Title: Typing by polymerase chain reaction mediated amplification of DNA fragments in the HLA class I region and direct DNA sequencing
Abstract: Until now, exploiting the polymorphism of the HLA class I genes for forensic purposes is limited to the surface (protein) antigens. The DNA polymorphism detected by restriction fragment length polymorphisms (RFLP) revealed a large number of bands varying between 15 and 25 (Mayr 1986). The DNA used for RFLP analysis has to be intact, a condition seldom met in forensic tasks. In addition, for RFLP analysis a certain microgram amount of DNA is necessary.
Publication Year: 1990
Publication Date: 1990-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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