The TLR7 agonist imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for melanoma

Name: Work Video:
Duration: 3 min 30 s
Jeonghyun Cho; Hyo-Ji Lee; Hyun‐Jeong Ko; Byung-Il Yoon; Jongseon Choe; Keun-Cheol Kim; Tae‐Wook Hahn; Jeong A. Han; Sun Shim Choi; Young Mee Jung; Kee-Ho Lee; Yun‐Sil Lee; Yu‐Jin Jung
{'id': 'https://openalex.org/W2588948315', 'doi': 'https://doi.org/10.18632/oncotarget.15326', 'title': 'The TLR7 agonist imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for melanoma', 'display_name': 'The TLR7 agonist imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for melanoma', 'publication_year': 2017, 'publication_date': '2017-02-15', 'ids': {'openalex': 'https://openalex.org/W2588948315', 'doi': 'https://doi.org/10.18632/oncotarget.15326', 'mag': '2588948315', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28212561', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5421900'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.15326', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=15326&path%5B%5D=48983', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=15326&path%5B%5D=48983', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5072451761', 'display_name': 'Jeonghyun Cho', 'orcid': 'https://orcid.org/0000-0003-4492-1197'}, 'institutions': [{'id': 'https://openalex.org/I165507594', 'display_name': 'Kangwon National University', 'ror': 'https://ror.org/01mh5ph17', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I165507594']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jeong Hyun Cho', 'raw_affiliation_strings': ['Department of Biological Sciences, Kangwon National University, Chuncheon, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences, Kangwon National University, Chuncheon, Republic of Korea', 'institution_ids': ['https://openalex.org/I165507594']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110110639', 'display_name': 'Hyo-Ji Lee', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165507594', 'display_name': 'Kangwon National University', 'ror': 'https://ror.org/01mh5ph17', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I165507594']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hyo-Ji Lee', 'raw_affiliation_strings': ['Department of Biological Sciences, Kangwon National University, Chuncheon, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences, Kangwon National University, Chuncheon, Republic of Korea', 'institution_ids': ['https://openalex.org/I165507594']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021016946', 'display_name': 'Hyun‐Jeong Ko', 'orcid': 'https://orcid.org/0000-0002-3844-928X'}, 'institutions': [{'id': 'https://openalex.org/I165507594', 'display_name': 'Kangwon National University', 'ror': 'https://ror.org/01mh5ph17', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I165507594']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hyun-Jeong Ko', 'raw_affiliation_strings': ['College of Pharmacy, Kangwon National University, Chuncheon, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'College of Pharmacy, Kangwon National University, Chuncheon, Republic of Korea', 'institution_ids': ['https://openalex.org/I165507594']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102123198', 'display_name': 'Byung-Il Yoon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165507594', 'display_name': 'Kangwon National University', 'ror': 'https://ror.org/01mh5ph17', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I165507594']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Byung-Il Yoon', 'raw_affiliation_strings': ['Department of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea', 'institution_ids': ['https://openalex.org/I165507594']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077659343', 'display_name': 'Jongseon Choe', 'orcid': 'https://orcid.org/0000-0002-0424-1667'}, 'institutions': [{'id': 'https://openalex.org/I165507594', 'display_name': 'Kangwon National University', 'ror': 'https://ror.org/01mh5ph17', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I165507594']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jongseon Choe', 'raw_affiliation_strings': ['Department of Microbiology, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea', 'institution_ids': ['https://openalex.org/I165507594']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113847852', 'display_name': 'Keun-Cheol Kim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165507594', 'display_name': 'Kangwon National University', 'ror': 'https://ror.org/01mh5ph17', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I165507594']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Keun-Cheol Kim', 'raw_affiliation_strings': ['Department of Biological Sciences, Kangwon National University, Chuncheon, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences, Kangwon National University, Chuncheon, Republic of Korea', 'institution_ids': ['https://openalex.org/I165507594']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078871289', 'display_name': 'Tae‐Wook Hahn', 'orcid': 'https://orcid.org/0000-0002-3919-1153'}, 'institutions': [{'id': 'https://openalex.org/I165507594', 'display_name': 'Kangwon National University', 'ror': 'https://ror.org/01mh5ph17', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I165507594']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Tae-Wook Hahn', 'raw_affiliation_strings': ['Department of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea', 'institution_ids': ['https://openalex.org/I165507594']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032814981', 'display_name': 'Jeong A. Han', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165507594', 'display_name': 'Kangwon National University', 'ror': 'https://ror.org/01mh5ph17', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I165507594']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jeong A. Han', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea', 'institution_ids': ['https://openalex.org/I165507594']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049666523', 'display_name': 'Sun Shim Choi', 'orcid': 'https://orcid.org/0000-0001-6289-4220'}, 'institutions': [{'id': 'https://openalex.org/I165507594', 'display_name': 'Kangwon National University', 'ror': 'https://ror.org/01mh5ph17', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I165507594']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Sun Shim Choi', 'raw_affiliation_strings': ['Department of Medical Biotechnology, College of Biomedical Science, Kangwon National University, Chuncheon, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Biotechnology, College of Biomedical Science, Kangwon National University, Chuncheon, Republic of Korea', 'institution_ids': ['https://openalex.org/I165507594']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016291864', 'display_name': 'Young Mee Jung', 'orcid': 'https://orcid.org/0000-0003-4362-0990'}, 'institutions': [{'id': 'https://openalex.org/I165507594', 'display_name': 'Kangwon National University', 'ror': 'https://ror.org/01mh5ph17', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I165507594']}], 'countries': ['KR'], 'is_corresponding': True, 'raw_author_name': 'Young Mee Jung', 'raw_affiliation_strings': ['Department of Chemistry, Kangwon National University, Chuncheon, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Kangwon National University, Chuncheon, Republic of Korea', 'institution_ids': ['https://openalex.org/I165507594']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110031133', 'display_name': 'Kee-Ho Lee', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210088603', 'display_name': 'Korea Institute of Radiological and Medical Sciences', 'ror': 'https://ror.org/00a8tg325', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210088603']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Kee-Ho Lee', 'raw_affiliation_strings': ['Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea', 'institution_ids': ['https://openalex.org/I4210088603']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067207199', 'display_name': 'Yun‐Sil Lee', 'orcid': 'https://orcid.org/0000-0002-7538-8850'}, 'institutions': [{'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Yun-Sil Lee', 'raw_affiliation_strings': ['Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seodaemun-gu, Seoul, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seodaemun-gu, Seoul, Republic of Korea', 'institution_ids': ['https://openalex.org/I138925566']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5065795527', 'display_name': 'Yu‐Jin Jung', 'orcid': 'https://orcid.org/0000-0002-4942-677X'}, 'institutions': [{'id': 'https://openalex.org/I165507594', 'display_name': 'Kangwon National University', 'ror': 'https://ror.org/01mh5ph17', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I165507594']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Yu-Jin Jung', 'raw_affiliation_strings': ['Department of Biological Sciences, Kangwon National University, Chuncheon, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences, Kangwon National University, Chuncheon, Republic of Korea', 'institution_ids': ['https://openalex.org/I165507594']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5016291864'], 'corresponding_institution_ids': ['https://openalex.org/I165507594'], 'apc_list': None, 'apc_paid': None, 'fwci': 4.378, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 79, 'citation_normalized_percentile': {'value': 0.999918, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '8', 'issue': '15', 'first_page': '24932', 'last_page': '24948'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10371', 'display_name': 'Immune Response and Inflammation', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/imiquimod', 'display_name': 'Imiquimod', 'score': 0.50963783}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.65097165}, {'id': 'https://openalex.org/C2779112978', 'wikidata': 'https://www.wikidata.org/wiki/Q423417', 'display_name': 'Imiquimod', 'level': 2, 'score': 0.50963783}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4936832}, {'id': 'https://openalex.org/C556039675', 'wikidata': 'https://www.wikidata.org/wiki/Q771035', 'display_name': 'Traditional medicine', 'level': 1, 'score': 0.39188448}, {'id': 'https://openalex.org/C161191863', 'wikidata': 'https://www.wikidata.org/wiki/Q199655', 'display_name': 'Library science', 'level': 1, 'score': 0.35423517}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.327832}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2970052}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.23704863}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000634', 'descriptor_name': 'Aminoquinolines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D008546', 'descriptor_name': 'Melanoma, Experimental', 'qualifier_ui': 'Q000532', 'qualifier_name': 'radiotherapy', 'is_major_topic': True}, {'descriptor_ui': 'D008546', 'descriptor_name': 'Melanoma, Experimental', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': True}, {'descriptor_ui': 'D051199', 'descriptor_name': 'Toll-Like Receptor 7', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': True}, {'descriptor_ui': 'D000634', 'descriptor_name': 'Aminoquinolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D059248', 'descriptor_name': 'Chemoradiotherapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077271', 'descriptor_name': 'Imiquimod', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008546', 'descriptor_name': 'Melanoma, Experimental', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008546', 'descriptor_name': 'Melanoma, Experimental', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D008546', 'descriptor_name': 'Melanoma, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051199', 'descriptor_name': 'Toll-Like Receptor 7', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.15326', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=15326&path%5B%5D=48983', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5421900', 'pdf_url': 'https://europepmc.org/articles/pmc5421900?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421900', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28212561', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.15326', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=15326&path%5B%5D=48983', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.78, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 67, 'referenced_works': ['https://openalex.org/W1523693806', 'https://openalex.org/W1832392026', 'https://openalex.org/W1923611821', 'https://openalex.org/W1961652302', 'https://openalex.org/W1965917728', 'https://openalex.org/W1973251492', 'https://openalex.org/W1983954904', 'https://openalex.org/W1984484036', 'https://openalex.org/W1985317418', 'https://openalex.org/W1990461051', 'https://openalex.org/W1993420926', 'https://openalex.org/W1994823455', 'https://openalex.org/W1995582211', 'https://openalex.org/W1995586746', 'https://openalex.org/W2002157461', 'https://openalex.org/W2004150448', 'https://openalex.org/W2005488333', 'https://openalex.org/W2006846913', 'https://openalex.org/W2008373353', 'https://openalex.org/W2009043654', 'https://openalex.org/W2009801524', 'https://openalex.org/W2023563981', 'https://openalex.org/W2023623233', 'https://openalex.org/W2026349319', 'https://openalex.org/W2038554653', 'https://openalex.org/W2043812762', 'https://openalex.org/W2051175209', 'https://openalex.org/W2053454833', 'https://openalex.org/W2063874265', 'https://openalex.org/W2066068067', 'https://openalex.org/W2070968699', 'https://openalex.org/W2073557608', 'https://openalex.org/W2076055196', 'https://openalex.org/W2082865800', 'https://openalex.org/W2082914082', 'https://openalex.org/W2086559292', 'https://openalex.org/W2090961350', 'https://openalex.org/W2093504658', 'https://openalex.org/W2095386620', 'https://openalex.org/W2112748255', 'https://openalex.org/W2117692326', 'https://openalex.org/W2118315567', 'https://openalex.org/W2118486765', 'https://openalex.org/W2119800239', 'https://openalex.org/W2123662098', 'https://openalex.org/W2124511866', 'https://openalex.org/W2130350123', 'https://openalex.org/W2133403756', 'https://openalex.org/W2139246522', 'https://openalex.org/W2140368744', 'https://openalex.org/W2152281757', 'https://openalex.org/W2154536286', 'https://openalex.org/W2155850584', 'https://openalex.org/W2156320420', 'https://openalex.org/W2157058802', 'https://openalex.org/W2158885476', 'https://openalex.org/W2160193764', 'https://openalex.org/W2160934660', 'https://openalex.org/W2163035374', 'https://openalex.org/W2185247439', 'https://openalex.org/W2196305814', 'https://openalex.org/W2320752006', 'https://openalex.org/W2338003717', 'https://openalex.org/W2517770328', 'https://openalex.org/W2517833681', 'https://openalex.org/W2548261792', 'https://openalex.org/W2792139654'], 'related_works': ['https://openalex.org/W4235705334', 'https://openalex.org/W29427278', 'https://openalex.org/W2419081025', 'https://openalex.org/W2412845680', 'https://openalex.org/W2381234067', 'https://openalex.org/W2340903188', 'https://openalex.org/W2121974005', 'https://openalex.org/W2072683499', 'https://openalex.org/W2028310746', 'https://openalex.org/W1945520115'], 'abstract_inverted_index': {'//': [0], 'Jeong': [1, 32], 'Hyun': [2], 'Cho': [3], '1,': [4, 9], '*': [5, 10, 183], ',': [6, 11, 15, 19, 23, 27, 31, 36, 41, 46, 50, 54], 'Hyo-Ji': [7], 'Lee': [8, 48, 52], 'Hyun-Jeong': [12], 'Ko': [13], '2': [14, 70], 'Byung-Il': [16], 'Yoon': [17], '3': [18, 30, 81], 'Jongseon': [20], 'Choe': [21], '4': [22, 93], 'Keun-Cheol': [24], 'Kim': [25], '1': [26, 57, 58], 'Tae-Wook': [28], 'Hahn': [29], 'A.': [33], 'Han': [34], '5': [35, 107], 'Sun': [37], 'Shim': [38], 'Choi': [39], '6': [40, 124], 'Young': [42], 'Mee': [43], 'Jung': [44, 56], '7': [45, 140], 'Kee-Ho': [47], '8': [49, 151], 'Yun-Sil': [51], '9': [53, 169], 'Yu-Jin': [55, 194], 'Department': [59, 82, 94, 108, 125, 141], 'of': [60, 68, 72, 79, 83, 91, 95, 98, 105, 109, 115, 122, 126, 130, 138, 142, 149, 153, 159, 167, 172, 181, 250, 262, 287, 294, 356, 374, 382, 403, 409, 434], 'Biological': [61], 'Sciences,': [62, 163, 174], 'Kangwon': [63, 74, 86, 100, 117, 133, 144], 'National': [64, 75, 87, 101, 118, 134, 145], 'University,': [65, 76, 88, 102, 119, 135, 146, 177], 'Chuncheon,': [66, 77, 89, 103, 120, 136, 147], 'Republic': [67, 78, 90, 104, 121, 137, 148, 166, 180], 'Korea': [69, 80, 92, 106, 123, 139, 150, 157, 168, 182], 'College': [71, 129], 'Pharmacy,': [73], 'Veterinary': [84], 'Medicine,': [85, 99, 116], 'Microbiology,': [96], 'School': [97, 114, 171], 'Biochemistry': [110], 'and': [111, 161, 229, 247, 290, 317, 346, 379, 387, 440, 453], 'Molecular': [112], 'Biology,': [113], 'Medical': [127, 162], 'Biotechnology,': [128], 'Biomedical': [131], 'Science,': [132], 'Chemistry,': [143], 'Division': [152], 'Radiation': [154], 'Cancer': [155], 'Research,': [156], 'Institute': [158], 'Radiological': [160], 'Nowon-gu,': [164], 'Seoul,': [165, 179], 'Graduate': [170], 'Pharmaceutical': [173], 'Ewha': [175], 'Womans': [176], 'Seodaemun-gu,': [178], 'These': [184], 'authors': [185], 'have': [186, 230], 'contributed': [187], 'equally': [188], 'to': [189, 233, 242, 275], 'this': [190], 'work': [191], 'Correspondence': [192], 'to:': [193], 'Jung,': [195], 'email:': [196], '[email protected]': [197], 'Keywords:': [198], 'melanoma,': [199], 'TLR7,': [200], 'imiquimod': [201, 254], '(IMQ),': [202], 'autophagy,': [203, 280], 'radiotherapy': [204, 257, 457], 'Received:': [205], 'February': [206, 214], '17,': [207], '2016&emsp;&emsp;&emsp;&emsp;': [208], 'Accepted:': [209], 'January': [210], '23,': [211], '2017&emsp;&emsp;&emsp;&emsp;': [212], 'Published:': [213], '15,': [215], '2017': [216], 'ABSTRACT': [217], 'Toll-like': [218], 'receptor': [219], '(TLR)': [220], 'ligands': [221], 'are': [222], 'strongly': [223], 'considered': [224], 'immune-adjuvants': [225], 'for': [226, 258, 458], 'cancer': [227], 'immunotherapy': [228], 'been': [231], 'shown': [232], 'exert': [234], 'direct': [235], 'anti-cancer': [236, 246, 354, 366, 428], 'effects.': [237], 'This': [238], 'study': [239], 'was': [240, 308], 'performed': [241], 'evaluate': [243], 'the': [244, 251, 305, 311, 322, 353, 362, 393, 397, 401, 407, 418, 423, 432], 'synergistic': [245], 'anti-metastatic': [248], 'effects': [249], 'TLR7': [252], 'agonist': [253], '(IMQ)': [255], 'during': [256, 456], 'melanoma.': [259], 'The': [260, 300], 'pretreatment': [261], 'B16F10': [263, 415], 'or': [264], 'B16F1': [265], 'cells': [266, 323, 335, 378, 385, 390, 416], 'with': [267, 270, 325, 328, 333, 344, 349, 359, 414], 'IMQ': [268, 326, 345, 357, 447], 'combined': [269, 327, 358], '&gamma;-ionizing': [271], 'radiation': [272], '(IR)': [273], 'led': [274], 'enhanced': [276, 365, 426], 'cell': [277, 298, 436], 'death': [278], 'via': [279, 310, 417], 'as': [281, 368, 450], 'demonstrated': [282, 369], 'by': [283, 370, 430], 'increased': [284, 292, 372], 'expression': [285], 'levels': [286], 'autophagy-related': [288], 'genes,': [289], 'an': [291, 371], 'number': [293, 373, 402], 'autophagosomes': [295], 'in': [296, 321, 392, 406], 'both': [297], 'lines.': [299], 'results': [301], 'also': [302], 'confirmed': [303], 'that': [304, 411, 446], 'autophagy': [306], 'process': [307], 'accelerated': [309], 'reactive': [312], 'oxygen': [313], 'species': [314], '(ROS)-mediated': [315], 'MAPK': [316], 'NF-&kappa;B': [318], 'signaling': [319], 'pathway': [320], 'pretreated': [324], 'IR.': [329, 347, 360], 'Mice': [330], 'subcutaneously': [331], 'injected': [332, 413], 'melanoma': [334, 459], 'showed': [336], 'a': [337, 451], 'reduced': [338], 'tumor': [339, 394], 'growth': [340], 'rate': [341], 'after': [342], 'treatment': [343], 'Treatment': [348], '3-methyladenine': [350], '(3-MA),': [351], 'ameliorated': [352], 'effect': [355], 'Additionally,': [361], 'combination': [363, 398, 424], 'therapy': [364, 399, 425], 'immunity,': [367], 'CD8': [375], '+': [376], 'T': [377, 384, 435], 'decreased': [380, 400], 'numbers': [381], 'regulatory': [383], '(Treg)': [386], 'myeloid-derived': [388], 'suppressor': [389], '(MDSCs)': [391], 'lesions.': [395], 'Moreover,': [396], 'metastatic': [404], 'nodules': [405], 'lungs': [408], 'mice': [410], 'were': [412], 'tail': [419], 'vein.': [420], 'In': [421], 'addition,': [422], 'systemic': [427], 'immunity': [429], 'increasing': [431], 'abundances': [433], 'populations': [437], 'expressing': [438], 'IFN-&gamma;': [439], 'TNF-&alpha;.': [441], 'Therefore,': [442], 'these': [443], 'findings': [444], 'suggest': [445], 'could': [448], 'serve': [449], 'radiosensitizer': [452], 'immune': [454], 'booster': [455], 'patients.': [460]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2588948315', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 3}], 'updated_date': '2024-12-24T11:43:32.169277', 'created_date': '2017-02-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
