Title: Total pancreatectomy and islet cell autotransplantation: long‐term assessment of graft function
Abstract: Total pancreatectomy (TP) without an islet autotransplant has an inevitable consequence of diabetes, and it is believed that rapid intestinal transit due to pancreatic insufficiency results in unpredictable glucose absorption and exacerbates the recurrent episodes of iatrogenic hypoglycemia. Islet autotransplantation following pancreatectomy offers the opportunity to ameliorate the complete loss of endocrine function normally associated with TP with resultant improvements in the quality of life (QoL) and diabetic control. Hence, long-term assessment of graft function must include QoL assessment, in addition to physiological parameters. As with all branches of transplant surgery, research and development allows progressive improvements in graft function and survival. The extensive global interest in islet allotransplantation for the treatment of diabetes mellitus means that there are a plethora of research strategies to improve islet isolation and transplantation and to prolong graft survival.
Publication Year: 2017
Publication Date: 2017-02-11
Language: en
Type: other
Indexed In: ['crossref']
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