Title: Comparison of 55° Wide-Field Spectral Domain Optical Coherence Tomography and Conventional 30° Optical Coherence Tomography for the Assessment of Diabetic Macular Edema
Abstract: <b><i>Purpose:</i></b> To compare conventional 30° spectral domain optical coherence tomography (SD-OCT) with 55° wide-field SD-OCT for the assessment of diabetic macular edema (DME). <b><i>Methods:</i></b> This study included 50 DME patients. Both 55° and 30° SD-OCT was conducted. Two readers evaluated scans according to a standardized grading protocol. Intergrader agreement as well as agreement between 30° and 55° SD-OCT were assessed. <b><i>Results:</i></b> Intergrader agreement (&#x03BA;) was strong and ranged from 0.79 to 1.0. Perfect interdevice agreement (&#x03BA; = 1.0) was found for the detection of intra- and subretinal fluid. Excellent agreement (&#x03BA; ≥ 0.9) was found for the presence of epiretinal membrane (&#x03BA; = 0.92) and cotton-wool spots (&#x03BA; = 0.92). A strong agreement was found for the presence of hard exudates (&#x03BA; = 0.89) and microaneurysms (&#x03BA; = 0.81). A moderate correlation was found for ellipsoid zone integrity (&#x03BA; = 0.69) and configuration of the vitreomacular interface (VMI) (&#x03BA; = 0.69). A weak agreement was found for retinal pigment epithelium atrophy (&#x03BA; = 0.51) and external limiting membrane integrity (&#x03BA; = 0.35). <b><i>Conclusion:</i></b> Wide-field OCT imaging may be beneficial for evaluating DME, particularly for assessing the VMI and the integrity of hyperreflective bands.