Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2591921185', 'doi': 'https://doi.org/10.1016/j.pharmthera.2017.03.001', 'title': 'Emerging role of DUBs in tumor metastasis and apoptosis: Therapeutic implication', 'display_name': 'Emerging role of DUBs in tumor metastasis and apoptosis: Therapeutic implication', 'publication_year': 2017, 'publication_date': '2017-09-01', 'ids': {'openalex': 'https://openalex.org/W2591921185', 'doi': 'https://doi.org/10.1016/j.pharmthera.2017.03.001', 'mag': '2591921185', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28279784', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5565705'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.pharmthera.2017.03.001', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S83493678', 'display_name': 'Pharmacology & Therapeutics', 'issn_l': '0163-7258', 'issn': ['0163-7258', '1879-016X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc5565705?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101665762', 'display_name': 'Mingjing He', 'orcid': 'https://orcid.org/0009-0008-1912-2100'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}, {'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Mingjing He', 'raw_affiliation_strings': ['Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA', 'State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, PR China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, PR China', 'institution_ids': ['https://openalex.org/I24185976']}, {'raw_affiliation_string': 'Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031741607', 'display_name': 'Zhuan Zhou', 'orcid': 'https://orcid.org/0000-0002-9683-5760'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhuan Zhou', 'raw_affiliation_strings': ['Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075730397', 'display_name': 'George Y. Wu', 'orcid': 'https://orcid.org/0000-0003-0068-1072'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'George Wu', 'raw_affiliation_strings': ['Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056257750', 'display_name': 'Qianming Chen', 'orcid': 'https://orcid.org/0000-0002-5371-4432'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qianming Chen', 'raw_affiliation_strings': ['State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, PR China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, PR China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101559436', 'display_name': 'Yong Wan', 'orcid': 'https://orcid.org/0000-0001-9358-9392'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Yong Wan', 'raw_affiliation_strings': ['Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA', 'institution_ids': ['https://openalex.org/I170201317']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5101559436'], 'corresponding_institution_ids': ['https://openalex.org/I170201317'], 'apc_list': {'value': 5260, 'currency': 'USD', 'value_usd': 5260, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.086, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 80, 'citation_normalized_percentile': {'value': 0.500929, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '177', 'issue': None, 'first_page': '96', 'last_page': '107'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin-Proteasome Proteolytic Pathway', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin-Proteasome Proteolytic Pathway', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11736', 'display_name': 'Role of Histone Deacetylases in Cellular Regulation', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/deubiquitinating-enzyme', 'display_name': 'Deubiquitinating enzyme', 'score': 0.97124845}, {'id': 'https://openalex.org/keywords/deubiquitinating-enzymes', 'display_name': 'Deubiquitinating Enzymes', 'score': 0.575518}, {'id': 'https://openalex.org/keywords/cancer-therapy', 'display_name': 'Cancer Therapy', 'score': 0.566018}, {'id': 'https://openalex.org/keywords/tumor-suppression', 'display_name': 'Tumor Suppression', 'score': 0.542305}], 'concepts': [{'id': 'https://openalex.org/C102658986', 'wikidata': 'https://www.wikidata.org/wiki/Q5266092', 'display_name': 'Deubiquitinating enzyme', 'level': 4, 'score': 0.97124845}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.78922975}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5793897}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.5751425}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5451722}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4996252}, {'id': 'https://openalex.org/C27740335', 'wikidata': 'https://www.wikidata.org/wiki/Q14878333', 'display_name': 'Proteasome', 'level': 2, 'score': 0.4252432}, {'id': 'https://openalex.org/C76419328', 'wikidata': 'https://www.wikidata.org/wiki/Q74419', 'display_name': 'Epithelial–mesenchymal transition', 'level': 4, 'score': 0.42308438}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.19275877}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.08973315}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.07835373}], 'mesh': [{'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072017', 'descriptor_name': 'Deubiquitinating Enzymes', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.pharmthera.2017.03.001', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S83493678', 'display_name': 'Pharmacology & Therapeutics', 'issn_l': '0163-7258', 'issn': ['0163-7258', '1879-016X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5565705', 'pdf_url': 'https://europepmc.org/articles/pmc5565705?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565705', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28279784', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5565705', 'pdf_url': 'https://europepmc.org/articles/pmc5565705?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.84, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'CA202963'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'CA202948'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'CA154695'}], 'datasets': [], 'versions': [], 'referenced_works_count': 154, 'referenced_works': ['https://openalex.org/W1538085254', 'https://openalex.org/W1551753600', 'https://openalex.org/W1579561590', 'https://openalex.org/W1780665720', 'https://openalex.org/W1864085864', 'https://openalex.org/W1890778551', 'https://openalex.org/W1963749512', 'https://openalex.org/W1963766715', 'https://openalex.org/W1963848568', 'https://openalex.org/W1964350129', 'https://openalex.org/W1964734680', 'https://openalex.org/W1967834264', 'https://openalex.org/W1969232124', 'https://openalex.org/W1972780353', 'https://openalex.org/W1973243344', 'https://openalex.org/W1973942025', 'https://openalex.org/W1974784117', 'https://openalex.org/W1977447872', 'https://openalex.org/W1984433241', 'https://openalex.org/W1985103588', 'https://openalex.org/W1986354685', 'https://openalex.org/W1987432765', 'https://openalex.org/W1987756203', 'https://openalex.org/W1987944936', 'https://openalex.org/W1991249033', 'https://openalex.org/W1992938097', 'https://openalex.org/W1994242450', 'https://openalex.org/W1995168336', 'https://openalex.org/W1998398174', 'https://openalex.org/W1998416671', 'https://openalex.org/W1999420561', 'https://openalex.org/W1999816037', 'https://openalex.org/W1999895549', 'https://openalex.org/W2001401529', 'https://openalex.org/W2002837572', 'https://openalex.org/W2005334224', 'https://openalex.org/W2006483529', 'https://openalex.org/W2008793606', 'https://openalex.org/W2010875872', 'https://openalex.org/W2011141547', 'https://openalex.org/W2012296420', 'https://openalex.org/W2014239122', 'https://openalex.org/W2014691022', 'https://openalex.org/W2015721987', 'https://openalex.org/W2023032337', 'https://openalex.org/W2024551920', 'https://openalex.org/W2029245460', 'https://openalex.org/W2031941215', 'https://openalex.org/W2033934505', 'https://openalex.org/W2034256208', 'https://openalex.org/W2036799948', 'https://openalex.org/W2038886121', 'https://openalex.org/W2040268901', 'https://openalex.org/W2040400130', 'https://openalex.org/W2043624735', 'https://openalex.org/W2044563744', 'https://openalex.org/W2044728857', 'https://openalex.org/W2045315430', 'https://openalex.org/W2047823765', 'https://openalex.org/W2049186181', 'https://openalex.org/W2050913482', 'https://openalex.org/W2054076752', 'https://openalex.org/W2056933970', 'https://openalex.org/W2059459557', 'https://openalex.org/W2060123496', 'https://openalex.org/W2061049933', 'https://openalex.org/W2062902539', 'https://openalex.org/W2068306128', 'https://openalex.org/W2068931555', 'https://openalex.org/W2071949127', 'https://openalex.org/W2072972860', 'https://openalex.org/W2073759231', 'https://openalex.org/W2074404204', 'https://openalex.org/W2074497895', 'https://openalex.org/W2074893271', 'https://openalex.org/W2075405828', 'https://openalex.org/W2076471871', 'https://openalex.org/W2081673344', 'https://openalex.org/W2081810700', 'https://openalex.org/W2082015682', 'https://openalex.org/W2084888861', 'https://openalex.org/W2087988002', 'https://openalex.org/W2088883749', 'https://openalex.org/W2089827566', 'https://openalex.org/W2092257847', 'https://openalex.org/W2092480387', 'https://openalex.org/W2094294936', 'https://openalex.org/W2095554214', 'https://openalex.org/W2099313339', 'https://openalex.org/W2100067355', 'https://openalex.org/W2102085111', 'https://openalex.org/W2102943306', 'https://openalex.org/W2103324798', 'https://openalex.org/W2106008571', 'https://openalex.org/W2106278833', 'https://openalex.org/W2109638794', 'https://openalex.org/W2110498443', 'https://openalex.org/W2111797871', 'https://openalex.org/W2112932498', 'https://openalex.org/W2118225942', 'https://openalex.org/W2123095893', 'https://openalex.org/W2123123035', 'https://openalex.org/W2124442379', 'https://openalex.org/W2128738081', 'https://openalex.org/W2129183209', 'https://openalex.org/W2133459528', 'https://openalex.org/W2134287597', 'https://openalex.org/W2134404356', 'https://openalex.org/W2134872883', 'https://openalex.org/W2135072453', 'https://openalex.org/W2136084746', 'https://openalex.org/W2137307677', 'https://openalex.org/W2140433041', 'https://openalex.org/W2142721942', 'https://openalex.org/W2144239144', 'https://openalex.org/W2146678830', 'https://openalex.org/W2146843907', 'https://openalex.org/W2147917253', 'https://openalex.org/W2148923106', 'https://openalex.org/W2149812033', 'https://openalex.org/W2155832320', 'https://openalex.org/W2156791414', 'https://openalex.org/W2159257443', 'https://openalex.org/W2165200432', 'https://openalex.org/W2166616170', 'https://openalex.org/W2166987747', 'https://openalex.org/W2168718892', 'https://openalex.org/W2169205569', 'https://openalex.org/W2169832079', 'https://openalex.org/W2170417672', 'https://openalex.org/W2188984095', 'https://openalex.org/W2194309244', 'https://openalex.org/W2209591601', 'https://openalex.org/W2227664873', 'https://openalex.org/W2255377321', 'https://openalex.org/W2267633848', 'https://openalex.org/W2272315791', 'https://openalex.org/W2307397595', 'https://openalex.org/W2315515072', 'https://openalex.org/W2316490952', 'https://openalex.org/W2316880913', 'https://openalex.org/W2333449990', 'https://openalex.org/W2409179396', 'https://openalex.org/W2410837864', 'https://openalex.org/W2414372990', 'https://openalex.org/W2415072672', 'https://openalex.org/W2439038120', 'https://openalex.org/W2549411794', 'https://openalex.org/W2551965620', 'https://openalex.org/W2563462164', 'https://openalex.org/W2566048396', 'https://openalex.org/W4210757594', 'https://openalex.org/W4211233744', 'https://openalex.org/W4238948186'], 'related_works': ['https://openalex.org/W2888617581', 'https://openalex.org/W2770653741', 'https://openalex.org/W2611649496', 'https://openalex.org/W2159751912', 'https://openalex.org/W2099095224', 'https://openalex.org/W2067364318', 'https://openalex.org/W2056210416', 'https://openalex.org/W2034032029', 'https://openalex.org/W1995789798', 'https://openalex.org/W1954801073'], 'abstract_inverted_index': {'Malfunction': [0], 'of': [1, 31, 51, 62, 77, 100, 105, 129, 136, 155], 'ubiquitin-proteasome': [2], 'system': [3], 'is': [4], 'tightly': [5], 'linked': [6], 'to': [7, 65, 75, 140], 'tumor': [8, 11, 64], 'formation': [9], 'and': [10, 59, 71, 81, 86, 102, 131, 147], 'metastasis.': [12], 'Targeting': [13], 'the': [14, 24, 34, 38, 48, 52, 63, 96, 127, 133, 153], 'ubiquitin-pathway': [15], 'provides': [16, 114], 'a': [17, 115, 158], 'new': [18, 116], 'strategy': [19, 117, 160], 'for': [20, 118, 161], 'anti-cancer': [21, 119, 162], 'therapy.': [22, 120, 163], 'Despite': [23], 'parts': [25], 'played': [26], 'by': [27, 37], 'ubiquitin': [28, 32], 'modifiers,': [29], 'removal': [30], 'from': [33], 'functional': [35], 'proteins': [36], 'deubiquitinating': [39], 'enzymes': [40], '(DUBs)': [41], 'plays': [42], 'an': [43], 'important': [44], 'role': [45, 128], 'in': [46], 'governing': [47], 'multiple': [49, 141], 'steps': [50], 'metastatic': [53, 142], 'cascade,': [54], 'including': [55, 144], 'local': [56], 'invasion,': [57], 'dissemination,': [58], 'eventual': [60], 'colonization': [61], 'distant': [66], 'organs.': [67], 'Both': [68], 'deregulated': [69], 'ubiquitination': [70], 'deubiquitination': [72, 130, 156], 'could': [73], 'lead': [74], 'dysregulation': [76], 'various': [78, 103], 'critical': [79], 'events': [80, 143], 'pathways': [82], 'such': [83], 'as': [84, 157], 'apoptosis': [85], 'epithelial-mesenchymal': [87], 'transition': [88], '(EMT).': [89], 'Recent': [90], 'TCGA': [91], 'study': [92], 'has': [93], 'further': [94, 151], 'revealed': [95], 'connection': [97], 'between': [98], 'mutations': [99], 'DUBs': [101, 113, 137], 'types': [104], 'tumors.': [106], 'In': [107, 121], 'addition,': [108], 'emerging': [109], 'drug': [110], 'design': [111], 'targeting': [112], 'this': [122], 'review,': [123], 'we': [124], 'will': [125, 150], 'summarize': [126], 'highlight': [132], 'recent': [134], 'discoveries': [135], 'with': [138], 'regards': [139], 'anti-apoptosis': [145], 'pathway': [146], 'EMT.': [148], 'We': [149], 'discuss': [152], 'regulation': [154], 'novel': [159]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2591921185', 'counts_by_year': [{'year': 2024, 'cited_by_count': 18}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 16}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-09-13T13:04:14.924564', 'created_date': '2017-03-16'}