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[40], 'that': [41], 'abnormal': [42], 'muscle': [43, 83], 'tone,': [44, 84], 'poor': [45], 'oral': [46], 'feeding,': [47], 'puberty,': [48], 'delays': [50], 'or': [51, 179, 188, 209], 'absence': [52], 'sitting': [54], 'balance': [55], 'ambulation': [57], 'may': [58], 'be': [59], 'responsible': [60], 'for': [61, 76, 204, 234, 239, 247], 'greater': [62], 'risk': [63, 217], 'RTT.': [65], 'Methods': [66], 'The': [67], 'multicenter': [68], 'RTT': [69, 126], 'Study': [72], 'gathered': [73], 'longitudinal': [74], 'data': [75], 'classic': [77, 125], 'RTT,': [78], 'including': [79], 'mutation': [80], 'type,': [81], 'scoliosis,': [82], 'sitting,': [85], 'ambulation,': [86], 'hand': [87], 'function,': [88], 'feeding.': [90], 'Cox': [91], 'regression': [92], 'models': [93], 'used': [95], 'to': [96, 185, 196], 'examine': [97], 'association': [99], 'between': [100], 'characteristics.': [104], 'All': [105], 'analyses': [106], 'utilized': [107], 'SAS': [108], '9.4;': [109], 'two-sided': [110], 'P': [111], 'values': [112], '<0.05': [114], 'considered': [116], 'significant.': [117], 'Results': [118], 'A': [119], 'total': [120], '913': [122], 'females': [123], 'with': [124, 134, 244], 'included.': [128], 'frequency': [130], 'severity': [132], 'increased': [133], 'age.': [135], 'Severe': [136, 159], 'was': [138], 'found': [139], '251': [141], 'participants': [142], '(27%),': [143], '113': [144], 'whom': [146], 'developed': [147], 'during': [150], 'follow-up': [152], 'assessments;': [153], '168': [154], '(18%)': [155], 'had': [156], 'surgical': [157], 'correction.': [158], 'MECP2': [160], 'mutations': [161, 222], '(R106W,': [162], 'R168X,': [163], 'R255X,': [164], 'R270X,': [165], 'large': [167], 'deletions)': [168], 'showed': [169], 'a': [170], 'higher': [171], 'proportion': [172], 'scoliosis.': [174], 'Individuals': [175], 'developing': [176], 'requiring': [180], 'less': [183], 'likely': [184, 195], 'sit,': [186], 'ambulate,': [187], 'use': [189], 'their': [190], 'hands': [191], 'more': [194], 'have': [197], 'begun': [198], 'puberty.': [199], 'Significant': [200], 'differences': [201], 'absent': [203], 'epilepsy': [205], 'rates,': [206], 'sleep': [207], 'problems,': [208], 'constipation.': [210], 'Discussion': [211], 'requires': [213], 'vigilance': [214], 'factors': [218], 'noted,': [219], 'particularly': [220], 'role': [225], 'puberty': [227], 'motor': [229], 'abilities.': [230], 'Bracing': [231], 'recommended': [233], 'moderate': [235], 'curves': [236, 241], 'accordance': [243], 'published': [245], 'guidelines': [246], 'management.': [249]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2587013730', 'counts_by_year': [{'year': 2024, 'cited_by_count': 12}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-09-11T20:12:30.195297', 'created_date': '2017-02-17'}