Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2598291547', 'doi': 'https://doi.org/10.18632/oncotarget.16468', 'title': 'Comparison of combined leflunomide and low-dose corticosteroid therapy with full-dose corticosteroid monotherapy for progressive IgA nephropathy', 'display_name': 'Comparison of combined leflunomide and low-dose corticosteroid therapy with full-dose corticosteroid monotherapy for progressive IgA nephropathy', 'publication_year': 2017, 'publication_date': '2017-03-22', 'ids': {'openalex': 'https://openalex.org/W2598291547', 'doi': 'https://doi.org/10.18632/oncotarget.16468', 'mag': '2598291547', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28415636', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5564655'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.16468', 'pdf_url': 'https://www.oncotarget.com/article/16468/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/16468/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004235884', 'display_name': 'Lulin Min', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lulin Min', 'raw_affiliation_strings': ['Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100422764', 'display_name': 'Qin Wang', 'orcid': 'https://orcid.org/0000-0001-6824-1351'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qin Wang', 'raw_affiliation_strings': ['Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071466575', 'display_name': 'Liou Cao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Liou Cao', 'raw_affiliation_strings': ['Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103068621', 'display_name': 'Wenyan Zhou', 'orcid': 'https://orcid.org/0000-0002-4541-6603'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wenyan Zhou', 'raw_affiliation_strings': ['Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013034202', 'display_name': 'Jiangzi Yuan', 'orcid': 'https://orcid.org/0000-0002-8195-5911'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiangzi Yuan', 'raw_affiliation_strings': ['Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000011443', 'display_name': 'Minfang Zhang', 'orcid': 'https://orcid.org/0000-0002-3983-3355'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Minfang Zhang', 'raw_affiliation_strings': ['Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041382816', 'display_name': 'Xiajing Che', 'orcid': 'https://orcid.org/0009-0003-7799-0823'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiajing Che', 'raw_affiliation_strings': ['Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091641134', 'display_name': 'Shan Mou', 'orcid': 'https://orcid.org/0000-0003-4160-1681'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shan Mou', 'raw_affiliation_strings': ['Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100410144', 'display_name': 'Wei Fang', 'orcid': 'https://orcid.org/0000-0002-2889-9463'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wei Fang', 'raw_affiliation_strings': ['Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100627871', 'display_name': 'Leyi Gu', 'orcid': 'https://orcid.org/0000-0003-4358-0132'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Leyi Gu', 'raw_affiliation_strings': ['Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011790674', 'display_name': 'Mingli Zhu', 'orcid': 'https://orcid.org/0000-0002-6412-1755'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Mingli Zhu', 'raw_affiliation_strings': ['Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100398674', 'display_name': 'Ling Wang', 'orcid': 'https://orcid.org/0000-0002-1542-3642'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ling Wang', 'raw_affiliation_strings': ['Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004328787', 'display_name': 'Zanzhe Yu', 'orcid': 'https://orcid.org/0009-0000-5297-3232'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zanzhe Yu', 'raw_affiliation_strings': ['Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089777309', 'display_name': 'Jiaqi Qian', 'orcid': 'https://orcid.org/0000-0001-6594-3614'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiaqi Qian', 'raw_affiliation_strings': ['Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5037338561', 'display_name': 'Zhaohui Ni', 'orcid': 'https://orcid.org/0000-0002-1334-7658'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhaohui Ni', 'raw_affiliation_strings': ['Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China', 'institution_ids': ['https://openalex.org/I183067930']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.788, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 11, 'citation_normalized_percentile': {'value': 0.86828, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '8', 'issue': '29', 'first_page': '48375', 'last_page': '48384'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11029', 'display_name': 'Pathophysiology of Glomerular Diseases and Nephrotic Syndromes', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2727', 'display_name': 'Nephrology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11029', 'display_name': 'Pathophysiology of Glomerular Diseases and Nephrotic Syndromes', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2727', 'display_name': 'Nephrology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10308', 'display_name': 'Systemic Lupus Erythematosus and Antiphospholipid Syndrome', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11964', 'display_name': 'Effects of Medication on Pregnancy Outcomes', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/leflunomide', 'display_name': 'Leflunomide', 'score': 0.6303143}, {'id': 'https://openalex.org/keywords/iga-nephropathy', 'display_name': 'IgA Nephropathy', 'score': 0.590061}], 'concepts': [{'id': 'https://openalex.org/C2776804153', 'wikidata': 'https://www.wikidata.org/wiki/Q210420', 'display_name': 'Corticosteroid', 'level': 2, 'score': 0.8657755}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.85963976}, {'id': 'https://openalex.org/C2781184683', 'wikidata': 'https://www.wikidata.org/wiki/Q1054718', 'display_name': 'Nephropathy', 'level': 3, 'score': 0.704574}, {'id': 'https://openalex.org/C2775905006', 'wikidata': 'https://www.wikidata.org/wiki/Q248550', 'display_name': 'Leflunomide', 'level': 3, 'score': 0.6303143}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.38948578}, {'id': 'https://openalex.org/C126894567', 'wikidata': 'https://www.wikidata.org/wiki/Q105650', 'display_name': 'Urology', 'level': 1, 'score': 0.32681945}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.18769082}, {'id': 'https://openalex.org/C2777575956', 'wikidata': 'https://www.wikidata.org/wiki/Q187255', 'display_name': 'Rheumatoid arthritis', 'level': 2, 'score': 0.09827554}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.058187336}], 'mesh': [{'descriptor_ui': 'D000305', 'descriptor_name': 'Adrenal Cortex Hormones', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D005922', 'descriptor_name': 'Glomerulonephritis, IGA', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D005922', 'descriptor_name': 'Glomerulonephritis, IGA', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D007166', 'descriptor_name': 'Immunosuppressive Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D007555', 'descriptor_name': 'Isoxazoles', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000305', 'descriptor_name': 'Adrenal Cortex Hormones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000305', 'descriptor_name': 'Adrenal Cortex Hormones', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005922', 'descriptor_name': 'Glomerulonephritis, IGA', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D005922', 'descriptor_name': 'Glomerulonephritis, IGA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005922', 'descriptor_name': 'Glomerulonephritis, IGA', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007166', 'descriptor_name': 'Immunosuppressive Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D007166', 'descriptor_name': 'Immunosuppressive Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007555', 'descriptor_name': 'Isoxazoles', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D007555', 'descriptor_name': 'Isoxazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053208', 'descriptor_name': 'Kaplan-Meier Estimate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077339', 'descriptor_name': 'Leflunomide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011507', 'descriptor_name': 'Proteinuria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.16468', 'pdf_url': 'https://www.oncotarget.com/article/16468/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5564655', 'pdf_url': 'https://europepmc.org/articles/pmc5564655?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564655', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28415636', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.16468', 'pdf_url': 'https://www.oncotarget.com/article/16468/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.62, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1489849588', 'https://openalex.org/W1549759255', 'https://openalex.org/W1550102585', 'https://openalex.org/W1907806406', 'https://openalex.org/W1970372218', 'https://openalex.org/W1987519860', 'https://openalex.org/W1990006280', 'https://openalex.org/W1992884829', 'https://openalex.org/W1997948783', 'https://openalex.org/W2010602089', 'https://openalex.org/W2068243562', 'https://openalex.org/W2105803357', 'https://openalex.org/W2107050894', 'https://openalex.org/W2107793847', 'https://openalex.org/W2117667423', 'https://openalex.org/W2120393706', 'https://openalex.org/W2123048854', 'https://openalex.org/W2125018102', 'https://openalex.org/W2125785855', 'https://openalex.org/W2135143233', 'https://openalex.org/W2154208029', 'https://openalex.org/W2162337442', 'https://openalex.org/W2165786389', 'https://openalex.org/W2171146698', 'https://openalex.org/W2184938431', 'https://openalex.org/W2207112713', 'https://openalex.org/W2236830829', 'https://openalex.org/W2293998981', 'https://openalex.org/W2315790274', 'https://openalex.org/W2334592849', 'https://openalex.org/W2514705101', 'https://openalex.org/W2925859987', 'https://openalex.org/W4210768724'], 'related_works': ['https://openalex.org/W4240830981', 'https://openalex.org/W2793393227', 'https://openalex.org/W2756114800', 'https://openalex.org/W2441065842', 'https://openalex.org/W2385417872', 'https://openalex.org/W2368637874', 'https://openalex.org/W2366353339', 'https://openalex.org/W2262263761', 'https://openalex.org/W2011986540', 'https://openalex.org/W1986158302'], 'abstract_inverted_index': {'//': [0, 87], 'Lulin': [1], 'Min': [2], '1': [3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 60], ',': [4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48, 52], 'Qin': [5], 'Wang': [6, 46], 'Liou': [9], 'Cao': [10], 'Wenyan': [13], 'Zhou': [14], 'Jiangzi': [17], 'Yuan': [18], 'Minfang': [21], 'Zhang': [22], 'Xiajing': [25], 'Che': [26], 'Shan': [29], 'Mou': [30], 'Wei': [33], 'Fang': [34], 'Leyi': [37], 'Gu': [38], 'Mingli': [41], 'Zhu': [42], 'Ling': [45], 'Zanzhe': [49], 'Yu': [50], 'Jiaqi': [53], 'Qian': [54], 'and': [56, 121, 149, 179, 213, 221, 238, 255, 340, 350], 'Zhaohui': [57, 84], 'Ni': [58], 'Department': [61], 'of': [62, 74, 123, 127, 154, 219, 225, 232, 242, 300, 336, 345], 'Nephrology,': [63], 'Molecular': [64], 'Cell': [65], 'Lab': [66], 'for': [67, 151, 333], 'Kidney': [68], 'Disease,': [69], 'Ren': [70], 'Ji': [71], 'Hospital,': [72], 'School': [73], 'Medicine,': [75], 'Shanghai': [76], 'Jiao': [77], 'Tong': [78], 'University,': [79], 'Shanghai,': [80], 'China': [81], 'Correspondence': [82], 'to:': [83], 'Ni,': [85], 'email:': [86], 'Keywords': [88], ':': [89, 98, 103, 108], 'IgA': [90, 113, 156, 166, 338], 'nephropathy,': [91, 157, 339], 'leflunomide,': [92], 'proteinuria,': [93], 'corticosteroids,': [94], 'renal': [95, 129, 207, 236], 'survival': [96], 'Received': [97], 'January': [99], '28,': [100], '2017': [101, 106, 111], 'Accepted': [102], 'March': [104, 109], '06,': [105], 'Published': [107], '22,': [110], 'Abstract': [112], 'nephropathy': [114, 167], 'is': [115, 147, 325], 'the': [116, 124, 152, 253, 277, 281, 294, 298, 306, 316, 334], 'most': [117], 'common': [118], 'primary': [119, 165, 204], 'glomerulonephritis': [120], 'one': [122], 'leading': [125], 'causes': [126], 'end-stage': [128, 235], 'disease.': [130], 'We': [131], 'performed': [132], 'a': [133, 245, 264, 285, 342], 'randomized,': [134], 'controlled,': [135], 'prospective,': [136], 'open-label': [137], 'trial': [138], 'to': [139, 160, 186], 'determine': [140], 'whether': [141], 'leflunomide': [142, 256, 295, 320], 'combined': [143, 321], 'with': [144, 169, 322], 'low-dose': [145, 323], 'corticosteroid': [146, 162, 189, 197, 317, 324, 331], 'safe': [148], 'effective': [150, 329], 'treatment': [153, 220, 282, 335], 'progressive': [155, 337], 'as': [158, 328, 330], 'compared': [159], 'full-dose': [161, 196], 'monotherapy.': [163], 'Biopsy-proved': [164], 'patients': [168, 233, 243], 'an': [170, 222], 'estimated': [171], 'glomerular': [172], 'filtration': [173], 'rate': [174], '≥': [175, 246], '30': [176], 'ml/min/1.73m': [177], '2': [178], 'proteinuria': [180, 212, 273, 346], '≥1.0': [181], 'g/24h': [182], 'were': [183, 211, 274, 312], 'randomly': [184], 'assigned': [185], 'receive': [187], 'leflunomide+low-dose': [188], '(leflunomide': [190], 'group;': [191, 199], 'n': [192, 200], '=': [193, 201], '40)': [194], 'or': [195], '(corticosteroids': [198], '45).': [202], 'The': [203], 'outcome': [205], 'was': [206, 289, 303], 'survival;': [208], 'secondary': [209], 'outcomes': [210], 'adverse': [214, 301, 310, 353], 'events.': [215, 354], 'After': [216], '12': [217], 'months': [218], 'average': [223], 'follow-up': [224, 292, 349], '88': [226], 'months,': [227], '11.1%': [228], 'vs': [229], '.': [230], '7.5%': [231], 'reached': [234], 'disease': [237], '20%': [239], 'versus': [240], '10%': [241], 'had': [244], '50%': [247], 'increase': [248], 'in': [249, 252, 267, 271, 276, 293, 305, 315], 'serum': [250], 'creatinine': [251], 'corticosteroids': [254], 'groups,': [257, 308], 'respectively.': [258], 'Kaplan-Meier': [259], 'analysis': [260], 'did': [261], 'not': [262], 'reveal': [263], 'between-group': [265], 'difference': [266], 'these': [268], 'outcomes.': [269], 'Decreases': [270], '24-hour': [272], 'similar': [275, 304], 'two': [278, 307], 'groups': [279], 'during': [280, 291, 347], 'period,': [283], 'but': [284], 'more': [286], 'marked': [287], 'reduction': [288, 344], 'observed': [290, 313], 'group.': [296, 318], 'Although': [297], 'incidence': [299], 'events': [302, 311], 'serious': [309], 'only': [314], 'Thus,': [319], 'at': [326], 'least': [327], 'alone': [332], 'showed': [341], 'greater': [343], 'long-term': [348], 'fewer': [351], 'severe': [352]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2598291547', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-09-19T07:01:33.175798', 'created_date': '2017-04-07'}