'demonstrated': [1734, 2624], 'viral': [1740, 1961, 2019, 2119, 2185, 3906], 'blunting': [1743], 'viruses': [1748, 2034, 3970], 'HIV,': [1750], 'hepatitis': [1751, 1756, 1910], '(HBV),': [1754], 'C': [1757], '(HCV).': [1759], 'lymphoid': [1766, 1804], 'mucosal': [1768], 'tissues': [1769, 1805], 'HIV': [1771, 1782, 1807, 1833, 1846, 1853, 1866, 2090, 3967], '(Epple': [1773], 'Nilsson': [1777], '2006).': [1780, 2619, 2889, 3086, 3974], 'Furthermore,': [1781], 'relocation': [1785], 'inducing': [1789], 'homing': [1790], 'receptors': [1791, 4044], 'CD62L': [1792], '(Ji': [1798, 1983], 'Cloyd,': [1800, 1985], '2009).': [1801, 1986, 2428, 2684, 3487, 3957, 4173], 'had': [1809], 'intact': [1810], 'suppressive': [1811, 2954, 3832], 'HIV-specific': [1814, 3877], '(Kinter': [1817], 'peripheral': [1828], 'augmented': [1835, 3899], 'anti-HIV': [1836, 3996], '(Weiss': [1838], '2004).': [1841, 2500, 2520, 2855, 3601], 'Memory': [1842], 'frequently': [1844], 'coreceptor': [1847], 'CCR5': [1848, 3145], 'hence': [1850, 2226, 2273, 3352, 3480, 3719], 'accelerate': [1852], '(Chachage': [1855], 'Low': [1859, 2685], 'frequencies': [1861, 2523, 2843, 3739], 'characteristics': [1863], 'elite': [1865], 'controllers': [1867], 'long-term': [1869], 'nonprogressors,': [1870], 'reduced': [1872, 3170], 'numbers': [1874], 'therapy': [1876, 1883], 'provide': [1877], 'pointer': [1878], 'towards': [1879, 2355, 2446, 2584, 3042, 3677], 'antiretroviral': [1882], '(Hunt': [1884], 'Montes': [1888], 'Piconi': [1892], '2010).': [1895, 3207, 3432], 'Increased': [1896], 'frequency': [1897], 'circulating': [1899], 'diminished': [1902], 'antigen-specific': [1903, 2390], '(Cabrera': [1912], 'Stoop': [1916], '2005;': [1919, 3596], 'HCV': [1922, 2028, 2047, 2067], 'alter': [1926, 2036], 'myeloid': [1930], 'DCs': [1931, 2040, 2062, 2084, 2097, 2135, 4061, 4075, 4098], 'augment': [1938, 2932], 'expansion.': [1940], 'Neutralizing': [1941], 'depleting': [1944], 'restored': [1946], '(Dolganiuc,': [1950], 'Paek,': [1951], 'Kodys,': [1952], 'Thomas,': [1953], 'Szabo,': [1955], 'Enhanced': [1957], 'might': [1963, 2652], 'Interaction': [1969], 'HIV-gp120': [1971], 'CD4': [1973], 'CD25+': [1975], 'favours': [1977], 'survival': [1979, 2798, 3950], 'superantigen-mediated': [1993], 'has': [1996, 2121, 2440, 3247, 3367, 3541, 3764, 3788, 3838, 4000, 4008, 4204], 'been': [1997, 2122, 2441, 2467, 3249, 3765, 4205], 'lymphocytic': [2001], 'choriomeningitis': [2002], '(LCMV)': [2004], '(Punkosdy': [2006], 'could': [2012, 3988], 'homology': [2017], 'peptide': [2020], 'protein': [2023], 'sequences': [2024], '(Losikoff': [2029], 'Additionally,': [2033], 'Chronic': [2044], 'HBV': [2045], 'liver': [2055, 2594], '(Larrea': [2056], 'IDO+': [2061, 2083], 'differentiated': [2063], 'monocytes': [2065], 'potent': [2070], 'inducers': [2071], 'blocking': [2075, 3889], 'significantly': [2078, 3346, 4139], 'abrogates': [2079], 'generation': [2081, 2656], '(Higashitani': [2085], '2013).': [2088, 2640, 3111, 3254, 3464, 4213], 'Similarly,': [2089, 2340], 'induces': [2092, 2131, 2376], 'plasmacytoid': [2096], '(Manches': [2102], 'A': [2106, 3027, 3290, 4191], 'coinhibitory': [2110], 'PD-1/PD-L1': [2112], 'orchestrating': [2114], 'effectuating': [2118, 2898], 'suggested': [2123], '(Penaloza-MacMaster': [2124], '2014).': [2127, 2148, 2258, 2289, 3140], 'Japanese': [2128], 'encephalitis': [2129], 'PD-L1': [2132, 2164], 'monocyte-derived': [2134], 'arbitrate': [2137], 'Th1': [2143, 2325, 2861], '(Gupta': [2145], 'PD-1': [2149, 3890, 3918, 3982, 4006], 'suppressed': [2153, 2654], 'murine': [2158, 2341, 3091], 'LCMV': [2159, 3896], 'expressed': [2165, 3259], '(Park': [2170], 'contrast': [2175], 'infections,': [2178], 'beneficial': [2181, 2730], 'acute': [2184, 2941, 2992, 3658], 'it': [2188, 2622, 3649, 3999], 'goes': [2189], 'beyond': [2190], 'controlling': [2191, 2278, 2462, 3038, 4013], 'excessive': [2192, 3007], 'immunopathology': [2195], '(Stross': [2196], 'Mucosal': [2200], 'HSV': [2201], 'vital': [2209], 'NK': [2214], 'DCs,': [2216], '(Lund,': [2232], 'Hsing,': [2233], 'Pham,': [2234], 'Rudensky,': [2236], 'Treg-derived': [2238], 'TGF-β': [2239, 3082], 'helps': [2240], 'maintenance': [2243, 2734], 'memory': [2245, 2738, 3582, 3938], 'West': [2250], 'Nile': [2251], '(Graham,': [2253], 'Da': [2254], 'Costa,': [2255], 'Lund,': [2257, 2285], 'influenza': [2261], 'model,': [2262, 2477], 'differentiation': [2265, 2934], 'follicular': [2268], 'helper': [2270], 'germinal': [2274], 'centre': [2275], 'availability': [2280], 'IL-2': [2282], '(Leon,': [2283], 'Bradley,': [2284], 'Randall,': [2286], 'Ballesteros-Tato,': [2288], '5': [2290], 'AND': [2292, 2753, 3187], 'PARASITIC': [2293], 'FRIEND': [2295], 'OR': [2296], 'FOE?': [2297], 'benefiting': [2299], 'parasite': [2302, 2585, 2688, 2709], 'Leishmania': [2312, 2475, 2552], 'accumulate': [2316], 'inoculation/infection': [2321], 'IL-10-dependent': [2329], '-independent': [2331, 3061], '(Belkaid,': [2333], 'Piccirillo,': [2334, 2496], 'Mendez,': [2335], 'Shevach,': [2336], 'Sacks,': [2338, 2497], '2002).': [2339, 2748], 'models': [2342, 3573], 'Plasmodium': [2344, 2374, 4156], 'yoelii': [2345], 'Trypanosoma': [2347], 'congolense': [2348], 'shown': [2350, 3417, 3542, 3575, 4206], 'negative': [2351], 'eradication': [2359], 'parasites': [2361], '(Hisaeda': [2362], 'Okwor': [2366], '2012;': [2369], 'humans,': [2373], 'falciparum': [2375], 'possibly': [2378], 'antigen': [2380], 'nonspecific': [2381], 'mechanism': [2382], '(implicating': [2383], 'TGF-β)': [2387], 'decreases': [2389], 'promotes': [2394, 4052], 'parasitaemia': [2395], '(Scholzen,': [2396], 'Mittag,': [2397], 'Rogerson,': [2398], 'Cooke,': [2399], 'Plebanski,': [2401], '2009;': [2402], 'Walther': [2403], '2005).': [2406], 'Further,': [2407, 2856, 3433], 'TNFRII+': [2408], 'subset': [2409, 3356], 'proposed': [2417, 4090], 'contribute': [2419, 3017], 'severity': [2422], 'malaria': [2424, 2447], '(Minigo': [2425], 'Of': [2429, 2760, 3887], 'note,': [2430, 3888], 'deficit': [2431], 'observed': [2435, 3124, 3800], 'Fulani': [2437], 'ethnic': [2438], 'group': [2439], 'attributed': [2442], 'lower': [2444, 2848], '(Torcia': [2448], 'All': [2452], 'detrimental': [2457], 'parasitic': [2463], 'infections.': [2464, 2868, 2902, 3784], 'implicated': [2468, 3830], 'reactivation': [2471, 2491, 2516, 2549], 'well.': [2473], 'transfer': [2478], 'infected': [2482, 2486], 'chronically': [2485], 'resulted': [2488], '(Mendez,': [2494], 'Reckling,': [2495], 'Belkaid,': [2499], 'agreement': [2502], 'this,': [2504], 'time': [2510, 4078], 'secondary': [2512], 'prevented': [2514], '(Mendez': [2517], 'Also,': [2521], 'higher': [2527, 2629, 2649, 3196], 'aged': [2529, 2544], 'individuals': [2530], 'than': [2533], 'younger': [2535], 'counterparts': [2536], '(Lages': [2537, 2554], 'spontaneously': [2546], 'triggered': [2547], 'do': [2565], 'benefit': [2566], 'host': [2567, 2697], 'parasite-associated': [2569], 'issue': [2572], 'damage.': [2573], 'Schistosoma': [2575, 2631], 'mansoni': [2576], 'dysregulated': [2578], 'eggs': [2587], 'leading': [2590, 2657, 4066], 'cause': [2591, 2767], 'colon': [2596, 3194, 3228, 3246, 3297, 3424, 3456], 'pathology': [2597, 2636, 3020], 'limit': [2600], 'those': [2601], '(Baumgart,': [2603], 'Tompkins,': [2604], 'Leng,': [2605], 'Hesse,': [2607], 'Herbert,': [2609], 'Orekov,': [2610], 'Perkins,': [2611], 'Finkelman,': [2613], 'Taylor,': [2615], 'Mohrs,': [2616], 'Pearce,': [2618], 'More': [2620], 'recently,': [2621], 'Th17/Treg': [2626], 'ratio': [2627], 'haematobium-infected': [2632], 'children': [2633], 'bladder': [2635], '(Mbow': [2637], 'regulated,': [2647], 'uncontrolled': [2659], 'inflammation.': [2660, 3647, 3680], 'Inability': [2661], 'control': [2665, 2829, 3646, 3944], 'sustained': [2666], 'Th1-mediated': [2667], 'lethal': [2674], 'oral': [2675, 3524], 'Toxoplasma': [2679], 'gondii': [2680], '(Oldenhove': [2681], 'level': [2686], 'fact': [2691], 'provides': [2692, 3726], 'lifelong': [2693], 'immunity': [2694, 2744, 3039, 3569], 'reinfection.': [2699], 'For': [2700], 'example,': [2701], 'failed': [2704], 'completely': [2706], 'eradicate': [2707], 'were': [2710, 2722, 3416, 3799, 4175, 4187], 'preimmune': [2711], 'subsequent': [2713], 'contrast,': [2716, 2950], 'achieved': [2719], 'sterile': [2720], 'susceptible.': [2723], 'By': [2724, 2928], 'persistence,': [2726], 'exert': [2728, 2952], 'recirculating': [2736], 'tissue-specific': [2737], 'confer': [2742], 'concomitant': [2743], '(Belkaid': [2745], 'INTERPLAY': [2750], 'BETWEEN': [2751], 'FUNGAL': [2754], 'MORE': [2756], 'THAN': [2757], 'COMMENSALISM': [2758], 'MAINTENANCE': [2759], 'diverse': [2762, 3387, 4147], 'classes': [2763], 'diseases,': [2769], 'fungal': [2770, 2797, 3025], 'least': [2774], 'often': [2777], 'underappreciated.': [2778], 'reason': [2781], 'healthy': [2785], 'individuals,': [2786], 'fungi': [2787], 'stay': [2788], 'commensal': [2791, 3362, 3449], 'ensures': [2796], 'commensalism': [2800], 'parts': [2803], 'body.': [2806], 'disseminated': [2812], 'candidiasis,': [2813], 'proinflammatory': [2816, 3472], 'candidiasis.': [2822], 'Toll-like': [2823], '(TLR2)': [2826], '(Sutmuller': [2836, 2886], '2006),': [2839], 'TLR2−/−': [2850, 2857, 2874], '(Netea': [2852], 'resistant': [2865], 'candida': [2867, 2901, 2939], 'fact,': [2870], 'neutralizing': [2871], 'TLR2': [2872, 2896], 'receive': [2877], 'wild-type': [2878], 'sufficient': [2881, 3665], 'Candida': [2884], 'These': [2890], 'results': [2891, 3979], 'employ': [2895], 'immunosuppression': [2899], 'Interestingly,': [2903], 'phase': [2911, 2942, 2993, 3047, 3069, 4102], 'mucocutaneous': [2914], 'candidiasis': [2915], 'plays': [2919], 'central': [2921], 'quenching': [2929], '(Pandiyan': [2945, 2961], 'effect': [2955], 'later': [2957, 3068], 'phases': [2958], 'depending': [2966], 'timing': [2969], 'effectuate': [2974], 'differential': [2975], 'context': [2980], 'Aspergillus': [2982], 'fumigatus,': [2983], 'allergic': [2989, 3076, 3175], 'During': [2991, 3045, 3067], 'neutrophils': [2996, 3015, 3056], 'essential': [2998], 'initiating': [3000], 'resolution': [3003], 'reactive': [3008], 'oxygen': [3009], 'species': [3010, 3404], 'proteases': [3012], 'released': [3013], 'lung': [3019], 'sepsis.': [3026], 'division': [3028], 'labour': [3030], 'distinct': [3033], 'subsets': [3034], 'A.': [3043, 3106], 'fumigatus.': [3044], 'cellular': [3053, 4141], 'contact-dependent': [3058], '(CTLA-4)': [3059], '(IL-10)': [3062], 'acting': [3064], 'IDO.': [3066], 'coordinate': [3073], 'Th2': [3077, 3116, 3149], '(Montagnoli': [3083], 'Studies': [3087], 'cystic': [3092], 'fibrosis': [3093], 'balancing': [3100], 'fumigatus': [3107], '(Iannitti': [3108], 'pathological': [3115], 'causes': [3119], 'pulmonary': [3120], 'injury': [3121], 'Pneumocystis': [3127], 'carinii': [3128], 'Cryptococcus': [3130, 3168], 'neoformans': [3131], '(McKinley': [3133], 'Schulze': [3137], 'Mechanistically,': [3141], 'used': [3143], 'IRF4-dependent': [3144], 'colocalise': [3147], '(Wiesner': [3154], 'Conversely,': [3158], 'administration': [3163, 3525, 4230], 'IL-2/anti-IL-2': [3165], 'IgE': [3171], 'decreased': [3174], 'airway': [3176], '(Schulze': [3178], '7': [3182], 'COLONIC': [3183], 'TREGS,': [3184], 'COMMENSAL': [3185], 'MICROBIOTA,': [3186], 'GASTROINTESTINAL': [3188], 'Compared': [3190], 'organs,': [3193], 'harbours': [3195], 'proportion': [3197, 3292], '(Atarashi': [3200, 3234, 3425], 'Round': [3204, 3429], 'Mazmanian,': [3206, 3431, 3486], 'Approximately': [3208], '30%': [3209], 'FoxP3.': [3216], 'helios−,': [3221], 'majority': [3222], 'nature': [3233], 'made': [3250], '(Cebula': [3251], 'helios': [3256, 3274], 'use': [3272, 3769], 'marker': [3277], 'distinguish': [3279], 'questionable': [3285], '(Szurek': [3286], 'substantial': [3291], 'expresses': [3298], 'RORγt,': [3299], 'lineage-specific': [3301], 'transcription': [3302], '(Sefik': [3307], 'Transcriptomic': [3311], 'analysis': [3312], 'RORγt+FoxP3+': [3314, 3349], 'indicate': [3316], 'display': [3320], 'dual': [3321], 'signatures': [3322], '(Yang': [3329, 3357], 'Treg-specific': [3334], 'signature': [3335], 'FoxP3,': [3339], 'CTLA-4,': [3340], 'Eos,': [3342], 'Helios': [3344], 'demethylated': [3347], 'represent': [3353, 3689, 4029], 'stable': [3354], 'microbiota': [3363, 3470, 3507, 3540], 'gut': [3366, 3385, 3506], 'regulating': [3372], 'intestine': [3377], 'intestinal': [3381], 'homeostasis.': [3382], 'encompasses': [3386], 'species,': [3389], 'recent': [3390], 'identified': [3393], 'colon.': [3402], 'Clostridium': [3403, 3547], 'cluster': [3407], 'IV': [3408], 'XIVa': [3410], 'well': [3412], 'Bacteroides': [3414], 'fragilis': [3415], 'IL-10-secreting': [3420], 'fermenting': [3435], 'dietary': [3436], 'fibres': [3437], 'chain': [3440], 'fatty': [3441], 'acids': [3442], 'acetate,': [3445], 'butyrate,': [3446], 'propionate,': [3448], 'regulate': [3451], 'induction': [3453, 3466], '(Furusawa': [3457], 'Smith': [3461], 'regulates': [3471], 'gastrointestinal': [3475], '(GI)': [3476], 'tract': [3477, 3511, 3539], 'suppresses': [3481], 'immunopathologies': [3483], '(Round': [3484], 'an': [3489], 'question': [3491], 'needs': [3493], 'addressed': [3496], 'whether': [3498], 'harness': [3501], 'potential': [3503], 'treating': [3509, 3546], 'GI': [3510, 3538], 'improving': [3514], 'Some': [3519], 'approaches': [3522], 'prebiotics': [3527], 'probiotics.': [3529], 'faecal': [3532], 'microbial': [3533], 'transplantation': [3534], 'aiming': [3535], 'replenishing': [3537], 'great': [3543], 'promise': [3544], 'difficile': [3548], '(Gough,': [3550], 'Shaikh,': [3551], 'Manges,': [3553], '8': [3555], 'DAMPEN': [3557], 'VACCINES': [3561], 'intensity': [3564], 'duration': [3566], 'vaccines.': [3571, 4112], 'Murine': [3572], 'vaccine-generated': [3579], 'primary': [3580], 'against': [3585, 3966], 'viruses,': [3586], 'recombinant': [3588], 'subunit,': [3589], 'DNA': [3591], '(Moore': [3593], 'Toka,': [3597], 'participation': [3606], '(Wang,': [3617], 'Tsai,': [3618], 'Lei,': [3619], 'Liu,': [3622], '9': [3624], 'FUTURE': [3625], 'DIRECTION:': [3626], 'TARGETING': [3627], 'INFECTIOUS': [3630], 'DISEASES': [3631], 'discussed': [3633], 'earlier,': [3634], 'may': [3650], 'ideal': [3653, 3690], 'generated': [3661], 'normally': [3664], 'confine': [3667], 'scenario': [3674], 'On': [3681], 'hand,': [3684], 'vaccination': [3688], 'situations': [3691], 'block': [3693, 3705], 'activity': [3695], '9.1': [3701], 'Potential': [3702], 'strategies': [3703], '9.1.1': [3707], 'Elimination': [3708], 'transient': [3720], 'desirable.': [3723], 'Oncology': [3724], 'options': [3728], 'deplete': [3730, 4208], 'Metronomic': [3732], 'doses': [3733], 'cyclophosphamide': [3735], 'transiently': [3736], 'decrease': [3737], 'whereas': [3740], 'preserved,': [3745], 'resulting': [3746], 'improved': [3748], 'vaccine': [3749, 3897, 4148], 'immunogenicity': [3750], 'trials': [3753], '(Le': [3754], 'Jaffee,': [3756], 'Daclizumab,': [3758], 'CD25': [3760], '(MAb),': [3763], 'approved': [3766], '(Vincenti': [3770], '1998)': [3773], 'another': [3776], 'way': [3777], 'improve': [3779], 'This': [3785], 'approach': [3786, 3813, 3987], 'however': [3787], 'limitation': [3789], 'adverse': [3791, 4115], '(such': [3793], 'appearance': [3795], 'autoimmune': [3797, 4185], 'response)': [3798], 'even': [3801], 'animals': [3805], 'CD25-based': [3807], 'depletion.': [3809], 'eliminate': [3815], 'CD25-expressing': [3816], 'activated': [3817], '9.1.2': [3827], 'Blocking': [3828, 4042], 'biology.': [3845], 'Inhibition': [3846], 'M.': [3858], '2015)': [3871], 'proliferative': [3874], 'capacity': [3875], 'ex': [3881, 4247], 'vivo': [3882, 3917], '(Peligero': [3883], 'combination': [3893], 'therapeutic': [3895, 3981], 'synergistically': [3898], 'epitope-specific': [3900], 'accelerated': [3905], '(Ha': [3910], 'macaques,': [3915], 'blockade': [3919], 'simian': [3921], 'immunodeficiency': [3922], '(SIV)-specific': [3924], 'culminating': [3941], 'better': [3943], 'SIV-infected': [3952], 'macaques': [3953], '(Velu': [3954], 'Perturbing': [3958], 'PD-1-PD-L1': [3960], '(Trautmann': [3971], 'view': [3976], 'encouraging': [3978], 'MAbs': [3983, 4237], 'cancer,': [3985], 'undertaken': [3990], 'along': [3991], 'anti-tuberculosis': [3993], 'chemotherapy': [3994], 'therapy.': [3997], 'noted': [4003], 'pivotal': [4010], 'immunopathology,': [4014], 'therefore': [4015], 'complete': [4016], 'abrogation': [4017], 'detrimental.': [4023], 'Inhibitors': [4024], 'additional': [4030], 'ways': [4031], '(Ohkura,': [4036], 'Hamaguchi,': [4037], 'Sakaguchi,': [4039], '9.1.3': [4041], 'CCR4': [4050, 4064, 4137, 4193, 4228, 4236], 'ligands': [4065], 'Because': [4072], 'encounter': [4080], 'determines': [4083], 'response,': [4088], 'we': [4089, 4120], 'impact': [4094], 'initial': [4101], 'boosts': [4106], 'To': [4113], 'avoid': [4114], 'depletion,': [4119], 'targeted': [4121], 'using': [4126], 'molecule': [4128], 'antagonists': [4129, 4138], 'CCR4.': [4131], 'hypothesis,': [4136], 'humoral': [4143], 'Mycobacterium,': [4151], 'Haematopinus': [4152], 'suis,': [4153], 'HBV,': [4154], '(Bayry,': [4157], 'Tartour,': [4158], 'Tough,': [4160], 'Davies': [4170], 'vaccinated': [4180], 'animals,': [4181], 'signs': [4183], 'observed.': [4190], 'humanised': [4192], 'MAb': [4194, 4229], 'mogamulizumab': [4195], 'developed': [4196], 'treatment': [4199], 'CCR4-expressing': [4201], 'lymphomas': [4203], '(Sugiyama': [4210], 'Experimental': [4214], 'anti-simian': [4219], 'leukaemia': [4221], '(Sugata': [4231], 'Whether': [4235], 'remains': [4244]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2604213724', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 3}], 'updated_date': '2024-12-07T21:04:18.683483', 'created_date': '2017-04-14'}