Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2566901884', 'doi': 'https://doi.org/10.1038/ng.3744', 'title': 'ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice', 'display_name': 'ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice', 'publication_year': 2016, 'publication_date': '2016-12-12', 'ids': {'openalex': 'https://openalex.org/W2566901884', 'doi': 'https://doi.org/10.1038/ng.3744', 'mag': '2566901884', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27941798', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5285448'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/ng.3744', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137905309', 'display_name': 'Nature Genetics', 'issn_l': '1061-4036', 'issn': ['1061-4036', '1546-1718'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc5285448?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5017882848', 'display_name': 'Radhika Mathur', 'orcid': 'https://orcid.org/0000-0002-3346-1781'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Radhika Mathur', 'raw_affiliation_strings': ['Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts, USA'], 'affiliations': [{'raw_affiliation_string': 'Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts, USA', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084957565', 'display_name': 'B. Alver', 'orcid': 'https://orcid.org/0000-0002-5019-7652'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Burak H Alver', 'raw_affiliation_strings': ['Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032452083', 'display_name': 'Adrianna K. San Roman', 'orcid': 'https://orcid.org/0000-0003-4511-3052'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Adrianna K San Roman', 'raw_affiliation_strings': ['Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts, USA'], 'affiliations': [{'raw_affiliation_string': 'Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts, USA', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030964439', 'display_name': 'Barbara G. Wilson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Boris G Wilson', 'raw_affiliation_strings': ['Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100333216', 'display_name': 'Xiaofeng Wang', 'orcid': 'https://orcid.org/0000-0001-7611-4491'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiaofeng Wang', 'raw_affiliation_strings': ['Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028047618', 'display_name': 'Agoston T. Agoston', 'orcid': 'https://orcid.org/0000-0003-2364-1479'}, 'institutions': [{'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Agoston T Agoston', 'raw_affiliation_strings': ["Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA"], 'affiliations': [{'raw_affiliation_string': "Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA", 'institution_ids': ['https://openalex.org/I1283280774', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022028438', 'display_name': 'Peter J. Park', 'orcid': 'https://orcid.org/0000-0001-9378-960X'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter J Park', 'raw_affiliation_strings': ['Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055619783', 'display_name': 'Ramesh A. Shivdasani', 'orcid': 'https://orcid.org/0000-0002-2828-1727'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ramesh A Shivdasani', 'raw_affiliation_strings': ['Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5068380379', 'display_name': 'Charles W.M. Roberts', 'orcid': 'https://orcid.org/0000-0003-1135-1896'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Charles W M Roberts', 'raw_affiliation_strings': ['Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA', 'institution_ids': ['https://openalex.org/I4210117453']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9750, 'currency': 'EUR', 'value_usd': 11690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 10.448, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 286, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '49', 'issue': '2', 'first_page': '296', 'last_page': '302'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12820', 'display_name': 'Chromatin Remodeling in Cancer and Development', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12820', 'display_name': 'Chromatin Remodeling in Cancer and Development', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13779', 'display_name': 'Role of Pim Oncogenes in Tumorigenesis', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13437', 'display_name': 'Molecular Mechanisms of Metastasis Suppressor Genes', 'score': 0.9915, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/arid1a', 'display_name': 'ARID1A', 'score': 0.9067569}, {'id': 'https://openalex.org/keywords/swi/snf', 'display_name': 'SWI/SNF', 'score': 0.6985769}, {'id': 'https://openalex.org/keywords/arid1a-mutations', 'display_name': 'ARID1A Mutations', 'score': 0.566582}, {'id': 'https://openalex.org/keywords/tumor-suppressor-genes', 'display_name': 'Tumor Suppressor Genes', 'score': 0.521776}, {'id': 'https://openalex.org/keywords/swi/snf-complexes', 'display_name': 'SWI/SNF Complexes', 'score': 0.500708}, {'id': 'https://openalex.org/keywords/smarca4', 'display_name': 'SMARCA4', 'score': 0.49459073}], 'concepts': [{'id': 'https://openalex.org/C2781273526', 'wikidata': 'https://www.wikidata.org/wiki/Q18032797', 'display_name': 'ARID1A', 'level': 4, 'score': 0.9067569}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8253473}, {'id': 'https://openalex.org/C111936080', 'wikidata': 'https://www.wikidata.org/wiki/Q913367', 'display_name': 'Enhancer', 'level': 4, 'score': 0.7614987}, {'id': 'https://openalex.org/C166941617', 'wikidata': 'https://www.wikidata.org/wiki/Q421708', 'display_name': 'SWI/SNF', 'level': 5, 'score': 0.6985769}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.6242953}, {'id': 'https://openalex.org/C167227067', 'wikidata': 'https://www.wikidata.org/wiki/Q5113739', 'display_name': 'Chromatin remodeling', 'level': 4, 'score': 0.6170947}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5596358}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.50203323}, {'id': 'https://openalex.org/C80828422', 'wikidata': 'https://www.wikidata.org/wiki/Q18031595', 'display_name': 'SMARCA4', 'level': 5, 'score': 0.49459073}, {'id': 'https://openalex.org/C165864922', 'wikidata': 'https://www.wikidata.org/wiki/Q411391', 'display_name': 'Regulation of gene expression', 'level': 3, 'score': 0.47590575}, {'id': 'https://openalex.org/C2778264664', 'wikidata': 'https://www.wikidata.org/wiki/Q422445', 'display_name': 'Tumor suppressor gene', 'level': 4, 'score': 0.45363623}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.42627075}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.3371641}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.24897495}], 'mesh': [{'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004742', 'descriptor_name': 'Enhancer Elements, Genetic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002843', 'descriptor_name': 'Chromatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002843', 'descriptor_name': 'Chromatin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D042002', 'descriptor_name': 'Chromatin Assembly and Disassembly', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D042002', 'descriptor_name': 'Chromatin Assembly and Disassembly', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004742', 'descriptor_name': 'Enhancer Elements, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045325', 'descriptor_name': 'HCT116 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051176', 'descriptor_name': 'beta Catenin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051176', 'descriptor_name': 'beta Catenin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/ng.3744', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137905309', 'display_name': 'Nature Genetics', 'issn_l': '1061-4036', 'issn': ['1061-4036', '1546-1718'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5285448', 'pdf_url': 'https://europepmc.org/articles/pmc5285448?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285448', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://nrs.harvard.edu/urn-3:HUL.InstRepos:33490851', 'pdf_url': 'https://dash.harvard.edu/bitstream/1/33490851/1/5285448.pdf', 'source': {'id': 'https://openalex.org/S4306401540', 'display_name': 'Digital Access to Scholarship at Harvard (DASH) (Harvard University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I136199984', 'host_organization_name': 'Harvard University', 'host_organization_lineage': ['https://openalex.org/I136199984'], 'host_organization_lineage_names': ['Harvard University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27941798', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5285448', 'pdf_url': 'https://europepmc.org/articles/pmc5285448?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.83}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1596380405', 'https://openalex.org/W1672352349', 'https://openalex.org/W1934094702', 'https://openalex.org/W1970064594', 'https://openalex.org/W1971578941', 'https://openalex.org/W1971967608', 'https://openalex.org/W1974353685', 'https://openalex.org/W1975283204', 'https://openalex.org/W1981030303', 'https://openalex.org/W1983254279', 'https://openalex.org/W2001258296', 'https://openalex.org/W2005657436', 'https://openalex.org/W2016015848', 'https://openalex.org/W2021120490', 'https://openalex.org/W2022093187', 'https://openalex.org/W2027356651', 'https://openalex.org/W2036619779', 'https://openalex.org/W2038970416', 'https://openalex.org/W2043880988', 'https://openalex.org/W2055732173', 'https://openalex.org/W2069237225', 'https://openalex.org/W2069281865', 'https://openalex.org/W2080278886', 'https://openalex.org/W2087638216', 'https://openalex.org/W2096489607', 'https://openalex.org/W2102904139', 'https://openalex.org/W2103441770', 'https://openalex.org/W2112484474', 'https://openalex.org/W2112728955', 'https://openalex.org/W2119079421', 'https://openalex.org/W2124985265', 'https://openalex.org/W2138601221', 'https://openalex.org/W2140729960', 'https://openalex.org/W2150625137', 'https://openalex.org/W2151337762', 'https://openalex.org/W2155943701', 'https://openalex.org/W2166820820', 'https://openalex.org/W2168303063', 'https://openalex.org/W2169744057', 'https://openalex.org/W2171987817', 'https://openalex.org/W2259938310', 'https://openalex.org/W2262414037', 'https://openalex.org/W4247053599'], 'related_works': ['https://openalex.org/W4379337130', 'https://openalex.org/W4308842336', 'https://openalex.org/W4281711008', 'https://openalex.org/W3032637176', 'https://openalex.org/W2911645717', 'https://openalex.org/W2768923632', 'https://openalex.org/W2406156173', 'https://openalex.org/W2331850616', 'https://openalex.org/W2056556069', 'https://openalex.org/W1996240653'], 'abstract_inverted_index': {'Genes': [0], 'encoding': [1], 'subunits': [2], 'of': [3, 13, 24, 69, 80, 119, 125, 147], 'SWI/SNF': [4, 89, 107, 115], '(BAF)': [5], 'chromatin-remodeling': [6], 'complexes': [7, 90], 'are': [8, 74], 'collectively': [9], 'mutated': [10], 'in': [11, 46, 77, 96, 109, 114, 133], '∼20%': [12], 'all': [14], 'human': [15, 61], 'cancers.': [16], 'Although': [17], 'ARID1A': [18, 86], 'is': [19, 34], 'the': [20, 26, 47, 52], 'most': [21], 'frequent': [22], 'target': [23], 'mutations,': [25], 'mechanism': [27], 'by': [28], 'which': [29, 73], 'its': [30], 'inactivation': [31], 'promotes': [32], 'tumorigenesis': [33], 'unclear.': [35], 'Here': [36], 'we': [37], 'demonstrate': [38], 'that': [39, 56, 85], 'Arid1a': [40], 'functions': [41], 'as': [42, 142], 'a': [43, 143], 'tumor': [44], 'suppressor': [45], 'mouse': [48], 'colon,': [49], 'but': [50, 112], 'not': [51], 'small': [53], 'intestine,': [54], 'and': [55, 117, 137], 'invasive': [57], 'ARID1A-deficient': [58, 110], 'adenocarcinomas': [59], 'resemble': [60], 'colorectal': [62], 'cancer': [63, 135], '(CRC).': [64], 'These': [65, 128], 'tumors': [66], 'lack': [67], 'deregulation': [68], 'APC/β-catenin': [70], 'signaling': [71], 'components,': [72], 'crucial': [75], 'gatekeepers': [76], 'common': [78], 'forms': [79], 'intestinal': [81], 'cancer.': [82], 'We': [83], 'find': [84], 'normally': [87], 'targets': [88], 'to': [91, 101], 'enhancers,': [92], 'where': [93], 'they': [94], 'function': [95, 108, 146], 'coordination': [97], 'with': [98], 'transcription': [99], 'factors': [100], 'facilitate': [102], 'gene': [103, 126, 140], 'activation.': [104], 'ARID1B': [105], 'preserves': [106], 'cells,': [111], 'defects': [113], 'targeting': [116], 'control': [118], 'enhancer': [120], 'activity': [121], 'cause': [122], 'extensive': [123], 'dysregulation': [124], 'expression.': [127], 'findings': [129], 'represent': [130], 'an': [131], 'advance': [132], 'colon': [134], 'modeling': [136], 'implicate': [138], 'enhancer-mediated': [139], 'regulation': [141], 'principal': [144], 'tumor-suppressor': [145], 'ARID1A.': [148]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2566901884', 'counts_by_year': [{'year': 2024, 'cited_by_count': 18}, {'year': 2023, 'cited_by_count': 37}, {'year': 2022, 'cited_by_count': 37}, {'year': 2021, 'cited_by_count': 57}, {'year': 2020, 'cited_by_count': 51}, {'year': 2019, 'cited_by_count': 36}, {'year': 2018, 'cited_by_count': 28}, {'year': 2017, 'cited_by_count': 19}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-09-15T03:38:21.267222', 'created_date': '2017-01-06'}