Niacin ameliorates ulcerative colitis via prostaglandin D <sub>2</sub> ‐mediated D prostanoid receptor 1 activation

Name: Work Video:
Duration: 3 min 30 s
Juanjuan Li; Deping Kong; Qi Wang; Wei Wu; Yanping Tang; Tingting Bai; Liang Guo; Lumin Wei; Qianqian Zhang; Yu Yu; Yuting Qian; Shengkai Zuo; Guizhu Liu; Qian Liu; Sheng Wu; Yi Zang; Qian Zhu; Daile Jia; Yuanyang Wang; Weiyan Yao; Yong Ji; Huiyong Yin; Masataka Nakamura; Michael Lazarus; Richard Breyer; Lifu Wang; Ying Yu
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'ameliorates': [8, 1967, 3781], 'ulcerative': [9, 1968, 2207], 'colitis': [10, 1969, 2073, 2097, 2165, 2208, 2233, 2273, 2807, 2856, 2966, 3360, 3391, 3443, 3488, 3502, 3525, 3694, 3783, 3807, 3822, 3952, 3960, 4125], 'via': [11, 1970], 'prostaglandin': [12, 1971, 2032, 2200, 2680], 'D2-mediated': [13, 1972], 'D': [14, 1973, 2075, 2734, 3370], 'prostanoid': [15, 1974, 2076, 2735, 3371], 'receptor': [16, 1975, 2077, 2085, 2544, 2600, 2631, 2736, 2742, 2780, 2897, 3354, 3383, 3788, 3804], '1': [17, 1976, 2078, 2737, 3568, 4002], 'activation': [18, 2169, 2215, 2632, 2894, 3508], 'Juanjuan': [19, 21, 873, 875, 1729], 'Li': [20, 22, 874, 876], 'Department': [23, 103, 130, 157, 184, 211, 225, 246, 358, 481, 508, 599, 623, 761, 772, 798, 853, 877, 957, 984, 1011, 1038, 1065, 1079, 1100, 1212, 1335, 1362, 1453, 1477, 1615, 1626, 1652, 1707], 'of': [24, 35, 41, 56, 73, 88, 104, 115, 131, 142, 158, 169, 185, 196, 212, 226, 247, 258, 264, 279, 296, 311, 328, 343, 359, 370, 387, 402, 419, 434, 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1835, 1882, 1922], 'Oncology,': [227, 1081, 1840], 'Medical': [229, 605, 608, 663, 716, 777, 859, 862, 1083, 1459, 1462, 1517, 1570, 1631, 1713, 1716, 1842, 1854, 1857, 1874, 1884, 1921], 'College,': [230, 1084, 1843], 'University,': [232, 609, 664, 719, 863, 1086, 1463, 1518, 1573, 1717, 1845, 1858, 1875, 1887], 'Lumin': [242, 244, 1096, 1098, 1743], 'Qianqian': [290, 292, 1144, 1146, 1745], 'Zhang': [291, 293, 1145, 1147], 'Yu': [322, 323, 324, 325, 822, 826, 1176, 1177, 1178, 1179, 1676, 1680, 1747, 1785], 'Yuting': [354, 356, 1208, 1210, 1749], 'Qian': [355, 357, 445, 447, 531, 533, 1209, 1211, 1299, 1301, 1385, 1387, 1755, 1761], 'Shengkai': [381, 383, 1235, 1237, 1751], 'Zuo': [382, 384, 1236, 1238], 'Guizhu': [413, 415, 1267, 1269, 1753], 'Liu': [414, 416, 446, 448, 1268, 1270, 1300, 1302], 'Sheng': [477, 479, 1331, 1333, 1757], 'Yi': [504, 506, 1358, 1360, 1759], 'Zang': [505, 507, 1359, 1361], 'Zhu': [532, 534, 1386, 1388], 'Daile': [563, 565, 1417, 1419, 1763], 'Jia': [564, 566, 1418, 1420], 'Yuanyang': [595, 597, 1449, 1451, 1765], 'Pharmacology,': [601, 855, 1455, 1709, 1850], 'Basic': [604, 858, 1458, 1712, 1853], 'Tianjin': [607, 861, 1461, 1715, 1856], 'Tianjin,': [610, 864, 1464, 1718, 1859], 'Weiyan': [619, 621, 1473, 1475, 1767], 'Yao': [620, 622, 1474, 1476], 'Yong': [646, 648, 1500, 1502, 1769], 'Ji': [647, 649, 1501, 1503], 'The': [650, 1504, 2173, 2541, 2569], 'Cardiovascular': [654, 1508, 1865], 'Disease': [655, 1509, 1866], 'and': [656, 717, 1510, 1571, 1783, 1867, 1885, 1985, 2003, 2063, 2092, 2109, 2130, 2148, 2211, 2226, 2247, 2262, 2309, 2313, 2329, 2351, 2362, 2393, 2430, 2438, 2450, 2479, 2492, 2528, 2531, 2555, 2578, 2592, 2687, 2713, 2749, 2805, 2860, 2873, 2887, 2902, 2916, 2954, 2980, 2999, 3013, 3020, 3045, 3133, 3232, 3294, 3358, 3366, 3374, 3413, 3472, 3538, 3546, 3551, 3558, 3606, 3732, 3738, 3800, 3812, 3873, 3892, 3901, 3915, 3943, 3974, 3981, 4015, 4035, 4141, 4148], 'Molecular': [657, 1511, 1868], 'Intervention,': [658, 1512, 1869], 'Atherosclerosis': [659, 1513, 1870], 'Centre,': [661, 1515, 1872], 'Nanjing': [662, 1516, 1873], 'Nanjing,': [665, 1519, 1876], 'Jiangsu,': [666, 1520, 1877], 'Huiyong': [675, 677, 1529, 1531, 1771], 'Yin': [676, 678, 1530, 1532], 'Masataka': [707, 709, 1561, 1563, 1773], 'Nakamura': [708, 710, 1562, 1564], 'Human': [711, 1565], 'Gene': [712, 1566, 1880], 'Sciences': [713, 1567, 1881], 'Tokyo': [715, 1569, 1883], 'Dental': [718, 1572, 1886], 'Bunkyo-ku,': [720, 1574, 1888], 'Tokyo,': [721, 1575, 1889], 'Japan': [722, 747, 1576, 1601, 1890, 1904], 'Michael': [730, 732, 1584, 1586, 1775], 'Lazarus': [731, 733, 1585, 1587], 'International': [734, 1588], 'Integrative': [737, 1591, 1894], 'Sleep': [738, 1592, 1895], 'Medicine': [739, 1593, 1896], '(WPI-IIIS),': [740, 1594, 1897], 'Tsukuba,': [743, 1597, 1900], 'Tsukuba': [744, 1598, 1901], 'City,': [745, 1599, 1902], 'Ibaraki,': [746, 1600, 1903], 'Richard': [755, 758, 1609, 1612, 1777], 'M': [756, 759, 1610, 1613, 1778], 'Breyer': [757, 760, 1611, 1614], 'Veterans': [763, 1617, 1907], 'Affairs,': [764, 1618, 1908], 'Tennessee': [765, 1619, 1909], 'Valley': [766, 1620, 1910], 'Health': [767, 1621, 1911], 'Authority,': [768, 1622, 1912], 'Nashville,': [769, 779, 1623, 1633, 1913, 1923], 'TN,': [770, 780, 1624, 1634, 1914, 1924], 'USA': [771, 781, 1625, 1635, 1915, 1925], 'Vanderbilt': [775, 1629, 1919], 'Lifu': [789, 793, 1643, 1647, 1780], 'Corresponding': [791, 823, 1645, 1677], 'Author': [792, 824, 1646, 1678, 1727], '[email': [795, 827, 829, 1649, 1681, 1683, 1945, 1954, 1956], 'protected]': [796, 828, 830, 1650, 1682, 1684, 1946, 1957], 'orcid.org/0000-0001-5172-9932': [797, 1651], 'Ying': [821, 825, 1675, 1679, 1784], 'orcid.org/0000-0002-6476-1752': [831, 1685], 'Information': [1728], 'Li1,2,‡,': [1730], 'Kong2,‡,': [1732], 'Wang1,‡,': [1734], 'Wu1,‡,': [1736], 'Tang1,': [1738], 'Bai1,': [1740], 'Guo3,4,': [1742], 'Wei1,2,': [1744], 'Zhang2,': [1746], 'Yu2,': [1748], 'Qian1,': [1750], 'Zuo2,': [1752], 'Liu2,': [1754, 1756], 'Wu1,': [1758], 'Zang1,': [1760], 'Zhu2,': [1762], 'Jia2,': [1764], 'Wang5,': [1766], 'Yao1,': [1768], 'Ji6,': [1770], 'Yin2,': [1772], 'Nakamura7,': [1774], 'Lazarus8,': [1776], 'Breyer9,10,': [1779], '*,1': [1782], '*,*,2,5': [1786], '1Department': [1787], '2Key': [1803], '3Department': [1824], '4Department': [1838], '5Department': [1848], '6The': [1861], '7Human': [1879], '8International': [1891], '9Department': [1905], '10Department': [1916], '‡These': [1926], 'authors': [1927], 'contributed': [1928], 'equally': [1929], 'work': [1932], '*Corresponding': [1933, 1947], 'author.': [1934, 1948], 'Tel:': [1935, 1949], '+86': [1936, 1941, 1950], '021': [1937, 1942], '64370045': [1938], '665290;': [1939], 'Fax:': [1940], '66295266;': [1943], 'E-mail:': [1944], '21': [1951], '54920970;': [1952], 'E-mails:': [1953], 'protected];': [1955], 'EMBO': [1958], 'Mol': [1959], 'Med': [1960], '(2017)9:571-588https://doi.org/10.15252/emmm.201606987': [1961], 'Correction(s)': [1962], 'article': [1965, 1983], 'activation07': [1977], 'December': [1978], '2020': [1979], 'PDFDownload': [1980], 'PDF': [1981], 'text': [1984], 'main': [1986], 'figures.': [1987], 'Peer': [1988], 'ReviewDownload': [1989], 'a': [1990, 2025, 2193, 2276, 2482, 2699, 2994, 3837, 4175], 'summary': [1991], 'the': [1993, 2214, 2292, 2294, 2307, 2337, 2359, 2457, 2588, 2598, 2654, 2703, 2715, 2728, 2850, 3379, 3439, 3577, 3581, 3666, 3704, 3708, 4082, 4217], 'editorial': [1994, 1998], 'decision': [1995, 1999], 'including': [1997, 2447, 3446], 'letters,': [2000], 'reviewer': [2001], 'comments': [2002], 'responses': [2005], 'feedback.': [2007], 'ToolsAdd': [2008], 'favoritesDownload': [2010], 'CitationsTrack': [2011], 'CitationsPermissions': [2012], 'ShareFacebookTwitterLinked': [2013], 'InMendeleyWechatReddit': [2014], 'Figures': [2015], '&': [2016, 2317, 2538, 2602, 2694, 2723], 'Info': [2017], 'Abstract': [2018], 'Niacin,': [2019, 2186], 'as': [2020, 2424, 2476, 2481, 2487, 2548, 2556, 3073, 3147, 3315, 3614, 3752, 4053, 4162], 'an': [2021, 2187, 2346, 2363], 'antidyslipidemic': [2022], 'drug,': [2023], 'elicits': [2024, 2192], 'strong': [2026, 2194], 'flushing': [2027, 2195, 2717, 2730], 'response': [2028, 2196, 2367, 3562, 3742, 3985, 4019, 4152], 'release': [2030, 2198, 2222, 2683, 2712, 3794], '(PG)': [2033, 2201], 'D2.': [2034, 2202], 'However,': [2035, 3055, 3491], 'whether': [2036, 2836, 2934], 'niacin': [2037, 2050, 2158, 2177, 2257, 2564, 2573, 2624, 2659, 2674, 2854, 2870, 2911, 2935, 2988, 3003, 3028, 3037, 3056, 3181, 3187, 3228, 3249, 3260, 3273, 3300, 3791, 3816, 3831, 3909, 3934, 3956, 3967, 3998, 4007, 4026, 4129], 'is': [2038, 2275, 2340, 2473, 2580, 2607, 2675, 2819], 'beneficial': [2039, 2161, 2570, 3931], 'inflammatory': [2041, 2278, 2303, 2458, 2613, 2880, 2938, 3465], 'bowel': [2042, 2279, 2939], 'disease': [2043, 2280, 2391, 3547, 3727, 3975, 4136], '(IBD)': [2044, 2281], 'remains': [2045, 2327, 2832], 'unclear.': [2046], 'Here,': [2047], 'we': [2048, 2848, 2945, 3035, 3377], 'observed': [2049, 2796, 3036, 3937], 'administration-enhanced': [2051], 'PGD2': [2052, 2221, 2711, 2726, 2772, 2793, 2843, 2928, 2949, 2958, 2975, 3086, 3096, 3112, 3363, 3382, 3793], 'production': [2053, 2794, 2950, 2976, 3097, 3234, 3245, 3296], 'in': [2054, 2057, 2074, 2086, 2098, 2151, 2166, 2178, 2209, 2223, 2234, 2265, 2408, 2412, 2463, 2553, 2558, 2610, 2684, 2702, 2747, 2797, 2824, 2858, 2861, 2898, 2919, 2930, 2951, 2977, 2990, 2993, 3008, 3024, 3050, 3066, 3088, 3098, 3136, 3235, 3246, 3272, 3297, 3361, 3392, 3444, 3467, 3503, 3526, 3561, 3576, 3695, 3703, 3741, 3784, 3795, 3808, 3898, 3924, 3938, 3961, 3984, 4018, 4151], 'colon': [2055, 2799, 2952, 3009, 3067, 3449, 3468, 3552, 3579, 3706, 3733, 3796, 3876, 3918, 4010, 4142], 'tissues': [2056, 2800, 2953, 3010, 3068, 3469, 3797], 'dextran': [2058], 'sulfate': [2059], 'sodium': [2060], '(DSS)-challenged': [2061], 'mice,': [2062, 2554, 3026, 3071, 3605, 3900], 'protected': [2064], 'mice': [2065, 2099, 2167, 2210, 2225, 2235, 2686, 2748, 2859, 2931, 2992, 3090, 3102, 3117, 3236, 3252, 3303, 3362, 3395, 3445, 3481, 3504, 3515, 3527, 3560, 3582, 3696, 3709, 3740, 3785, 3809, 3925, 3940, 3949, 3983, 3996, 4017, 4034, 4121, 4150], 'against': [2066, 2231, 2839, 2937, 3516, 4122], 'DSS': [2067, 3104, 3119, 3238, 3254, 3305, 3421, 3564, 3585, 3825, 3896, 3987, 4021], 'or': [2068, 2296, 3389, 3826], '2,4,6-trinitrobenzene': [2069], 'sulfonic': [2070], 'acid': [2071, 2550, 2577, 2961], '(TNBS)-induced': [2072], '(DP1)-dependent': [2079], 'manner.': [2080], 'Specific': [2081], 'ablation': [2082], 'DP1': [2084, 2741, 2779, 2896, 3353, 3373, 3398, 3436, 3510, 3521, 3690, 3787, 3803], 'vascular': [2087, 2102, 2120, 2240, 2445, 2452, 2885], 'endothelial': [2088, 2900], 'cells,': [2089, 2108, 2125, 2901], 'colonic': [2090, 2244, 2461, 2879, 2890, 2903], 'epithelium,': [2091], 'myeloid': [2093], 'cells': [2094, 3466], 'augmented': [2095, 3438], 'DSS/TNBS-induced': [2096, 2164, 2232, 3517, 3782, 3806], 'through': [2100, 2197, 2213, 2236, 2629, 2731, 2778, 2876, 2942, 3786], 'increasing': [2101], 'permeability,': [2103, 2121, 2886], 'promoting': [2104], 'apoptosis': [2105, 2892], 'epithelial': [2107, 2124, 2127, 2425, 3455], 'stimulating': [2110], 'pro-inflammatory': [2111, 2132, 2250], 'cytokine': [2112, 2251, 2881], 'secretion': [2113, 2956, 3087], 'macrophages,': [2115, 2899], 'respectively.': [2116], 'treatment': [2118, 2138, 2255, 2906, 3004, 3038, 3957, 3968, 4008, 4027, 4130], 'improved': [2119], 'reduced': [2122, 3903], 'apoptotic': [2123], 'promoted': [2126, 2144, 2913], 'cell': [2128, 3456], 'update,': [2129], 'suppressed': [2131], 'gene': [2133], 'expression': [2134, 2606, 3135], 'macrophages.': [2136], 'Moreover,': [2137, 2444, 2619], 'with': [2139, 2153, 2267, 2311, 2662, 2821, 2863, 2907, 2921, 3140, 3396, 3584, 3638, 3673, 3771, 3790, 4097, 4195], 'niacin-containing': [2140], 'retention': [2141, 2908], 'enema': [2142, 2254, 2909], 'effectively': [2143, 2258, 2912], 'UC': [2145, 2338, 2394, 2464, 2663, 2803, 2840], 'clinical': [2146, 2260, 2666, 2914, 3819], 'remission': [2147, 2261, 2823, 2915], 'mucosal': [2149, 2263, 2365, 2917], 'healing': [2150, 2264, 2918], 'patients': [2152, 2266, 2465, 2661, 2804, 2862, 2920], 'moderately': [2154, 2268, 2864, 2922], 'active': [2155, 2269, 2287, 2774, 2865, 2923], 'disease.': [2156], 'Therefore,': [2157], 'displayed': [2159], 'multiple': [2160, 2626], 'effects': [2162, 2589, 2754, 3380, 3932], 'on': [2163, 2574, 2590, 2660, 2755, 2842, 2855, 3061, 3229, 3385, 3958, 3969, 4009, 4028, 4131], 'PGD2/DP1': [2171, 2217], 'axis.': [2172, 2218], 'potential': [2174, 2655], 'efficacy': [2175, 2657], 'management': [2179], 'IBD': [2181, 2409], 'warrants': [2182, 2664], 'further': [2183, 2665], 'investigation.': [2184, 2667], 'Synopsis': [2185], 'ancient': [2188], 'lipid-lowering': [2189], 'drug': [2190], 'that': [2191, 2354, 2623, 2869], 'improves': [2204], 'experimentally': [2205], 'induced': [2206, 3005, 3823], 'humans': [2212, 2688, 2750, 2825], 'increases': [2220], 'both': [2224, 2297, 2685, 2802, 2857, 3356], 'humans.': [2227], 'confers': [2229], 'protection': [2230, 2838], 'DP1-mediated': [2237], 'inhibition': [2238, 2888], 'leakage,': [2241], 'suppression': [2242, 2584, 2883], 'epithelium': [2245, 2891], 'apoptosis,': [2246], 'reduction': [2248, 3447], 'secretion.': [2252], 'Retention': [2253], 'containing': [2256, 2910], 'promotes': [2259, 2727, 3792], 'UC.': [2270, 2866, 2924], 'Introduction': [2271], 'Ulcerative': [2272], '(UC)': [2274], 'chronic': [2277, 2302], 'characterized': [2282], 'recurrent': [2284], 'episodes': [2285], 'disease,': [2288], 'which': [2289, 2386, 2417, 2498, 2697, 2818], 'commonly': [2290], 'affects': [2291], 'colon,': [2293], 'rectum,': [2295], 'simultaneously.': [2298], 'Histologically,': [2299], 'it': [2300, 2517, 2831], 'displays': [2301, 2625], 'alterations': [2304], 'limited': [2305], 'mucosa': [2308, 2462], 'submucosa': [2310], 'cryptitis': [2312], 'crypt': [2314], 'abscesses': [2315], '(Danese': [2316], 'Fiocchi,': [2318], '2011).': [2319, 2371, 2402, 2443], 'Despite': [2320], 'UC-related': [2321], 'mortality': [2322, 3476, 3904], 'being': [2323], 'low,': [2324], 'its': [2325, 2732, 2753], 'morbidity': [2326], 'high': [2328], '10–20%': [2330], 'affected': [2332], 'individuals': [2333], 'undergo': [2334], 'colectomy.': [2335], 'Although': [2336], 'etiology': [2339], 'largely': [2341], 'unknown,': [2342], 'accumulated': [2343], 'evidence': [2344, 2621], 'supports': [2345], 'interaction': [2347], 'between': [2348, 2389], 'genetic': [2349, 2379], 'predisposition': [2350], 'microbial/environmental': [2352], 'factors': [2353], 'trigger': [2355], 'pro-colitogenic': [2356], 'perturbations': [2357], 'host–commensal': [2360], 'relationship': [2361], 'aberrant': [2364], 'immune': [2366, 2432], '(Khor': [2368, 2440], 'et': [2369, 2396, 2400, 2441, 2467, 2566, 2616, 2634, 2638, 2642, 2646, 2650, 2690, 2719, 2759, 2763, 2767, 2782, 2786, 2811, 2815, 2827, 3495], 'al,': [2370, 2397, 2401, 2442, 2468, 2567, 2617, 2635, 2639, 2643, 2647, 2651, 2691, 2720, 2760, 2764, 2768, 2783, 2787, 2812, 2816, 2828, 3496], 'Genome-wide': [2372], 'association': [2373], 'studies': [2374], '(GWAS)': [2375], 'have': [2376], 'identified': [2377], '47': [2378], 'susceptibility': [2380], 'loci': [2381, 2406], 'UC,': [2383], '28': [2384], 'are': [2387, 2410, 2418, 2499, 2594, 3145, 3152, 3313, 3320, 3612, 3619, 3750, 4041, 4051, 4160], 'shared': [2388], "Crohn's": [2390], '(CD)': [2392], '(Franke': [2395], '2010;': [2398, 2692], 'Anderson': [2399], 'Indeed,': [2403, 2974, 3828], 'these': [2404, 3930], 'risk': [2405], 'implicated': [2407], 'involved': [2411], 'different': [2413], 'key': [2414], 'signal': [2415], 'pathways': [2416], 'essential': [2419, 2500], 'intestinal': [2421, 3460], 'homeostasis,': [2422], 'such': [2423, 2486, 3072], 'restitution,': [2426], 'barrier': [2427], 'function,': [2428], 'innate': [2429], 'adaptive': [2431], 'regulation,': [2433], 'microbial': [2434], 'defense,': [2435], 'cellular': [2436], 'stress,': [2437], 'metabolism': [2439, 2757], 'injury': [2446], 'dilated': [2448], 'vessels': [2449], 'increased': [2451, 3014], 'permeability': [2453], 'also': [2454, 2474, 2546, 3483, 3910, 4215], 'contributes': [2455], 'disorder': [2459], '(Deng': [2466], '2013).': [2469, 2540, 2725], '(nicotinic': [2471], 'acid)': [2472], 'known': [2475, 2547], 'vitamin': [2477], 'B3': [2478], 'serves': [2480], 'precursor': [2483], 'coenzymes': [2485], 'nicotinamide': [2488, 2493], 'adenine': [2489, 2494], 'dinucleotide': [2490, 2495], '(NAD)': [2491], 'phosphate': [2496], '(NADP),': [2497], 'living': [2502], 'cells.': [2503], 'has': [2505], 'been': [2506], 'used': [2507], 'than': [2510, 3407, 3418], 'five': [2511], 'decades': [2512], 'treat': [2514], 'dyslipidemia,': [2515], 'because': [2516], 'reduces': [2518], 'low-density': [2519, 2524], 'lipoprotein': [2520, 2525, 2534], 'cholesterol': [2521, 2526, 2535], '(LDLc),': [2522], 'very': [2523], '(VLDLc),': [2527], 'triglycerides': [2529], '(TGs),': [2530], 'elevates': [2532], 'high-density': [2533], '(HDLc)': [2536], '(Song': [2537], 'FitzGerald,': [2539, 2695, 2724], 'orphan': [2542], 'G-protein-coupled': [2543], 'GPR109A,': [2545], 'hydroxycarboxylic': [2549], '2': [2551, 3811], '(HCA2)': [2552], 'HM74A': [2557], 'humans,': [2559], 'can': [2560], 'be': [2561, 2834], 'activated': [2562], '(Wise': [2565], '2003).': [2568], 'effect': [2571, 2671, 2852, 4218], 'free': [2575], 'fatty': [2576], 'TGs': [2579], 'mediated': [2581, 2596], 'GPR109A': [2583, 2599, 2605, 2630], 'lipolysis;': [2586], 'however,': [2587], 'HDLc': [2591], 'LDLc': [2593], 'not': [2595, 3499, 3512, 3936], '(Bodor': [2601], 'Offermanns,': [2603], '2008).': [2604], 'markedly': [2608, 2985, 3059, 3841], 'upregulated': [2609, 3039], 'macrophages': [2611, 3052], 'upon': [2612], 'stimulation': [2614], '(Feingold': [2615], '2014).': [2618, 2652], 'emerging': [2620], 'demonstrated': [2622], 'anti-inflammatory': [2627, 2872], 'properties': [2628, 2875], '(Holzhauser': [2633], '2011;': [2636], 'Digby': [2637], '2012;': [2640, 2644], 'Godin': [2641], 'Zandi-Nejad': [2645], '2013;': [2648], 'Zhou': [2649], 'Thus,': [2653, 3507], 'therapeutic': [2656, 2851], 'One': [2668], 'unpleasant': [2669], 'side': [2670], 'caused': [2672, 3894, 3920], 'cutaneous': [2676], 'flushing.': [2677, 2705], 'stimulates': [2679], 'D2': [2681], '(PGD2)': [2682], '(Hanson': [2689], 'Song': [2693, 2722], '2013),': [2696], 'plays': [2698], 'central': [2700], 'role': [2701], 'niacin-induced': [2704, 2745, 2948], 'Low-dose': [2706], 'aspirin': [2707], 'could': [2708, 3817], 'depress': [2709], 'niacin-evoked': [2710, 2729], 'reduce': [2714], 'associated': [2716, 2820], '(Cefali': [2718], '2007;': [2721, 2784], 'specific': [2733], '(DP1).': [2738], 'Blockade': [2739], 'completely': [2743], 'inhibits': [2744], 'vasodilation': [2746], 'without': [2751], 'affecting': [2752], 'lipid': [2756], '(Cheng': [2758], '2006;': [2761], 'Paolini': [2762], '2008;': [2765], 'Maccubbin': [2766], '2009).': [2769], 'In': [2770, 2845, 3001, 3907, 3928], 'addition,': [2771, 3002, 3908], 'mediates': [2773], 'resolution': [2775], 'inflammation': [2777], '(Rajakariar': [2781], '2016).': [2788], 'Interestingly,': [2789, 3394], 'marked': [2790], 'elevation': [2791, 3858], 'was': [2795, 2984, 3162, 3330, 3628, 3663, 3758, 4059, 4079, 4168], 'inflamed': [2798], 'from': [2801, 2964, 3069, 3100, 3115, 3248, 3299, 3535, 3580, 3707, 3950, 3994, 4123], 'experimental': [2806], 'murine': [2808], 'models': [2809], '(Ajuebor': [2810], '2000;': [2813], 'Vong': [2814], '2010),': [2817], 'long-term': [2822], '(Vong': [2826], '2010).': [2829], 'Yet,': [2830], 'determined': [2835, 3163, 3331, 3629, 3759, 4169], 'niacin-mediated': [2837], 'depends': [2841], 'production.': [2844], 'study,': [2847], 'investigated': [2849, 3378], 'We': [2867, 3814, 4214], 'found': [2868], 'shows': [2871], 'anti-apoptotic': [2874], 'downregulation': [2877], 'levels,': [2882], 'epithelium.': [2904], 'Furthermore,': [2905], 'Results': [2925], 'boosts': [2927], 'generation': [2929], 'To': [2932], 'explore': [2933], 'protects': [2936, 3514, 3948, 4120], 'diseases': [2940], '(IBDs)': [2941], 'releasing': [2943], 'PGD2,': [2944], 'first': [2946], 'examined': [2947, 4216], 'urinary': [2955, 2981, 3015, 3111, 3268], 'metabolites-': [2959], '11,15-Dioxo-9α-hydroxy-2,3,4,5-tetranorprostan-1,20-dioic': [2960], '(tetranor': [2962], 'PGDM)': [2963], 'DSS-induced': [2965, 3442, 3501, 3524, 3951, 3959], 'mouse': [2967], 'model': [2968], 'using': [2970, 3164, 3332, 3630, 3665, 3760, 4061, 4081, 4170], 'mass': [2971], 'spectrometry': [2972, 3093, 3108, 3241, 3290], 'analysis.': [2973], 'homogenized': [2978], 'colons': [2979, 3099, 3247, 3298, 3993], 'tetranor': [2982], 'PGDM': [2983], 'elevated': [2986], 'administration': [2989, 3829], 'DSS-challenged': [2991, 3025, 3070, 3089, 3602, 3995, 4032], 'dose-dependent': [2995], 'manner': [2996], '(Fig': [2997, 3011, 3022, 3053, 3080, 3400, 3411, 3451, 3470, 3477, 3489, 3505, 3798, 3905, 3926], '1A': [2998], 'B).': [3000], 'PGF2α': [3006, 3021], 'product': [3007], 'EV1A)': [3012], 'metabolites': [3016, 3113], 'PGE2,': [3018], 'PGI2,': [3019], 'EV1B)': [3023], 'indicating': [3027], 'may': [3029], 'upregulate': [3030], 'PG': [3031, 3244], 'biosynthesis': [3032], 'pathway.': [3033], 'Accordingly,': [3034, 3435], 'cytosolic': [3040], 'phospholipase': [3041], 'A2': [3042], '(cPLA2),': [3043], 'COX-2,': [3044, 3132], 'hematopoietic': [3046], 'PGD': [3047], 'synthase': [3048], '(hPGDS)': [3049], 'peritoneal': [3051, 3137], '1C–E).': [3054], 'had': [3057, 3414], 'no': [3058], 'influence': [3060, 3500], 'specialized': [3062], 'pro-resolving': [3063], 'mediators': [3064], '(SPMs)': [3065], 'lipoxin': [3074], '(LX)': [3075], 'A4,': [3076], 'resolvin': [3077], '(Rv)': [3078], 'E1': [3079], 'EV1C).': [3081], 'Figure': [3082, 3224, 3519, 3688, 3945, 4117], '1.': [3083], 'induces': [3085], 'A.': [3091, 3528, 3697, 3953], 'Mass': [3092, 3107, 3240, 3289], 'analysis': [3094, 3109, 3128, 3242, 3291, 3530, 4058], 'niacin-treated': [3101, 3116], 'after': [3103, 3118, 3237, 3253, 3304, 3420, 3710, 3997], 'challenge.': [3105, 3120, 3255, 3306, 3565, 3712, 3746, 3988, 4022, 4156], 'B.': [3106], '(PGDM)': [3114], 'PGDM,': [3121], '11,15-dioxo-9': [3122], 'alpha-hydroxy-2,3,4,5-tetranorprostan-1,20-dioic': [3123], 'acid.': [3124], 'C–E.': [3125], 'Real-time': [3126], 'PCR': [3127, 3529], 'cPLA2,': [3130], 'COX-1,': [3131], 'hPGDS': [3134], 'macrophage': [3138], 'treated': [3139], 'niacin.': [3141], 'Data': [3142, 3144, 3151, 3310, 3312, 3319, 3609, 3611, 3618, 3747, 3749, 4038, 4040, 4050, 4157, 4159], 'information:': [3143, 3311, 3610, 3748, 4039, 4158], 'shown': [3146, 3314, 3613, 3751, 4052, 4161], 'mean': [3148, 3316, 3615, 3753, 4054, 4163], '±': [3149, 3317, 3424, 3428, 3616, 3754, 3847, 3851, 3862, 3866, 3879, 3884, 4055, 4164], 'SEM.': [3150, 3318, 3617, 3755, 4056, 4165], 'representative': [3153, 3321, 3620, 4042], 'at': [3155, 3323], 'least': [3156, 3324], 'two': [3157, 3325, 3368, 4044], 'independent': [3158, 3326, 3623, 4045], 'experiments.': [3159, 3327, 3624, 4046], 'Statistical': [3160, 3328, 3626, 3756, 4057, 4166], 'significance': [3161, 3329, 3627, 3757, 4167], 'unpaired': [3165, 3333, 3631, 3761, 4062], "Student's": [3166, 3334, 3632, 3762, 4063], 't-tests.': [3167, 3335, 3633, 3763], '(A)': [3168, 3336], '#P': [3169, 3194, 3206, 3341, 4065, 4085, 4180], '<': [3170, 3173, 3195, 3198, 3207, 3338, 3342, 3345, 3431, 3635, 3670, 3765, 3768, 3854, 3869, 3888, 4066, 4069, 4086, 4091, 4094, 4181, 4184, 4189, 4192], '0.05,': [3171, 3196, 3343, 3671, 3766, 4067, 4087, 4092, 4182, 4190], '##P': [3172, 3197, 3337, 3344, 4068, 4183], '0.01': [3174, 3199, 3636, 3769, 4070, 4095, 4185, 4193], 'vs.': [3175, 3200, 3209, 3426, 3849, 3864, 3882, 4071, 4088, 4186], 'vehicle;': [3176, 3201, 3210, 4072], 'vehicle,': [3177, 4089], 'n': [3178, 3184, 3190, 3202, 3211, 3257, 3263, 3286, 3307, 3643, 3647, 3653, 3657, 3675, 3773, 4073, 4100, 4104, 4198, 4202, 4207, 4220], '=': [3179, 3185, 3191, 3203, 3212, 3258, 3264, 3287, 3308, 3644, 3648, 3654, 3658, 3676, 3774, 4074, 4101, 4105, 4199, 4203, 4208], '6;': [3180, 3259], '300': [3182], 'mg/kg,': [3183, 3189, 3262], '5;': [3186], '600': [3188, 3261], '7.': [3192, 3265], '(B)': [3193, 3340, 3545, 3973], '6.': [3204, 3288, 3309, 3775, 4209], '(C–E)': [3205], '0.05': [3208], '4.': [3213], 'Download': [3214, 3216, 3347, 3349, 3678, 3680, 3776, 3778, 4107, 4109, 4210, 4212], 'figure': [3215, 3348, 3679, 3777, 4108, 4211], 'PowerPoint': [3217, 3350, 3681, 3779, 4110, 4213], 'Click': [3218, 3682, 4111], 'here': [3219, 3683, 4112], 'expand': [3221, 3685, 4114], 'figure.': [3223, 3687, 4116], 'EV1.': [3225], 'Effect': [3226, 3965, 4005, 4024, 4127], 'PG,': [3230], 'RvE1,': [3231], 'LXA4': [3233, 3295], 'challenge': [3239, 3422, 3897, 3923], '(600': [3250, 3274, 3301, 3832], 'mg/kg)-treated': [3251, 3275, 3302], 'Vehicle,': [3256], 'Measurement': [3266], 'metabolite': [3269], 'PGs': [3271], 'mice.': [3276, 3393, 3540, 3962], 'PGEM,': [3277], '11α-hydroxy-9,15-dioxo-2,3,4,5-tetranor-prostane-1,20-dioic': [3278], 'acid;': [3279], 'PGIM,': [3280], '2,3-dinor-6-keto-PGF1α;': [3281], 'TxM,': [3282], '2,3-dinor-TxB2;': [3283], 'PGFM,': [3284], '13,14-dihydro-15-keto-PGF2α.': [3285], 'RvE1': [3293], '0.01.': [3339, 3346], 'Disruption': [3351], 'deteriorates': [3355], 'DSS-': [3357, 3388], 'TNBS-induced': [3359, 3390, 3487, 3693, 4124], 'specifically': [3364], 'binds': [3365], 'activates': [3367], 'distinct': [3369], 'receptors': [3372], 'DP2.': [3375], 'Next,': [3376], 'deficiency': [3384, 3493, 3691], 'development': [3386], 'global': [3397], 'disruption': [3399, 3801], '2A)': [3401], 'lost': [3402], 'over': [3403], '12%': [3404], 'weight': [3406, 3543, 3724, 3844, 3913, 3971, 4133], 'wild-type': [3408], '(WT)': [3409], 'controls': [3410], '2B),': [3412], 'significantly': [3415], 'higher': [3416], 'DAI': [3417, 3860], 'WT': [3419, 3539, 3559, 3607, 3739, 3899, 3982, 4016, 4036, 4149], '(2.33': [3423], '0.33': [3425], '0.42': [3427], '0.22,': [3429], 'P': [3430, 3853, 3868, 3887], '0.01,': [3432, 3855, 3870, 3889], 'Fig': [3433, 3839, 3856, 3871, 3890], '2C).': [3434], 'deletion': [3437], 'severity': [3440], 'length': [3450, 3553, 3734, 3877, 3919, 4011, 4143], '2D),': [3452], 'increase': [3453, 3473], 'lost,': [3457], 'thickening': [3458], 'wall,': [3461], 'enhanced': [3462], 'infiltration': [3463], '2E),': [3471], 'overall': [3475, 3595, 3719], '2F).': [3478], 'Likewise,': [3479], 'DP1−/−': [3480, 3737, 3980, 4014, 4033, 4147], 'were': [3482, 3935], 'vulnerable': [3485], 'EV2).': [3490, 3813], 'DP2': [3492], '(Satoh': [3494], '2006)': [3497], 'did': [3498], '2A–F).': [3506], 'receptor,': [3511], 'DP2,': [3513], 'colitis.': [3518], '2.': [3520], 'knockout': [3522], 'augments': [3523, 3692], 'tail': [3532], 'genomic': [3533], 'DNA': [3534], 'DP1−/−,': [3536, 3556, 3603, 3646, 4103], 'DP2−/−,': [3537, 3557, 3656], 'B–D.': [3541, 3722], 'Body': [3542, 3723], 'loss': [3544, 3725, 3845, 3914, 3972, 4134], 'activity': [3548, 3728, 3976, 4137], 'index': [3549, 3729, 3977, 4138], '(C),': [3550], '(D)': [3554, 3735], 'Scale': [3566, 3589, 3713, 4000], 'bar:': [3567, 3714, 4001], 'cm.': [3569, 4003], 'E.': [3570, 4004], 'H&E': [3571, 3698], 'staining': [3572, 3699], 'histological': [3574, 3701], 'sections': [3575, 3702], 'distal': [3578, 3705], 'administered': [3583], '6': [3587], 'days.': [3588], 'bars:': [3590], '100': [3591, 3715], 'μm.': [3592, 3716], 'Graphs': [3593, 3717], 'represent': [3594, 3718], 'histology': [3596, 3720], 'score.': [3597, 3721], 'F.': [3598, 4023], 'Survival': [3599, 3661, 4077], 'rates': [3600, 4030], 'DP2−/−': [3604], 'controls.': [3608, 4037], 'three': [3622], '(B–D)': [3625], '**P': [3634, 3767, 4093, 4191], 'compared': [3637, 3664, 3672, 3770, 4080, 4096, 4194], 'WT.': [3639, 4196], 'Left': [3640], 'panel:': [3641, 3651], 'WT,': [3642, 3652, 4099], '8;': [3645, 4204], '8.': [3649, 3659, 4075], 'Right': [3650], '7;': [3655, 4200], '(F)': [3660, 4076], 'rate': [3662, 4078], 'log-rank': [3667, 4083], 'test.': [3668, 4084, 4179], '*P': [3669, 3764, 4090, 4188], 'WT;': [3674, 3772, 4098], '10.': [3677], 'EV2.': [3689], 'TNBS': [3711, 3745, 3922, 4155], '(B),': [3726], '(DAI,': [3730, 4139], 'C),': [3731], '2.5%': [3744, 4154], 'Treatment': [3789], '1A),': [3799], 'worsens': [3805], '(Figs': [3810, 3941], 'hypothesized': [3815], 'improve': [3818], 'manifestation': [3820], 'TNBS.': [3827], 'mg/kg': [3833], 'gavage,': [3835], 'once': [3836], 'day,': [3838], '3A)': [3840], 'delayed': [3842], 'body': [3843, 3912, 3970, 4132], '(7.94': [3846], '1.44%': [3848], '14.25': [3850], '1.03%,': [3852], '3B),': [3857], '(1.46': [3861], '0.14': [3863], '2.58': [3865], '0.16,': [3867], '3C),': [3872], 'shortening': [3874, 3916], '(6.26': [3878], '0.19': [3880], 'cm': [3881], '4.43': [3883], '0.27': [3885], 'cm,': [3886], '3D': [3891], 'E)': [3893, 4049], 'consequently': [3902], '3F).': [3906], 'ameliorated': [3911], 'EV3).': [3927, 3944], 'contrast,': [3929], 'DP1-deficient': [3939], '3B–F': [3942], '3.': [3946], 'Protocol': [3954], 'B,': [3963], 'C.': [3964], '(C)': [3978, 4145], 'D.': [3989], 'Macroscopic': [3990], 'appearance': [3991], 'treatment.': [3999], '(centimeter)': [4012, 4144], 'survival': [4029], '(B,': [4047], 'C,': [4048], 'performed': [4060], 't-test.': [4064], '17;': [4102], '20.': [4106], 'EV3.': [4118], 'A–C.': [4126], '(A),': [4135], 'B),': [4140], 'two-way': [4171], 'ANOVA': [4172], 'followed': [4173], 'Bonferroni': [4176], 'post': [4177], 'hoc': [4178], 'vehicle.': [4187], 'WT-vehicle,': [4197], 'WT-niacin,': [4201], 'DP1−/−-vehicle,': [4205], 'DP1−/−-niacin,': [4206]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2600704889', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 20}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 5}], 'updated_date': '2024-12-24T11:38:32.410580', 'created_date': '2017-04-07'}
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