Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2602933632', 'doi': 'https://doi.org/10.2147/ijn.s131367', 'title': 'A dual-mediated liposomal drug delivery system targeting the brain: rational construction, integrity evaluation across the blood–brain barrier, and the transporting mechanism to glioma cells', 'display_name': 'A dual-mediated liposomal drug delivery system targeting the brain: rational construction, integrity evaluation across the blood–brain barrier, and the transporting mechanism to glioma cells', 'publication_year': 2017, 'publication_date': '2017-03-01', 'ids': {'openalex': 'https://openalex.org/W2602933632', 'doi': 'https://doi.org/10.2147/ijn.s131367', 'mag': '2602933632', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28405164', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5378461'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/ijn.s131367', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=35709', 'source': {'id': 'https://openalex.org/S101287785', 'display_name': 'International Journal of Nanomedicine', 'issn_l': '1176-9114', 'issn': ['1176-9114', '1178-2013'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.dovepress.com/getfile.php?fileID=35709', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100353299', 'display_name': 'Chang Liu', 'orcid': 'https://orcid.org/0000-0002-7867-6807'}, 'institutions': [{'id': 'https://openalex.org/I275847375', 'display_name': 'American Pharmacists Association', 'ror': 'https://ror.org/02cbrh206', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I275847375']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chang Liu', 'raw_affiliation_strings': ['Beijing Key laboratory of Molecular Pharmaceutics and New Drug Delivery systems,', 'Department of Pharmaceutics,', 'school of Pharmaceutical sciences,'], 'affiliations': [{'raw_affiliation_string': 'Beijing Key laboratory of Molecular Pharmaceutics and New Drug Delivery systems,', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Pharmaceutics,', 'institution_ids': ['https://openalex.org/I275847375']}, {'raw_affiliation_string': 'school of Pharmaceutical sciences,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100780667', 'display_name': 'Xiaona Liu', 'orcid': 'https://orcid.org/0000-0001-8934-056X'}, 'institutions': [{'id': 'https://openalex.org/I275847375', 'display_name': 'American Pharmacists Association', 'ror': 'https://ror.org/02cbrh206', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I275847375']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiao-Na Liu', 'raw_affiliation_strings': ['Beijing Key laboratory of Molecular Pharmaceutics and New Drug Delivery systems,', 'Department of Pharmaceutics,', 'school of Pharmaceutical sciences,'], 'affiliations': [{'raw_affiliation_string': 'Beijing Key laboratory of Molecular Pharmaceutics and New Drug Delivery systems,', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Pharmaceutics,', 'institution_ids': ['https://openalex.org/I275847375']}, {'raw_affiliation_string': 'school of Pharmaceutical sciences,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100744277', 'display_name': 'Guiling Wang', 'orcid': 'https://orcid.org/0000-0001-7304-1610'}, 'institutions': [{'id': 'https://openalex.org/I275847375', 'display_name': 'American Pharmacists Association', 'ror': 'https://ror.org/02cbrh206', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I275847375']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gui-Ling Wang', 'raw_affiliation_strings': ['Beijing Key laboratory of Molecular Pharmaceutics and New Drug Delivery systems,', 'Department of Pharmaceutics,', 'school of Pharmaceutical sciences,'], 'affiliations': [{'raw_affiliation_string': 'Beijing Key laboratory of Molecular Pharmaceutics and New Drug Delivery systems,', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Pharmaceutics,', 'institution_ids': ['https://openalex.org/I275847375']}, {'raw_affiliation_string': 'school of Pharmaceutical sciences,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016194015', 'display_name': 'Yu Hei', 'orcid': 'https://orcid.org/0000-0002-8485-733X'}, 'institutions': [{'id': 'https://openalex.org/I275847375', 'display_name': 'American Pharmacists Association', 'ror': 'https://ror.org/02cbrh206', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I275847375']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yu Hei', 'raw_affiliation_strings': ['Beijing Key laboratory of Molecular Pharmaceutics and New Drug Delivery systems,', 'Department of Pharmaceutics,', 'school of Pharmaceutical sciences,'], 'affiliations': [{'raw_affiliation_string': 'Beijing Key laboratory of Molecular Pharmaceutics and New Drug Delivery systems,', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Pharmaceutics,', 'institution_ids': ['https://openalex.org/I275847375']}, {'raw_affiliation_string': 'school of Pharmaceutical sciences,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102986944', 'display_name': 'Shuai Meng', 'orcid': 'https://orcid.org/0009-0001-0052-6008'}, 'institutions': [{'id': 'https://openalex.org/I275847375', 'display_name': 'American Pharmacists Association', 'ror': 'https://ror.org/02cbrh206', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I275847375']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shuai Meng', 'raw_affiliation_strings': ['Beijing Key laboratory of Molecular Pharmaceutics and New Drug Delivery systems,', 'Department of Pharmaceutics,', 'school of Pharmaceutical sciences,'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutics,', 'institution_ids': ['https://openalex.org/I275847375']}, {'raw_affiliation_string': 'Beijing Key laboratory of Molecular Pharmaceutics and New Drug Delivery systems,', 'institution_ids': []}, {'raw_affiliation_string': 'school of Pharmaceutical sciences,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101924284', 'display_name': 'Lingfei Yang', 'orcid': 'https://orcid.org/0000-0002-2984-7294'}, 'institutions': [{'id': 'https://openalex.org/I275847375', 'display_name': 'American Pharmacists Association', 'ror': 'https://ror.org/02cbrh206', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I275847375']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ling-Fei Yang', 'raw_affiliation_strings': ['Beijing Key laboratory of Molecular Pharmaceutics and New Drug Delivery systems,', 'Department of Pharmaceutics,', 'school of Pharmaceutical sciences,'], 'affiliations': [{'raw_affiliation_string': 'Beijing Key laboratory of Molecular Pharmaceutics and New Drug Delivery systems,', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Pharmaceutics,', 'institution_ids': ['https://openalex.org/I275847375']}, {'raw_affiliation_string': 'school of Pharmaceutical sciences,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102768613', 'display_name': 'Lan Yuan', 'orcid': 'https://orcid.org/0000-0003-1595-8951'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lan Yuan', 'raw_affiliation_strings': ["Medical and healthy analysis center, Peking University, Beijing, People's republic of china"], 'affiliations': [{'raw_affiliation_string': "Medical and healthy analysis center, Peking University, Beijing, People's republic of china", 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101964043', 'display_name': 'Ying Xie', 'orcid': 'https://orcid.org/0000-0001-8410-5026'}, 'institutions': [{'id': 'https://openalex.org/I275847375', 'display_name': 'American Pharmacists Association', 'ror': 'https://ror.org/02cbrh206', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I275847375']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ying Xie', 'raw_affiliation_strings': ['Beijing Key laboratory of Molecular Pharmaceutics and New Drug Delivery systems,', 'Department of Pharmaceutics,', 'school of Pharmaceutical sciences,'], 'affiliations': [{'raw_affiliation_string': 'Beijing Key laboratory of Molecular Pharmaceutics and New Drug Delivery systems,', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Pharmaceutics,', 'institution_ids': ['https://openalex.org/I275847375']}, {'raw_affiliation_string': 'school of Pharmaceutical sciences,', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2836, 'currency': 'USD', 'value_usd': 2836, 'provenance': 'doaj'}, 'apc_paid': {'value': 2836, 'currency': 'USD', 'value_usd': 2836, 'provenance': 'doaj'}, 'fwci': 3.36, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 78, 'citation_normalized_percentile': {'value': 0.999983, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': 'Volume 12', 'issue': None, 'first_page': '2407', 'last_page': '2425'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10063', 'display_name': 'Nanoparticle-Based Drug Delivery', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10207', 'display_name': 'Advanced biosensing and bioanalysis techniques', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/transferrin-receptor', 'display_name': 'Transferrin receptor', 'score': 0.6364683}, {'id': 'https://openalex.org/keywords/internalization', 'display_name': 'Internalization', 'score': 0.5142996}, {'id': 'https://openalex.org/keywords/cell-penetrating-peptide', 'display_name': 'Cell-penetrating peptide', 'score': 0.4570714}], 'concepts': [{'id': 'https://openalex.org/C185154212', 'wikidata': 'https://www.wikidata.org/wiki/Q410454', 'display_name': 'Liposome', 'level': 2, 'score': 0.70713973}, {'id': 'https://openalex.org/C2778227246', 'wikidata': 'https://www.wikidata.org/wiki/Q1365309', 'display_name': 'Glioma', 'level': 2, 'score': 0.64271784}, {'id': 'https://openalex.org/C32264632', 'wikidata': 'https://www.wikidata.org/wiki/Q1134983', 'display_name': 'Transferrin receptor', 'level': 3, 'score': 0.6364683}, {'id': 'https://openalex.org/C2779820397', 'wikidata': 'https://www.wikidata.org/wiki/Q1392806', 'display_name': 'Drug delivery', 'level': 2, 'score': 0.5954004}, {'id': 'https://openalex.org/C22814914', 'wikidata': 'https://www.wikidata.org/wiki/Q410473', 'display_name': 'Transferrin', 'level': 2, 'score': 0.5739683}, {'id': 'https://openalex.org/C2778402981', 'wikidata': 'https://www.wikidata.org/wiki/Q221694', 'display_name': 'Blood–brain barrier', 'level': 3, 'score': 0.530456}, {'id': 'https://openalex.org/C139770010', 'wikidata': 'https://www.wikidata.org/wiki/Q1339807', 'display_name': 'Internalization', 'level': 3, 'score': 0.5142996}, {'id': 'https://openalex.org/C102747710', 'wikidata': 'https://www.wikidata.org/wiki/Q824237', 'display_name': 'Endosome', 'level': 3, 'score': 0.48946774}, {'id': 'https://openalex.org/C2776929087', 'wikidata': 'https://www.wikidata.org/wiki/Q189096', 'display_name': 'Cell-penetrating peptide', 'level': 3, 'score': 0.4570714}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.42596173}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.41872478}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4137302}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.39524496}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.36847937}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.3596562}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3077551}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.26986402}, {'id': 'https://openalex.org/C529278444', 'wikidata': 'https://www.wikidata.org/wiki/Q47273', 'display_name': 'Central nervous system', 'level': 2, 'score': 0.17377812}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.12576371}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001812', 'descriptor_name': 'Blood-Brain Barrier', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D016503', 'descriptor_name': 'Drug Delivery Systems', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D005910', 'descriptor_name': 'Glioma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008081', 'descriptor_name': 'Liposomes', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001812', 'descriptor_name': 'Blood-Brain Barrier', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057846', 'descriptor_name': 'Cell-Penetrating Peptides', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D057846', 'descriptor_name': 'Cell-Penetrating Peptides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D057846', 'descriptor_name': 'Cell-Penetrating Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D016503', 'descriptor_name': 'Drug Delivery Systems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042783', 'descriptor_name': 'Endothelial Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D042783', 'descriptor_name': 'Endothelial Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D042783', 'descriptor_name': 'Endothelial Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005910', 'descriptor_name': 'Glioma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D005910', 'descriptor_name': 'Glioma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008081', 'descriptor_name': 'Liposomes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D008081', 'descriptor_name': 'Liposomes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008081', 'descriptor_name': 'Liposomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008970', 'descriptor_name': 'Molecular Weight', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011092', 'descriptor_name': 'Polyethylene Glycols', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011092', 'descriptor_name': 'Polyethylene Glycols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014168', 'descriptor_name': 'Transferrin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014168', 'descriptor_name': 'Transferrin', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D014168', 'descriptor_name': 'Transferrin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/ijn.s131367', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=35709', 'source': {'id': 'https://openalex.org/S101287785', 'display_name': 'International Journal of Nanomedicine', 'issn_l': '1176-9114', 'issn': ['1176-9114', '1178-2013'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5378461', 'pdf_url': 'https://europepmc.org/articles/pmc5378461?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378461', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28405164', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/ijn.s131367', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=35709', 'source': {'id': 'https://openalex.org/S101287785', 'display_name': 'International Journal of Nanomedicine', 'issn_l': '1176-9114', 'issn': ['1176-9114', '1178-2013'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.77, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W125261686', 'https://openalex.org/W1568106481', 'https://openalex.org/W173430209', 'https://openalex.org/W1874838347', 'https://openalex.org/W1976041621', 'https://openalex.org/W1977467418', 'https://openalex.org/W1979524509', 'https://openalex.org/W1982128520', 'https://openalex.org/W1989230986', 'https://openalex.org/W1991720510', 'https://openalex.org/W2001609281', 'https://openalex.org/W2008028087', 'https://openalex.org/W2008576706', 'https://openalex.org/W2027076158', 'https://openalex.org/W2038382009', 'https://openalex.org/W2041187942', 'https://openalex.org/W2041692481', 'https://openalex.org/W2044569715', 'https://openalex.org/W2046138985', 'https://openalex.org/W2059699128', 'https://openalex.org/W2064761355', 'https://openalex.org/W2065172289', 'https://openalex.org/W2066748446', 'https://openalex.org/W2066912376', 'https://openalex.org/W2069009184', 'https://openalex.org/W2079142824', 'https://openalex.org/W2079335891', 'https://openalex.org/W2083465277', 'https://openalex.org/W2083840015', 'https://openalex.org/W2086664688', 'https://openalex.org/W2099771419', 'https://openalex.org/W2110604363', 'https://openalex.org/W2112851003', 'https://openalex.org/W2135986253', 'https://openalex.org/W2136226057', 'https://openalex.org/W2155035501', 'https://openalex.org/W2159262456', 'https://openalex.org/W2200083991', 'https://openalex.org/W2550281505', 'https://openalex.org/W2772405156', 'https://openalex.org/W4302168902', 'https://openalex.org/W757337304'], 'related_works': ['https://openalex.org/W2358166573', 'https://openalex.org/W2110968446', 'https://openalex.org/W2066822786', 'https://openalex.org/W2033602362', 'https://openalex.org/W2025935935', 'https://openalex.org/W2001564713', 'https://openalex.org/W1991250386', 'https://openalex.org/W1985279299', 'https://openalex.org/W1754259525', 'https://openalex.org/W1155390618'], 'abstract_inverted_index': {'A': [0], 'dual-mediated': [1, 108], 'liposomal': [2, 283], 'drug': [3, 239], 'delivery': [4], 'system': [5, 94], 'targeting': [6, 199, 316], 'the': [7, 14, 18, 79, 91, 134, 142, 152, 159, 173, 182, 197, 236, 252, 282, 286, 296], 'brain:': [8], 'rational': [9], 'construction,': [10], 'integrity': [11], 'evaluation': [12], 'across': [13, 235], 'blood-brain': [15], 'barrier,': [16], 'and': [17, 46, 59, 87, 98, 110, 138, 144, 169, 177, 180, 187, 191, 206, 221, 226, 254, 274], 'transporting': [19], 'mechanism': [20], 'to': [21, 74, 120, 172, 280, 298], 'glioma': [22, 139, 227, 257, 271], 'cells': [23, 140, 229, 273], 'Chang': [24], 'Liu,1,*': [25, 27], 'Xiao-Na': [26], 'Gui-Ling': [28], 'Wang,1': [29], 'Yu': [30], 'Hei,1': [31], 'Shuai': [32], 'Meng,1': [33], 'Ling-Fei': [34], 'Yang,1': [35], 'Lan': [36], 'Yuan,2': [37], 'Ying': [38], 'Xie1': [39], '1Beijing': [40], 'Key': [41], 'Laboratory': [42], 'of': [43, 52, 55, 68, 90, 129, 148, 155, 185, 224, 245, 270], 'Molecular': [44], 'Pharmaceutics': [45], 'New': [47], 'Drug': [48], 'Delivery': [49], 'Systems,': [50], 'Department': [51], 'Pharmaceutics,': [53], 'School': [54], 'Pharmaceutical': [56], 'Sciences,': [57], '2Medical': [58], 'Healthy': [60], 'Analysis': [61], 'Center,': [62], 'Peking': [63], 'University,': [64], 'Beijing,': [65], 'People’s': [66], 'Republic': [67], 'China': [69], '*These': [70], 'authors': [71], 'contributed': [72], 'equally': [73], 'this': [75], 'work': [76], 'Abstract:': [77], 'As': [78], 'global': [80], 'population': [81], 'ages,': [82], 'cancer': [83], 'rates': [84], 'increase': [85], 'worldwide,': [86], 'degenerative': [88], 'diseases': [89], 'central': [92], 'nervous': [93], '(CNS),': [95], 'brain': [96, 202], 'tumors,': [97], 'inflammation': [99], 'threaten': [100], 'human': [101], 'health': [102], 'more': [103], 'frequently.': [104], 'We': [105], 'designed': [106], 'a': [107], '(receptor-mediated': [109], 'adsorption-mediated)': [111], 'liposome,': [112], 'named': [113], 'transferrin–cell': [114], 'penetrating': [115], 'peptide–sterically': [116], 'stabilized': [117], 'liposome': [118, 241], '(TF-CPP-SSL),': [119], 'improve': [121], 'therapy': [122], 'for': [123, 201, 250], 'gliomas': [124], 'through': [125], 'combining': [126], 'molecular': [127], 'recognition': [128], 'transferrin': [130], 'receptors': [131], '(TF-Rs)': [132], 'on': [133, 151, 158], 'blood–brain': [135], 'barrier': [136], '(BBB)': [137], 'with': [141], 'internalization': [143], 'lysosomal': [145], 'escaping': [146], 'ability': [147], 'CPP.': [149], 'Based': [150], 'systematic': [153], 'investigation': [154], 'structure–activity': [156], 'relations': [157], 'cellular': [160], 'level,': [161], 'we': [162], 'constructed': [163], 'TF-CPP-SSL': [164, 232, 247, 265], 'rationally': [165], 'by': [166, 213], 'conjugating': [167], 'TF': [168, 186], 'CPP': [170, 188], 'moieties': [171], 'liposomes': [174, 195], 'via': [175], 'PEG3.4K': [176], 'PEG2.0K,': [178], 'respectively,': [179], 'found': [181], 'optimum': [183], 'densities': [184], 'were': [189], '1.8%': [190], '4%,': [192], 'respectively.': [193], 'These': [194], 'had': [196], 'highest': [198], 'efficacy': [200], 'microvascular': [203], 'endothelial': [204], 'cell': [205, 208], 'C6': [207, 228, 258, 272], 'uptake': [209], 'but': [210], 'avoided': [211], 'capture': [212], 'normal': [214], 'cells.': [215, 259], 'Fluorescence': [216], 'resonance': [217, 312], 'energy': [218, 313], 'transfer': [219], 'technology': [220], 'coculture': [222], 'models': [223], 'BBB': [225, 237, 253], 'indicated': [230], 'that': [231, 264], 'was': [233, 266], 'transported': [234], 'without': [238], 'leakage,': [240], 'breakup,': [242], 'or': [243], 'cleavage': [244], 'ligand.': [246], 'offered': [248], 'advantages': [249], 'crossing': [251], 'entering': [255], 'into': [256, 285], 'Real-time': [260], 'confocal': [261], 'viewing': [262], 'revealed': [263], 'entrapped': [267], 'in': [268], 'endosomes': [269], 'then': [275, 294], 'escaped': [276], 'from': [277], 'lysosomes': [278], 'successfully': [279], 'release': [281], 'contents': [284], 'cytosol.': [287], 'Entrapped': [288], 'contents,': [289], 'such': [290], 'as': [291], 'doxorubicin,': [292], 'could': [293], 'enter': [295], 'nucleus': [297], 'exert': [299], 'pharmacological': [300], 'effects.': [301], 'Keywords:': [302], 'dual': [303], 'ligand-modified': [304], 'liposomes,': [305], 'transferrin,': [306], 'cell-penetrating': [307], 'peptide,': [308], 'real-time': [309], 'confocal,': [310], 'fluorescence': [311], 'transfer,': [314], 'tumor': [315]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2602933632', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 2}], 'updated_date': '2025-01-04T18:14:21.801315', 'created_date': '2017-04-07'}