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558, 653, 698, 750, 979, 1096, 1193, 1305, 1343, 2220, 2516, 2735], 'variants': [125, 140, 521, 559, 672, 699, 729, 820, 946, 1306, 2010, 2110, 2146, 2513, 2573], 'at': [126, 560, 1970, 2111, 2147], 'three': [127, 561], 'principal': [128, 562], 'loci:': [129], 'BCL11A,': [130, 564, 1972], 'HBS1L-MYB': [131], 'HBB': [133, 567], 'cluster.': [134], 'The': [135, 637, 666, 861, 936, 1336, 1544, 1941, 2704], 'co-inheritance': [136, 667], 'α-thalassemia': [138, 669, 2340], 'APOL1': [142, 702, 2545], 'HMOX1': [144, 704, 2712], 'has': [145, 380, 418, 551, 848, 1429, 3083], 'been': [146, 367, 381, 399, 590, 679, 706, 849], 'associated': [147, 168, 522, 707, 752, 1048, 1051, 2302, 2474, 2548], 'with': [148, 289, 292, 392, 506, 708, 753, 858, 868, 931, 1008, 1210, 1257, 1327, 1373, 1436, 1441, 1449, 1608, 1667, 1846, 1881, 1916, 1978, 2059, 2115, 2193, 2278, 2303, 2313, 2349, 2417, 2475, 2549, 2612, 2681, 2773, 2827, 2832, 2918, 3090, 3095, 3103], 'development': [150, 648, 755, 1885, 2382], 'nephropathies.': [155], 'However,': [156, 304, 407, 833], 'lack': [160, 742, 1169], 'validation': [162, 744, 1302], 'multiple': [164, 529, 746, 1304], 'suggestive': [165, 749], 'loci': [167, 677, 827, 1976], 'key': [170, 818], 'subphenotypes': [171, 525, 758, 983, 1313], 'such': [172, 374, 481, 761], 'as': [173, 305, 375, 456, 458, 482, 553, 659, 762, 892, 894, 1631, 2514, 2791], 'stroke,': [174, 643, 763], 'painful': [175, 764], 'episodes': [176], 'or': [177, 646, 1074, 1083, 1091, 1191, 1402, 1433, 1439, 1446, 1453, 1466, 1471, 1474, 1476, 3087, 3093, 3100, 3107, 3120, 3125, 3128, 3130], 'acute': [178, 766], 'chest': [179, 767], 'syndrome.': [180], 'This': [181, 1195, 1459, 3113], 'highlights': [182, 1196], 'need': [184, 491, 1198], 'interdisciplinary': [187, 1201], 'research': [188, 493, 958, 1161, 1202, 1242], 'on': [189, 462, 748, 837, 934, 1163, 1203, 1244, 2021, 2449, 2673, 2714, 3053], 'adequately': [190, 1204, 1280], 'phenotyped': [191, 1205, 1282], 'large': [192, 962, 1206, 1241, 1246, 1283], 'cohorts': [193, 1207], 'patients': [195, 414, 461, 504, 577, 594, 857, 866, 1006, 1209, 1250, 1276, 1371, 2058, 2124, 2159, 2443, 2917], 'from': [196, 1178, 1212, 1289, 1724, 2444], 'different': [197, 1213], 'populations': [198, 1214, 1291], 'environments,': [200, 1216], 'specifically': [201], 'Africa,': [203, 329, 960, 1235, 1252], 'epicenter': [205, 1237], 'disease.The': [208], 'diseaseSickle': [214], '(SCD)': [217], 'most': [220, 1005, 1129], 'common': [221, 862, 1312], 'single': [222, 233], 'gene': [223, 1052, 1405, 2378], 'disorder': [224], 'world.': [227], 'It': [228, 1001], 'caused': [230], 'by': [231, 369, 661, 865, 2191, 2245], 'point': [234], 'mutation': [235, 273], '(Glub6Val)': [236], 'that': [237, 282, 350, 446, 538, 652, 724, 806, 913, 1004, 1057, 1060, 1183, 1307, 1347, 2372], 'promotes': [238], 'polymerization': [239], 'hemoglobin': [241, 549, 1945, 1980, 2026, 2053, 2085, 2116, 2153, 2195, 2224, 2576, 2862], '(Hb)': [242], 'S': [243, 2047, 2210, 2701, 2929], 'sickling': [245], 'erythrocytes.': [247], 'Inflammation,': [248], 'hemolysis,': [249], 'microvascular': [250], 'obstruction': [251], 'organ': [253], 'damage': [254, 2821], 'characterize': [255], 'clinical': [257, 348, 544, 639, 684, 1160, 2955], 'expression': [258, 545, 603], 'SCD': [260, 290, 316, 393, 413, 451, 465, 507, 537, 576, 593, 620, 626, 692, 709, 760, 795, 859, 869, 972, 982, 996, 1009, 1039, 1101, 1122, 1211, 1249, 1275, 1287], '[1].': [261], 'There': [262, 487], 'strong': [265], 'association': [266, 2081, 2634], 'between': [267, 2145, 2411], 'frequency': [269], 'HbS': [272], 'endemicity': [275], 'malaria,': [277], 'it': [279, 320, 443, 1054, 1103], 'estimated': [281], '305,800': [283], 'babies': [284], 'are': [285, 721, 870, 877, 989, 1061, 1127, 1184, 1946, 2013, 2546], 'born': [286], 'each': [287], 'year': [288, 1842], 'worldwide,': [291], 'nearly': [293], '75%': [294], 'births': [297], 'occurring': [298], 'sub-Saharan': [300], '(SSA)': [302], '[2].': [303], 'result': [307, 1633], 'migration,': [309], 'countries': [318, 326, 405, 1182], 'where': [319, 853], 'was': [321, 1480, 3134], 'not': [322, 419, 2897], 'initially': [323], 'prevalent.': [324], 'These': [325], 'include:': [327], 'Ireland,': [330], 'Italy,': [331], 'Germany,': [332], 'England': [333], 'France': [335], '[3–8].': [336], 'In': [337, 696], 'addition,': [338, 697], 'care': [349, 1263], 'includes': [351, 1460, 3114], 'hydroxyurea': [355, 1386, 1394, 1398, 2769], '(HU)': [356], 'west,': [360], 'SCD-related': [362], 'premature': [363], 'childhood': [364, 1269], 'deaths': [365], 'have': [366, 398, 589, 678, 705, 725, 944, 1011], 'reduced': [368], '70%': [370], 'high-income': [372], 'nations': [373], 'USA.': [377], 'Consequently,': [378], 'considerable': [383], 'increase': [384, 2341], 'life': [387, 438, 501, 1224, 1366], 'expectancy': [388], 'people': [390], 'living': [391, 505, 595, 867, 1007, 1372, 1880], '[9];': [394], 'similar': [396], 'trends': [397], 'observed': [400, 641], 'few': [403, 663, 937, 1180], 'African': [404, 1181, 2959], '[10,11].': [406], 'death': [409], 'rate': [410, 2609], 'adult': [412, 1697, 2189], 'USA': [417, 1993, 2034], 'improved': [420], 'last': [423, 1737], 'thirty': [424], 'years,': [425], 'additional': [428], 'debilitating': [429], 'complications': [430], '[11–13],': [431], 'overall': [434], 'poor': [435], 'quality': [436, 1364, 1926], '[14,15].': [439], 'As': [440, 1033], 'result,': [442], 'anticipated': [445], 'will': [452, 1010, 1065, 1253, 1338], 'continue': [453], 'increase,': [455], 'well': [457, 893, 1281], 'dependency': [459], 'chronic': [463, 1732, 2522], 'medications.': [464], 'now': [467], 'accepted': [469], 'worldwide': [470], 'health': [471, 1141, 1261, 1876, 1950], 'problem': [472], 'comparable': [474], 'other': [476], 'major': [477, 490, 629, 974, 1107, 2017], 'noncommunicable': [479], 'diseases': [480, 1943], 'diabetes': [483], 'hypertension': [485, 647], '[16].': [486], 'help': [495, 1218], 'develop': [496, 1219], 'effective': [497, 1220], 'therapies': [498, 1221], 'across': [499, 1222], 'span': [502], 'all': [509], 'parts': [510], 'world,': [513], 'should': [515], 'incorporate': [516], 'personalized': [517], 'medicine': [518], 'pharmacogenomics.Genetic': [520], 'specific': [524, 671], 'SCDEnvironmental': [527], 'factors': [531, 654], 'influence': [532], 'many': [533], 'pathophysiological': [534, 1111], 'aspects': [535], 'contribute': [539], 'highly': [542], 'variable': [543, 895, 919, 1290], 'patients.': [547, 636, 2489, 2803], '(HbF)': [550], 'emerged': [552], 'modifier;': [557], 'loci,': [563], 'HBS1L–MYB': [565, 2012, 2114], 'cluster,': [568], 'account': [569], '10–20%': [571], 'HbF': [573, 675, 809, 825, 1063], 'variation': [574, 2221], 'among': [575, 711, 728, 2121, 2155], 'USA,': [579], 'Brazil': [580], 'UK': [583], '[17,18]': [584], '(Table': [585, 694, 717, 821], '1);': [586], 'these': [587, 605], 'findings': [588], 'replicated': [591, 942, 1377], 'Tanzania': [597], 'Cameroon': [599], '[19–22].': [600], 'Interestingly,': [601], 'modifiers': [606, 751, 980, 1379, 2599], 'amenable': [608], 'therapeutic': [610, 2165], 'manipulation,': [611], 'leading': [612], 'new': [614], 'hope': [615], 'routes': [618], '[23–25].': [621], 'Moreover,': [622], 'cardiovascular': [623, 2273], 'phenotypes': [624], 'represent': [627], 'cause': [630], 'morbidity': [632], 'mortality': [634, 1817, 1843], 'vast': [638], 'heterogeneity': [640, 2738], 'kidney': [644, 687, 2523], 'SCD,': [650, 1315], 'indicates': [651], 'may': [655], 'play': [656], 'substantiated': [660], 'studies': [664, 723, 747, 912, 943, 964, 1126, 1162], '[26].': [665], 'promoting': [676, 826], 'proven': [680], 'delay': [682], 'progression': [685, 2520], 'stroke': [690], '[27–32]': [693], '1).': [695, 718], 'both': [701, 1135, 2547], 'nephropathy': [710], 'African–American': [712], 'adults': [713, 797, 1845, 1879, 1915, 2416], 'children': [715, 1729, 2312, 2348, 2611, 2680, 2772], '[33–36]': [716], 'Lastly,': [719], 'consistent': [722], 'shown': [726], 'associations': [727], 'UGT1A1': [731, 2710], 'serum': [733, 2674], 'bilirubin,': [734], 'cholelithiasis': [736, 2640, 2678, 2715], '[37–39].': [737], 'Nevertheless,': [738], 'various': [757], 'episodes,': [765], 'syndrome,': [768], 'bacteremia/infection,': [769], 'osteonecrosis,': [770], 'priapism,': [771], 'leg': [772], 'ulcers,': [773], 'vasculophathies': [775], 'hemolysis': [777, 2412], '[40].Early': [778], 'days': [779], '&': [782, 961, 965, 1424, 2941, 3014, 3078], 'drug': [783], 'metabolism': [784], 'SCDHU': [786], 'only': [789, 907, 1254], 'US': [790], 'FDA': [791], 'approved': [792], 'children.': [799], 'HU': [800, 815, 841, 1017], 'ribonucleotide': [803], 'reductase': [804], 'inhibitor': [805], 'increases': [807, 1022], 'level.': [810, 2225], 'Patients': [811], 'respond': [812], 'differently': [813], 'genomic': [819, 1378], '1),': [822, 1708], 'mainly': [823], '(BCL11A,': [828], 'HBG2': [829], 'HBS1L–MYB;': [831], '[41–43]).': [832], 'complete': [835], 'picture': [836], 'pharmacogenomic': [838], 'determinants': [839], 'remains': [842], 'elusive': [843], '[44].': [844], 'Strikingly,': [845], 'no': [846, 1430, 3084], 'study': [847, 2082, 2635, 2799], 'conducted': [850], 'SSA': [852, 1151], 'majority': [855], 'live.': [860], 'medications': [863, 1059], 'used': [864, 1350], 'analgesics,': [871, 1014], 'manage': [873], 'pain.': [874], 'Genetic': [875, 2572, 2598], 'differences': [876], 'also': [878], 'suggested': [879], 'be': [881, 1066, 1153, 1231, 1255, 1339, 1349], 'reason': [883], 'inter-individual': [885], 'variability': [886], 'pain': [888, 1983], 'perception': [889], 'experience,': [891], 'responses': [896, 920, 1600], 'anti-inflammatory': [898], 'opioid': [900], 'drugs.': [901], 'Surprisingly,': [902], 'our': [903], 'recent': [904], 'review': [905, 2277, 2855, 2889, 2953], 'identified': [906, 945], 'limited': [909, 990], 'number': [910], 'addressed': [914], 'genetic/genomic': [916], 'basis': [917, 1097, 2736], 'pain,': [922], 'pharmacogenomics': [924, 2891], 'analgesics': [926], 'opioids': [928], 'general,': [930], 'little': [932], 'focus': [933], 'SCD.': [935, 1032, 1239], 'available': [938], 'largely': [940], 'non': [941], 'OPRM1,': [948], 'HMOX-1,': [949], 'GCH1,': [950], 'VEGFA,': [951], 'STAT6,': [952], 'ABCB1': [953], 'COMT': [955], 'genes': [956], '[45].Future': [957], 'directions:': [959], 'cohort': [963, 1125, 1247, 1285], 'pharmacogeneticsDespite': [966], 'progress': [975], 'understanding': [977, 1035, 1134], 'response': [985], 'HU,': [987], 'data': [991], 'support': [993], 'therapeutics': [997], 'precision': [999, 2902], 'medicine.': [1000, 2903], 'expected': [1003, 1154], 'access': [1012], 'antibiotics': [1015], 'worldwide;': [1019], 'which': [1020, 1228], 'could': [1021, 1230, 1296, 1348], 'interest': [1025, 1444, 3098], 'field': [1028], 'pathophysiology': [1037], 'advances': [1040], 'more': [1042, 1058], 'known': [1044, 2857], 'about': [1045], 'regulatory': [1046], 'mechanisms,': [1047], 'pathways': [1049], 'expressions,': [1053], 'likely': [1056], 'outside': [1062], 'induction': [1064], 'developed.': [1067], 'For': [1068], 'example': [1069], 'induce': [1071], 'stress': [1072], 'hematopoiesis': [1073], 'endothelial': [1075], 'nitric': [1076], 'oxide': [1077], 'release,': [1078], 'reduce': [1080], 'leukocytes': [1081, 2824], 'counts': [1082], 'red': [1084, 2450], 'blood': [1085, 1603, 2451, 2602, 2823], 'cells': [1086], 'adhesion': [1087], 'endothelium': [1090], 'inflammation': [1092], 'processes': [1093, 1119], '[45].Understanding': [1094], 'severity': [1099, 2740], 'endeavor,': [1108], 'given': [1109], 'complexity': [1112], 'interlocking': [1114], 'nature': [1115], 'biological': [1118, 1920], 'culminating': [1120], 'subphenotypes.': [1123], 'Longitudinal': [1124], 'scientifically': [1130], 'rigorous': [1131], 'methods': [1132], 'environmental': [1136, 1345], 'genetics': [1138], 'risk': [1139, 2305, 2343, 2517, 2641], 'factors,': [1140], 'outcomes.': [1144], 'While': [1145], 'high': [1146], 'regional': [1147], 'prevalence': [1149], 'would': [1152], 'facilitate': [1156], 'epidemiologic,': [1157], 'translational': [1158], 'SCD;': [1164, 1227], 'still': [1167], 'integration': [1171], 'coordination': [1173, 1273], 'emerging': [1176, 1948], 'efforts': [1177], 'implementing': [1185], 'initiating': [1192], 'studies.': [1194], 'course': [1225], 'clearly': [1229], 'best': [1232], 'established': [1233], 'Developing': [1240], 'activities': [1243], 'successful': [1256], 'establishing': [1258], 'appropriate': [1259], 'public': [1260], 'infrastructures,': [1264], 'order': [1266, 1359], 'improve': [1268, 1361], 'mortality,': [1270], 'serious': [1272], 'follow-up': [1277], 'plans.': [1278], 'An': [1279, 2213, 2887], 'multicentre': [1284], 'individuals': [1288, 2826], 'environments': [1293], 'allow': [1297], 'careful': [1299], 'exploration': [1300], 'modulate': [1308], 'some': [1309], 'using': [1316], 'high-throughput': [1317], 'genotyping': [1318], 'methods,': [1319], 'whole': [1320, 1323], 'exome': [1321], 'genome': [1324], 'sequencing,': [1325], 'coupled': [1326], 'innovative': [1328], 'bioinformatics,': [1329], 'biostatics': [1331], 'geocoding': [1333], 'analytical': [1334], 'techniques.': [1335], 'aim': [1337], 'possibly': [1341], 'generate': [1342], 'markers': [1346], 'integrated': [1353], 'model,': [1354], 'anticipate': [1356], 'guidance': [1357], 'ultimately': [1368], 'survival': [1369], 'SCD.Table': [1374], '1.': [1375], 'Selected': [1376], 'disease.GeneSNPsChromosome:': [1383], 'locusPhenotypesEffectRef.HBS1L–MYBrs283845136:135417902HbF': [1384], 'induced': [1387, 1395, 1399], 'HbFProtectiveProtective[17–22][41–43]': [1388], 'rs93991376:135460711': [1389], 'Protective': [1390], 'rs48954416:135468266': [1391], 'BCL11Ars46713932:60574475HbF': [1392], 'HbFProtective[17–22][41–43]HBG2rs748214411:5254939HbF': [1396], 'HbFProtective[17,42–43]HBA': [1400], '(3.7': [1401], '4.2kb': [1403], 'α-globin': [1404], 'deletion)': [1406], '16Hematological': [1407], 'indices': [1408, 1412], 'strokeProtective[27,28]': [1410], 'Hematological': [1411], 'nephropathyProtective[29–32]APOL1rs7388531922:36265860NephropathyRisk[33–36]': [1414], 'rs6091014522:36265988': [1415], 'rs7178531322:36266000–36266005': [1416], 'HMOX1rs307437222:35380894–35380895NephropathyRisk[35,36]': [1417], 'rs74381122:35396981NephropathyProtective/risk[35,36]UGT1A1rs8878292:234333309Serum': [1418], 'bilirubin': [1419, 2638, 2667, 2675], 'cholelithiasisProtective[37–39]HbF:': [1421], 'hemoglobin.Financial': [1423], 'competing': [1425, 3079], 'interests': [1426, 3080], 'disclosureThe': [1427, 3081], 'author': [1428, 3082], 'relevant': [1431, 3085], 'affiliations': [1432, 3086], 'financial': [1434, 1443, 1447, 3088, 3097, 3101], 'involvement': [1435, 3089], 'any': [1437, 3091], 'organization': [1438, 3092], 'entity': [1440, 3094], 'conflict': [1448, 3102], 'subject': [1451, 2218, 3105], 'matter': [1452, 3106], 'materials': [1454, 3108], 'discussed': [1455, 3109], 'manuscript.': [1458, 3112], 'employment,': [1461, 3115], 'consultancies,': [1462, 3116], 'honoraria,': [1463, 3117], 'stock': [1464, 3118], 'ownership': [1465, 3119], 'options,': [1467, 3121], 'expert': [1468, 2276, 2888, 3122], 'testimony,': [1469, 3123], 'grants': [1470, 3124], 'patents': [1472, 3126], 'received': [1473, 3127], 'pending,': [1475, 3129], 'royalties.No': [1477, 3131], 'writing': [1478, 3132], 'assistance': [1479, 3133], 'utilized': [1481, 3135], 'production': [1484, 3138], 'this': [1486, 3140], 'manuscript.References1': [1487], 'Malowany': [1488], 'JI,': [1489], 'Butany': [1490], 'J.': [1491, 1556, 1583, 1615, 1672, 1741, 1768, 1801, 1855, 1929, 2317, 2354, 2389, 2555, 2685, 2721], 'Pathology': [1492], 'disease.': [1496, 1853, 1988, 2719, 2744, 2868], 'Semin.': [1497], 'Diagn.': [1498], 'Pathol.': [1499, 1770], '29(1),': [1500], '49–55': [1501], '(2012).Crossref,': [1502, 1559, 1859, 2424, 2650], 'Medline,': [1503, 1533, 1560, 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2703, 2763, 2819], 'Global': [1514], 'epidemiology': [1515], 'haemoglobin': [1518], 'neonates:': [1520], 'contemporary': [1522], 'geostatistical': [1523], 'model-based': [1524], 'map': [1525], 'population': [1527], 'estimates.': [1528], 'Lancet': [1529], '381(9861),': [1530], '142–151': [1531], '(2013).Crossref,': [1532, 1620, 1805, 1828, 2229], 'Scholar3': [1535], 'Wonkam': [1536, 2100, 2267, 2851, 2885], 'A,': [1537, 1684, 1752, 2101, 2260, 2364, 2731], 'Ponde': [1538], 'C,': [1539, 1564, 2178, 2467, 2884], 'Nicholson': [1540], 'N': [1541, 2434, 2629], 'Town.': [1552], 'S.': [1553], 'Afr.': [1554], 'Med.': [1555, 1582, 1704, 2747], '102(9),': [1557], '752–754': [1558], 'Scholar4': [1562], 'Gibbons': [1563], 'Geoghegan': [1565], 'R,': [1566, 1591], 'Conroy': [1567], 'H': [1568, 2076], 'Sickle': [1571, 1813, 3034], 'disease:': [1573, 1700, 1884, 1919, 2274, 2798], 'time': [1574], 'targeted': [1577], 'neonatal': [1578], 'programme.': [1580], 'Ir.': [1581], '108(2),': [1584], '43–45': [1585], '(2015).Medline,': [1586], 'CAS,': [1587, 1644, 1680, 1712, 1775, 1957, 1998, 2039, 2068, 2172, 2202, 2231, 2256, 2288, 2360, 2397, 2426, 2498, 2534, 2561, 2587, 2652, 2693, 2727, 2753, 2782, 2809, 2840, 2876, 2909], 'Scholar5': [1589], 'Colombatti': [1590], 'Perrotta': [1592], 'S,': [1593, 1716, 1904, 2004, 2045, 2699, 2846], 'Samperi': [1594], 'P': [1595], 'Organizing': [1598], 'national': [1599], 'rare': [1602], 'disorders:': [1604], 'Italian': [1606], 'experience': [1607], 'childhood.': [1613], 'Orphanet': [1614], 'Rare': [1616], 'Dis.': [1617, 2493], '8,': [1618], '169': [1619], 'Scholar6': [1623], 'Zur': [1624], 'B.': [1625], 'Increase': [1626], 'genetically': [1628], 'determined': [1629], 'anemia': [1630, 1796, 2089, 2442, 2488], 'migration': [1635], 'Germany.': [1637], 'Internist': [1638], '(Berl.)': [1639], '57(5),': [1640], '444–451': [1641], '(2016).Crossref,': [1642, 1745, 2286, 2358, 2620, 2751, 2907], 'Scholar7': [1646], 'Pizzo': [1647], 'E,': [1648], 'Laverty': [1649], 'AA,': [1650], 'Phekoo': [1651], 'KJ': [1652], 'A': [1655, 1786, 2632, 2853, 2922, 3038], 'retrospective': [1656], 'analysis': [1657], 'cost': [1660], 'hospitalizations': [1662], 'crisis': [1668], 'England,': [1670], '2010/11.': [1671], 'Public': [1673], '(Oxf)': [1675], '37(3),': [1676], '529–539': [1677], '(2015).Crossref,': [1678, 1710, 2170, 2254, 2585, 2874], 'Scholar8': [1682], 'Habibi': [1683], 'Arlet': [1685], 'JB,': [1686], 'Stankovic': [1687], 'K': [1688, 2332, 2469], 'French': [1691], 'guidelines': [1692], 'management': [1695], '2015': [1701], 'update.': [1702], 'Rev.': [1703, 2870], 'Interne': [1705], '36(5': [1706], 'Suppl.': [1707], '5S3–5S84': [1709], 'Scholar9': [1714], 'Chaturvedi': [1715], 'DeBaun': [1717], 'MR.': [1718], 'Evolution': [1719], 'life-threatening': [1726], 'adults:': [1735], '40': [1738], 'years.': [1739], 'Am.': [1740, 1800, 2390], 'Hematol.': [1742, 1802, 2319, 2687, 2871], '91(1),': [1743], '5–14': [1744], 'Scholar10': [1748], 'Rahimy': [1749], 'MC,': [1750, 2235], 'Gangbo': [1751], 'Ahouignan': [1753], 'G,': [1754, 1961], 'Alihonou': [1755], 'E.': [1756], 'Newborn': [1757], 'Republic': [1765], 'Benin.': [1767], 'Clin.': [1769, 2455], '62(1),': [1771], '46–48': [1772], '(2009).Crossref,': [1773], 'Scholar11': [1777], 'McGann': [1778], 'PT,': [1779], 'Ferris': [1780], 'MG,': [1781], 'Ramamurthy': [1782], 'U': [1783], 'prospective': [1787], 'program': [1792], 'Luanda,': [1798], 'Angola.': [1799], '88(12),': [1803], '984–989': [1804], 'Scholar12': [1808], 'Hamideh': [1809], 'D,': [1810, 2264, 2465, 2815], 'Alvarez': [1811, 2594], 'O.': [1812], 'related': [1816], 'United': [1820], 'States': [1821], '(1999–2009).': [1822], 'Pediatr.': [1823, 1930, 2318, 2686], 'Blood': [1824, 1952, 2063, 2490, 2777], 'Cancer': [1825], '60(9),': [1826], '1482–1486': [1827], 'Scholar13': [1831], 'McClellan': [1832], 'AC,': [1833], 'Luthi': [1834], 'JC,': [1835], 'Lynch': [1836], 'JR': [1837, 2368], 'High': [1840], 'one': [1841], 'end-stage': [1851], 'renal': [1852], 'Br.': [1854, 2554, 2720], 'Haematol.': [1856, 2355, 2556, 2722], '159(3),': [1857], '360–367': [1858], 'Scholar14': [1862], 'Keller': [1863], 'SD,': [1864], 'Yang': [1865], 'M,': [1866, 2432], 'Treadwell': [1867], 'MJ,': [1868], 'Werner': [1869], 'EM,': [1870], 'Hassell': [1871], 'KL.': [1872], 'Patient': [1873], 'reports': [1874], 'outcome': [1877], 'testing': [1887, 2915], 'ASCQ-Me': [1890], 'item': [1891], 'banks.': [1892], 'Qual.': [1894], 'Life': [1895], 'Outcomes': [1896], '12,': [1897], '125': [1898], '(2014).Crossref,': [1899, 1935, 2096, 2131, 2460], 'Scholar15': [1902], 'Ameringer': [1903], 'Elswick': [1905], 'RK': [1906], 'Jr,': [1907], 'Smith': [1908, 2236], 'W.': [1909], 'Fatigue': [1910], 'adolescents': [1912], 'young': [1914], 'behavioral': [1922], 'correlates': [1923], 'health-related': [1925], 'life.': [1928], 'Oncol.': [1931, 2320, 2688], 'Nurs.': [1932], '31(1),': [1933], '6–17': [1934], 'Scholar16': [1938], 'Weatherall': [1939], 'DJ.': [1940], 'inherited': [1942], 'burden.': [1951], '115(22),': [1953], '4331–4336': [1954], '(2010).Crossref,': [1955, 2496], 'Scholar17': [1959], 'Lettre': [1960], 'Sankaran': [1962, 2179], 'VG,': [1963], 'Bezerra': [1964], 'MA': [1965], 'DNA': [1968, 2820], 'polymorphisms': [1969, 2672, 2713], 'HBS1L–MYB,': [1973], 'beta-globin': [1975], 'associate': [1977], 'fetal': [1979, 2025, 2052, 2084, 2152, 2194, 2223, 2861], 'levels': [1981, 2027, 2154, 2676], 'crises': [1984], 'Proc.': [1989, 2030], 'Natl': [1990, 2031], 'Acad.': [1991, 2032], 'Sci.': [1992, 2033], '105(33),': [1994], '11869–11874': [1995], '(2008).Crossref,': [1996, 2838], 'Scholar18': [2000], 'Thein': [2001, 2408], 'SL,': [2002, 2502, 2565], 'Menzel': [2003, 2044, 2698], 'Peng': [2005, 2177], 'X': [2006, 2506], 'Intergenic': [2009], 'responsible': [2014], 'quantitative': [2018], 'trait': [2019], 'locus': [2020], 'chromosome': [2022], '6q23': [2023], 'influencing': [2024], 'adults.': [2029], '104(27),': [2035], '11346–11351': [2036], '(2007).Crossref,': [2037, 2725], 'Scholar19': [2041], 'Makani': [2042], 'J,': [2043, 2176], 'Nkya': [2046], 'Genetics': [2050, 2269], 'Tanzanian': [2055], 'British': [2057], 'anemia.': [2062, 2316, 2352, 2420, 2528, 2615, 2645, 2684, 2776], '117(4),': [2064], '1390–1392': [2065], '(2011).Crossref,': [2066, 2200, 2559, 2780, 2807], 'Scholar20': [2070], 'Mtatiro': [2071], 'SN,': [2072], 'Singh': [2073], 'T,': [2074, 2405], 'Rooks': [2075], 'Genome': [2079], 'Tanzania.': [2091], 'PLoS': [2092, 2127, 2616, 2646], 'ONE': [2093, 2128, 2617, 2647], '9(11),': [2094], 'e111464': [2095], 'Scholar21': [2099], 'Bitoungui': [2102, 2138, 2265], 'VJN,': [2103], 'Vorster': [2104], 'AA': [2105], 'Association': [2108, 2144, 2410], 'BCL11A': [2112, 2148, 2217, 2242, 2512], 'F': [2117, 2239, 2790], 'hospitalization': [2119], 'rates': [2120], 'Cameroon.': [2126], '9(3),': [2129], 'e92506': [2130], 'Scholar22': [2134], 'Pule': [2135, 2261, 2843, 2881], 'GD,': [2136, 2262, 2844, 2882], 'Ngo': [2137], 'VJ,': [2139, 2266], 'Chetcha': [2140], 'CB': [2141], 'erythroid-specific': [2149], 'enhancer': [2150, 2215, 2243], 'Cameroon:': [2161], 'implications': [2162], 'future': [2164], 'interventions.': [2166], 'OMICS': [2167, 2283, 2904], '19(10),': [2168], '627–631': [2169], 'Scholar23': [2174], 'Xu': [2175], 'VG': [2180], 'Correction': [2183], 'mice': [2190], 'interference': [2192], 'silencing.': [2196], 'Science': [2197, 2226], '334(6058),': [2198], '993–996': [2199], 'Scholar24': [2204], 'Bauer': [2205], 'DE,': [2206], 'Kamran': [2207], 'SC,': [2208], 'Lessard': [2209], 'erythroid': [2214], 'determines': [2222], '342(6155),': [2227], '253–257': [2228], 'Scholar25': [2233], 'Canver': [2234], 'EC,': [2237], 'Sher': [2238], 'dissection': [2244], 'Cas9-mediated': [2246], 'situ': [2248], 'saturating': [2249], 'mutagenesis.': [2250], 'Nature': [2251], '527(7577),': [2252], '192–197': [2253], 'Scholar26': [2258], 'Geard': [2259], 'Chelo': [2263], 'A.': [2268, 2852, 2886], 'cell-associated': [2272], 'lessons': [2279], 'learned': [2280], 'Africa.': [2282], '20(10),': [2284, 2905], '581–592': [2285], 'Scholar27': [2290], 'Hsu': [2291], 'LL,': [2292], 'Miller': [2293], 'ST,': [2294], 'Wright': [2295], 'E': [2296], 'Alpha': [2299, 2437], 'Thalassemia': [2300], 'decreased': [2304, 2477], 'abnormal': [2307], 'transcranial': [2308], 'Doppler': [2309], 'ultrasonography': [2310], '25(8),': [2321], '622–628': [2322], '(2003).Crossref,': [2323], 'Scholar28': [2326], 'Joly': [2327], 'P,': [2328, 2627], 'Garnier': [2329], 'N,': [2330, 2697, 2848], 'Kebaili': [2331], 'G6PD': [2335], 'deficiency': [2336], 'absence': [2338], 'cerebral': [2345], 'vasculopathy': [2346], 'Eur.': [2353], '96(4),': [2356], '404–408': [2357], 'Scholar29': [2362], 'Guasch': [2363], 'Zayas': [2365], 'CF,': [2366], 'Eckman': [2367], 'Evidence': [2371], 'microdeletions': [2373], 'alpha': [2376], 'globin': [2377], 'protect': [2379], 'against': [2380], 'glomerulopathy': [2386], 'humans.': [2388], 'Soc.': [2391], 'Nephrol.': [2392], '10(5),': [2393], '1014–1019': [2394], '(1999).Crossref,': [2395], 'Scholar30': [2399], 'Day': [2400], 'TG,': [2401], 'Drasar': [2402], 'ER,': [2403], 'Fulford': [2404], 'Sharpe': [2406], 'CC,': [2407], 'SL.': [2409], 'albuminuria': [2414, 2484, 2605], 'Haematologica': [2421, 2529, 2582], '97(2),': [2422], '201–205': [2423], 'Scholar31': [2428], 'Lamarre': [2429], 'Y,': [2430], 'Romana': [2431], 'Lemonne': [2433], 'thalassemia': [2438], 'protects': [2439], 'macro-albuminuria': [2445], 'through': [2446], 'its': [2447], 'effects': [2448, 2706], 'rheological': [2453], 'properties.': [2454], 'Hemorheol.': [2456], 'Microcirc.': [2457], '57(1),': [2458], '63–72': [2459], 'Scholar32': [2463], 'Nebor': [2464], 'Broquere': [2466], 'Brudey': [2468], 'Alpha-thalassemia': [2472], 'occurrence': [2478], 'delayed': [2481], 'age-at-onset': [2482], 'Cells': [2491], 'Mol.': [2492], '45(2),': [2494], '154–158': [2495], 'Scholar33': [2500], 'Saraf': [2501, 2564], 'Shah': [2503, 2568], 'BN,': [2504], 'Zhang': [2505, 2566], 'APOL1,': [2509], 'α-thalassemia,': [2510], 'profile': [2518], '102(1),': [2530], 'e1–e6': [2531], '(2017).Crossref,': [2532], 'Scholar34': [2536], 'Ashley-Koch': [2537], 'AE,': [2538], 'Okocha': [2539], 'EC': [2540], 'MYH9': [2543], 'nephropathy.': [2553, 2581], '155(3),': [2557], '386–394': [2558], 'Scholar35': [2563], 'X,': [2567], 'B': [2569], 'cell-free': [2575], 'processing': [2577], '100(10),': [2583], '1275–1284': [2584], 'Scholar36': [2589], 'Schaefer': [2590], 'BA,': [2591], 'Flanagan': [2592], 'JM,': [2593, 2759], 'OA': [2595], 'white': [2601], 'count,': [2604], 'glomerular': [2607], 'filtration': [2608], '11(10),': [2618], 'e0164364': [2619], 'Scholar37': [2623], 'Milton': [2624], 'JN,': [2625], 'Sebastiani': [2626], 'Solovieff': [2628], 'genome-wide': [2633], 'total': [2637], '7(4),': [2648], 'e34741': [2649], 'Scholar38': [2654], 'Passon': [2655], 'RG,': [2656], 'Howard': [2657], 'TA,': [2658], 'Zimmerman': [2659], 'SA,': [2660], 'Schultz': [2661], 'WH,': [2662], 'Ware': [2663, 2756], 'RE.': [2664], 'Influence': [2665], 'uridine': [2668], 'diphosphate-glucuronosyltransferase': [2669], '1A': [2670], 'promoter': [2671], '23(7),': [2689], '448–451': [2690], '(2001).Crossref,': [2691], 'Scholar39': [2695], 'Vasavda': [2696], 'Kondaveeti': [2700], 'linear': [2705], 'alpha-thalassaemia,': [2708], '138(2),': [2723], '263–270': [2724], 'Scholar40': [2729], 'Habara': [2730], 'Steinberg': [2732], 'MH.': [2733], 'Minireview:': [2734], 'Exp.': [2745], 'Biol.': [2746], '(Maywood)': [2748], '241(7),': [2749], '689–696': [2750], 'Scholar41': [2755], 'RE,': [2757], 'Despotovic': [2758], 'Mortier': [2760], 'NA': [2761], 'Pharmacokinetics,': [2764], 'pharmacodynamics,': [2765], '118(18),': [2778], '4985–4991': [2779], 'Scholar42': [2784], 'Adekile': [2785], 'AD.': [2786], 'Limitations': [2787], 'Hb': [2789], 'phenotypic': [2793], 'modifier': [2794], 'Kuwaiti': [2801], 'Arab': [2802], 'Hemoglobin': [2804], '35(5–6),': [2805], '607–617': [2806], 'Scholar43': [2811], 'Friedrisch': [2812], 'JR,': [2813], 'Prá': [2814], 'Maluf': [2816], 'SW': [2817], 'treated': [2831], 'Mutat.': [2834], 'Res.': [2835], '649(1–2),': [2836], '213–220': [2837], 'Scholar44': [2842], 'Mowla': [2845], 'Novitzky': [2847], 'Wiysonge': [2849], 'CS,': [2850], 'systematic': [2854], 'mechanisms': [2858], 'hydroxyurea-induced': [2860], 'Expert': [2869], '8(5),': [2872], '669–679': [2873], 'Scholar45': [2878], 'Mnika': [2879], 'K,': [2880], 'Dandara': [2883], 'therapeutics:': [2896], 'yet': [2898], 'ready': [2899], '565–574': [2906], 'ScholarFiguresReferencesRelatedDetailsCited': [2911], 'ByOpportunity': [2912], 'anemiaKatherine': [2921], 'Gallaway,': [2923], 'Colleen': [2924], 'Sakon,': [2925], 'Jefney': [2926], 'Ongeri,': [2927], 'Krina': [2928], 'Patel,': [2930], 'Johnathan': [2931], 'Oliver,': [2932], 'Heather': [2933], 'Patacca,': [2934], 'Andrew': [2935], 'RW': [2936], "O'Brien,": [2937], 'Todd': [2938], 'C': [2939], 'Skaar': [2940], 'Emma': [2942], 'M': [2943], 'Tillman2': [2944], 'November': [2945], '2022': [2946], '|': [2947, 3019], 'Pharmacogenomics,': [2948], 'Vol.': [2949, 3022, 3043, 3047], '23,': [2950], '17A': [2952], 'Studies': [2957], 'populationsFouzia': [2960], 'Radouani,': [2961], 'Lyndon': [2962], 'Zass,': [2963], 'Yosr': [2964], 'Hamdi,': [2965], 'Jorge': [2966], 'da': [2967], 'Rocha,': [2968], 'Reem': [2969], 'Sallam,': [2970], 'Sonia': [2971], 'Abdelhak,': [2972], 'Samah': [2973], 'Ahmed,': [2974], 'Maryame': [2975], 'Azzouzi,': [2976], 'Ichrak': [2977], 'Benamri,': [2978], 'Alia': [2979], 'Benkahla,': [2980], 'Balkiss': [2981], 'Bouhaouala-Zahar,': [2982], 'Melek': [2983], 'Chaouch,': [2984], 'Haifa': [2985], 'Jmel,': [2986], 'Rym': [2987], 'Kefi,': [2988], 'Ayoub': [2989], 'Ksouri,': [2990], 'Judit': [2991], 'Kumuthini,': [2992], 'Phumlani': [2993], 'Masilela,': [2994], 'Collen': [2995], 'Masimirembwa,': [2996], 'Houcemeddine': [2997], 'Othman,': [2998], 'Sumir': [2999], 'Panji,': [3000], 'Lilia': [3001], 'Romdhane,': [3002], 'Chaimae': [3003], 'Samtal,': [3004], 'Rania': [3005], 'Sibira,': [3006], 'Kais': [3007], 'Ghedira,': [3008], 'Faisal': [3009], 'Fadlelmola,': [3010], 'Samar': [3011], 'Kamal': [3012], 'Kassim': [3013], 'Nicola': [3015], 'Mulder3': [3016], 'March': [3017, 3070], '2020': [3018], 'Personalized': [3020], '17,': [3023], '2A': [3025], 'Glimpse': [3026], 'into': [3027], 'Pharmacogenomics': [3028], 'AfricaKey': [3030], 'Pharmacogenomic': [3031], 'Considerations': [3032], 'Cell': [3035], 'Disease': [3036], 'PatientsOMICS:': [3037], 'Journal': [3039], 'Integrative': [3041], 'Biology,': [3042], '21,': [3044], '6': [3046], 'Follow': [3051], 'us': [3052], 'social': [3054], 'media': [3055], 'latest': [3058], 'updates': [3059], 'Metrics': [3060], 'History': [3061], 'online': [3063], '2017': [3066, 3071], 'print': [3069], 'Information©': [3072], 'Future': [3073], 'Medicine': [3074], 'LtdKeywordsAfricapharmacogeneticssickle': [3075], 'diseaseFinancial': [3077], 'manuscript.PDF': [3141], 'download': [3142]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2587789390', 'counts_by_year': [{'year': 2022, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-08-21T19:14:54.331195', 'created_date': '2017-02-24'}