Publication Information

{'id': 'https://openalex.org/W2574505563', 'doi': 'https://doi.org/10.1002/pro.3116', 'title': 'Energetics, kinetics, and pathway of <scp>SNARE</scp> folding and assembly revealed by optical tweezers', 'display_name': 'Energetics, kinetics, and pathway of <scp>SNARE</scp> folding and assembly revealed by optical tweezers', 'publication_year': 2017, 'publication_date': '2017-01-18', 'ids': {'openalex': 'https://openalex.org/W2574505563', 'doi': 'https://doi.org/10.1002/pro.3116', 'mag': '2574505563', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28097727', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5477538'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/pro.3116', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.3116', 'source': {'id': 'https://openalex.org/S156919612', 'display_name': 'Protein Science', 'issn_l': '0961-8368', 'issn': ['0961-8368', '1469-896X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.3116', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5085519824', 'display_name': 'Yongli Zhang', 'orcid': 'https://orcid.org/0000-0001-7079-7973'}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Yongli Zhang', 'raw_affiliation_strings': ['Department of Cell Biology, Yale School of Medicine, Yale University, New Haven, Connecticut, 06511'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Yale School of Medicine, Yale University, New Haven, Connecticut, 06511', 'institution_ids': ['https://openalex.org/I32971472']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5085519824'], 'corresponding_institution_ids': ['https://openalex.org/I32971472'], 'apc_list': {'value': 4070, 'currency': 'USD', 'value_usd': 4070, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.546, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 51, 'citation_normalized_percentile': {'value': 0.99784, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '26', 'issue': '7', 'first_page': '1252', 'last_page': '1265'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10407', 'display_name': 'Lipid Membrane Structure and Behavior', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/zipper', 'display_name': 'Zipper', 'score': 0.64678967}, {'id': 'https://openalex.org/keywords/snare-complex', 'display_name': 'SNARE complex', 'score': 0.58921206}, {'id': 'https://openalex.org/keywords/tethering', 'display_name': 'Tethering', 'score': 0.4794637}, {'id': 'https://openalex.org/keywords/folding', 'display_name': 'Folding (DSP implementation)', 'score': 0.42561924}], 'concepts': [{'id': 'https://openalex.org/C103038307', 'wikidata': 'https://www.wikidata.org/wiki/Q6556360', 'display_name': 'Lipid bilayer fusion', 'level': 3, 'score': 0.7289954}, {'id': 'https://openalex.org/C105782903', 'wikidata': 'https://www.wikidata.org/wiki/Q6577686', 'display_name': 'Zipper', 'level': 2, 'score': 0.64678967}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.596614}, {'id': 'https://openalex.org/C2908790754', 'wikidata': 'https://www.wikidata.org/wiki/Q279694', 'display_name': 'SNARE complex', 'level': 4, 'score': 0.58921206}, {'id': 'https://openalex.org/C201815810', 'wikidata': 'https://www.wikidata.org/wiki/Q833066', 'display_name': 'Tethering', 'level': 2, 'score': 0.4794637}, {'id': 'https://openalex.org/C2776545253', 'wikidata': 'https://www.wikidata.org/wiki/Q5464292', 'display_name': 'Folding (DSP implementation)', 'level': 2, 'score': 0.42561924}, {'id': 'https://openalex.org/C148785051', 'wikidata': 'https://www.wikidata.org/wiki/Q671136', 'display_name': 'Synaptic vesicle', 'level': 4, 'score': 0.41986072}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.41809866}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.40852746}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39210358}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.38762605}, {'id': 'https://openalex.org/C130316041', 'wikidata': 'https://www.wikidata.org/wiki/Q189206', 'display_name': 'Vesicle', 'level': 3, 'score': 0.3499472}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1909081}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.07160267}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C11413529', 'wikidata': 'https://www.wikidata.org/wiki/Q8366', 'display_name': 'Algorithm', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C119599485', 'wikidata': 'https://www.wikidata.org/wiki/Q43035', 'display_name': 'Electrical engineering', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004734', 'descriptor_name': 'Energy Metabolism', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D008561', 'descriptor_name': 'Membrane Fusion', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052898', 'descriptor_name': 'Optical Tweezers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072417', 'descriptor_name': 'Protein Domains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017510', 'descriptor_name': 'Protein Folding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050600', 'descriptor_name': 'SNARE Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/pro.3116', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.3116', 'source': {'id': 'https://openalex.org/S156919612', 'display_name': 'Protein Science', 'issn_l': '0961-8368', 'issn': ['0961-8368', '1469-896X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5477538', 'pdf_url': 'https://europepmc.org/articles/pmc5477538?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477538', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28097727', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/pro.3116', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.3116', 'source': {'id': 'https://openalex.org/S156919612', 'display_name': 'Protein Science', 'issn_l': '0961-8368', 'issn': ['0961-8368', '1469-896X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Affordable and clean energy', 'id': 'https://metadata.un.org/sdg/7', 'score': 0.9}], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'RO1GM093341'}], 'datasets': [], 'versions': [], 'referenced_works_count': 118, 'referenced_works': ['https://openalex.org/W1543112938', 'https://openalex.org/W1599046084', 'https://openalex.org/W1822005186', 'https://openalex.org/W1822252127', 'https://openalex.org/W1891848250', 'https://openalex.org/W1965158583', 'https://openalex.org/W1968306435', 'https://openalex.org/W1970573820', 'https://openalex.org/W1971603103', 'https://openalex.org/W1974537340', 'https://openalex.org/W1978098224', 'https://openalex.org/W1979635240', 'https://openalex.org/W1981403821', 'https://openalex.org/W1983387895', 'https://openalex.org/W1983920643', 'https://openalex.org/W1984341897', 'https://openalex.org/W1988321285', 'https://openalex.org/W1990473626', 'https://openalex.org/W1990556167', 'https://openalex.org/W1990558068', 'https://openalex.org/W1992294030', 'https://openalex.org/W1996037892', 'https://openalex.org/W1996598000', 'https://openalex.org/W1999017647', 'https://openalex.org/W1999367496', 'https://openalex.org/W2000302106', 'https://openalex.org/W2001389730', 'https://openalex.org/W2001508625', 'https://openalex.org/W2002033106', 'https://openalex.org/W2003813143', 'https://openalex.org/W2013334700', 'https://openalex.org/W2019594298', 'https://openalex.org/W2020460460', 'https://openalex.org/W2024136850', 'https://openalex.org/W2027775552', 'https://openalex.org/W2035865918', 'https://openalex.org/W2036620149', 'https://openalex.org/W2036908053', 'https://openalex.org/W2038275015', 'https://openalex.org/W2039794026', 'https://openalex.org/W2040025072', 'https://openalex.org/W2045306333', 'https://openalex.org/W2045375596', 'https://openalex.org/W2047808133', 'https://openalex.org/W2048465987', 'https://openalex.org/W2051103934', 'https://openalex.org/W2052999464', 'https://openalex.org/W2055569374', 'https://openalex.org/W2059160047', 'https://openalex.org/W2059240367', 'https://openalex.org/W2060384627', 'https://openalex.org/W2060821973', 'https://openalex.org/W2063616898', 'https://openalex.org/W2065220292', 'https://openalex.org/W2065359945', 'https://openalex.org/W2076142556', 'https://openalex.org/W2081407528', 'https://openalex.org/W2081918336', 'https://openalex.org/W2085680244', 'https://openalex.org/W2086696756', 'https://openalex.org/W2091653401', 'https://openalex.org/W2092338449', 'https://openalex.org/W2093668438', 'https://openalex.org/W2094479838', 'https://openalex.org/W2104536170', 'https://openalex.org/W2104994285', 'https://openalex.org/W2105851216', 'https://openalex.org/W2107230480', 'https://openalex.org/W2112488366', 'https://openalex.org/W2116479507', 'https://openalex.org/W2121966104', 'https://openalex.org/W2124045323', 'https://openalex.org/W2127061791', 'https://openalex.org/W2132653427', 'https://openalex.org/W2138103294', 'https://openalex.org/W2140717014', 'https://openalex.org/W2141634848', 'https://openalex.org/W2149231882', 'https://openalex.org/W2150109115', 'https://openalex.org/W2151819406', 'https://openalex.org/W2151858671', 'https://openalex.org/W2153349989', 'https://openalex.org/W2154475799', 'https://openalex.org/W2154649008', 'https://openalex.org/W2154913782', 'https://openalex.org/W2156300176', 'https://openalex.org/W2158350205', 'https://openalex.org/W2158988413', 'https://openalex.org/W2159529647', 'https://openalex.org/W2159876084', 'https://openalex.org/W2161367731', 'https://openalex.org/W2162310257', 'https://openalex.org/W2165499430', 'https://openalex.org/W2165901553', 'https://openalex.org/W2167150894', 'https://openalex.org/W2203780822', 'https://openalex.org/W2212406399', 'https://openalex.org/W2235178287', 'https://openalex.org/W2249464159', 'https://openalex.org/W2278038000', 'https://openalex.org/W2278163172', 'https://openalex.org/W2298030758', 'https://openalex.org/W2299388482', 'https://openalex.org/W2308736914', 'https://openalex.org/W2313890271', 'https://openalex.org/W2318666297', 'https://openalex.org/W2322708715', 'https://openalex.org/W2411541314', 'https://openalex.org/W2441542994', 'https://openalex.org/W2464112691', 'https://openalex.org/W2465474420', 'https://openalex.org/W2468606323', 'https://openalex.org/W2509145907', 'https://openalex.org/W2554576573', 'https://openalex.org/W2555236069', 'https://openalex.org/W2557708678', 'https://openalex.org/W4234689925', 'https://openalex.org/W4244030894'], 'related_works': ['https://openalex.org/W99754648', 'https://openalex.org/W2161378572', 'https://openalex.org/W2138181980', 'https://openalex.org/W2124216175', 'https://openalex.org/W2123942529', 'https://openalex.org/W2122235477', 'https://openalex.org/W2052347607', 'https://openalex.org/W2030972230', 'https://openalex.org/W1975642381', 'https://openalex.org/W113080609'], 'abstract_inverted_index': {'Soluble': [0], 'N-ethylmaleimide-sensitive': [1], 'factor': [2], 'attachment': [3], 'protein': [4], 'receptors': [5], '(SNAREs)': [6], 'are': [7, 220], 'universal': [8], 'molecular': [9], 'engines': [10], 'that': [11, 76, 130, 168], 'drive': [12, 207], 'membrane': [13, 39, 208], 'fusion.': [14, 71, 209], 'Particularly,': [15], 'synaptic': [16, 29, 169], 'SNAREs': [17, 42, 77, 170], 'mediate': [18], 'fast': [19], 'calcium-triggered': [20], 'fusion': [21], 'of': [22, 33, 99, 114, 153, 198, 216], 'neurotransmitter-containing': [23], 'vesicles': [24], 'with': [25, 176], 'plasma': [26], 'membranes': [27, 47, 86], 'for': [28, 70, 237], 'transmission,': [30], 'the': [31, 63, 67, 84, 110, 120, 147, 199, 203, 212, 217, 229], 'basis': [32], 'all': [34], 'thought': [35], 'and': [36, 51, 89, 112, 117, 138, 151, 156, 190, 194, 202, 214, 233], 'action.': [37], 'During': [38], 'fusion,': [40], 'complementary': [41], 'located': [43], 'on': [44, 141], 'two': [45, 85], 'apposed': [46], '(often': [48], 'called': [49], 't-': [50], 'v-SNAREs)': [52], 'join': [53], 'together': [54], 'to': [55, 65, 82, 93, 108, 118, 134], 'assemble': [56, 171], 'into': [57, 87], 'a': [58, 80, 96, 186], 'parallel': [59], 'four-helix': [60], 'bundle,': [61], 'releasing': [62], 'energy': [64, 68], 'overcome': [66], 'barrier': [69], 'A': [72], 'long-standing': [73], 'hypothesis': [74, 103, 232], 'suggests': [75], 'act': [78], 'like': [79], 'zipper': [81], 'draw': [83], 'proximity': [88], 'thereby': [90], 'force': [91], 'them': [92], 'fuse.': [94], 'However,': [95], 'quantitative': [97], 'test': [98], 'this': [100, 162], 'SNARE': [101, 115, 136, 158, 184, 192, 224, 230, 238], 'zippering': [102, 197, 231], 'was': [104], 'hindered': [105], 'by': [106, 222, 241], 'difficulties': [107], 'determine': [109], 'energetics': [111], 'kinetics': [113, 213], 'assembly': [116, 137, 219, 239], 'identify': [119], 'relevant': [121], 'folding': [122, 148], 'intermediates.': [123], 'Here,': [124], 'we': [125], 'first': [126], 'review': [127], 'different': [128, 177], 'approaches': [129], 'have': [131], 'been': [132], 'applied': [133], 'study': [135], 'then': [139], 'focus': [140], 'high-resolution': [142], 'optical': [143], 'tweezers.': [144], 'We': [145], 'summarize': [146], 'energies,': [149], 'kinetics,': [150], 'pathways': [152], 'both': [154], 'wild-type': [155], 'mutant': [157], 'complexes': [159], 'derived': [160], 'from': [161], 'new': [163, 235], 'approach.': [164], 'These': [165, 226], 'results': [166], 'show': [167], 'in': [172], 'four': [173], 'distinct': [174], 'stages': [175], 'functions:': [178], 'slow': [179], 'N-terminal': [180], 'domain': [181, 188, 201, 205], 'association': [182], 'initiates': [183], 'assembly;': [185, 193], 'middle': [187], 'suspends': [189], 'controls': [191], 'rapid': [195], 'sequential': [196], 'C-terminal': [200], 'linker': [204], 'directly': [206], 'In': [210], 'addition,': [211], 'pathway': [215], 'stagewise': [218], 'shared': [221], 'other': [223, 242], 'complexes.': [225], 'measurements': [227], 'prove': [228], 'suggest': [234], 'mechanisms': [236], 'regulated': [240], 'proteins.': [243]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2574505563', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 15}, {'year': 2022, 'cited_by_count': 12}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 4}], 'updated_date': '2024-12-15T14:12:35.290313', 'created_date': '2017-01-26'}