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934], 'from': [176, 364, 453, 497, 588, 1061, 1522, 2081], 'several': [177], 'clinical': [178, 941, 1170], 'trials': [179], 'support': [180], 'prophylactic': [181, 261], 'defibrillator': [182, 201, 232, 262, 290, 333, 365, 474, 915, 993], 'implantation': [183, 202, 263, 291, 334, 916, 994, 1471], 'in': [184, 249, 264, 409, 431, 530, 639, 643, 685, 734, 820, 841, 917, 953, 1072, 1159, 1169, 1331, 1403, 1472, 1676, 1732, 1790, 1830, 1898, 1967, 2013, 2110, 2138], 'with': [186, 217, 251, 260, 266, 284, 354, 435, 460, 507, 532, 624, 635, 736, 748, 801, 850, 919, 955, 1333, 1474, 1513, 1678, 1792, 1832, 1961, 1969, 2112], 'symptoms': [187], 'heart': [189, 268, 552, 1416, 1477, 1835], 'failure': [190, 269], 'left': [192, 391, 464, 555, 626, 661, 692, 812, 923, 956, 1035, 1516, 1599, 1685], 'ejection': [194, 393, 466, 557, 628, 663, 694, 814, 958, 1037, 1556, 1601, 2175], 'fraction': [195, 394, 467, 629, 664, 695, 815, 959, 1602], '≤35%.1,2': [196], 'Yet,': [197], 'existing': [198], 'guidelines': [199, 472, 965], 'direct': [200, 436], 'small': [205, 852], 'subset': [206, 987], 'overall': [209], 'population': [210, 687], 'death,': [215], 'an': [218, 230, 424, 622, 867, 1359, 1411], 'average': [219], 'annual': [220], 'shock': [222], 'rate': [223], '5.1%,': [225], 'many': [226, 315], 'that': [228, 287, 308, 990], 'receive': [229], 'never': [233], 'require': [234], 'therapies': [236], 'exposed': [239], 'device-related': [241, 1013], 'risks.3,4': [242], 'DANISH': [245, 1468], 'trial': [246, 891, 908], '(Defibrillator': [247], 'Implantation': [248, 1272, 1323], 'Patients': [250, 2111], 'Non-Ischemic': [252], 'Systolic': [253, 901], 'Heart': [254, 548, 1086, 1255, 1306, 1404, 1905, 2114, 2163], 'Failure)': [255], 'found': [256], 'no': [257], 'mortality': [258, 351, 1962], 'benefit': [259, 363], 'symptomatic': [267], 'nonischemic': [271, 285, 461, 737, 842, 1475, 1733, 1778, 1793, 1970], 'cardiomyopathy.5': [272], 'Thus,': [273], 'additional': [274], 'necessary': [277, 775], 'refine': [279], 'patient': [280], 'selection': [281], 'among': [282, 306], 'cardiomyopathy': [286, 462, 1680], 'currently': [288, 310, 991], 'meet': [289, 327], 'criteria.': [292], 'At': [293], 'same': [295, 655], 'time,': [296], 'identify': [299, 985], 'death': [305, 357, 373, 430, 493, 524, 529, 598, 619, 1512, 1546, 1608, 1675, 1897, 1966], 'excluded': [311], 'must': [312, 983, 1018], 'evolve.': [313], 'As': [314], 'as': [316, 404, 883, 1041, 1824], '80%': [317], 'those': [319, 533, 1078], 'who': [320, 340, 1161], 'experience': [321, 858], 'out-of-hospital': [322], 'arrests': [324], 'would': [325, 632, 668], 'not': [326, 469, 725, 1001, 1076, 1163, 1166], 'current': [328, 471], 'primary': [331, 406, 913], 'prevention': [332, 914], 'before': [335], 'event.6–9': [337], 'These': [338, 673, 932], 'patients,': [339, 855], 'generally': [341], 'have': [342, 349, 521, 830, 846], 'preserved': [343, 346, 819], 'nearly': [345, 501], 'function,': [348], 'lower': [350], 'risks': [352], 'competing': [353], 'stand': [359], 'derive': [361], 'significant': [362, 677, 808], 'implantation.': [366, 475], 'Currently': [367], 'used': [368, 403], 'measures': [369], 'risk,': [374], 'however,': [375, 981], 'function': [380], 'rather': [381], 'than': [382], 'identification': [383], 'substrate': [386, 1727], 'arrhythmia.': [389, 499], 'is': [395, 415, 422, 724, 746, 859, 999, 1054, 1088, 1576], 'readily': [396], 'quantifiable': [397], 'echocardiography': [399], 'has': [401], 'been': [402, 847], 'stratification': [407, 840, 952, 1024], 'tool': [408], 'all': [410], 'major': [411], 'trials,': [412], 'but': [413, 728, 856, 1008, 1552], 'it': [414], 'highly': [416], 'dependent': [417], 'loading': [419], 'conditions,': [420], 'only': [423, 1002, 1026], 'effective': [425], 'predictor': [426], 'subgroups': [432], 'association': [437, 868], 'between': [438, 869, 1667], 'scar': [439, 770, 948, 1779], 'extent': [440], 'function.In': [443], 'issue': [445], 'Circulation,': [447], 'Halliday': [448, 1616], 'et': [449], 'al10': [450], 'report': [451, 1299], 'findings': [452, 962, 1521], 'prospective': [455, 933], 'registry': [456], '399': [458], '≥40%': [468], 'meeting': [470], 'All': [476], 'underwent': [478], 'baseline': [479, 513], 'cardiovascular': [480, 514], 'MRI': [481], 'were': [483, 517, 657], 'followed': [484], 'prespecified': [487], 'composite': [488], 'end': [489], 'point': [490], 'successful': [495], 'resuscitation': [496], 'Over': [500], '5': [502], 'years': [503], 'follow-up,': [505], 'midmyocardial': [508, 742, 802, 824, 870], 'late': [509, 535, 562, 610, 636, 647, 681, 717, 743, 763, 803, 825, 871, 1028, 1669], 'gadolinium': [510, 536, 563, 611, 637, 648, 682, 718, 744, 764, 804, 826, 872, 1029, 1670, 1887], 'enhancement': [511, 537, 564, 683, 719, 745, 765, 873, 1030, 1671, 1888], 'magnetic': [515, 722, 836, 946], 'resonance': [516, 723, 837, 1723], 'more': [518, 968], 'likely': [519], 'aborted': [526, 572], 'comparison': [531], 'without': [534, 995, 1515], '(17.8%': [538], 'versus': [539], '2.3%,': [540], 'P<0.001).': [541], 'After': [542], 'adjustment': [543], 'age,': [545], 'New': [546], 'York': [547], 'Association': [549, 1256, 1280, 1307, 1336, 1666, 1958], 'class': [550], 'failure,': [553], 'fraction,': [558], 'presence': [560, 606, 740], 'predicted': [565, 592], 'actual': [566], '(hazard': [567, 573], 'ratio,': [568, 574], '4.8;': [569], 'P=0.003)': [570], '35.9;': [575], 'P<0.001)': [576], 'Based': [580], 'Cox': [582], 'proportional': [583], 'hazard': [584], 'model': [585], 'parameters': [586], 'derived': [587], 'their': [589], 'data,': [590], '5-year': [593, 616], 'was': [599], 'substantially': [600], 'attenuated': [601], 'after': [602], 'accounting': [603], 'absence': [608, 645], 'enhancement.': [612, 649, 827], 'In': [613, 788, 977], 'fact,': [614, 789], 'individual': [623, 656], '45%': [631], 'be': [633, 669, 817, 936], '20%': [634], 'enhancement,': [638], 'contrast': [640], '3%': [642], 'If': [650], 'assessed': [658], 'alone,': [665, 696], 'estimated': [670], '8%.': [672], 'results': [674, 880], 'demonstrate': [675], 'incremental': [678], 'value': [679], 'assessment': [684, 949, 1724], 'over': [688], 'indicate': [698], 'possibility': [700], 'identifying': [702], 'previously': [704], 'neglected': [705], 'subgroup': [706], 'especially': [710], 'death.Midmyocardial': [716], 'disease': [726], 'specific,': [727], 'often': [729, 797], 'represents': [730], 'focal': [731], 'replacement': [732], 'fibrosis': [733, 1960], 'cardiomyopathy.': [738, 843], 'associated': [747], 'inducibility': [749], 'tachycardia': [752, 795, 1731, 1788, 1829], 'electrophysiology': [754], 'study11': [755], 'reduced': [757], 'voltage': [758], 'endocardial': [760], 'mapping.12': [761], 'Midmyocardial': [762], 'sites': [766, 796], 'appear': [767], 'represent': [769], 'heterogeneous': [772], 'myocardial': [773, 930, 2078], 'tissues': [774], 'functional': [777], 'block,': [778], 'slow': [779], 'conduction,': [780], 'perpetuation': [783], 'reentrant': [785], 'arrhythmias.13': [787], 'invasive': [791], 'mapping,': [792], 'critical': [793], 'correspond': [798], 'regions': [800], 'enhancement.12': [805], 'Notably,': [806], 'despite': [807], 'arrhythmogenic': [809], 'potential,': [810], 'may': [816, 963], 'relatively': [818, 851], 'setting': [822], 'Several': [828], 'studies': [829, 849, 1017], 'evaluated': [831], 'role': [833, 911, 1579], 'majority': [845], 'single-center': [848], 'numbers': [853], 'growing': [860], 'bulk': [863], 'supports': [866], 'death.14,15Halliday': [877], "colleagues'": [879], 'encouraging': [882], 'we': [884, 982], 'look': [885], 'toward': [886], 'ongoing': [888], 'CMR': [889], 'GUIDE': [890], '(Cardiovascular': [892], 'Magnetic': [893, 1722, 2133], 'Resonance': [894, 2134], 'Guided': [895], 'Management': [896], 'Mild-Moderate': [898], 'Left': [899], 'Ventricular': [900, 2108], 'Dysfunction;': [902], 'NCT01918215),': [903], 'prospective,': [905], 'multicenter': [906], 'randomized': [907], 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