Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2593435788', 'doi': 'https://doi.org/10.1158/1557-3265.pdx16-a12', 'title': 'Abstract A12: Developing PDeX (Patient Derived Explant) to determine the basis for response to AR-directed therapeutics', 'display_name': 'Abstract A12: Developing PDeX (Patient Derived Explant) to determine the basis for response to AR-directed therapeutics', 'publication_year': 2016, 'publication_date': '2016-08-15', 'ids': {'openalex': 'https://openalex.org/W2593435788', 'doi': 'https://doi.org/10.1158/1557-3265.pdx16-a12', 'mag': '2593435788'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1557-3265.pdx16-a12', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S183149254', 'display_name': 'Clinical Cancer Research', 'issn_l': '1078-0432', 'issn': ['1078-0432', '1557-3265'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5058055467', 'display_name': 'Ayesha A. Shafi', 'orcid': 'https://orcid.org/0000-0003-0335-638X'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ayesha Shafi', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA,'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA,', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071840998', 'display_name': 'Matthew J. Schiewer', 'orcid': 'https://orcid.org/0000-0002-2325-4228'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Matthew Schiewer', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA,'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA,', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062007054', 'display_name': 'Renée de Leeuw', 'orcid': 'https://orcid.org/0000-0002-5550-7613'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Renee de Leeuw', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA,'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA,', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012659487', 'display_name': 'Peter A. McCue', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter McCue', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA,'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA,', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074384753', 'display_name': 'Ruth Birbe', 'orcid': 'https://orcid.org/0000-0002-0651-2360'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ruth Birbe', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA,'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA,', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071741514', 'display_name': 'Leonard G. Gomella', 'orcid': 'https://orcid.org/0000-0002-9466-489X'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Leonard Gomella', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA,'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA,', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038973155', 'display_name': 'Costas D. Lallas', 'orcid': 'https://orcid.org/0000-0001-8937-7661'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Costas Lallas', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA,'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA,', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000741843', 'display_name': 'Edouard J. Trabulsi', 'orcid': 'https://orcid.org/0000-0002-1058-6493'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Edouard Trabulsi', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA,'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA,', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053069471', 'display_name': 'Ganesh V. Raj', 'orcid': 'https://orcid.org/0000-0001-5098-6347'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ganesh Raj', 'raw_affiliation_strings': ['2UT Southwestern, Dallas, TX.'], 'affiliations': [{'raw_affiliation_string': '2UT Southwestern, Dallas, TX.', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5042472942', 'display_name': 'Karen E. Knudsen', 'orcid': 'https://orcid.org/0000-0002-1301-890X'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Karen Knudsen', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA,'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA,', 'institution_ids': ['https://openalex.org/I149251103']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': '22', 'issue': '16_Supplement', 'first_page': 'A12', 'last_page': 'A12'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.7711, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.7711, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.6926, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ex-vivo', 'display_name': 'Ex vivo', 'score': 0.5134207}], 'concepts': [{'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.65112245}, {'id': 'https://openalex.org/C2776107976', 'wikidata': 'https://www.wikidata.org/wiki/Q1786433', 'display_name': 'Tumor microenvironment', 'level': 3, 'score': 0.59319234}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5727853}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.57027245}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5485729}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5316105}, {'id': 'https://openalex.org/C26291073', 'wikidata': 'https://www.wikidata.org/wiki/Q310484', 'display_name': 'Ex vivo', 'level': 3, 'score': 0.5134207}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.4215002}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38662368}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.37900078}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.33070907}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.21669614}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.07114643}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1557-3265.pdx16-a12', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S183149254', 'display_name': 'Clinical Cancer Research', 'issn_l': '1078-0432', 'issn': ['1078-0432', '1557-3265'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.62, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4387341186', 'https://openalex.org/W4295900113', 'https://openalex.org/W3111390827', 'https://openalex.org/W2914484697', 'https://openalex.org/W2888003396', 'https://openalex.org/W2611803138', 'https://openalex.org/W2602761843', 'https://openalex.org/W2131077462', 'https://openalex.org/W2071753433', 'https://openalex.org/W1864918391'], 'abstract_inverted_index': {'Abstract': [0], 'Prostate': [1], 'cancer': [2, 9], '(PCa)': [3], 'is': [4, 24, 45, 64, 82], 'the': [5, 11, 36, 59, 69, 83, 95, 98, 105, 132, 135, 193, 230, 281, 292, 307], 'most': [6], 'common': [7, 47], 'non-cutanenous': [8], 'and': [10, 38, 58, 97, 142, 200, 216, 300], 'second': [12], 'leading': [13], 'cause': [14], 'of': [15, 40, 71, 85, 100, 134, 203, 214, 238, 291], 'cancer-related': [16], 'death': [17], 'in': [18, 34, 79, 195, 241], 'American': [19], 'men.': [20], 'Androgen': [21, 42], 'receptor': [22], '(AR)': [23], 'a': [25, 46, 65, 116, 235], 'hormone-activated': [26], 'transcription': [27], 'factor': [28], 'that': [29], 'plays': [30], 'an': [31], 'important': [32], 'role': [33], 'both': [35], 'development': [37, 70], 'progression': [39], 'PCa.': [41], 'deprivation': [43], 'therapy': [44, 57], 'first-line': [48], 'therapy.': [49], 'However,': [50], 'many': [51], 'patients': [52, 215], 'become': [53], 'resistant': [54], 'to': [55, 107, 118, 159, 188, 197, 222, 245, 279, 285, 306], 'such': [56], 'tumor': [60, 137, 139, 165], 'recurs.': [61], 'Thus,': [62, 229], 'there': [63], 'vital': [66], 'need': [67], 'for': [68, 226, 234, 283], 'novel,': [72], 'more': [73, 248], 'effective': [74, 249], 'drugs.': [75], 'One': [76], 'major': [77], 'hurdle': [78], 'this': [80, 169], 'aspect': [81], 'lack': [84], 'adequate': [86], 'preclinical': [87], 'models.': [88], 'Current': [89], 'models': [90], 'do': [91], 'not': [92], 'effectively': [93], 'recapitulate': [94], 'heterogeneity': [96], 'microenvironment': [99, 244], 'human': [101], 'PCa': [102], 'tumors': [103, 121, 240], 'hindering': [104], 'ability': [106], 'accurately': [108], 'predict': [109], 'therapeutic': [110, 154, 227], 'response.': [111], 'Our': [112], 'lab': [113], 'has': [114], 'generated': [115], 'method': [117], 'culture': [119], 'patient': [120, 125], 'ex': [122], 'vivo': [123], 'termed': [124], 'derived': [126], 'explant': [127], '(PDeX).': [128], 'This': [129], 'approach': [130], 'maintains': [131], 'integrity': [133], 'native': [136, 243], 'microenvironment,': [138], 'tissue': [140, 221], 'morphology,': [141], 'molecular': [143], 'signaling.': [144], 'Intriguingly,': [145], 'our': [146], 'PDEX': [147], 'model': [148, 170, 232], 'can': [149, 172, 208], 'be': [150, 189], 'targeted': [151], 'with': [152, 168], 'various': [153], 'agents': [155], 'or': [156], 'lentiviral-based': [157], 'shRNAs': [158], 'determine': [160, 280], 'specific': [161], 'responses': [162], 'on': [163, 177], 'individual': [164, 239], 'growth.': [166], 'Furthermore,': [167], 'we': [171, 207], 'quantitatively': [173], 'assess': [174, 192], 'drug': [175], 'efficacy': [176], 'numerous': [178], 'parameters': [179], '(i.e.': [180], 'AR': [181], 'levels,': [182], 'Ki67': [183], 'staining,': [184], 'apoptosis': [185], 'screening).': [186], 'Data': [187], 'discussed': [190], 'will': [191], 'variances': [194], 'response': [196, 284], 'AR-directed': [198, 286], 'therapeutics': [199], 'underlying': [201], 'mechanisms': [202], 'action.': [204], 'In': [205], 'addition,': [206], 'potentially': [209], 'identify': [210], 'clinically': [211], 'relevant': [212], 'subpopulations': [213], 'molecularly': [217], 'profile': [218], 'their': [219, 242], 'cultured': [220], 'uncover': [223], 'new': [224], 'pathways': [225], 'intervention.': [228], 'PDeX': [231, 275], 'allows': [233], 'comprehensive': [236], 'evaluation': [237], 'ultimately': [246], 'develop': [247], 'therapies.': [250], 'Citation': [251], 'Format:': [252], 'Ayesha': [253], 'Shafi,': [254], 'Matthew': [255], 'Schiewer,': [256], 'Renee': [257], 'de': [258], 'Leeuw,': [259], 'Peter': [260], 'McCue,': [261], 'Ruth': [262], 'Birbe,': [263], 'Leonard': [264], 'Gomella,': [265], 'Costas': [266], 'Lallas,': [267], 'Edouard': [268], 'Trabulsi,': [269], 'Ganesh': [270], 'Raj,': [271], 'Karen': [272], 'Knudsen.': [273], 'Developing': [274], '(Patient': [276], 'Derived': [277], 'Explant)': [278], 'basis': [282], 'therapeutics.': [287], '[abstract].': [288], 'In:': [289], 'Proceedings': [290], 'AACR': [293], 'Special': [294], 'Conference:': [295], 'Patient-Derived': [296], 'Cancer': [297, 319], 'Models:': [298], 'Present': [299], 'Future': [301], 'Applications': [302], 'from': [303], 'Basic': [304], 'Science': [305], 'Clinic;': [308], 'Feb': [309], '11-14,': [310], '2016;': [311], 'New': [312], 'Orleans,': [313], 'LA.': [314], 'Philadelphia': [315], '(PA):': [316], 'AACR;': [317], 'Clin': [318], 'Res': [320], '2016;22(16_Suppl):Abstract': [321], 'nr': [322], 'A12.': [323]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2593435788', 'counts_by_year': [], 'updated_date': '2024-12-16T13:14:08.683542', 'created_date': '2017-03-16'}