Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2566822139', 'doi': 'https://doi.org/10.1182/blood.v112.11.5065.5065', 'title': 'Molecular Biological Mechanisms of Cyclosporine a, Tetrandrine and Their Combination on the Reversion of Multidrug Resistance in Leukemia Cell Line', 'display_name': 'Molecular Biological Mechanisms of Cyclosporine a, Tetrandrine and Their Combination on the Reversion of Multidrug Resistance in Leukemia Cell Line', 'publication_year': 2008, 'publication_date': '2008-11-16', 'ids': {'openalex': 'https://openalex.org/W2566822139', 'doi': 'https://doi.org/10.1182/blood.v112.11.5065.5065', 'mag': '2566822139'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1182/blood.v112.11.5065.5065', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S200071133', 'display_name': 'Blood', 'issn_l': '0006-4971', 'issn': ['0006-4971', '1528-0020'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101665245', 'display_name': 'Baoan Chen', 'orcid': 'https://orcid.org/0000-0003-1490-1259'}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Bao-An Chen', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015324870', 'display_name': 'Jingjing Guo', 'orcid': 'https://orcid.org/0000-0002-8962-0980'}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jing-jing Guo', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009949350', 'display_name': 'Jian Cheng', 'orcid': 'https://orcid.org/0009-0008-7059-9764'}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jian Cheng', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038612067', 'display_name': 'Feng Gao', 'orcid': 'https://orcid.org/0000-0002-4461-6611'}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Feng Gao', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074775577', 'display_name': 'Wenlin Xu', 'orcid': 'https://orcid.org/0000-0001-7518-7912'}, 'institutions': [{'id': 'https://openalex.org/I115592961', 'display_name': 'Jiangsu University', 'ror': 'https://ror.org/03jc41j30', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I115592961']}, {'id': 'https://openalex.org/I4210111628', 'display_name': 'Affiliated Hospital of Jiangsu University', 'ror': 'https://ror.org/028pgd321', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210111628']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wen-lin Xu', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, China', 'institution_ids': ['https://openalex.org/I115592961', 'https://openalex.org/I4210111628']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061945783', 'display_name': 'Hui-lin Shen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I115592961', 'display_name': 'Jiangsu University', 'ror': 'https://ror.org/03jc41j30', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I115592961']}, {'id': 'https://openalex.org/I4210111628', 'display_name': 'Affiliated Hospital of Jiangsu University', 'ror': 'https://ror.org/028pgd321', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210111628']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hui-lin Shen', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, China', 'institution_ids': ['https://openalex.org/I115592961', 'https://openalex.org/I4210111628']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052960352', 'display_name': 'Chong Gao', 'orcid': 'https://orcid.org/0000-0001-7639-0808'}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jia-hua Ding', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052960352', 'display_name': 'Chong Gao', 'orcid': 'https://orcid.org/0000-0001-7639-0808'}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chong Gao', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5106668173', 'display_name': 'Yun-Yu Sun', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yun-Yu Sun', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100384671', 'display_name': 'Jun Wang', 'orcid': 'https://orcid.org/0000-0001-9957-9208'}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jun Wang', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100756368', 'display_name': 'Gang Zhao', 'orcid': 'https://orcid.org/0000-0002-3904-0216'}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Gang Zhao', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101086778', 'display_name': 'Huihui Song', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hui-hui Song', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100964698', 'display_name': 'Wen Bao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wen Bao', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100609062', 'display_name': 'Xinchen Sun', 'orcid': 'https://orcid.org/0000-0002-7512-779X'}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xin-chen Sun', 'raw_affiliation_strings': ['Department of Oncology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100696386', 'display_name': 'Hongyan Cheng', 'orcid': 'https://orcid.org/0000-0003-4785-1497'}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hong-yan Cheng', 'raw_affiliation_strings': ['Department of Oncology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071666031', 'display_name': 'Yuxia Deng', 'orcid': 'https://orcid.org/0000-0002-6294-2111'}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yu-xia Deng', 'raw_affiliation_strings': ['Department of Oncology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105287614', 'display_name': 'Guohong Li', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Guo-hong Li', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100632233', 'display_name': 'Lijie Liu', 'orcid': 'https://orcid.org/0000-0002-8309-609X'}, 'institutions': [{'id': 'https://openalex.org/I76569877', 'display_name': 'Southeast University', 'ror': 'https://ror.org/04ct4d772', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76569877']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Li-jie Liu', 'raw_affiliation_strings': ['Institution of physiology, Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Institution of physiology, Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I76569877']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014351158', 'display_name': 'Wenji Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wen-ji Chen', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073970759', 'display_name': 'Jue-qiong Wang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jue-qiong Wang', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067143974', 'display_name': 'Yuan Peng', 'orcid': 'https://orcid.org/0000-0001-9563-9568'}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Peng Yuan', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041521212', 'display_name': 'Xiao-Ping Pei', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiao-ping Pei', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085834518', 'display_name': 'Ning-Na Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105806', 'display_name': 'Zhongda Hospital Southeast University', 'ror': 'https://ror.org/01k3hq685', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105806']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ning-na Chen', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I4210105806']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100390604', 'display_name': 'Xuemei Wang', 'orcid': 'https://orcid.org/0000-0001-6882-7774'}, 'institutions': [{'id': 'https://openalex.org/I76569877', 'display_name': 'Southeast University', 'ror': 'https://ror.org/04ct4d772', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76569877']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xue-mei Wang', 'raw_affiliation_strings': ['State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I76569877']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5000, 'currency': 'USD', 'value_usd': 5000, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 63}, 'biblio': {'volume': '112', 'issue': '11', 'first_page': '5065', 'last_page': '5065'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10570', 'display_name': 'Mechanisms of Multidrug Resistance in Cancer', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10570', 'display_name': 'Mechanisms of Multidrug Resistance in Cancer', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12059', 'display_name': 'Therapeutic Potential of Berberine Alkaloids', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11845', 'display_name': 'DNA Topoisomerases: Structure, Function, and Inhibition', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tetrandrine', 'display_name': 'Tetrandrine', 'score': 0.94225633}, {'id': 'https://openalex.org/keywords/k562-cells', 'display_name': 'K562 cells', 'score': 0.7683888}, {'id': 'https://openalex.org/keywords/reversion', 'display_name': 'Reversion', 'score': 0.5576047}, {'id': 'https://openalex.org/keywords/multidrug-resistance', 'display_name': 'Multidrug Resistance', 'score': 0.55013}, {'id': 'https://openalex.org/keywords/p-glycoprotein', 'display_name': 'P-glycoprotein', 'score': 0.4810272}], 'concepts': [{'id': 'https://openalex.org/C2779934757', 'wikidata': 'https://www.wikidata.org/wiki/Q7706612', 'display_name': 'Tetrandrine', 'level': 2, 'score': 0.94225633}, {'id': 'https://openalex.org/C133936738', 'wikidata': 'https://www.wikidata.org/wiki/Q643839', 'display_name': 'Multiple drug resistance', 'level': 3, 'score': 0.77193}, {'id': 'https://openalex.org/C171122931', 'wikidata': 'https://www.wikidata.org/wiki/Q6324626', 'display_name': 'K562 cells', 'level': 3, 'score': 0.7683888}, {'id': 'https://openalex.org/C553184892', 'wikidata': 'https://www.wikidata.org/wiki/Q1141429', 'display_name': 'Flow cytometry', 'level': 2, 'score': 0.6534697}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.58284676}, {'id': 'https://openalex.org/C70883133', 'wikidata': 'https://www.wikidata.org/wiki/Q7318316', 'display_name': 'Reversion', 'level': 4, 'score': 0.5576047}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.52722764}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.522699}, {'id': 'https://openalex.org/C2778707650', 'wikidata': 'https://www.wikidata.org/wiki/Q412902', 'display_name': 'P-glycoprotein', 'level': 4, 'score': 0.4810272}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.4710398}, {'id': 'https://openalex.org/C2778461978', 'wikidata': 'https://www.wikidata.org/wiki/Q29496', 'display_name': 'Leukemia', 'level': 2, 'score': 0.4705767}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.42155254}, {'id': 'https://openalex.org/C2781303535', 'wikidata': 'https://www.wikidata.org/wiki/Q18936', 'display_name': 'Doxorubicin', 'level': 3, 'score': 0.41358587}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.3296627}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.286748}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.26215044}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12926495}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07325941}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.058858156}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.050112486}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1182/blood.v112.11.5065.5065', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S200071133', 'display_name': 'Blood', 'issn_l': '0006-4971', 'issn': ['0006-4971', '1528-0020'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.55}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2981075507', 'https://openalex.org/W2950442272', 'https://openalex.org/W2890679154', 'https://openalex.org/W2409600407', 'https://openalex.org/W2393565490', 'https://openalex.org/W2374499813', 'https://openalex.org/W2094924740', 'https://openalex.org/W2074950338', 'https://openalex.org/W1998956539', 'https://openalex.org/W1976597800'], 'abstract_inverted_index': {'Abstract': [0], 'Objective': [1], 'Previous': [2], 'researches': [3], 'confirmed': [4], 'that': [5, 113], 'multidrugresistance(MDR)': [6], 'plays': [7], 'an': [8], 'important': [9], 'role': [10], 'in': [11, 96, 104, 114, 122], 'the': [12, 24, 57, 92, 151, 170], 'failure': [13], 'of': [14, 28, 59, 72, 101, 112, 120, 153, 172], 'chemotherapy': [15], 'on': [16, 35], 'malignant': [17], 'tumors.': [18], 'This': [19], 'study': [20], 'was': [21, 74, 107, 127, 134, 146, 156], 'to': [22], 'investigate': [23], 'molecular': [25], 'biological': [26], 'mechanisms': [27], 'cyclosporine': [29, 47], 'A(CsA),': [30], 'tetrandrine(Tet)': [31], 'and': [32, 49, 56, 86, 109, 124, 129, 140, 142, 150], 'their': [33, 154], 'combination': [34, 155, 171], 'multidrug': [36], 'resistance': [37, 160], 'cell': [38], 'line': [39], 'K562/A02.': [40], 'Methods': [41], 'K562/A02': [42, 97, 105, 125], 'cells': [43, 106, 126], 'were': [44, 62], 'treated': [45, 137], 'with': [46, 138], 'A': [48], '(or)': [50], 'tetrandrine.': [51], 'The': [52, 69, 117, 131], 'intracellular': [53, 93], 'DNR': [54, 94, 103], 'concentration': [55, 95], 'expression': [58, 71, 133], 'P-glyco-protein': [60], '(P-gp)': [61], 'observed': [63], 'by': [64, 76, 166], 'flow': [65], 'cytometry': [66], '(FCM)': [67], 'assay.': [68], 'mRNA': [70, 145], 'mdr-1': [73], 'measured': [75], 'fluorescent': [77], 'semi-quantitative': [78], 'reverse': [79], 'transcriptase': [80], 'polymerase': [81], 'chain': [82], 'reaction(RT-PCR).': [83], 'Resulds': [84], 'CsA': [85, 167], 'Tet': [87], '(alone': [88], 'or': [89, 168], 'combination)': [90], 'elevated': [91], 'cells(the': [98], 'fluorescence': [99, 118], 'intensity': [100, 119], 'intracellelar': [102], '60%,65%': [108], '98%': [110], 'respectively': [111], 'K562': [115, 123], 'cells);': [116], 'P-gp': [121, 132], '0.5%': [128], '97.97%.': [130], 'down': [135, 148], 'after': [136], 'CsA,Tet': [139], 'both(75.32%,76.86%': [141], '48.61%);': [143], 'mdr1': [144], 'also': [147], 'regulated,': [149], 'effect': [152], 'greater.': [157], 'Conclusion': [158], 'Multidrug': [159], '(MDR)': [161], 'can': [162], 'be': [163], 'partially': [164], 'reversed': [165], 'Tet,': [169], 'both': [173], 'drugs': [174], 'shows': [175], 'a': [176], 'great': [177], 'synergistic': [178], 'reversal': [179], 'effect.': [180]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2566822139', 'counts_by_year': [], 'updated_date': '2024-09-10T13:21:22.797561', 'created_date': '2017-01-06'}