Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2587783932', 'doi': 'https://doi.org/10.18632/oncotarget.15204', 'title': 'Didymin: an orally active citrus flavonoid for targeting neuroblastoma', 'display_name': 'Didymin: an orally active citrus flavonoid for targeting neuroblastoma', 'publication_year': 2017, 'publication_date': '2017-02-08', 'ids': {'openalex': 'https://openalex.org/W2587783932', 'doi': 'https://doi.org/10.18632/oncotarget.15204', 'mag': '2587783932', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28187004', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5438742'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.15204', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=15204&path%5B%5D=48623', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=15204&path%5B%5D=48623', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5087056879', 'display_name': 'Sharad S. Singhal', 'orcid': 'https://orcid.org/0000-0002-6415-8160'}, 'institutions': [{'id': 'https://openalex.org/I1301076528', 'display_name': 'City Of Hope National Medical Center', 'ror': 'https://ror.org/00w6g5w60', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Sharad S. Singhal', 'raw_affiliation_strings': ['Department of Molecular Medicine, Beckman Research Institute of the City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Medicine, Beckman Research Institute of the City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA, USA', 'institution_ids': ['https://openalex.org/I1301076528']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072819832', 'display_name': 'Sulabh Singhal', 'orcid': 'https://orcid.org/0000-0002-1582-0613'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sulabh Singhal', 'raw_affiliation_strings': ['University of California at San Diego, La Jolla, San Diego, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'University of California at San Diego, La Jolla, San Diego, CA, USA', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013649200', 'display_name': 'Preeti Singhal', 'orcid': 'https://orcid.org/0000-0002-2090-722X'}, 'institutions': [{'id': 'https://openalex.org/I165951966', 'display_name': 'The University of Texas Health Science Center at San Antonio', 'ror': 'https://ror.org/02f6dcw23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165951966']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Preeti Singhal', 'raw_affiliation_strings': ['University of Texas Health, San Antonio, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'University of Texas Health, San Antonio, TX, USA', 'institution_ids': ['https://openalex.org/I165951966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112903915', 'display_name': 'Jyotsana Singhal', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1301076528', 'display_name': 'City Of Hope National Medical Center', 'ror': 'https://ror.org/00w6g5w60', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jyotsana Singhal', 'raw_affiliation_strings': ['Department of Molecular Medicine, Beckman Research Institute of the City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Medicine, Beckman Research Institute of the City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA, USA', 'institution_ids': ['https://openalex.org/I1301076528']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075374559', 'display_name': 'David Horne', 'orcid': 'https://orcid.org/0000-0002-9300-1082'}, 'institutions': [{'id': 'https://openalex.org/I1301076528', 'display_name': 'City Of Hope National Medical Center', 'ror': 'https://ror.org/00w6g5w60', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David Horne', 'raw_affiliation_strings': ['Department of Molecular Medicine, Beckman Research Institute of the City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Medicine, Beckman Research Institute of the City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA, USA', 'institution_ids': ['https://openalex.org/I1301076528']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5021056534', 'display_name': 'Sanjay Awasthi', 'orcid': 'https://orcid.org/0000-0002-5214-5717'}, 'institutions': [{'id': 'https://openalex.org/I1301076528', 'display_name': 'City Of Hope National Medical Center', 'ror': 'https://ror.org/00w6g5w60', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528']}, {'id': 'https://openalex.org/I926076166', 'display_name': 'Texas Tech University Health Sciences Center', 'ror': 'https://ror.org/033ztpr93', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I926076166']}, {'id': 'https://openalex.org/I12315562', 'display_name': 'Texas Tech University', 'ror': 'https://ror.org/0405mnx93', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I12315562']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sanjay Awasthi', 'raw_affiliation_strings': ['Department of Molecular Medicine, Beckman Research Institute of the City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA, USA', 'Texas Tech University Health Sciences Center, Lubbock, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Medicine, Beckman Research Institute of the City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA, USA', 'institution_ids': ['https://openalex.org/I1301076528']}, {'raw_affiliation_string': 'Texas Tech University Health Sciences Center, Lubbock, TX, USA', 'institution_ids': ['https://openalex.org/I926076166', 'https://openalex.org/I12315562']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5087056879'], 'corresponding_institution_ids': ['https://openalex.org/I1301076528'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.702, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.998929, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '8', 'issue': '17', 'first_page': '29428', 'last_page': '29441'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12226', 'display_name': 'Neuroblastoma Research and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12226', 'display_name': 'Neuroblastoma Research and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9776, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12534', 'display_name': 'Protein Degradation and Inhibitors', 'score': 0.9729, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2776715637', 'wikidata': 'https://www.wikidata.org/wiki/Q938205', 'display_name': 'Neuroblastoma', 'level': 3, 'score': 0.93903196}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.64990765}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.5229902}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4466187}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.43074146}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.39000177}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.16266313}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.119645}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.09111014}], 'mesh': [{'descriptor_ui': 'D002957', 'descriptor_name': 'Citrus', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D009447', 'descriptor_name': 'Neuroblastoma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002648', 'descriptor_name': 'Child', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002675', 'descriptor_name': 'Child, Preschool', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005419', 'descriptor_name': 'Flavonoids', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D006027', 'descriptor_name': 'Glycosides', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.15204', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=15204&path%5B%5D=48623', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5438742', 'pdf_url': 'https://europepmc.org/articles/pmc5438742?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438742', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28187004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.15204', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=15204&path%5B%5D=48623', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.79, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 89, 'referenced_works': ['https://openalex.org/W1271723105', 'https://openalex.org/W1716978847', 'https://openalex.org/W1951744812', 'https://openalex.org/W1963621555', 'https://openalex.org/W1964081206', 'https://openalex.org/W1964630467', 'https://openalex.org/W1967438883', 'https://openalex.org/W1970174011', 'https://openalex.org/W1970211293', 'https://openalex.org/W1980615604', 'https://openalex.org/W1981599633', 'https://openalex.org/W1982139221', 'https://openalex.org/W1982205351', 'https://openalex.org/W1983442034', 'https://openalex.org/W1983784090', 'https://openalex.org/W1991774590', 'https://openalex.org/W1993166459', 'https://openalex.org/W1994023206', 'https://openalex.org/W1999278135', 'https://openalex.org/W2001020067', 'https://openalex.org/W2005957118', 'https://openalex.org/W2005999315', 'https://openalex.org/W2008496424', 'https://openalex.org/W2009991551', 'https://openalex.org/W2011848229', 'https://openalex.org/W2012565790', 'https://openalex.org/W2013978636', 'https://openalex.org/W2015409532', 'https://openalex.org/W2017009693', 'https://openalex.org/W2018498920', 'https://openalex.org/W2021346058', 'https://openalex.org/W2024037712', 'https://openalex.org/W2029922807', 'https://openalex.org/W2030703491', 'https://openalex.org/W2033119814', 'https://openalex.org/W2033898136', 'https://openalex.org/W2034081204', 'https://openalex.org/W2039660061', 'https://openalex.org/W2044033792', 'https://openalex.org/W2047038623', 'https://openalex.org/W2061075042', 'https://openalex.org/W2064772366', 'https://openalex.org/W2067178867', 'https://openalex.org/W2067606868', 'https://openalex.org/W2067670322', 'https://openalex.org/W2069523988', 'https://openalex.org/W2076798834', 'https://openalex.org/W2077447884', 'https://openalex.org/W2082674140', 'https://openalex.org/W2085870741', 'https://openalex.org/W2087687899', 'https://openalex.org/W2091501109', 'https://openalex.org/W2094156327', 'https://openalex.org/W2098671913', 'https://openalex.org/W2103184621', 'https://openalex.org/W2106663496', 'https://openalex.org/W2111469768', 'https://openalex.org/W2118268682', 'https://openalex.org/W2119081952', 'https://openalex.org/W2124358755', 'https://openalex.org/W2124857275', 'https://openalex.org/W2124895836', 'https://openalex.org/W2126597415', 'https://openalex.org/W2130925781', 'https://openalex.org/W2130926603', 'https://openalex.org/W2131605616', 'https://openalex.org/W2133735016', 'https://openalex.org/W2134137372', 'https://openalex.org/W2135803007', 'https://openalex.org/W2136627244', 'https://openalex.org/W2138366746', 'https://openalex.org/W2139752108', 'https://openalex.org/W2140116844', 'https://openalex.org/W2141474275', 'https://openalex.org/W2144056225', 'https://openalex.org/W2149730494', 'https://openalex.org/W2149768039', 'https://openalex.org/W2155123226', 'https://openalex.org/W2156055427', 'https://openalex.org/W2161551303', 'https://openalex.org/W2169238639', 'https://openalex.org/W2191417886', 'https://openalex.org/W2239608358', 'https://openalex.org/W2265961601', 'https://openalex.org/W2418054261', 'https://openalex.org/W2477661506', 'https://openalex.org/W2550459417', 'https://openalex.org/W2557403891', 'https://openalex.org/W2562674945'], 'related_works': ['https://openalex.org/W4391375266', 'https://openalex.org/W3025904015', 'https://openalex.org/W2788277189', 'https://openalex.org/W2130076355', 'https://openalex.org/W2119695867', 'https://openalex.org/W2082860237', 'https://openalex.org/W2046158694', 'https://openalex.org/W2013243191', 'https://openalex.org/W1993764875', 'https://openalex.org/W1990804418'], 'abstract_inverted_index': {'//': [0, 86], 'Sharad': [1, 82], 'S.': [2, 83], 'Singhal': [3, 7, 11, 15], '1': [4, 16, 20, 25], ',': [5, 9, 13, 17], 'Sulabh': [6], '2': [8, 48], 'Preeti': [10], '3': [12, 61], 'Jyotsana': [14], 'David': [18], 'Horne': [19], 'and': [21, 41, 126, 160, 178, 246, 276, 284, 289, 302, 311], 'Sanjay': [22], 'Awasthi': [23], '4': [24, 70], 'Department': [26], 'of': [27, 33, 36, 50, 63, 124, 154, 158, 167, 186, 215, 257, 274, 304], 'Molecular': [28], 'Medicine,': [29], 'Beckman': [30], 'Research': [31], 'Institute': [32], 'the': [34, 119, 127, 152, 156, 183, 254, 318], 'City': [35], 'Hope,': [37], 'Comprehensive': [38], 'Cancer': [39], 'Center': [40], 'National': [42], 'Medical': [43], 'Center,': [44, 76], 'Duarte,': [45], 'CA,': [46, 59], 'USA': [47, 60, 69, 79], 'University': [49, 62, 73], 'California': [51], 'at': [52], 'San': [53, 57, 66], 'Diego,': [54, 58], 'La': [55], 'Jolla,': [56], 'Texas': [64, 71], 'Health,': [65], 'Antonio,': [67], 'TX,': [68, 78], 'Tech': [72], 'Health': [74], 'Sciences': [75], 'Lubbock,': [77], 'Correspondence': [80], 'to:': [81], 'Singhal,': [84], 'email:': [85], 'Keywords': [87], ':': [88, 95, 100, 105], 'neuroblastoma,': [89, 155], 'p53,': [90], 'didymin,': [91, 245], 'N-Myc,': [92], 'RKIP': [93, 232], 'Received': [94], 'December': [96], '30,': [97], '2016': [98], 'Accepted': [99], 'January': [101], '27,': [102], '2017': [103, 108], 'Published': [104], 'February': [106], '08,': [107], 'Abstract': [109], 'Neuroblastoma,': [110], 'a': [111, 143, 191, 234, 250, 307], 'rapidly': [112], 'growing': [113], 'yet': [114], 'treatment': [115, 320], 'responsive': [116], 'cancer,': [117], 'is': [118, 163, 190, 233, 241], 'third': [120], 'most': [121, 128], 'common': [122, 129], 'cancer': [123], 'children': [125], 'solid': [130], 'tumor': [131], 'in': [132, 165, 206, 218, 253, 268], 'infants.': [133], 'Unfortunately,': [134], 'neuroblastoma': [135, 204, 216, 270], 'that': [136, 195, 237, 315], 'has': [137, 142], 'lost': [138], 'p53': [139, 159, 197], 'function': [140], 'often': [141], 'highly': [144], 'treatment-resistant': [145], 'phenotype': [146], 'leading': [147], 'to': [148, 223, 248], 'tragic': [149], 'outcomes.': [150], 'In': [151, 208, 259, 292], 'context': [153], 'functions': [157], 'MYCN': [161, 239, 275], '(which': [162], 'amplified': [164], '~25%': [166], 'neuroblastomas)': [168], 'are': [169, 174], 'integrally': [170], 'linked': [171], 'because': [172, 179], 'they': [173, 180], 'mutually': [175], 'transcriptionally': [176, 242], 'regulated,': [177], 'together': [181], 'regulate': [182], 'catalytic': [184], 'activity': [185], 'RNA': [187], 'polymerases.': [188], 'Didymin': [189], 'citrus-derived': [192], 'natural': [193], 'compound': [194], 'kills': [196], 'wild-type': [198], 'as': [199, 201, 306], 'well': [200], 'drug-resistant': [202], 'p53-mutant': [203, 269], 'cells': [205], 'culture.': [207], 'addition,': [209, 293], 'orally': [210], 'administered': [211], 'didymin': [212, 265, 305], 'causes': [213], 'regression': [214], 'xenografts': [217], 'mouse': [219], 'models,': [220], 'without': [221], 'toxicity': [222], 'non-malignant': [224], 'cells,': [225], 'neural': [226, 229], 'tissues,': [227], 'or': [228], 'stem': [230], 'cells.': [231], 'Raf-inhibitory': [235], 'protein': [236], 'regulates': [238], 'activation,': [240], 'upregulated': [243], 'by': [244, 287], 'appears': [247], 'play': [249], 'key': [251], 'role': [252], 'anti-neuroblastoma': [255], 'actions': [256], 'didymin.': [258], 'this': [260], 'review,': [261], 'we': [262, 294], 'discuss': [263, 296], 'how': [264], 'overcomes': [266], 'drug-resistance': [267], 'through': [271], 'RKIP-mediated': [272], 'inhibition': [273], 'its': [277], 'effects': [278], 'on': [279], 'GRK2,': [280], 'PKCs,': [281], 'Let-7': [282], 'micro-RNA,': [283], 'clathrin-dependent': [285], 'endocytosis': [286], 'Raf-dependent': [288], '-independent': [290], 'mechanisms.': [291], 'will': [295], 'studies': [297], 'supporting': [298], 'potential': [299], 'clinical': [300], 'impact': [301], 'translation': [303], 'low': [308], 'cost,': [309], 'safe,': [310], 'effective': [312], 'oral': [313], 'agent': [314], 'could': [316], 'change': [317], 'current': [319], 'paradigm': [321], 'for': [322], 'refractory': [323], 'neuroblastoma.': [324]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2587783932', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}], 'updated_date': '2025-01-04T20:09:30.654228', 'created_date': '2017-02-24'}