Abstract: Neurogenesis occurs in the adult mammalian—including human—brain, primarily in the subgranular zone of the hippocampal dentate gyrus and the rostral subventricular zone that lines the anterior horns of the lateral ventricles. Both ischemic stroke and intracerebral hemorrhage can enhance neurogenesis, resulting in migration of neuroblasts from the subventricular zone to the site of injury. Stroke-induced neurogenesis appears to have functional significance because its ablation worsens outcome in rodent models of stroke. However, the number of neurons produced by this process is far smaller than the number lost, suggesting that mechanisms other than cell replacement must be involved. Mechanisms proposed include the secretion of neuroprotective trophic factors and of antiinflammatory cytokines from neuroblasts.
Publication Year: 2017
Publication Date: 2017-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 2
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