Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2586637063', 'doi': 'https://doi.org/10.1038/s41467-016-0009-6', 'title': 'In situ click chemistry generation of cyclooxygenase-2 inhibitors', 'display_name': 'In situ click chemistry generation of cyclooxygenase-2 inhibitors', 'publication_year': 2017, 'publication_date': '2017-02-09', 'ids': {'openalex': 'https://openalex.org/W2586637063', 'doi': 'https://doi.org/10.1038/s41467-016-0009-6', 'mag': '2586637063', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28232747', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5431875'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41467-016-0009-6', 'pdf_url': 'https://www.nature.com/articles/s41467-016-0009-6.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/s41467-016-0009-6.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068005545', 'display_name': 'Atul Bhardwaj', 'orcid': 'https://orcid.org/0000-0001-6446-4267'}, 'institutions': [{'id': 'https://openalex.org/I154425047', 'display_name': 'University of Alberta', 'ror': 'https://ror.org/0160cpw27', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I154425047']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Atul Bhardwaj', 'raw_affiliation_strings': ['Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, Alberta, Canada, T6G 1Z2'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, Alberta, Canada, T6G 1Z2', 'institution_ids': ['https://openalex.org/I154425047']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018891381', 'display_name': 'Jatinder Kaur', 'orcid': 'https://orcid.org/0000-0001-6565-7909'}, 'institutions': [{'id': 'https://openalex.org/I154425047', 'display_name': 'University of Alberta', 'ror': 'https://ror.org/0160cpw27', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I154425047']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Jatinder Kaur', 'raw_affiliation_strings': ['Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, Alberta, Canada, T6G 1Z2'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, Alberta, Canada, T6G 1Z2', 'institution_ids': ['https://openalex.org/I154425047']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064506209', 'display_name': 'Melinda Wuest', 'orcid': 'https://orcid.org/0000-0003-0735-2749'}, 'institutions': [{'id': 'https://openalex.org/I154425047', 'display_name': 'University of Alberta', 'ror': 'https://ror.org/0160cpw27', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I154425047']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Melinda Wuest', 'raw_affiliation_strings': ['Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, Alberta, Canada, T6G 1Z2'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, Alberta, Canada, T6G 1Z2', 'institution_ids': ['https://openalex.org/I154425047']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5081387229', 'display_name': 'Frank Wuest', 'orcid': 'https://orcid.org/0000-0002-6705-6450'}, 'institutions': [{'id': 'https://openalex.org/I154425047', 'display_name': 'University of Alberta', 'ror': 'https://ror.org/0160cpw27', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I154425047']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Frank Wuest', 'raw_affiliation_strings': ['Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta, 8613-114 Street, Edmonton, Alberta, Canada, T6G 2H7'], 'affiliations': [{'raw_affiliation_string': 'Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta, 8613-114 Street, Edmonton, Alberta, Canada, T6G 2H7', 'institution_ids': ['https://openalex.org/I154425047']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3920, 'currency': 'GBP', 'value_usd': 4808, 'provenance': 'doaj'}, 'apc_paid': {'value': 3920, 'currency': 'GBP', 'value_usd': 4808, 'provenance': 'doaj'}, 'fwci': 214.642, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 6613, 'citation_normalized_percentile': {'value': 0.999944, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '8', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11440', 'display_name': 'Click Chemistry in Chemical Biology and Drug Development', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11440', 'display_name': 'Click Chemistry in Chemical Biology and Drug Development', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12505', 'display_name': 'Role of Fibroblast Activation in Cancer Progression', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10911', 'display_name': 'Peptide Synthesis and Drug Discovery', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/click-chemistry', 'display_name': 'Click Chemistry', 'score': 0.517245}], 'concepts': [{'id': 'https://openalex.org/C2779689624', 'wikidata': 'https://www.wikidata.org/wiki/Q410251', 'display_name': 'Cyclooxygenase', 'level': 3, 'score': 0.8899456}, {'id': 'https://openalex.org/C119795356', 'wikidata': 'https://www.wikidata.org/wiki/Q407801', 'display_name': 'Isozyme', 'level': 3, 'score': 0.6983152}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.5782463}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.54100275}, {'id': 'https://openalex.org/C69610077', 'wikidata': 'https://www.wikidata.org/wiki/Q912270', 'display_name': 'Click chemistry', 'level': 2, 'score': 0.45017526}, {'id': 'https://openalex.org/C74187038', 'wikidata': 'https://www.wikidata.org/wiki/Q1418791', 'display_name': 'Drug discovery', 'level': 2, 'score': 0.43515807}, {'id': 'https://openalex.org/C53345823', 'wikidata': 'https://www.wikidata.org/wiki/Q5531554', 'display_name': 'Gene isoform', 'level': 3, 'score': 0.43319687}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.42731246}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.3892964}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.3358763}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.26774347}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.20319271}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0848836}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.072429985}], 'mesh': [{'descriptor_ui': 'D000894', 'descriptor_name': 'Anti-Inflammatory Agents, Non-Steroidal', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D057930', 'descriptor_name': 'Click Chemistry', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D051546', 'descriptor_name': 'Cyclooxygenase 2', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D052246', 'descriptor_name': 'Cyclooxygenase 2 Inhibitors', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D004487', 'descriptor_name': 'Edema', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D014230', 'descriptor_name': 'Triazoles', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000894', 'descriptor_name': 'Anti-Inflammatory Agents, Non-Steroidal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000894', 'descriptor_name': 'Anti-Inflammatory Agents, Non-Steroidal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002351', 'descriptor_name': 'Carrageenan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057930', 'descriptor_name': 'Click Chemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051545', 'descriptor_name': 'Cyclooxygenase 1', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D051545', 'descriptor_name': 'Cyclooxygenase 1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051545', 'descriptor_name': 'Cyclooxygenase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051545', 'descriptor_name': 'Cyclooxygenase 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051546', 'descriptor_name': 'Cyclooxygenase 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051546', 'descriptor_name': 'Cyclooxygenase 2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051546', 'descriptor_name': 'Cyclooxygenase 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052246', 'descriptor_name': 'Cyclooxygenase 2 Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D052246', 'descriptor_name': 'Cyclooxygenase 2 Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004487', 'descriptor_name': 'Edema', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D004487', 'descriptor_name': 'Edema', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D004487', 'descriptor_name': 'Edema', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D004487', 'descriptor_name': 'Edema', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006614', 'descriptor_name': 'Hindlimb', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D062105', 'descriptor_name': 'Molecular Docking Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017433', 'descriptor_name': 'Protein Structure, Secondary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013816', 'descriptor_name': 'Thermodynamics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014230', 'descriptor_name': 'Triazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014230', 'descriptor_name': 'Triazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41467-016-0009-6', 'pdf_url': 'https://www.nature.com/articles/s41467-016-0009-6.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/0aaf6cbf6f6f49aab5b878a4d847aa9e', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5431875', 'pdf_url': 'https://europepmc.org/articles/pmc5431875?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431875', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28232747', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41467-016-0009-6', 'pdf_url': 'https://www.nature.com/articles/s41467-016-0009-6.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.73, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 60, 'referenced_works': ['https://openalex.org/W1923974573', 'https://openalex.org/W1964909390', 'https://openalex.org/W1969421719', 'https://openalex.org/W1971170829', 'https://openalex.org/W1974450761', 'https://openalex.org/W1974518329', 'https://openalex.org/W1980990431', 'https://openalex.org/W1995291470', 'https://openalex.org/W1999025277', 'https://openalex.org/W2008633997', 'https://openalex.org/W2008742048', 'https://openalex.org/W2011843450', 'https://openalex.org/W2016004451', 'https://openalex.org/W2019177139', 'https://openalex.org/W2023200971', 'https://openalex.org/W2024289681', 'https://openalex.org/W2030793740', 'https://openalex.org/W2030850720', 'https://openalex.org/W2033044862', 'https://openalex.org/W2041887070', 'https://openalex.org/W2052731133', 'https://openalex.org/W2054099595', 'https://openalex.org/W2056546282', 'https://openalex.org/W2062699336', 'https://openalex.org/W2072000048', 'https://openalex.org/W2077605453', 'https://openalex.org/W2079888227', 'https://openalex.org/W2081521523', 'https://openalex.org/W2082708934', 'https://openalex.org/W2085649597', 'https://openalex.org/W2087765372', 'https://openalex.org/W2093175298', 'https://openalex.org/W2099885559', 'https://openalex.org/W2104312767', 'https://openalex.org/W2114374331', 'https://openalex.org/W2126853519', 'https://openalex.org/W2127161627', 'https://openalex.org/W2129935236', 'https://openalex.org/W2132799399', 'https://openalex.org/W2145662716', 'https://openalex.org/W2146910635', 'https://openalex.org/W2147105537', 'https://openalex.org/W2150804079', 'https://openalex.org/W2151534353', 'https://openalex.org/W2157208011', 'https://openalex.org/W2158960911', 'https://openalex.org/W2159973565', 'https://openalex.org/W2161483205', 'https://openalex.org/W2165464520', 'https://openalex.org/W2168581452', 'https://openalex.org/W2172013390', 'https://openalex.org/W2294641125', 'https://openalex.org/W2322153439', 'https://openalex.org/W2331359878', 'https://openalex.org/W2332024781', 'https://openalex.org/W2345206543', 'https://openalex.org/W2950663668', 'https://openalex.org/W4210998150', 'https://openalex.org/W4246061912', 'https://openalex.org/W4256503849'], 'related_works': ['https://openalex.org/W613887516', 'https://openalex.org/W2356922729', 'https://openalex.org/W2095539628', 'https://openalex.org/W2081960730', 'https://openalex.org/W2080901561', 'https://openalex.org/W2080141603', 'https://openalex.org/W2040812767', 'https://openalex.org/W2003309220', 'https://openalex.org/W1992623945', 'https://openalex.org/W1490427075'], 'abstract_inverted_index': {'Abstract': [0], 'Cyclooxygenase-2': [1], 'isozyme': [2, 77, 124], 'is': [3, 14, 137], 'a': [4, 37, 56, 87], 'promising': [5], 'anti-inflammatory': [6, 129], 'drug': [7], 'target,': [8], 'and': [9, 20, 26, 32, 121], 'overexpression': [10], 'of': [11, 50, 64, 89, 102, 117, 131, 142], 'this': [12], 'enzyme': [13], 'also': [15, 106], 'associated': [16], 'with': [17, 99], 'several': [18], 'cancers': [19], 'neurodegenerative': [21], 'diseases.': [22], 'The': [23, 126], 'amino-acid': [24], 'sequence': [25], 'structural': [27], 'similarity': [28], 'between': [29], 'inducible': [30], 'cyclooxygenase-2': [31, 43, 52, 76, 123, 146], 'housekeeping': [33], 'cyclooxygenase-1': [34], 'isoforms': [35], 'present': [36], 'significant': [38], 'challenge': [39], 'to': [40, 91], 'design': [41], 'selective': [42, 122, 145], 'inhibitors.': [44, 69, 125, 147], 'Herein,': [45, 98], 'we': [46, 113], 'describe': [47, 114], 'the': [48, 51, 60, 75, 100, 115], 'use': [49, 101], 'active': [53], 'site': [54], 'as': [55, 108], 'reaction': [57], 'vessel': [58], 'for': [59], 'in': [61, 109, 127], 'situ': [62, 110], 'generation': [63], 'its': [65, 93], 'own': [66, 94], 'highly': [67, 95, 119], 'specific': [68], 'Multi-component': [70], 'competitive-binding': [71], 'studies': [72], 'confirmed': [73], 'that': [74, 141], 'can': [78], 'judiciously': [79], 'select': [80], 'most': [81], 'appropriate': [82], 'chemical': [83], 'building': [84], 'blocks': [85], 'from': [86], 'pool': [88], 'chemicals': [90], 'build': [92], 'potent': [96, 120], 'inhibitor.': [97], 'kinetic': [103], 'target-guided': [104], 'synthesis,': [105], 'termed': [107], 'click': [111], 'chemistry,': [112], 'discovery': [116], 'two': [118, 133], 'vivo': [128], 'activity': [130], 'these': [132], 'novel': [134], 'small': [135], 'molecules': [136], 'significantly': [138], 'higher': [139], 'than': [140], 'widely': [143], 'used': [144]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2586637063', 'counts_by_year': [{'year': 2024, 'cited_by_count': 354}, {'year': 2023, 'cited_by_count': 942}, {'year': 2022, 'cited_by_count': 1358}, {'year': 2021, 'cited_by_count': 1813}, {'year': 2020, 'cited_by_count': 1268}, {'year': 2019, 'cited_by_count': 483}, {'year': 2018, 'cited_by_count': 317}, {'year': 2017, 'cited_by_count': 53}, {'year': 2016, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-17T06:06:54.893635', 'created_date': '2017-02-17'}