Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2570496805', 'doi': 'https://doi.org/10.1016/s2213-8587(16)30320-5', 'title': 'Key European guidelines for the diagnosis and management of patients with phenylketonuria', 'display_name': 'Key European guidelines for the diagnosis and management of patients with phenylketonuria', 'publication_year': 2017, 'publication_date': '2017-09-01', 'ids': {'openalex': 'https://openalex.org/W2570496805', 'doi': 'https://doi.org/10.1016/s2213-8587(16)30320-5', 'mag': '2570496805', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28082082'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s2213-8587(16)30320-5', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2529869117', 'display_name': 'The Lancet Diabetes & Endocrinology', 'issn_l': '2213-8587', 'issn': ['2213-8587', '2213-8595'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.spdm.org.pt/media/1373/pku-guidelines_2017.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5016946363', 'display_name': 'Francjan J. van Spronsen', 'orcid': 'https://orcid.org/0000-0002-3773-1929'}, 'institutions': [{'id': 'https://openalex.org/I1334415907', 'display_name': 'University Medical Center Groningen', 'ror': 'https://ror.org/03cv38k47', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334415907']}, {'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}], 'countries': ['NL'], 'is_corresponding': True, 'raw_author_name': 'Francjan J van Spronsen', 'raw_affiliation_strings': ["Division of Metabolic Diseases, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands"], 'affiliations': [{'raw_affiliation_string': "Division of Metabolic Diseases, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands", 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058575073', 'display_name': 'Annemiek M. J. van Wegberg', 'orcid': 'https://orcid.org/0000-0002-9402-4833'}, 'institutions': [{'id': 'https://openalex.org/I1334415907', 'display_name': 'University Medical Center Groningen', 'ror': 'https://ror.org/03cv38k47', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334415907']}, {'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Annemiek MJ van Wegberg', 'raw_affiliation_strings': ["Division of Metabolic Diseases, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands"], 'affiliations': [{'raw_affiliation_string': "Division of Metabolic Diseases, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands", 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086561073', 'display_name': 'Kirsten Ahring', 'orcid': 'https://orcid.org/0000-0002-6518-2226'}, 'institutions': [{'id': 'https://openalex.org/I2802567020', 'display_name': 'Copenhagen University Hospital', 'ror': 'https://ror.org/05bpbnx46', 'country_code': 'DK', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802567020']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Kirsten Ahring', 'raw_affiliation_strings': ['Department of PKU, Kennedy Centre, Copenhagen University Hospital, Glostrup, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of PKU, Kennedy Centre, Copenhagen University Hospital, Glostrup, Denmark', 'institution_ids': ['https://openalex.org/I2802567020']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055807322', 'display_name': 'Luis Peña Quintana', 'orcid': 'https://orcid.org/0000-0001-6052-5894'}, 'institutions': [{'id': 'https://openalex.org/I4210161852', 'display_name': 'Hospital Universitario Ramón y Cajal', 'ror': 'https://ror.org/050eq1942', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139293', 'https://openalex.org/I4210161852']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Amaya Bélanger-Quintana', 'raw_affiliation_strings': ['Metabolic Diseases Unit, Department of Pediatrics, Hospital Ramon y Cajal, Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Metabolic Diseases Unit, Department of Pediatrics, Hospital Ramon y Cajal, Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210161852']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027259737', 'display_name': 'Nenad Blau', 'orcid': 'https://orcid.org/0000-0003-4347-3230'}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I2802164966', 'display_name': 'University Hospital Heidelberg', 'ror': 'https://ror.org/013czdx64', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802164966']}, {'id': 'https://openalex.org/I4210128593', 'display_name': "University Children's Hospital Zurich", 'ror': 'https://ror.org/035vb3h42', 'country_code': 'CH', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128593']}], 'countries': ['CH', 'DE'], 'is_corresponding': False, 'raw_author_name': 'Nenad Blau', 'raw_affiliation_strings': ["University Children's Hospital Zurich, Zurich, Switzerland", "University Children's Hospital, Dietmar-Hoppe Metabolic Centre, Heidelberg, Germany"], 'affiliations': [{'raw_affiliation_string': "University Children's Hospital, Dietmar-Hoppe Metabolic Centre, Heidelberg, Germany", 'institution_ids': ['https://openalex.org/I223822909', 'https://openalex.org/I2802164966']}, {'raw_affiliation_string': "University Children's Hospital Zurich, Zurich, Switzerland", 'institution_ids': ['https://openalex.org/I4210128593']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002973087', 'display_name': 'Annet M. Bosch', 'orcid': 'https://orcid.org/0000-0001-5027-5916'}, 'institutions': [{'id': 'https://openalex.org/I887064364', 'display_name': 'University of Amsterdam', 'ror': 'https://ror.org/04dkp9463', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I887064364']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Annet M Bosch', 'raw_affiliation_strings': ['Department of Paediatrics, Division of Metabolic Disorders, Academic Medical Centre, University Hospital of Amsterdam, Amsterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Paediatrics, Division of Metabolic Disorders, Academic Medical Centre, University Hospital of Amsterdam, Amsterdam, Netherlands', 'institution_ids': ['https://openalex.org/I887064364']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052556691', 'display_name': 'Alberto Burlina', 'orcid': 'https://orcid.org/0000-0001-7724-137X'}, 'institutions': [{'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Alberto Burlina', 'raw_affiliation_strings': ['Division of Inherited Metabolic Diseases, Department of Paediatrics, University Hospital of Padova, Padova, Italy'], 'affiliations': [{'raw_affiliation_string': 'Division of Inherited Metabolic Diseases, Department of Paediatrics, University Hospital of Padova, Padova, Italy', 'institution_ids': ['https://openalex.org/I138689650']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103457176', 'display_name': 'Jaime Campistol', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1307323311', 'display_name': 'Hospital Sant Joan de Déu Barcelona', 'ror': 'https://ror.org/001jx2139', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1307323311']}, {'id': 'https://openalex.org/I71999127', 'display_name': 'Universitat de Barcelona', 'ror': 'https://ror.org/021018s57', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I71999127']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Jaime Campistol', 'raw_affiliation_strings': ['Neuropaediatrics Department, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Neuropaediatrics Department, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain', 'institution_ids': ['https://openalex.org/I1307323311', 'https://openalex.org/I71999127']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101944755', 'display_name': 'François Feillet', 'orcid': 'https://orcid.org/0000-0002-8717-469X'}, 'institutions': [{'id': 'https://openalex.org/I4210105722', 'display_name': "Hôpital d'Enfants", 'ror': 'https://ror.org/01gvaa828', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105722']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Francois Feillet', 'raw_affiliation_strings': ["Department of Pediatrics, Hôpital d'Enfants Brabois, CHU Nancy, Vandoeuvre les Nancy, France"], 'affiliations': [{'raw_affiliation_string': "Department of Pediatrics, Hôpital d'Enfants Brabois, CHU Nancy, Vandoeuvre les Nancy, France", 'institution_ids': ['https://openalex.org/I4210105722']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001311498', 'display_name': 'Maria Giżewska', 'orcid': 'https://orcid.org/0000-0001-8433-0864'}, 'institutions': [{'id': 'https://openalex.org/I79833322', 'display_name': 'Pomeranian Medical University', 'ror': 'https://ror.org/01v1rak05', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I79833322']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Maria Giżewska', 'raw_affiliation_strings': ['Department of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases and Cardiology of the Developmental Age, Pomeranian Medical University, Szczecin, Poland'], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases and Cardiology of the Developmental Age, Pomeranian Medical University, Szczecin, Poland', 'institution_ids': ['https://openalex.org/I79833322']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010218352', 'display_name': 'Stephan C. J. Huijbregts', 'orcid': 'https://orcid.org/0000-0002-7209-1912'}, 'institutions': [{'id': 'https://openalex.org/I121797337', 'display_name': 'Leiden University', 'ror': 'https://ror.org/027bh9e22', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I121797337']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Stephan C Huijbregts', 'raw_affiliation_strings': ['Department of Clinical Child and Adolescent Studies–Neurodevelopmental Disorders, Faculty of Social Sciences, Leiden University, Leiden, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Child and Adolescent Studies–Neurodevelopmental Disorders, Faculty of Social Sciences, Leiden University, Leiden, Netherlands', 'institution_ids': ['https://openalex.org/I121797337']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087887507', 'display_name': 'Shauna Kearney', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100347', 'display_name': "Birmingham Children's Hospital", 'ror': 'https://ror.org/017k80q27', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100347', 'https://openalex.org/I4210155225']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Shauna Kearney', 'raw_affiliation_strings': ["Clinical Psychology Department, Birmingham Children's Hospital, Birmingham, UK"], 'affiliations': [{'raw_affiliation_string': "Clinical Psychology Department, Birmingham Children's Hospital, Birmingham, UK", 'institution_ids': ['https://openalex.org/I4210100347']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041511891', 'display_name': 'Vincenzo Leuzzi', 'orcid': 'https://orcid.org/0000-0002-2314-6139'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Vincenzo Leuzzi', 'raw_affiliation_strings': ['Department of Pediatrics, Child Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatrics, Child Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071681341', 'display_name': 'F. Maillot', 'orcid': 'https://orcid.org/0000-0002-1979-5769'}, 'institutions': [{'id': 'https://openalex.org/I110017253', 'display_name': 'Université de Tours', 'ror': 'https://ror.org/02wwzvj46', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I110017253']}, {'id': 'https://openalex.org/I4210095477', 'display_name': 'Centre Hospitalier Universitaire de Tours', 'ror': 'https://ror.org/00jpq0w62', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210095477']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Francois Maillot', 'raw_affiliation_strings': ['Internal Medicine Service, CHRU de Tours, François Rabelais University, Tours, France'], 'affiliations': [{'raw_affiliation_string': 'Internal Medicine Service, CHRU de Tours, François Rabelais University, Tours, France', 'institution_ids': ['https://openalex.org/I110017253', 'https://openalex.org/I4210095477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006650621', 'display_name': 'Ania C. Muntau', 'orcid': 'https://orcid.org/0000-0002-2900-8378'}, 'institutions': [{'id': 'https://openalex.org/I4210108711', 'display_name': 'University Medical Center Hamburg-Eppendorf', 'ror': 'https://ror.org/01zgy1s35', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I159176309', 'https://openalex.org/I4210108711']}, {'id': 'https://openalex.org/I159176309', 'display_name': 'Universität Hamburg', 'ror': 'https://ror.org/00g30e956', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I159176309']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ania C Muntau', 'raw_affiliation_strings': ["University Children's Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"], 'affiliations': [{'raw_affiliation_string': "University Children's Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany", 'institution_ids': ['https://openalex.org/I4210108711', 'https://openalex.org/I159176309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085061086', 'display_name': 'F. K. Trefz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802164966', 'display_name': 'University Hospital Heidelberg', 'ror': 'https://ror.org/013czdx64', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802164966']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Fritz K Trefz', 'raw_affiliation_strings': ["University Children's Hospital, Dietmar-Hoppe Metabolic Centre, Heidelberg, Germany"], 'affiliations': [{'raw_affiliation_string': "University Children's Hospital, Dietmar-Hoppe Metabolic Centre, Heidelberg, Germany", 'institution_ids': ['https://openalex.org/I2802164966', 'https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103510526', 'display_name': 'Margreet van Rijn', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1334415907', 'display_name': 'University Medical Center Groningen', 'ror': 'https://ror.org/03cv38k47', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334415907']}, {'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Margreet van Rijn', 'raw_affiliation_strings': ["Department of Dietetics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands"], 'affiliations': [{'raw_affiliation_string': "Department of Dietetics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands", 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011228847', 'display_name': 'John H. Walter', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2799725268', 'display_name': 'Manchester Academic Health Science Centre', 'ror': 'https://ror.org/04rrkhs81', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799725268']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'John H Walter', 'raw_affiliation_strings': ['Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK'], 'affiliations': [{'raw_affiliation_string': 'Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK', 'institution_ids': ['https://openalex.org/I2799725268']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048169226', 'display_name': 'Anita MacDonald', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100347', 'display_name': "Birmingham Children's Hospital", 'ror': 'https://ror.org/017k80q27', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100347', 'https://openalex.org/I4210155225']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Anita MacDonald', 'raw_affiliation_strings': ["Dietetic Department, Birmingham Children's Hospital, Birmingham, UK"], 'affiliations': [{'raw_affiliation_string': "Dietetic Department, Birmingham Children's Hospital, Birmingham, UK", 'institution_ids': ['https://openalex.org/I4210100347']}]}], 'countries_distinct_count': 9, 'institutions_distinct_count': 21, 'corresponding_author_ids': ['https://openalex.org/A5016946363'], 'corresponding_institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384'], 'apc_list': {'value': 6300, 'currency': 'USD', 'value_usd': 6300, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 6.91, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 323, 'citation_normalized_percentile': {'value': 0.990244, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '5', 'issue': '9', 'first_page': '743', 'last_page': '756'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11027', 'display_name': 'Metabolic Disorders and Biochemical Genetics', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11027', 'display_name': 'Metabolic Disorders and Biochemical Genetics', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12267', 'display_name': 'Effects of Ketogenic Diet on Health', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Dynamics and Reactive Oxygen Species Regulation', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/phenylketonuria', 'display_name': 'Phenylketonuria', 'score': 0.558868}, {'id': 'https://openalex.org/keywords/epilepsy-treatment', 'display_name': 'Epilepsy Treatment', 'score': 0.54329}, {'id': 'https://openalex.org/keywords/hyperphenylalaninemia', 'display_name': 'Hyperphenylalaninemia', 'score': 0.4942863}, {'id': 'https://openalex.org/keywords/phenylketonurias', 'display_name': 'Phenylketonurias', 'score': 0.49057359}, {'id': 'https://openalex.org/keywords/dietary-management', 'display_name': 'Dietary management', 'score': 0.45897928}, {'id': 'https://openalex.org/keywords/phenylalanine-hydroxylase', 'display_name': 'Phenylalanine hydroxylase', 'score': 0.45249507}, {'id': 'https://openalex.org/keywords/blood-concentration', 'display_name': 'Blood concentration', 'score': 0.44538018}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.92279613}, {'id': 'https://openalex.org/C2776145790', 'wikidata': 'https://www.wikidata.org/wiki/Q419808', 'display_name': 'Tetrahydrobiopterin', 'level': 4, 'score': 0.6008333}, {'id': 'https://openalex.org/C187212893', 'wikidata': 'https://www.wikidata.org/wiki/Q123028', 'display_name': 'Pediatrics', 'level': 1, 'score': 0.56212205}, {'id': 'https://openalex.org/C2777431362', 'wikidata': 'https://www.wikidata.org/wiki/Q170545', 'display_name': 'Phenylalanine', 'level': 3, 'score': 0.49506178}, {'id': 'https://openalex.org/C2780968477', 'wikidata': 'https://www.wikidata.org/wiki/Q5898279', 'display_name': 'Hyperphenylalaninemia', 'level': 4, 'score': 0.4942863}, {'id': 'https://openalex.org/C2908963387', 'wikidata': 'https://www.wikidata.org/wiki/Q194041', 'display_name': 'Phenylketonurias', 'level': 4, 'score': 0.49057359}, {'id': 'https://openalex.org/C2779234561', 'wikidata': 'https://www.wikidata.org/wiki/Q11995', 'display_name': 'Pregnancy', 'level': 2, 'score': 0.48307493}, {'id': 'https://openalex.org/C2776263783', 'wikidata': 'https://www.wikidata.org/wiki/Q5275067', 'display_name': 'Dietary management', 'level': 2, 'score': 0.45897928}, {'id': 'https://openalex.org/C207009774', 'wikidata': 'https://www.wikidata.org/wiki/Q420604', 'display_name': 'Phenylalanine hydroxylase', 'level': 4, 'score': 0.45249507}, {'id': 'https://openalex.org/C3020580990', 'wikidata': 'https://www.wikidata.org/wiki/Q3918988', 'display_name': 'Blood concentration', 'level': 2, 'score': 0.44538018}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.36941928}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C2777622882', 'wikidata': 'https://www.wikidata.org/wiki/Q417619', 'display_name': 'Nitric oxide synthase', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D010661', 'descriptor_name': 'Phenylketonurias', 'qualifier_ui': 'Q000178', 'qualifier_name': 'diet therapy', 'is_major_topic': True}, {'descriptor_ui': 'D010661', 'descriptor_name': 'Phenylketonurias', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': True}, {'descriptor_ui': 'D001708', 'descriptor_name': 'Biopterins', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D001708', 'descriptor_name': 'Biopterins', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D001708', 'descriptor_name': 'Biopterins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003697', 'descriptor_name': 'Delphi Technique', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019468', 'descriptor_name': 'Disease Management', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005060', 'descriptor_name': 'Europe', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010649', 'descriptor_name': 'Phenylalanine', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D010649', 'descriptor_name': 'Phenylalanine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010661', 'descriptor_name': 'Phenylketonurias', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D010661', 'descriptor_name': 'Phenylketonurias', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s2213-8587(16)30320-5', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2529869117', 'display_name': 'The Lancet Diabetes & Endocrinology', 'issn_l': '2213-8587', 'issn': ['2213-8587', '2213-8595'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://www.spdm.org.pt/media/1373/pku-guidelines_2017.pdf', 'pdf_url': 'http://www.spdm.org.pt/media/1373/pku-guidelines_2017.pdf', 'source': None, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28082082', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'http://www.spdm.org.pt/media/1373/pku-guidelines_2017.pdf', 'pdf_url': 'http://www.spdm.org.pt/media/1373/pku-guidelines_2017.pdf', 'source': None, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.68, 'display_name': 'Zero hunger', 'id': 'https://metadata.un.org/sdg/2'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 104, 'referenced_works': ['https://openalex.org/W1502430027', 'https://openalex.org/W1511892464', 'https://openalex.org/W1519335762', 'https://openalex.org/W1548203477', 'https://openalex.org/W1649326348', 'https://openalex.org/W1831367434', 'https://openalex.org/W1842911909', 'https://openalex.org/W1851031265', 'https://openalex.org/W1885051646', 'https://openalex.org/W1964326423', 'https://openalex.org/W1964471120', 'https://openalex.org/W1967701933', 'https://openalex.org/W1976337547', 'https://openalex.org/W1979831854', 'https://openalex.org/W1989323794', 'https://openalex.org/W1990289924', 'https://openalex.org/W1990591430', 'https://openalex.org/W1991239301', 'https://openalex.org/W1991454288', 'https://openalex.org/W1992459813', 'https://openalex.org/W1995375488', 'https://openalex.org/W1995649373', 'https://openalex.org/W1997792861', 'https://openalex.org/W1998138901', 'https://openalex.org/W2001072757', 'https://openalex.org/W2002640982', 'https://openalex.org/W2003794037', 'https://openalex.org/W2005300185', 'https://openalex.org/W2005813935', 'https://openalex.org/W2006694188', 'https://openalex.org/W2009059536', 'https://openalex.org/W2009781339', 'https://openalex.org/W2013134165', 'https://openalex.org/W2013362605', 'https://openalex.org/W2014883692', 'https://openalex.org/W2018628343', 'https://openalex.org/W2019843119', 'https://openalex.org/W2029330831', 'https://openalex.org/W2032614914', 'https://openalex.org/W2035554753', 'https://openalex.org/W2036064499', 'https://openalex.org/W2038837313', 'https://openalex.org/W2039346195', 'https://openalex.org/W2048200506', 'https://openalex.org/W2051842120', 'https://openalex.org/W2052394711', 'https://openalex.org/W2053108937', 'https://openalex.org/W2053248521', 'https://openalex.org/W2054755825', 'https://openalex.org/W2055395216', 'https://openalex.org/W2056351997', 'https://openalex.org/W2063631591', 'https://openalex.org/W2067026728', 'https://openalex.org/W2069270123', 'https://openalex.org/W2070682452', 'https://openalex.org/W2073216511', 'https://openalex.org/W2073714321', 'https://openalex.org/W2076571723', 'https://openalex.org/W2077989867', 'https://openalex.org/W2078856645', 'https://openalex.org/W2086428720', 'https://openalex.org/W2089845234', 'https://openalex.org/W2089882814', 'https://openalex.org/W2090555470', 'https://openalex.org/W2092022059', 'https://openalex.org/W2093350983', 'https://openalex.org/W2094632091', 'https://openalex.org/W2099237952', 'https://openalex.org/W2099577231', 'https://openalex.org/W2101011631', 'https://openalex.org/W2110283085', 'https://openalex.org/W2112600616', 'https://openalex.org/W2114313193', 'https://openalex.org/W2114872570', 'https://openalex.org/W2118895261', 'https://openalex.org/W2119637378', 'https://openalex.org/W2121652536', 'https://openalex.org/W2124862267', 'https://openalex.org/W2129725593', 'https://openalex.org/W2133545438', 'https://openalex.org/W2133823631', 'https://openalex.org/W2136126674', 'https://openalex.org/W2138122824', 'https://openalex.org/W2138340059', 'https://openalex.org/W2141996787', 'https://openalex.org/W2148355987', 'https://openalex.org/W2149285529', 'https://openalex.org/W2149399554', 'https://openalex.org/W2151598366', 'https://openalex.org/W2152642740', 'https://openalex.org/W2152804478', 'https://openalex.org/W2156249289', 'https://openalex.org/W2159138409', 'https://openalex.org/W2160613309', 'https://openalex.org/W2162050340', 'https://openalex.org/W2164112661', 'https://openalex.org/W2167394380', 'https://openalex.org/W2170491580', 'https://openalex.org/W2171539030', 'https://openalex.org/W2247750189', 'https://openalex.org/W2327762977', 'https://openalex.org/W2993398065', 'https://openalex.org/W31760838', 'https://openalex.org/W4249791806'], 'related_works': ['https://openalex.org/W2755267419', 'https://openalex.org/W2736128066', 'https://openalex.org/W2336645361', 'https://openalex.org/W2136967346', 'https://openalex.org/W2110853830', 'https://openalex.org/W2099866402', 'https://openalex.org/W2094784564', 'https://openalex.org/W2091270589', 'https://openalex.org/W2089659821', 'https://openalex.org/W1988163976'], 'abstract_inverted_index': {'We': [0, 31], 'developed': [1], 'European': [2], 'guidelines': [3], 'to': [4, 24, 104, 138, 155, 199, 202], 'optimise': [5], 'phenylketonuria': [6], '(PKU)': [7], 'care.': [8], 'To': [9], 'develop': [10], 'the': [11, 25, 33, 44, 59, 64, 91, 105, 111, 128, 188], 'guidelines,': [12], 'we': [13, 51, 55], 'did': [14], 'a': [15], 'literature': [16], 'search,': [17], 'critical': [18], 'appraisal,': [19], 'and': [20, 119, 122, 140, 171, 175, 190, 204, 209], 'evidence': [21, 40], 'grading': [22], 'according': [23, 198], 'Scottish': [26], 'Intercollegiate': [27], 'Guidelines': [28], 'Network': [29], 'method.': [30], 'used': [32], 'Delphi': [34], 'method': [35], 'when': [36], 'little': [37], 'or': [38], 'no': [39], 'was': [41], 'available.': [42], 'From': [43], '70': [45], 'recommendations': [46], 'formulated,': [47], 'in': [48], 'this': [49], 'Review': [50], 'describe': [52], 'ten': [53], 'that': [54], 'deem': [56], 'as': [57, 162], 'having': [58], 'highest': [60], 'priority.': [61], 'Diet': [62], 'is': [63, 88, 95, 101, 115, 125, 130, 212], 'cornerstone': [65], 'of': [66, 82, 107, 149, 192, 218], 'treatment,': [67, 203], 'although': [68], 'some': [69], 'patients': [70, 193], 'can': [71], 'benefit': [72], 'from': [73], 'tetrahydrobiopterin': [74], '(BH4).': [75], 'Untreated': [76], 'blood': [77, 92, 113, 147], 'phenylalanine': [78, 93, 112, 146], 'concentrations': [79, 148, 160], 'determine': [80], 'management': [81, 189], 'people': [83], 'with': [84, 194], 'PKU.': [85], 'No': [86], 'intervention': [87], 'required': [89], 'if': [90, 110, 127], 'concentration': [94, 114, 129], 'less': [96], 'than': [97, 132, 151, 182], '360': [98, 117, 152], 'μmol/L.': [99, 134], 'Treatment': [100, 158], 'recommended': [102, 126], 'up': [103], 'age': [106], '12': [108, 183], 'years': [109, 170], 'between': [116], 'μmol/L': [118, 153, 165, 177], '600': [120, 133], 'μmol/L,': [121], 'lifelong': [123], 'treatment': [124], 'more': [131, 150], 'For': [135], 'women': [136], 'trying': [137], 'conceive': [139], 'during': [141], 'pregnancy': [142], '(maternal': [143], 'PKU),': [144], 'untreated': [145], 'need': [154], 'be': [156], 'reduced.': [157], 'target': [159], 'are': [161, 196], 'follows:': [163], '120-360': [164], 'for': [166, 172, 178, 187, 214], 'individuals': [167, 180], 'aged': [168], '0-12': [169], 'maternal': [173], 'PKU,': [174], '120-600': [176], 'non-pregnant': [179], 'older': [181], 'years.': [184], 'Minimum': [185], 'requirements': [186], 'follow-up': [191, 211], 'PKU': [195], 'scheduled': [197], 'age,': [200], 'adherence': [201], 'clinical': [205], 'status.': [206], 'Nutritional,': [207], 'clinical,': [208], 'biochemical': [210], 'necessary': [213], 'all': [215], 'patients,': [216], 'regardless': [217], 'therapy.': [219]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2570496805', 'counts_by_year': [{'year': 2024, 'cited_by_count': 36}, {'year': 2023, 'cited_by_count': 38}, {'year': 2022, 'cited_by_count': 41}, {'year': 2021, 'cited_by_count': 34}, {'year': 2020, 'cited_by_count': 48}, {'year': 2019, 'cited_by_count': 52}, {'year': 2018, 'cited_by_count': 40}, {'year': 2017, 'cited_by_count': 29}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-09-13T12:59:44.439218', 'created_date': '2017-01-13'}