Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2593604375', 'doi': 'https://doi.org/10.1172/jci.insight.90780', 'title': 'Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response', 'display_name': 'Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response', 'publication_year': 2017, 'publication_date': '2017-03-08', 'ids': {'openalex': 'https://openalex.org/W2593604375', 'doi': 'https://doi.org/10.1172/jci.insight.90780', 'mag': '2593604375', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28289714', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5333973'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci.insight.90780', 'pdf_url': 'http://insight.jci.org/articles/view/90780/files/pdf', 'source': {'id': 'https://openalex.org/S2764964142', 'display_name': 'JCI Insight', 'issn_l': '2379-3708', 'issn': ['2379-3708'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://insight.jci.org/articles/view/90780/files/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5010793553', 'display_name': 'Shi‐Ying Cai', 'orcid': 'https://orcid.org/0000-0001-6601-4040'}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shi-Ying Cai', 'raw_affiliation_strings': ['Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.', 'institution_ids': ['https://openalex.org/I32971472']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075760728', 'display_name': 'Xinshou Ouyang', 'orcid': 'https://orcid.org/0000-0003-3423-0042'}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xinshou Ouyang', 'raw_affiliation_strings': ['Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.', 'institution_ids': ['https://openalex.org/I32971472']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101483046', 'display_name': 'Yonglin Chen', 'orcid': 'https://orcid.org/0000-0001-9306-4043'}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yonglin Chen', 'raw_affiliation_strings': ['Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.', 'institution_ids': ['https://openalex.org/I32971472']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069138417', 'display_name': 'Carol J. Soroka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carol J. Soroka', 'raw_affiliation_strings': ['Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.', 'institution_ids': ['https://openalex.org/I32971472']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025426421', 'display_name': 'Juxian Wang', 'orcid': 'https://orcid.org/0000-0002-9000-1132'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Juxian Wang', 'raw_affiliation_strings': ['Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038402765', 'display_name': 'Albert Mennone', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Albert Mennone', 'raw_affiliation_strings': ['Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.', 'institution_ids': ['https://openalex.org/I32971472']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100410451', 'display_name': 'Yucheng Wang', 'orcid': 'https://orcid.org/0000-0002-0644-920X'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yucheng Wang', 'raw_affiliation_strings': ['Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059996727', 'display_name': 'Wajahat Z. Mehal', 'orcid': 'https://orcid.org/0000-0001-8481-3671'}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wajahat Z. Mehal', 'raw_affiliation_strings': ['Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.', 'institution_ids': ['https://openalex.org/I32971472']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011657347', 'display_name': 'Dhanpat Jain', 'orcid': 'https://orcid.org/0000-0003-3845-0798'}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dhanpat Jain', 'raw_affiliation_strings': ['Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.', 'institution_ids': ['https://openalex.org/I32971472']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048480496', 'display_name': 'James L. Boyer', 'orcid': 'https://orcid.org/0000-0002-8959-6036'}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James L. Boyer', 'raw_affiliation_strings': ['Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.', 'institution_ids': ['https://openalex.org/I32971472']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4100, 'currency': 'USD', 'value_usd': 4100, 'provenance': 'doaj'}, 'apc_paid': {'value': 4100, 'currency': 'USD', 'value_usd': 4100, 'provenance': 'doaj'}, 'fwci': 11.428, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 196, 'citation_normalized_percentile': {'value': 0.999956, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '2', 'issue': '5', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10570', 'display_name': 'Mechanisms of Multidrug Resistance in Cancer', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10570', 'display_name': 'Mechanisms of Multidrug Resistance in Cancer', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10351', 'display_name': 'Epidemiology and Management of NAFLD', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11834', 'display_name': 'Diagnosis and Management of Liver Diseases', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bile-acids', 'display_name': 'Bile Acids', 'score': 0.557357}, {'id': 'https://openalex.org/keywords/inflammatory-response', 'display_name': 'Inflammatory response', 'score': 0.48214218}], 'concepts': [{'id': 'https://openalex.org/C2776200302', 'wikidata': 'https://www.wikidata.org/wiki/Q827450', 'display_name': 'Hepatocyte', 'level': 3, 'score': 0.7774233}, {'id': 'https://openalex.org/C2778593092', 'wikidata': 'https://www.wikidata.org/wiki/Q1075923', 'display_name': 'Cholestasis', 'level': 2, 'score': 0.65834224}, {'id': 'https://openalex.org/C2776637226', 'wikidata': 'https://www.wikidata.org/wiki/Q6658207', 'display_name': 'Liver injury', 'level': 2, 'score': 0.57660973}, {'id': 'https://openalex.org/C2779399885', 'wikidata': 'https://www.wikidata.org/wiki/Q413288', 'display_name': 'Bile acid', 'level': 2, 'score': 0.5476295}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.48698434}, {'id': 'https://openalex.org/C3020196126', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammatory response', 'level': 3, 'score': 0.48214218}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.4337334}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.39871323}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3828519}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.34840718}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.20892143}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.07354209}], 'mesh': [{'descriptor_ui': 'D001647', 'descriptor_name': 'Bile Acids and Salts', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D002779', 'descriptor_name': 'Cholestasis', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D008107', 'descriptor_name': 'Liver Diseases', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001647', 'descriptor_name': 'Bile Acids and Salts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001647', 'descriptor_name': 'Bile Acids and Salts', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D001647', 'descriptor_name': 'Bile Acids and Salts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002779', 'descriptor_name': 'Cholestasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018836', 'descriptor_name': 'Inflammation Mediators', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D018836', 'descriptor_name': 'Inflammation Mediators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008107', 'descriptor_name': 'Liver Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci.insight.90780', 'pdf_url': 'http://insight.jci.org/articles/view/90780/files/pdf', 'source': {'id': 'https://openalex.org/S2764964142', 'display_name': 'JCI Insight', 'issn_l': '2379-3708', 'issn': ['2379-3708'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5333973', 'pdf_url': 'https://europepmc.org/articles/pmc5333973?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333973', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28289714', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci.insight.90780', 'pdf_url': 'http://insight.jci.org/articles/view/90780/files/pdf', 'source': {'id': 'https://openalex.org/S2764964142', 'display_name': 'JCI Insight', 'issn_l': '2379-3708', 'issn': ['2379-3708'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.82, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1483610036', 'https://openalex.org/W1534017202', 'https://openalex.org/W1559776411', 'https://openalex.org/W1852965224', 'https://openalex.org/W1945887236', 'https://openalex.org/W1974572767', 'https://openalex.org/W2000239572', 'https://openalex.org/W2004830908', 'https://openalex.org/W2004981017', 'https://openalex.org/W2007456787', 'https://openalex.org/W2009887653', 'https://openalex.org/W2011001621', 'https://openalex.org/W2013972435', 'https://openalex.org/W2018063452', 'https://openalex.org/W2029456365', 'https://openalex.org/W2029964044', 'https://openalex.org/W2043493714', 'https://openalex.org/W2052663559', 'https://openalex.org/W2056647420', 'https://openalex.org/W2065462174', 'https://openalex.org/W2065929630', 'https://openalex.org/W2072227423', 'https://openalex.org/W2078771263', 'https://openalex.org/W2084722601', 'https://openalex.org/W2110796494', 'https://openalex.org/W2121541608', 'https://openalex.org/W2134219545', 'https://openalex.org/W2138608324', 'https://openalex.org/W2142196461', 'https://openalex.org/W2142811986', 'https://openalex.org/W2143778535', 'https://openalex.org/W2145658582', 'https://openalex.org/W2162439940', 'https://openalex.org/W2163637735', 'https://openalex.org/W2164110949', 'https://openalex.org/W2168413006', 'https://openalex.org/W2170228248', 'https://openalex.org/W2259003342', 'https://openalex.org/W2402243697'], 'related_works': ['https://openalex.org/W4386800416', 'https://openalex.org/W3136387998', 'https://openalex.org/W3014200072', 'https://openalex.org/W2885798408', 'https://openalex.org/W2614321760', 'https://openalex.org/W2096210798', 'https://openalex.org/W2094988798', 'https://openalex.org/W2020348266', 'https://openalex.org/W2014009986', 'https://openalex.org/W1973472003'], 'abstract_inverted_index': {'Mechanisms': [0], 'of': [1, 13, 80, 88, 116, 120], 'bile': [2, 73], 'acid–induced': [3], '(BA-induced)': [4], 'liver': [5, 21, 25, 141, 159, 174, 189], 'injury': [6, 22, 62, 142, 175], 'in': [7, 43, 50, 65, 85, 97, 126, 135, 146, 157], 'cholestasis': [8], 'are': [9], 'controversial,': [10], 'limiting': [11], 'development': [12], 'new': [14], 'therapies.': [15], 'We': [16], 'examined': [17], 'how': [18], 'BAs': [19, 38, 117, 132, 168], 'initiate': [20], 'using': [23], 'isolated': [24], 'cells': [26, 52], 'from': [27, 90, 137], 'humans': [28], 'and': [29, 31, 45, 123, 148, 180], 'mice': [30, 67], 'in-vivo': [32], 'mouse': [33, 44, 127], 'models.': [34], 'At': [35], 'pathophysiologic': [36], 'concentrations,': [37], 'induced': [39, 118], 'proinflammatory': [40], 'cytokine': [41], 'expression': [42], 'human': [46], 'hepatocytes,': [47], 'but': [48], 'not': [49], 'nonparenchymal': [51], 'or': [53, 71], 'cholangiocytes.': [54], 'These': [55, 161], 'hepatocyte-specific': [56, 149, 171], 'cytokines': [57], 'stimulated': [58], 'neutrophil': [59], 'chemotaxis.': [60], 'Inflammatory': [61], 'was': [63, 82, 133, 143], 'mitigated': [64], 'Ccl2–/–': [66], 'treated': [68], 'with': [69, 95], 'BA': [70, 106], 'after': [72], 'duct': [74], 'ligation,': [75], 'where': [76], 'less': [77], 'hepatic': [78], 'infiltration': [79], 'neutrophils': [81], 'detected.': [83], 'Neutrophils': [84], 'periportal': [86], 'areas': [87], 'livers': [89], 'cholestatic': [91, 188], 'patients': [92], 'also': [93], 'correlated': [94], 'elevations': [96], 'their': [98], 'serum': [99], 'aminotransferases.': [100], 'This': [101], 'liver-specific': [102], 'inflammatory': [103, 173], 'response': [104], 'required': [105], 'entry': [107], 'into': [108], 'hepatocytes': [109, 136], 'via': [110], 'basolateral': [111], 'transporter': [112], 'Ntcp.': [113], 'Pathophysiologic': [114], 'levels': [115], 'markers': [119], 'ER': [121], 'stress': [122], 'mitochondrial': [124], 'damage': [125], 'hepatocytes.': [128], 'Chemokine': [129], 'induction': [130], 'by': [131], 'reduced': [134], 'Tlr9–/–': [138, 150], 'mice,': [139, 151], 'while': [140], 'diminished': [144], 'both': [145], 'conventional': [147], 'confirming': [152], 'a': [153, 170], 'role': [154], 'for': [155, 186], 'Tlr9': [156], 'BA-induced': [158], 'injury.': [160], 'findings': [162], 'reveal': [163], 'potentially': [164], 'novel': [165, 184], 'mechanisms': [166], 'whereby': [167], 'elicit': [169], 'cytokine-induced': [172], 'that': [176], 'involves': [177], 'innate': [178], 'immunity': [179], 'point': [181], 'to': [182], 'likely': [183], 'pathways': [185], 'treating': [187], 'disease.': [190]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2593604375', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 25}, {'year': 2022, 'cited_by_count': 24}, {'year': 2021, 'cited_by_count': 35}, {'year': 2020, 'cited_by_count': 41}, {'year': 2019, 'cited_by_count': 28}, {'year': 2018, 'cited_by_count': 18}, {'year': 2017, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-09-17T19:00:11.738287', 'created_date': '2017-03-16'}