Title: Novel Renal Biomarker Cystatin C for Diagnosis of Impaired Renal Function for Uncontrolled Iraqi Diabetics
Abstract: Diagnosis of mild or moderate impaired renal function is very important especially for uncontrolled diabetic patients. The study was conducted in the National Diabetes Center/Al-Mustansiriya University. Renal biomarkers were used to evaluate the reduced renal function in 44 uncontrolled diabetic patients (fasting blood glucose is more than 125 mg/dl), by estimating glomerular filtration rate GFR which represents the best overall index of kidney function. These biomarkers include urea, creatinine and cystatin C as a novel renal biomarker. Elevated levels of serum urea nitrogen more than normal range with mean=39.29 and SD=+19.36 serum creatinine within the normal range with mean=0.78 and SD=+0.26. The ratio of serum urea nitrogen/serum creatinine significantly high than normal with mean=49.91 and SD=+15.42. This high ratio of urea/creatinine shows a definite renal impairment. Serum cystatin C levels also shows a high values more than the normal range with mean=1.95 and SD=+0.93. Estimating the glomerular filtration rate GFR, by the application of Modified Diet Renal Disease (MDRD) equation for serum creatinine, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for serum cystatin C and also (CKD-EPI) equation for both serum creatinine and serum cystatin C. The estimated GFR with cystatin C (by application of CKD-EPI equation) is more correlated to the estimated GFR for both serum creatinine and serum cystatin C (by application of CKD-EPI equation) with r =0.59 while the correlation of estimated GFR for serum creatinine (by application of MDRD equation) is less correlate to the estimated GFR for both serum creatinine and serum cystatin C (by application of CKD-EPI equation) with r =0.56. The study findings support that the cystatin C, as a new novel GFR marker providing more sensitivity and overcoming many limitations of the creatinine-based methods. So, serum cystatin C levels indicate the exact stage of the impaired renal function by the estimation of GFR for the uncontrolled diabetic patients.
Publication Year: 2013
Publication Date: 2013-04-17
Language: en
Type: article
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