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1198, 1236, 1248, 1276, 1294, 1425, 1452, 1463, 1524, 1561, 1565, 1630, 1792, 1801, 1878, 1890, 1918, 1936, 2067, 2094, 2105, 2167, 2204, 2208, 2273, 2435, 2444, 2644, 2918, 2935, 2946, 2956, 3078, 3147, 3181, 3200, 3205, 3222, 3231, 3286, 3294, 3300, 3304, 3328, 3333, 3355, 3369, 3401, 3416, 3449, 3453, 3469, 3603, 3717, 3753, 3793, 3818, 3866, 3873, 3902], 'hotbed': [20], 'device': [23, 80, 1085, 1201, 2748, 3371], 'development.': [24, 81], 'Materials': [25], 'such': [26, 35, 115, 215, 1162, 1540, 1686, 1721, 2183, 2329, 2364, 3153, 3159, 3189, 3217, 3292, 3342, 3408, 3490, 3511, 3585, 3973], 'plastic,': [28, 1149, 1673, 2316, 3852], 'adhesive,': [29, 3377], 'paper,': [31, 1150, 3853], 'along': [32, 3830], 'with': [33, 155, 255, 334, 498, 842, 914, 980, 1732, 2375, 2934, 2998, 3146, 3225, 3277, 3436, 3476, 3525, 3722, 3799, 3831], 'plotter/laser': [37], 'cutters': [38, 3878, 4002, 4009], '3D': [40, 122, 222, 1074], 'printers,': [41], 'enable': [42, 71, 1796, 2439, 2867], 'building': [43, 143, 243], 'integrated': [44, 2727, 2794, 2828, 3685], 'systems': [46, 600, 619, 1322, 1404, 1964, 2046, 2729], 'that': [47, 760, 773, 2730, 2856, 3433], 'are': [48, 1154, 2528, 2545, 2555, 2945, 3255, 3458, 3481, 3504, 3550, 3572, 3843, 3860], 'more': [49, 422, 1155, 1681, 2324, 2604], 'easily': [50, 1682, 2325], 'translated': [51, 355, 2734], 'large-scale': [53, 3173], 'manufacturing.': [54, 2865], 'Makerspaces': [55, 100, 200], 'provide': [56, 101, 109, 201, 209, 1139, 1557, 2200], 'low-cost': [57, 110, 210], 'access': [58, 63, 111, 169, 211, 269, 2558, 3278], 'prototyping': [60, 616, 759, 771, 976, 998, 1059, 1186, 1202, 1401, 1554, 2043, 2197, 2629, 3923], 'technically': [65], 'diverse': [66, 131, 231], 'human': [67], 'capital,': [68], 'they': [70, 108, 208, 2953, 3084], 'those': [72], 'without': [73, 3204], 'advanced': [74, 3015], 'skills': [75, 90, 190], 'participate': [77], 'in': [78, 152, 252, 302, 322, 341, 394, 433, 496, 535, 557, 565, 601, 620, 714, 737, 763, 816, 828, 835, 860, 908, 920, 981, 1024, 1125, 1264, 1273, 1323, 1356, 1384, 1405, 1474, 1604, 1658, 1661, 1667, 1783, 1828, 1851, 1906, 1915, 1965, 1998, 2026, 2047, 2116, 2247, 2301, 2304, 2310, 2426, 2471, 2494, 2517, 2632, 2709, 2872, 2910, 3074, 3089, 3172, 3266, 3310, 3580, 3597, 3615, 3632, 3666, 3752, 3812, 3851, 3862, 3865], 'traditional': [83, 183, 1518, 2161, 2716, 3465], 'requirement': [84, 184, 3900], 'clean': [86, 106, 186, 206, 767], 'rooms': [87, 187], 'specialized': [89, 189], 'has': [91, 191, 492, 1015, 1617, 2260, 2641], 'inhibited': [92, 192], 'many': [93, 193], 'biologists': [94, 194], 'from': [95, 195, 337, 391, 837, 894, 946, 1229, 1281, 1500, 1871, 1923, 2143, 2715, 2917, 3340, 3545, 3583, 3699, 3961], 'pursuing': [96, 196], 'new': [97, 197], 'innovations.': [99, 199], 'growing': [103, 203, 426, 2645], 'alternative': [104, 204, 2510], 'rooms:': [107, 207], 'fabrication': [113, 213, 597, 904, 1036, 1086, 1283, 1319, 1925, 1961, 2580, 2621, 3359], 'equipment': [114, 214, 2907, 3897], 'laser': [117, 217, 807, 895, 911, 1193, 1208, 3110, 3155, 3183, 3206, 3214, 3874, 3962], 'cutters,': [118, 120, 218, 220], 'plotter': [119, 219, 3841], 'printers;': [123, 223], 'commercially': [125, 225], 'available': [126, 226, 3573], 'materials;': [127, 227], 'attract': [129, 229], 'community': [132, 232, 2522], 'product': [134, 234, 2876, 3389], 'designers.': [135, 235], 'This': [136, 236, 376, 2894], 'Opinion': [137, 237, 753, 2926], 'discusses': [138, 238], 'the': [139, 162, 173, 239, 262, 273, 283, 364, 380, 401, 408, 434, 486, 510, 755, 793, 1140, 1146, 1242, 1252, 1309, 1342, 1347, 1448, 1488, 1501, 1517, 1528, 1534, 1572, 1575, 1597, 1600, 1608, 1655, 1659, 1884, 1894, 1951, 1984, 1989, 2090, 2131, 2144, 2160, 2171, 2177, 2215, 2218, 2240, 2243, 2251, 2298, 2302, 2518, 2541, 2551, 2578, 2598, 2612, 2617, 2624, 2636, 2678, 2690, 2710, 2723, 2747, 2751, 2770, 2851, 2882, 2897, 2939, 3125, 3132, 3337, 3382, 3388, 3398, 3532, 3537, 3541, 3553, 3598, 3618, 3639, 3661, 3691, 3813, 3823, 3828, 3880, 3892, 3899, 3917], 'materials,': [140, 240, 716, 1677, 1786, 1830, 2320, 2429, 2473], 'tools,': [141, 241], 'methodologies': [144, 244], 'particularly': [145, 245], 'suited': [146, 246, 1595, 2238, 2514, 3484, 3505], 'developing': [148, 248, 3628], 'novel': [149, 249, 289], 'these': [153, 253, 384, 777, 1135, 1497, 2140, 2509, 2892, 3858], 'spaces,': [154, 254, 2547], 'insight': [156, 256], 'into': [157, 257, 1177, 3381, 3804], 'biological': [158, 258, 1094, 1339, 1981, 2686, 3290, 3772, 3956], 'applications': [159, 259, 298, 1280, 1340, 1804, 1922, 1982, 2447, 2681, 3291, 3487, 3508], 'leveraging': [161, 261], 'maker': [163, 263], 'community.': [164, 264], 'lower': [166, 266], 'barrier': [167, 267, 2618], 'ameliorates': [172, 272], 'otherwise': [174, 274], 'poor': [175, 275], 'accessibility': [176, 276], 'scalability': [178, 278, 1603, 2246], 'prototyping.': [181, 281], 'Over': [282], 'past': [284, 2637], 'few': [285, 348], 'decades,': [286], 'thousands': [287], 'point-of-care': [291, 658, 1701, 1745, 2344, 2388], '(POC,': [292], 'see': [293], 'Glossary)': [294], 'diagnostic': [295, 352, 3688], 'platforms': [296, 2901], 'have': [299, 309, 354, 420, 781, 1077, 1270, 1790, 1912, 2433, 2615, 2684, 2972, 2992, 3400, 3468, 3879, 3967], 'been': [300, 493, 782, 1017, 2643, 2973, 3968], 'published': [301], 'peer-reviewed': [303], 'journals;': [304], 'however,': [305, 1574, 2217, 3175], 'low': [307, 3137, 3223, 3526], 'percentage': [308], 'reached': [310], 'market': [311, 382, 451, 1664, 2307], '[1Sackmann': [312], 'E.K.': [313], 'et': [314, 515, 532, 562, 580, 594, 614, 654, 712, 732, 824, 865, 900, 974, 1034, 1057, 1089, 1105, 1289, 1316, 1381, 1399, 1471, 1648, 1697, 1741, 1826, 1846, 1931, 1958, 2023, 2041, 2113, 2291, 2340, 2384, 2469, 2489, 2658, 2762, 2783, 2802, 2817, 2834, 3100, 3637, 3682, 3711, 3741, 3768, 3921, 3981], 'al.The': [315, 3101], 'present': [316], 'future': [318, 365], 'role': [319], 'microfluidics': [321, 554, 736, 780, 1092, 1225, 1274, 1784, 1850, 1867, 1916, 2427, 2493, 2683, 2913, 2951, 3806], 'biomedical': [323], 'research.Nature.': [324], '2014;': [325, 644, 678, 741, 848, 924, 1048, 1069, 1634, 1765, 1855, 2277, 2408, 2498, 3758, 3994], '507:': [326], '181-189Crossref': [327], 'PubMed': [328, 371, 543, 573, 607, 626, 647, 664, 686, 705, 725, 744, 882, 967, 989, 1100, 1114, 1131, 1329, 1392, 1411, 1482, 1637, 1707, 1751, 1773, 1819, 1839, 1858, 1971, 2034, 2053, 2124, 2280, 2350, 2394, 2416, 2462, 2482, 2501, 2986, 3026, 3095, 3116, 3706, 3734, 3761, 3780, 3938], 'Scopus': [329, 372, 526, 544, 574, 608, 627, 648, 665, 687, 706, 726, 745, 801, 851, 883, 927, 968, 990, 1010, 1051, 1115, 1330, 1393, 1412, 1483, 1638, 1708, 1752, 1774, 1820, 1840, 1859, 1972, 2035, 2054, 2125, 2281, 2351, 2395, 2417, 2463, 2483, 2502, 2776, 2987, 3027, 3058, 3117, 3735, 3762, 3781, 3939, 3997], '(1935)': [330], 'Google': [331, 374, 528, 546, 576, 610, 629, 650, 667, 689, 708, 728, 747, 803, 853, 885, 929, 970, 992, 1012, 1053, 1072, 1101, 1117, 1132, 1332, 1395, 1414, 1485, 1640, 1710, 1754, 1776, 1822, 1842, 1861, 1974, 2037, 2056, 2127, 2283, 2353, 2397, 2419, 2465, 2485, 2504, 2538, 2778, 2814, 2845, 2989, 3029, 3060, 3096, 3119, 3707, 3737, 3764, 3783, 3941, 3999], 'Scholar].': [332, 375, 483, 547, 748, 804, 930, 1013, 1073, 1133, 1300, 1333, 1415, 1641, 1711, 1777, 1862, 1942, 1975, 2057, 2128, 2284, 2354, 2420, 2505, 2539, 2586, 2779, 2815, 2846, 2990, 3120, 3326, 3652, 3784, 3942, 4000], 'Even': [333], 'large': [335, 3195, 3419], 'investments': [336], 'government': [338], 'industry': [340], 'both': [342, 3395, 3439, 3474], 'Europe': [343], 'North': [345], 'America,': [346], 'surprisingly': [347], 'lab-on-a-chip': [349, 2741], '(LOC)': [350], 'tests': [353], 'commercial': [357, 1179, 1619, 2262], 'products': [358, 3571, 3576, 3960], '[2Whitesides': [359], 'G.M.': [360, 531, 561, 1380, 1470, 2022, 2112], 'origins': [362], 'microfluidics.Nature.': [367], '2006;': [368], '442:': [369], '368-373Crossref': [370], '(6790)': [373], 'discrepancy': [377], 'somewhat': [378], 'constrains': [379], 'potential': [381, 1620, 2263, 3912], 'devices,': [385], 'which': [386, 419, 1678, 2321, 2663, 2971, 3668], 'is': [387, 407, 555, 754, 1192, 1254, 1308, 1336, 1370, 1526, 1530, 1536, 1578, 1896, 1950, 1978, 2012, 2169, 2173, 2179, 2221, 2512, 2722, 2743, 3122, 3390, 3446, 3531, 3656], 'expected': [388], 'grow': [390], '$1.6': [392], 'billion': [393, 398], '2013': [395], '$3.6–5.7': [397], 'by': [399, 452, 509, 959, 1233, 1424, 1646, 1875, 2066, 2289, 2887, 3213, 3374, 3430, 3827, 3871], '2018;': [400], 'key': [402, 1302, 1944, 2707, 3351], 'driver': [403], 'this': [405, 752, 2633, 2873, 2925], 'growth': [406], 'need': [409, 3518], 'early': [411], 'detection': [412, 3088, 3695], 'personalized': [414], 'treatment': [415], 'lifestyle': [417], 'diseases,': [418], 'become': [421], 'prominent': [423], 'within': [424], 'geriatric': [427], 'population': [428], '[3Yole': [429], 'Development': [430], 'Microfluidic': [431], 'Applications': [432], 'Pharmaceutical,': [435], 'Life': [436, 3787], 'Sciences,': [437], 'In-Vitro': [438], 'Diagnostic': [439], 'Medical': [441], 'Device': [442], 'Markets': [443, 448], 'Report.2013http://www.prnewswire.com/news-releases/microfluidic-applications-in-the-pharmaceutical-life-sciences-in-vitro-diagnostic-and-medical-device-markets-report-242837751.htmlGoogle': [444], 'Scholar,': [445, 529, 577, 591, 611, 630, 651, 668, 690, 709, 729, 971, 993, 1054, 1102, 1118, 1396, 1755, 1823, 1843, 2038, 2398, 2466, 2486, 3097, 3708, 3738, 3765], '4Markets': [446], '(2013)': [449], 'Microfluidics': [450, 1217, 1547, 2190, 3318], '(polymers,': [454], 'silicon,': [455], 'glass),': [456], 'pharmaceuticals': [457], '(microreactors,': [458], 'toxicity': [459], 'screening,': [460], 'lab': [461], 'on': [462, 636, 1042, 1239, 1571, 1626, 1881, 2214, 2269, 2928, 3180, 3438, 3473, 3552, 3593, 3660, 3716, 3746], 'chip,': [464], 'proteomic': [465], '&': [466, 479], 'genomic': [467], 'analysis),': [468], 'drug': [469, 3728], 'delivery': [470], '(microneedles,': [472], 'micropumps),': [473], 'IVD': [474], '(POC)': [475], '-': [476], 'global': [477], 'trends': [478], 'forecast': [480], '2018,Google': [482], 'Thus': [484], 'far,': [485], 'field': [487], 'POC': [489], 'diagnostics': [491, 1663, 2306, 3631, 3642], 'predominantly': [494], 'addressed': [495], 'academia': [497], 'polydimethylsiloxane': [499], '(PDMS)': [500, 1238, 1880], 'manufactured': [502, 1586, 2229], 'using': [503, 910, 1001, 1203, 2902, 3930], 'soft': [504, 552, 1204, 1305, 1491, 1552, 1605, 1947, 2134, 2195, 2248], 'lithography': [505, 534, 553, 564, 582, 1205, 1222, 1268, 1291, 1306, 1383, 1473, 1492, 1553, 1606, 1864, 1910, 1933, 1948, 2025, 2115, 2135, 2196, 2249], 'techniques,': [506], 'originally': [507], 'popularized': [508], 'Whitesides': [511], 'group': [512], '[5Zhao': [513], 'X.-M.': [514], 'al.Soft': [516, 533, 563, 581, 1290, 1382, 1472, 1932, 2024, 2114], 'lithographic': [517], 'methods': [518, 772, 1136, 1160, 1206, 1223, 1307, 1493, 1717, 1865, 1949, 2136, 2360, 2718, 3846, 3859], 'nano-fabrication.J.': [520], 'Mater.': [521], 'Chem.': [522, 622, 643, 847, 1407, 1633, 2049, 2276, 3022, 3757], '1997;': [523], '7:': [524], '1069-1074Crossref': [525], '(400)': [527], '6Whitesides': [530], 'biology.Annu.': [536, 566, 1385, 1475, 2027, 2117], 'Rev.': [537, 567, 1386, 1476, 2028, 2118], 'Biomed.': [538, 568, 1387, 1477, 2029, 2119], 'Eng.': [539, 569, 1388, 1478, 2030, 2120, 2772], '2001;': [540, 570, 1389, 1479, 2031, 2121], '3:': [541, 571, 1390, 1480, 2032, 2122, 3093], '335-373Crossref': [542, 572, 1391, 1481, 2033, 2123], '(2228)': [545, 575, 1394, 1484, 2036, 2126], 'A': [548, 1642, 1778, 2285, 2421, 2706, 2737, 3528], 'brief': [549, 2936], 'review': [550, 2881], 'presented': [556], 'Box': [558], '1': [559, 1196, 1263, 1905], '[6Whitesides': [560, 1379, 1469, 2021, 2111], '7Kim': [578], 'P.': [579, 954, 1288, 1930, 3068, 3920, 3980], 'microfluidics:': [584, 1293, 1935], 'review.Biochip': [586, 1295, 1937], 'J.': [587, 788, 1296, 1938, 2535, 3041], '2008;': [588, 1297, 1939], '2:': [589, 880, 1298, 1940], '1-11Google': [590, 1299, 1941], '8Mcdonald': [592], 'J.C.': [593, 1315, 1957], 'al.Review': [595, 1317, 1959], '–': [596, 1161, 1171, 1218, 1318, 1960, 2560, 2566, 3077], 'poly': [602, 1324, 1966], '(dimethylsiloxane).Electrophoresis.': [603, 1325, 1967], '2000;': [604, 1326, 1968], '21:': [605, 1327, 1969], '27-40Crossref': [606, 1328, 1970], '(2802)': [609, 1331, 1973], '9Duffy': [612, 1397, 2039], 'D.C.': [613, 1398, 2040], 'al.Rapid': [615, 1400, 2042, 3922], 'poly(dimethylsiloxane).Anal.': [621, 1406, 2048], '1998;': [623, 1408, 2050], '70:': [624, 1409, 2051], '4974-4984Crossref': [625, 1410, 2052], '(4516)': [628, 1413, 2055], '10Plouffe': [631], 'B.D.': [632, 1622, 2265], 'Murthy': [633, 1623, 2266], 'S.K.': [634, 1624, 2267], 'Perspective': [635, 1625, 2268], 'cell': [638, 1628, 2271, 3017, 3295, 3302, 3513, 3678, 3723], 'separation:': [639, 1629, 2272], 'solved': [641, 1631, 2274], 'problem?.Anal.': [642, 1632, 2275], '86:': [645, 1635, 2278, 3759], '11481-11488Crossref': [646, 1636, 2279], '(31)': [649, 1639, 2282], '11Chin': [652], 'C.': [653, 917, 1696, 1740, 2339, 2383], 'al.Commercialization': [655, 1698, 1742, 2341, 2385], 'devices.Lab': [659, 1702, 1746, 2345, 2389], 'Chip.': [660, 878, 1068, 1096, 1127, 1703, 1747, 2346, 2390, 2811, 2842, 3091, 3112, 3702, 3934], '2012;': [661, 1704, 1748, 2347, 2391, 2536, 2583, 3023], '12:': [662, 987, 1705, 1749, 2348, 2392], '2118-2134Crossref': [663, 1706, 1750, 2349, 2393], '(832)': [666, 1709, 1753, 2352, 2396], '12Volpatti': [669, 1756, 2399], 'L.R.': [670, 1757, 2400], 'Yetisen': [671, 1758, 2401], 'A.K.': [672, 1104, 1759, 2402], 'Commercialization': [673, 1760, 2403], 'devices.Trends': [676, 1763, 2406], 'Biotechnol.': [677, 740, 1764, 1854, 2407, 2497], '32:': [679, 1766, 2409], '347-350Abstract': [680, 1767, 2410], 'Full': [681, 683, 1768, 1770, 2411, 2413], 'Text': [682, 684, 1769, 1771, 2412, 2414], 'PDF': [685, 1772, 2415], '(289)': [688, 1775, 2418], '13Fiorini': [691], 'G.S.': [692, 1806, 2449], 'Chiu': [693, 1807, 2450], 'D.T.': [694, 1808, 2451], 'Disposable': [695, 1809, 2452], 'devices:': [697, 1811, 2454, 2764], 'fabrication,': [698, 1725, 1812, 2368, 2455], 'function,': [699, 1813, 2456], 'application.Biotechniques.': [701, 1815, 2458], '2005;': [702, 1007, 1816, 2459, 3113], '38:': [703, 1817, 2460], '429-446Crossref': [704, 1818, 2461], '(387)': [707, 1821, 2464], '14Nge': [710, 1824, 2467], 'P.N.': [711, 1825, 2468], 'al.Advances': [713, 1827, 2470], 'functions,': [717, 1787, 1831, 2430, 2474], 'integration,': [718, 1832, 2475], 'applications.Chemical': [720, 1834, 2477], 'Reviews.': [721, 1835, 2478], '2013;': [722, 964, 1836, 2479, 3055], '113:': [723, 1837, 2480], '2550-2583Crossref': [724, 1838, 2481], '(635)': [727, 1841, 2484], '15Ren': [730, 1844, 2487], 'K.': [731, 786, 1845, 2488], 'al.New': [733, 1847, 2490], 'biology.Curr.': [738, 1852, 2495], 'Opin.': [739, 1853, 2496], '25:': [742, 1856, 2499], '78-85Crossref': [743, 1857, 2500], '(86)': [746, 1860, 2503], 'focus': [750], 'discussion': [756, 2937], 'takes': [761], 'place': [762], 'rather': [765], 'than': [766], 'rooms.': [768], 'Alternative': [769], 'rapid': [770, 872, 997, 1185, 2628], 'take': [774, 2870], 'advantage': [775], 'reviewed': [783, 2631, 2691, 2974], 'previously': [784, 2975], '[16Pataky': [785], 'Brugger': [787], 'Rapid': [789], 'Prototyping': [790], 'Techniques': [791], 'Fabrication': [794, 955], 'Biosensors.': [796], 'Woodhead': [797], 'Publishing': [798], 'Limited,': [799], '2014Crossref': [800], '(4)': [802], 'For': [805, 2780, 3202, 3229, 3367], 'example,': [806, 2781, 3230], 'cutting': [808, 1003, 1209, 1693, 2336, 3215, 3378, 3842, 3848, 3884, 3918, 3963], 'can': [809, 1345, 1419, 1433, 1556, 1679, 1987, 2061, 2075, 2199, 2322, 2589, 2731, 2858, 2914, 3085, 3209, 3269, 3331, 3384, 3422, 3427, 3560, 3577], 'be': [810, 1420, 1434, 1585, 1593, 1680, 2062, 2076, 2228, 2236, 2323, 2590, 2695, 2732, 2915, 3163, 3178, 3210, 3270, 3332, 3385, 3423, 3428, 3499, 3520, 3578, 3869], 'used': [811, 1018, 1494, 2137, 2785, 2819, 2886, 3826], 'cut': [813, 896, 912, 943, 1021, 3179, 3870], 'channels': [815, 826, 859, 1023, 3380, 3850], 'double-sided': [817, 830, 2823, 3252, 3375, 3454, 3466, 3502], 'pressure': [818], 'sensitive': [819, 3743, 3955], 'adhesive': [820, 897, 3253, 3267, 3330, 3383, 3399, 3444, 3462, 3467, 3539, 3931, 3987], '(PSA)': [821], '[17Patko': [822], 'D.': [823], 'al.Microfluidic': [825], 'laser-cut': [827, 2820], 'thin': [829], 'tapes:': [831], 'cost-effective': [832, 903], 'biocompatible': [833], 'fluidics': [834], 'minutes': [836], 'design': [838, 1576, 2219, 2877], 'final': [840, 3529], 'integration': [841, 1731, 2374, 3034, 3803], 'optical': [843, 2963, 3140, 3168], 'biochips.Sensors': [844], 'Actuators,': [845], 'B': [846], '196:': [849], '352-356Crossref': [850], '(53)': [852], 'Scholar],': [854, 886, 2662, 3030, 3061], 'directly': [856, 1020], 'ablate': [857], 'polymer': [861, 1360, 1450, 1529, 2002, 2092, 2172, 3075], '[18Klank': [863], 'H.': [864, 2977, 3636], 'al.CO(2)-laser': [866], 'micromachining': [867], 'back-end': [869], 'processing': [870], 'production': [873], 'PMMA-based': [875], 'systems.Lab': [877], '2002;': [879, 2983], '242-246Crossref': [881], '(410)': [884], 'even': [888, 1016, 1350, 1992, 3166, 3309, 3677], 'create': [890, 1226, 1496, 1868, 2139], 'molds': [891, 913, 1228, 1559, 1583, 1870, 2202, 2226], 'PDMS': [893, 909, 1025, 1359, 1417, 1432, 1449, 1590, 1612, 1666, 2001, 2059, 2074, 2091, 2233, 2255, 2309], '[19Samuel': [898], 'R.': [899], 'al.Simple': [901], 'microvalve': [906], 'arrays': [907], 'application': [915], 'elegans': [918], 'manipulation': [919], 'microfluidics.J.': [921], 'Micromechanics': [922, 3053], 'Microengineering.': [923, 3054], '24:': [925], '105007Crossref': [926], '(8)': [928], 'Plotter': [931, 4001], 'cutting,': [932, 1165], 'also': [933, 1078, 1550, 2193, 2642, 2694], 'known': [934], 'xurography,': [936], 'uses': [937], 'drag': [939], 'knife': [940], 'printer': [941], 'designs': [945], 'laminate': [947, 1152], 'masking': [949], 'films': [950, 1030], '[20Pessoa': [951], 'de': [952], 'Santana': [953], 'glass': [957, 1260, 1902], 'microchannels': [958, 3265], 'xurography': [960], 'electrophoresis': [962], 'applications.Analyst.': [963], '138:': [965], '1660-1664Crossref': [966], '(28)': [969], '21Pješčić': [972], 'I.': [973], 'al.Glass-composite': [975], 'flow': [978, 2840], 'PCR': [979], 'situ': [982], 'DNA': [983], 'analysis.Biomed.': [984], 'Microdevices.': [985, 3730], '2010;': [986, 3935], '333-343Crossref': [988], '(43)': [991], '22Bartholomeusz': [994], 'D.A.': [995], 'Xurography:': [996], 'microstructures': [1000], 'plotter.J.': [1004], 'Microelectromechanical': [1005], 'Syst.': [1006], '14:': [1008], '1364-1374Crossref': [1009], '(275)': [1011], 'Xurography': [1014], 'cyclic': [1027, 1043], 'olefin': [1028, 1044], 'copolymer': [1029], '[23Azouz': [1031], 'A.': [1032, 3099], 'Ben': [1033], 'al.Fast': [1035], 'process': [1037, 1577, 2220], 'based': [1041, 3745, 3990], 'copolymer.Mater.': [1045], 'Manuf.': [1046], 'Process.': [1047], '29:': [1049], '93-99Crossref': [1050], '(24)': [1052], '24Cosson': [1055], 'S.': [1056, 3315, 3767], 'al.Ultra-rapid': [1058], 'flexible,': [1061], 'multi-layered': [1062], 'via': [1065], 'razor': [1066], 'writing.Lab': [1067], '15:': [1070, 1098], '72-76Crossref': [1071], 'printing': [1075], 'technologies': [1076, 2848], 'begun': [1079], 'show': [1081, 2849], 'promise': [1082, 2940, 2994], '[25Ho': [1087], 'C.M.B.': [1088], 'al.3D': [1090], 'printed': [1091], 'applications.Lab': [1095], '2015;': [1097, 2773], '3627-3637Crossref': [1099], '26Au': [1103], 'al.3D-printed': [1106], 'microfluidics.Angewandte': [1107], 'Chemie': [1108], 'Int': [1109], 'Ed.': [1110], '2016;': [1111, 1128, 2812, 2843, 3703, 3731, 3777], '55:': [1112], '3862-3881Crossref': [1113], '(534)': [1116], '27Bhattacharjee': [1119], 'N.': [1120, 2572], 'upcoming': [1122], '3D-printing': [1123], 'revolution': [1124], 'microfluidics.Lab': [1126], '16:': [1129, 3704], '1720-1742Crossref': [1130], 'While': [1134, 1589, 2232, 2912, 3404, 3943], 'do': [1137], 'not': [1138, 3391], 'superior': [1141], 'resolution': [1142, 1344, 1986], 'photolithographic': [1144, 2717], 'methods,': [1145, 2924, 2970], 'substrates': [1153, 2789, 3611, 3798, 3825], 'translatable': [1156], 'scalable': [1158, 2968], 'manufacturing': [1159, 1191, 1714, 2357, 2714, 2906, 2969, 3151], 'die': [1164, 1692, 2335], 'hot': [1166], 'embossing,': [1167], 'injecting': [1169], 'molding': [1170, 1521, 2164], 'translate': [1173], 'finished': [1175], 'prototype': [1176, 1313, 1955], 'product.': [1180], 'An': [1181], 'example': [1182], 'method': [1187], 'amenable': [1188], 'scaled-up': [1190], 'cutting.': [1194], 'Figure': [1195, 1262, 1904], 'shows': [1197, 1650, 2293], 'comparison': [1199], 'versus': [1207], 'plastics,': [1211, 2929, 3158], 'laminates,': [1212], 'paper.Box': [1214], '1Soft': [1215], 'Lithography': [1216], 'Pros': [1219], 'ConsSoft': [1221], 'master': [1227, 1869], 'photolithography': [1230, 1489, 1872, 2132], 'techniques': [1231, 1269, 1873, 1911, 2565, 2630, 2692], 'followed': [1232, 1874], 'curing': [1234, 1876], 'pre-polymer': [1237, 1879], 'top': [1240, 1882], 'mold': [1243, 1253, 1525, 1569, 1885, 1895, 2168, 2212], 'master,': [1244, 1886], 'where': [1245, 1523, 1887, 2166, 2553, 3496, 3515], 'after': [1246, 1888], 'curing,': [1247, 1889], 'PDMS-negative': [1249, 1891], 'stamp': [1250, 1892], 'created': [1255, 1897, 3915], 'bonded': [1257, 1422, 1899, 2064], 'irreversibly': [1258, 1421, 1900, 2063], '(see': [1261, 1903], 'main': [1265, 1907], 'text).': [1266, 1908], 'Soft': [1267, 1863, 1909], 'proven': [1271, 1913], 'useful': [1272, 1914, 3129], 'under': [1275, 1917, 3109], 'wide': [1277, 1453, 1779, 1919, 2095, 2422, 2919, 2957, 3142, 3148, 3287, 3794], 'range': [1278, 1920, 3554], 'channel': [1282, 1924], 'pattern': [1285, 1927], 'generation': [1286, 1928], '[7Kim': [1287, 1929], 'benefit': [1303, 1945, 3881], 'ability': [1310, 1952], 'rapidly': [1312, 1531, 1954, 2174, 2861], '[8Mcdonald': [1314, 1956], 'technique': [1335, 1977], 'ideal': [1337, 1363, 1979, 2005, 3256], 'because': [1341, 1983, 3134], 'feature': [1343, 1352, 1985, 1994, 2665], 'match': [1346, 1988], 'micrometer': [1348, 1990], 'nanometer': [1351, 1993], 'sizes': [1353, 1995], 'often': [1354, 1996, 2908, 3193, 3958], 'found': [1355, 1997, 2909], 'biology.': [1357, 1999], 'candidate': [1364, 2006], 'it': [1369, 2011], 'nontoxic,': [1371, 2013], 'widely': [1372, 2014], 'available,': [1373, 2015], 'transparent,': [1374, 2016], 'hydrophobic,': [1375, 2017], 'gas-permeable,': [1376, 2018], 'elastomeric': [1378, 2020], 'Oxidized': [1416, 2058], 'surfaces': [1418, 2060], 'together': [1423, 2065, 3373], 'spontaneous': [1426, 2068], 'dehydration': [1427, 2069], 'SiOH': [1429, 2071], 'groups,': [1430, 2072], 'passivated': [1435, 2077], 'functionalized': [1437, 2079], 'through': [1438, 1684, 2080, 2327], 'various': [1439, 2081], 'chemistries': [1440, 2082], 'high-efficiency': [1442, 2084], 'molecular': [1443, 2085, 2672, 3687], 'assays.': [1444, 2086], 'flexibility': [1446, 2088], 'enables': [1451, 2093], 'variety': [1454, 1780, 2096, 2423, 2920, 2958, 3149, 3288, 3795], 'geometries,': [1456, 2098], 'layering,': [1457, 2099], 'unit': [1459, 2101], 'operations': [1460, 1789, 2102, 2432], 'applicable': [1461, 2103], 'plethora': [1464, 1802, 2106, 2445], 'unique': [1466, 2108], 'manipulations': [1468, 2110], 'Scholar].By': [1486], 'contrast,': [1487, 2130], 'suffer': [1499, 2142], 'nature': [1502, 2145], 'artisanal': [1504, 2147], 'resource-consuming': [1506, 2149], 'processes': [1507, 1685, 2150, 2328], '(pour,': [1508, 2151], 'cure,': [1509, 2152], 'cut,': [1510, 2153], 'punch,': [1511, 2154], 'bond)': [1513, 2156], 'opposed': [1515, 2158], 'industry-standard': [1519, 2162], 'injection': [1520, 1688, 2163, 2331], 'process,': [1522, 2165], 'filled,': [1527, 2170], 'cured,': [1532, 2175], 'part': [1535, 2178, 2593, 2871], 'ejected.': [1537, 2180], 'Contract': [1538, 2181], 'manufacturers,': [1539, 2182, 3188], 'FlowJEM': [1542, 2185], '(Ontario,': [1543, 2186], 'Canada)': [1544, 2187], 'SIMTech': [1546, 2189], 'Foundry': [1548, 2191], '(Singapore),': [1549, 2192], 'perform': [1551, 2194], 'custom': [1558, 2201, 3232], 'fee': [1562, 2205], '($100–200': [1563, 2206], 'single': [1566, 2209], 'layer': [1567, 2210, 3471], 'SU-8': [1568, 2211], 'depending': [1570, 2213, 3592], 'design);': [1573, 2216], 'slowed': [1579, 2222], 'down': [1580, 2223], 'waiting': [1581, 2224], 'shipped.': [1588, 2231], 'may': [1592, 2235, 3162, 3498, 3517, 3950], 'well': [1594, 2237, 2513], 'research': [1598, 2241], 'setting,': [1599, 2242], 'lack': [1601, 2244], 'high': [1609, 2252, 3139], 'cost': [1610, 2253, 3224, 3424, 3533, 3561], '(relative': [1613, 2256], 'cost-efficient': [1615, 2258], 'thermoplastics)': [1616, 2259], 'limited': [1618, 2261], '[10Plouffe': [1621, 2264], 'technology': [1643, 2286], 'map': [1644, 2287], 'developed': [1645, 2288], 'Chin': [1647, 2290], 'al.': [1649, 2292, 2784, 2818], 'how': [1651, 2294, 3083], 'virtually': [1652, 2295], 'none': [1653, 2296], 'major': [1656, 2299, 2738], 'players': [1657, 2300], 'vitro': [1662, 2305, 3311], 'their': [1668, 2311, 3575], 'products,': [1669, 2312], 'instead': [1670, 2313], 'leaning': [1671, 2314], 'towards': [1672, 2315], 'glass,': [1674, 2317], 'or': [1675, 2318, 2603, 3547, 3574, 3875, 4010], 'paper': [1676, 2319, 2788, 2932, 3654, 3755, 3797, 3824, 3837], 'mass-manufactured': [1683, 2326], 'molding,': [1689, 2332], 'casting,': [1690, 2333], 'respectively': [1694, 2337], '[11Chin': [1695, 1739, 2338, 2382], 'These': [1712, 2355, 2847, 3888], 'common': [1713, 2356], 'offer': [1718, 2361, 2955, 3413], 'additional': [1719, 2362], 'benefits': [1720, 2363, 3889], 'standardization': [1723, 2366, 3171], 'improving': [1726, 2369], 'quality': [1727, 2370], 'control,': [1728, 2371], 'better': [1730, 2373, 3483], 'other': [1733, 2376], 'parts': [1734, 2377], 'made': [1735, 2378, 2916], 'similar': [1737, 2380, 2652, 3861], 'material': [1738, 2381, 2948, 3063, 3463, 3600, 3815, 3944], 'advances': [1782, 2425], 'manufacturing,': [1785, 2428], 'yielded': [1791, 2434], 'powerful': [1793, 2436], 'toolkit': [1794, 2437], 'plastic': [1797, 2440, 3104, 3276, 3370], 'development': [1799, 2442, 2898], '[13Fiorini': [1805, 2448], 'By': [2129], 'investigation': [2507], 'exploration': [2516, 2625], 'emerging': [2519], 'ecosystem': [2520], '[28Van': [2524], 'Holm': [2525], 'E.J.': [2526], 'What': [2527], 'makerspaces,': [2529], 'hackerspaces,': [2530], 'fab': [2532], 'labs?.SSRN': [2533], 'Electron.': [2534], 'https://doi.org/10.2139/ssrn.2548211Crossref': [2537], 'In': [2540, 2635], 'broadest': [2542], 'sense,': [2543], 'physical': [2546], 'usually': [2548], 'accessible': [2549], 'public,': [2552], 'communities': [2554, 2703], 'able': [2556], 'spanning': [2561], 'additive': [2562], 'subtractive': [2564], 'fabricating': [2568, 3368], 'almost': [2569, 2576], 'anything': [2570], '[29Gershenfeld': [2571], 'How': [2573, 2765], 'make': [2575, 2859, 3199], 'anything:': [2577], 'digital': [2579], 'revolution.Foreign': [2581], 'Aff.': [2582], '91:': [2584], '43-57Google': [2585], 'Such': [2587], 'spaces': [2588, 2610, 3203], 'formalized': [2591], 'organization': [2596], 'like': [2597], 'Fab': [2599], 'Lab': [2600], 'network': [2601], '(www.fabfoundation.org),': [2602], 'informally': [2605], 'organized.': [2606], 'With': [2607], '>1000': [2608], 'active': [2609], 'around': [2611], 'world,': [2613], 'lowered': [2616], 'accessing': [2620], 'technologies,': [2622], 'enabling': [2623], 'work.': [2634], 'several': [2638], 'years,': [2639], 'there': [2640], 'movement': [2646], "'do-it-yourself'": [2648], '(DIY)': [2649], 'biology': [2650, 2673, 2702], 'emergence': [2653], 'bio-makerspaces': [2655], '[30Scroggins': [2656], 'M.': [2657, 3039], 'al.BioCoder.': [2659], "O'Rielly,": [2660], '2013Google': [2661], 'typically': [2664, 3482, 3551], 'basic': [2668], 'infrastructure': [2669], 'conducting': [2671], 'microbiology': [2675], 'projects.': [2676], 'As': [2677], 'majority': [2679], 'involved': [2685], 'systems,': [2687], 'we': [2688, 2880], 'believe': [2689], 'will': [2693], 'interest,': [2697], 'accessible,': [2699], 'DIY': [2701], 'well.': [2705], 'factor': [2708], 'shift': [2711], "'maker": [2720], "manufacturing'": [2721], 'push': [2724], 'fully': [2726, 3684], 'readily': [2733], 'industry.': [2736], 'roadblock': [2739], 'plugging': [2744], 'sealing': [2746], 'all': [2750, 3821], 'interfaces': [2752], 'needed': [2753], '(e.g.,': [2754], 'detection,': [2755], 'electric': [2756], 'manipulation,': [2757], 'inlets/outlets)': [2759], '[31Temiz': [2760], 'Y.': [2761], 'al.Lab-on-a-chip': [2763], 'close': [2767], 'plug': [2769], 'lab?.Microelectron.': [2771], '132:': [2774], '156-175Crossref': [2775], '(341)': [2777], 'Lafluer': [2782], '3D-printed': [2786, 2942], 'develop': [2791, 2826, 2891], 'entirely': [2793, 3459], 'sample-to-result': [2795, 2806], 'nucleic': [2796, 2807, 3670, 3697], 'acid': [2797, 2808, 3671], 'amplification': [2798, 2809], 'test': [2799], '[32Lafleur': [2800], 'L.': [2801], 'al.A': [2803, 3683, 3712], 'rapid,': [2804], 'instrument-free,': [2805], 'test.Lab': [2810], 'https://doi.org/10.1039/C6LC00677ACrossref': [2813], 'Kinahan': [2816], 'acrylic': [2821, 3242], 'PSA': [2824], 'biplex': [2829], 'liver': [2830], 'assay': [2831, 3306], '[33Kinahan': [2832], 'D.J.': [2833], 'al.Xurography': [2835], 'actuated': [2836], 'valving': [2837], 'centrifugal': [2839], 'control.Lab': [2841], 'https://doi.org/10.1039/C6LC00568CCrossref': [2844], 'off': [2850], 'power': [2852], 'anyone': [2857], 'scale': [2862], 'bulk': [2864, 3196], 'To': [2866], 'others': [2868], 'type': 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