Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2571883939', 'doi': 'https://doi.org/10.1007/s10517-017-3619-z', 'title': 'Detection of Rare Mutations by Routine Analysis of KRAS, NRAS, and BRAF Oncogenes', 'display_name': 'Detection of Rare Mutations by Routine Analysis of KRAS, NRAS, and BRAF Oncogenes', 'publication_year': 2017, 'publication_date': '2017-01-01', 'ids': {'openalex': 'https://openalex.org/W2571883939', 'doi': 'https://doi.org/10.1007/s10517-017-3619-z', 'mag': '2571883939', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28091917'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s10517-017-3619-z', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S141734485', 'display_name': 'Bulletin of Experimental Biology and Medicine', 'issn_l': '0007-4888', 'issn': ['0007-4888', '1573-8221'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5005278712', 'display_name': 'Д. С. Михайленко', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117042', 'display_name': 'Ministry of Health of the Russian Federation', 'ror': 'https://ror.org/01p8ehb87', 'country_code': 'RU', 'type': 'government', 'lineage': ['https://openalex.org/I4210117042']}, {'id': 'https://openalex.org/I4210126689', 'display_name': 'Research Centre for Medical Genetics', 'ror': 'https://ror.org/03dhz7247', 'country_code': 'RU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1313323035', 'https://openalex.org/I4210110862', 'https://openalex.org/I4210126689']}], 'countries': ['RU'], 'is_corresponding': True, 'raw_author_name': 'D. S. Mikhailenko', 'raw_affiliation_strings': ['N. A. Lopatkin Research Institute of Urology and Intervention Radiology, Affiliated Department of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia', 'Research Center for Medical Genetics, Moscow, Russia'], 'affiliations': [{'raw_affiliation_string': 'N. A. Lopatkin Research Institute of Urology and Intervention Radiology, Affiliated Department of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia', 'institution_ids': ['https://openalex.org/I4210117042']}, {'raw_affiliation_string': 'Research Center for Medical Genetics, Moscow, Russia', 'institution_ids': ['https://openalex.org/I4210126689']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068494176', 'display_name': 'Г. Д. Ефремов', 'orcid': 'https://orcid.org/0000-0002-8822-8119'}, 'institutions': [{'id': 'https://openalex.org/I4210117042', 'display_name': 'Ministry of Health of the Russian Federation', 'ror': 'https://ror.org/01p8ehb87', 'country_code': 'RU', 'type': 'government', 'lineage': ['https://openalex.org/I4210117042']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'G. D. Efremov', 'raw_affiliation_strings': ['N. A. Lopatkin Research Institute of Urology and Intervention Radiology, Affiliated Department of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia'], 'affiliations': [{'raw_affiliation_string': 'N. A. Lopatkin Research Institute of Urology and Intervention Radiology, Affiliated Department of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia', 'institution_ids': ['https://openalex.org/I4210117042']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070066626', 'display_name': 'N. Yu. Safronova', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117042', 'display_name': 'Ministry of Health of the Russian Federation', 'ror': 'https://ror.org/01p8ehb87', 'country_code': 'RU', 'type': 'government', 'lineage': ['https://openalex.org/I4210117042']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'N. Yu. Safronova', 'raw_affiliation_strings': ['N. A. Lopatkin Research Institute of Urology and Intervention Radiology, Affiliated Department of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia'], 'affiliations': [{'raw_affiliation_string': 'N. A. Lopatkin Research Institute of Urology and Intervention Radiology, Affiliated Department of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia', 'institution_ids': ['https://openalex.org/I4210117042']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055199063', 'display_name': 'V. V. Strelnikov', 'orcid': 'https://orcid.org/0000-0001-9283-902X'}, 'institutions': [{'id': 'https://openalex.org/I4210126689', 'display_name': 'Research Centre for Medical Genetics', 'ror': 'https://ror.org/03dhz7247', 'country_code': 'RU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1313323035', 'https://openalex.org/I4210110862', 'https://openalex.org/I4210126689']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'V. V. Strelnikov', 'raw_affiliation_strings': ['Research Center for Medical Genetics, Moscow, Russia'], 'affiliations': [{'raw_affiliation_string': 'Research Center for Medical Genetics, Moscow, Russia', 'institution_ids': ['https://openalex.org/I4210126689']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5019977496', 'display_name': 'B. Yа. Alekseev', 'orcid': 'https://orcid.org/0000-0002-3398-4128'}, 'institutions': [{'id': 'https://openalex.org/I4210117042', 'display_name': 'Ministry of Health of the Russian Federation', 'ror': 'https://ror.org/01p8ehb87', 'country_code': 'RU', 'type': 'government', 'lineage': ['https://openalex.org/I4210117042']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'B. Ya. Alekseev', 'raw_affiliation_strings': ['N. A. Lopatkin Research Institute of Urology and Intervention Radiology, Affiliated Department of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia'], 'affiliations': [{'raw_affiliation_string': 'N. A. Lopatkin Research Institute of Urology and Intervention Radiology, Affiliated Department of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia', 'institution_ids': ['https://openalex.org/I4210117042']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5005278712'], 'corresponding_institution_ids': ['https://openalex.org/I4210117042', 'https://openalex.org/I4210126689'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.134, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.477182, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 64, 'max': 71}, 'biblio': {'volume': '162', 'issue': '3', 'first_page': '375', 'last_page': '378'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11067', 'display_name': 'Advancements in Colorectal Cancer Research', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11067', 'display_name': 'Advancements in Colorectal Cancer Research', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11533', 'display_name': 'Mammalian MAP Kinase Signaling Pathways', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11287', 'display_name': 'Genomic Landscape of Cancer and Mutational Signatures', 'score': 0.9934, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sanger-sequencing', 'display_name': 'Sanger sequencing', 'score': 0.86148846}, {'id': 'https://openalex.org/keywords/concordance', 'display_name': 'Concordance', 'score': 0.6781706}, {'id': 'https://openalex.org/keywords/v600e', 'display_name': 'V600E', 'score': 0.67004955}, {'id': 'https://openalex.org/keywords/kras-mutations', 'display_name': 'KRAS Mutations', 'score': 0.615096}, {'id': 'https://openalex.org/keywords/mutation-testing', 'display_name': 'Mutation testing', 'score': 0.60615975}, {'id': 'https://openalex.org/keywords/braf-mutations', 'display_name': 'BRAF Mutations', 'score': 0.559564}, {'id': 'https://openalex.org/keywords/braf-gene', 'display_name': 'BRAF gene', 'score': 0.559138}, {'id': 'https://openalex.org/keywords/cancer-genomics', 'display_name': 'Cancer Genomics', 'score': 0.500651}, {'id': 'https://openalex.org/keywords/ion-semiconductor-sequencing', 'display_name': 'Ion semiconductor sequencing', 'score': 0.47889033}, {'id': 'https://openalex.org/keywords/high-resolution-melt', 'display_name': 'High Resolution Melt', 'score': 0.4512599}], 'concepts': [{'id': 'https://openalex.org/C21790070', 'wikidata': 'https://www.wikidata.org/wiki/Q18030215', 'display_name': 'Neuroblastoma RAS viral oncogene homolog', 'level': 5, 'score': 0.9578548}, {'id': 'https://openalex.org/C2781187634', 'wikidata': 'https://www.wikidata.org/wiki/Q20969980', 'display_name': 'KRAS', 'level': 4, 'score': 0.8744024}, {'id': 'https://openalex.org/C76818968', 'wikidata': 'https://www.wikidata.org/wiki/Q181940', 'display_name': 'Sanger sequencing', 'level': 4, 'score': 0.86148846}, {'id': 'https://openalex.org/C160798450', 'wikidata': 'https://www.wikidata.org/wiki/Q4230870', 'display_name': 'Concordance', 'level': 2, 'score': 0.6781706}, {'id': 'https://openalex.org/C2776470698', 'wikidata': 'https://www.wikidata.org/wiki/Q21851559', 'display_name': 'V600E', 'level': 4, 'score': 0.67004955}, {'id': 'https://openalex.org/C163565370', 'wikidata': 'https://www.wikidata.org/wiki/Q4308623', 'display_name': 'Mutation testing', 'level': 4, 'score': 0.60615975}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.5660089}, {'id': 'https://openalex.org/C2777658100', 'wikidata': 'https://www.wikidata.org/wiki/Q180614', 'display_name': 'Melanoma', 'level': 2, 'score': 0.5223944}, {'id': 'https://openalex.org/C51679486', 'wikidata': 'https://www.wikidata.org/wiki/Q380546', 'display_name': 'DNA sequencing', 'level': 3, 'score': 0.5156173}, {'id': 'https://openalex.org/C164928082', 'wikidata': 'https://www.wikidata.org/wiki/Q6063435', 'display_name': 'Ion semiconductor sequencing', 'level': 4, 'score': 0.47889033}, {'id': 'https://openalex.org/C34372108', 'wikidata': 'https://www.wikidata.org/wiki/Q5756291', 'display_name': 'High Resolution Melt', 'level': 4, 'score': 0.4512599}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.44521245}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.40740526}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4070063}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.3706044}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.35454503}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.34495765}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.33881104}, {'id': 'https://openalex.org/C49105822', 'wikidata': 'https://www.wikidata.org/wiki/Q176996', 'display_name': 'Polymerase chain reaction', 'level': 3, 'score': 0.28668696}], 'mesh': [{'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': True}, {'descriptor_ui': 'D020558', 'descriptor_name': 'GTP Phosphohydrolases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': True}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D048493', 'descriptor_name': 'Proto-Oncogene Proteins B-raf', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D016283', 'descriptor_name': 'Proto-Oncogene Proteins p21(ras)', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D012878', 'descriptor_name': 'Skin Neoplasms', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': True}, {'descriptor_ui': 'D000465', 'descriptor_name': 'Algorithms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004252', 'descriptor_name': 'DNA Mutational Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005091', 'descriptor_name': 'Exons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020558', 'descriptor_name': 'GTP Phosphohydrolases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007438', 'descriptor_name': 'Introns', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016612', 'descriptor_name': 'Paraffin Embedding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048493', 'descriptor_name': 'Proto-Oncogene Proteins B-raf', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016283', 'descriptor_name': 'Proto-Oncogene Proteins p21(ras)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060888', 'descriptor_name': 'Real-Time Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012878', 'descriptor_name': 'Skin Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012878', 'descriptor_name': 'Skin Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012878', 'descriptor_name': 'Skin Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D016707', 'descriptor_name': 'Tissue Fixation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s10517-017-3619-z', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S141734485', 'display_name': 'Bulletin of Experimental Biology and Medicine', 'issn_l': '0007-4888', 'issn': ['0007-4888', '1573-8221'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28091917', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 13, 'referenced_works': ['https://openalex.org/W1523025497', 'https://openalex.org/W1757252422', 'https://openalex.org/W1758647832', 'https://openalex.org/W1973031450', 'https://openalex.org/W2025130458', 'https://openalex.org/W2050866238', 'https://openalex.org/W2088756930', 'https://openalex.org/W2098462873', 'https://openalex.org/W2103789431', 'https://openalex.org/W2131059542', 'https://openalex.org/W2132992059', 'https://openalex.org/W2144303933', 'https://openalex.org/W2404498717'], 'related_works': ['https://openalex.org/W3040170206', 'https://openalex.org/W3018596499', 'https://openalex.org/W2965864052', 'https://openalex.org/W2602146182', 'https://openalex.org/W2571883939', 'https://openalex.org/W2478901347', 'https://openalex.org/W2102151452', 'https://openalex.org/W2043145553', 'https://openalex.org/W1520577253', 'https://openalex.org/W1499291662'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2571883939', 'counts_by_year': [{'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-09-24T20:41:17.568160', 'created_date': '2017-01-26'}