Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2566747388', 'doi': 'https://doi.org/10.1080/13543784.2017.1274730', 'title': 'Recent early clinical drug development for acute kidney injury', 'display_name': 'Recent early clinical drug development for acute kidney injury', 'publication_year': 2016, 'publication_date': '2016-12-20', 'ids': {'openalex': 'https://openalex.org/W2566747388', 'doi': 'https://doi.org/10.1080/13543784.2017.1274730', 'mag': '2566747388', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27997816'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/13543784.2017.1274730', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S131064935', 'display_name': 'Expert Opinion on Investigational Drugs', 'issn_l': '1354-3784', 'issn': ['1354-3784', '1744-7658'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://hdl.handle.net/20.500.11820/1d77be49-b2c9-41c1-acf2-0cbb428aff75', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5086299675', 'display_name': 'Kevin Gallagher', 'orcid': 'https://orcid.org/0000-0001-5485-5336'}, 'institutions': [{'id': 'https://openalex.org/I4210151647', 'display_name': 'Centre for Inflammation Research', 'ror': 'https://ror.org/05wcr1b38', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I4210151647', 'https://openalex.org/I90344618', 'https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I2802789809', 'display_name': 'Edinburgh Royal Infirmary', 'ror': 'https://ror.org/009bsy196', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802789809']}, {'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Kevin M. Gallagher', 'raw_affiliation_strings': ['MRC Centre for Inflammation Research, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Centre for Inflammation Research, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, UK', 'institution_ids': ['https://openalex.org/I4210151647', 'https://openalex.org/I2802789809', 'https://openalex.org/I98677209']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040963359', 'display_name': 'Stephen O’Neill', 'orcid': 'https://orcid.org/0000-0002-3252-340X'}, 'institutions': [{'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I4210151647', 'display_name': 'Centre for Inflammation Research', 'ror': 'https://ror.org/05wcr1b38', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I4210151647', 'https://openalex.org/I90344618', 'https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I2802789809', 'display_name': 'Edinburgh Royal Infirmary', 'ror': 'https://ror.org/009bsy196', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802789809']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Stephen O’neill', 'raw_affiliation_strings': ['MRC Centre for Inflammation Research, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Centre for Inflammation Research, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, UK', 'institution_ids': ['https://openalex.org/I98677209', 'https://openalex.org/I4210151647', 'https://openalex.org/I2802789809']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075334231', 'display_name': 'Ewen M. Harrison', 'orcid': 'https://orcid.org/0000-0002-5018-3066'}, 'institutions': [{'id': 'https://openalex.org/I4210151647', 'display_name': 'Centre for Inflammation Research', 'ror': 'https://ror.org/05wcr1b38', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I4210151647', 'https://openalex.org/I90344618', 'https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I2802789809', 'display_name': 'Edinburgh Royal Infirmary', 'ror': 'https://ror.org/009bsy196', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802789809']}, {'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Ewen M Harrison', 'raw_affiliation_strings': ['MRC Centre for Inflammation Research, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Centre for Inflammation Research, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, UK', 'institution_ids': ['https://openalex.org/I4210151647', 'https://openalex.org/I2802789809', 'https://openalex.org/I98677209']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112766141', 'display_name': 'James A. Ross', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210108209', 'display_name': 'MRC Centre for Regenerative Medicine', 'ror': 'https://ror.org/01x802g65', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I4210108209', 'https://openalex.org/I90344618', 'https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I2802789809', 'display_name': 'Edinburgh Royal Infirmary', 'ror': 'https://ror.org/009bsy196', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802789809']}, {'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'James A Ross', 'raw_affiliation_strings': ['MRC Centre for Regenerative Medicine, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Centre for Regenerative Medicine, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, UK', 'institution_ids': ['https://openalex.org/I4210108209', 'https://openalex.org/I2802789809', 'https://openalex.org/I98677209']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068413563', 'display_name': 'Stephen J. Wigmore', 'orcid': 'https://orcid.org/0000-0002-3614-8002'}, 'institutions': [{'id': 'https://openalex.org/I2802789809', 'display_name': 'Edinburgh Royal Infirmary', 'ror': 'https://ror.org/009bsy196', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802789809']}, {'id': 'https://openalex.org/I4210151647', 'display_name': 'Centre for Inflammation Research', 'ror': 'https://ror.org/05wcr1b38', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I4210151647', 'https://openalex.org/I90344618', 'https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Stephen J Wigmore', 'raw_affiliation_strings': ['MRC Centre for Inflammation Research, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Centre for Inflammation Research, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, UK', 'institution_ids': ['https://openalex.org/I2802789809', 'https://openalex.org/I4210151647', 'https://openalex.org/I98677209']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5079055699', 'display_name': 'Jeremy Hughes', 'orcid': 'https://orcid.org/0000-0002-3470-0422'}, 'institutions': [{'id': 'https://openalex.org/I4210151647', 'display_name': 'Centre for Inflammation Research', 'ror': 'https://ror.org/05wcr1b38', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I4210151647', 'https://openalex.org/I90344618', 'https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I2802789809', 'display_name': 'Edinburgh Royal Infirmary', 'ror': 'https://ror.org/009bsy196', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802789809']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Jeremy Hughes', 'raw_affiliation_strings': ['MRC Centre for Inflammation Research, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Centre for Inflammation Research, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, UK', 'institution_ids': ['https://openalex.org/I4210151647', 'https://openalex.org/I98677209', 'https://openalex.org/I2802789809']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5086299675'], 'corresponding_institution_ids': ['https://openalex.org/I4210151647', 'https://openalex.org/I2802789809', 'https://openalex.org/I98677209'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.374, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 26, 'citation_normalized_percentile': {'value': 0.576291, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '26', 'issue': '2', 'first_page': '141', 'last_page': '154'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10684', 'display_name': 'Acute Kidney Injury Research', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2727', 'display_name': 'Nephrology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10684', 'display_name': 'Acute Kidney Injury Research', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2727', 'display_name': 'Nephrology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11465', 'display_name': 'Drug-Induced Hepatotoxicity and Protection', 'score': 0.9935, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10408', 'display_name': 'Chronic Kidney Disease and Diabetes', 'score': 0.9867, 'subfield': {'id': 'https://openalex.org/subfields/2727', 'display_name': 'Nephrology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/drug-development', 'display_name': 'Drug Development', 'score': 0.69602025}], 'concepts': [{'id': 'https://openalex.org/C2780472472', 'wikidata': 'https://www.wikidata.org/wiki/Q424337', 'display_name': 'Acute kidney injury', 'level': 2, 'score': 0.7088623}, {'id': 'https://openalex.org/C64903051', 'wikidata': 'https://www.wikidata.org/wiki/Q2198549', 'display_name': 'Drug development', 'level': 3, 'score': 0.69602025}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6238156}, {'id': 'https://openalex.org/C177713679', 'wikidata': 'https://www.wikidata.org/wiki/Q679690', 'display_name': 'Intensive care medicine', 'level': 1, 'score': 0.61796165}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.5544026}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.38845083}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2994038}], 'mesh': [{'descriptor_ui': 'D058186', 'descriptor_name': 'Acute Kidney Injury', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015507', 'descriptor_name': 'Drugs, Investigational', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D058186', 'descriptor_name': 'Acute Kidney Injury', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058186', 'descriptor_name': 'Acute Kidney Injury', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D058186', 'descriptor_name': 'Acute Kidney Injury', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004353', 'descriptor_name': 'Drug Evaluation, Preclinical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004353', 'descriptor_name': 'Drug Evaluation, Preclinical', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D015507', 'descriptor_name': 'Drugs, Investigational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015507', 'descriptor_name': 'Drugs, Investigational', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/13543784.2017.1274730', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S131064935', 'display_name': 'Expert Opinion on Investigational Drugs', 'issn_l': '1354-3784', 'issn': ['1354-3784', '1744-7658'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/20.500.11820/1d77be49-b2c9-41c1-acf2-0cbb428aff75', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400320', 'display_name': 'Edinburgh Research Explorer (University of Edinburgh)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I98677209', 'host_organization_name': 'University of Edinburgh', 'host_organization_lineage': ['https://openalex.org/I98677209'], 'host_organization_lineage_names': ['University of Edinburgh'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/20.500.11820/1d77be49-b2c9-41c1-acf2-0cbb428aff75', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400321', 'display_name': 'Edinburgh Research Explorer (University of Edinburgh)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I98677209', 'host_organization_name': 'University of Edinburgh', 'host_organization_lineage': ['https://openalex.org/I98677209'], 'host_organization_lineage_names': ['University of Edinburgh'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.research.ed.ac.uk/portal/en/publications/recent-early-clinical-drug-development-for-acute-kidney-injury(1d77be49-b2c9-41c1-acf2-0cbb428aff75).html', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400320', 'display_name': 'Edinburgh Research Explorer (University of Edinburgh)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I98677209', 'host_organization_name': 'University of Edinburgh', 'host_organization_lineage': ['https://openalex.org/I98677209'], 'host_organization_lineage_names': ['University of Edinburgh'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.pure.ed.ac.uk/ws/files/29655781/Gallagher_et_al_Expert_Opinion_on_Investigational_Drugs_Accepted.docx', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400320', 'display_name': 'Edinburgh Research Explorer (University of Edinburgh)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I98677209', 'host_organization_name': 'University of Edinburgh', 'host_organization_lineage': ['https://openalex.org/I98677209'], 'host_organization_lineage_names': ['University of Edinburgh'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27997816', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/20.500.11820/1d77be49-b2c9-41c1-acf2-0cbb428aff75', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400320', 'display_name': 'Edinburgh Research Explorer (University of Edinburgh)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I98677209', 'host_organization_name': 'University of Edinburgh', 'host_organization_lineage': ['https://openalex.org/I98677209'], 'host_organization_lineage_names': ['University of Edinburgh'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.79, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 89, 'referenced_works': ['https://openalex.org/W1677186713', 'https://openalex.org/W1847056372', 'https://openalex.org/W1854923616', 'https://openalex.org/W1864661279', 'https://openalex.org/W1865602869', 'https://openalex.org/W1955383272', 'https://openalex.org/W1966022628', 'https://openalex.org/W1969323641', 'https://openalex.org/W1970120554', 'https://openalex.org/W1975087901', 'https://openalex.org/W1977352193', 'https://openalex.org/W1981821798', 'https://openalex.org/W1983708786', 'https://openalex.org/W1985491668', 'https://openalex.org/W1985828578', 'https://openalex.org/W1987952896', 'https://openalex.org/W1990337194', 'https://openalex.org/W1991997670', 'https://openalex.org/W1992433651', 'https://openalex.org/W1992536611', 'https://openalex.org/W1992756444', 'https://openalex.org/W1995632131', 'https://openalex.org/W1996446862', 'https://openalex.org/W1997437547', 'https://openalex.org/W2015690288', 'https://openalex.org/W2017093466', 'https://openalex.org/W2017583766', 'https://openalex.org/W2021032925', 'https://openalex.org/W2021690806', 'https://openalex.org/W2026314831', 'https://openalex.org/W2030927418', 'https://openalex.org/W2031796309', 'https://openalex.org/W2032432920', 'https://openalex.org/W2040371936', 'https://openalex.org/W2045171661', 'https://openalex.org/W2046149192', 'https://openalex.org/W2055970849', 'https://openalex.org/W2060843217', 'https://openalex.org/W2066802700', 'https://openalex.org/W2067107606', 'https://openalex.org/W2069249538', 'https://openalex.org/W2074608383', 'https://openalex.org/W2076381257', 'https://openalex.org/W2080627387', 'https://openalex.org/W2081053802', 'https://openalex.org/W2083893575', 'https://openalex.org/W2086974843', 'https://openalex.org/W2100234757', 'https://openalex.org/W2102544848', 'https://openalex.org/W2103060185', 'https://openalex.org/W2107284173', 'https://openalex.org/W2108130826', 'https://openalex.org/W2110048031', 'https://openalex.org/W2111822216', 'https://openalex.org/W2114317477', 'https://openalex.org/W2122443379', 'https://openalex.org/W2124044470', 'https://openalex.org/W2128603782', 'https://openalex.org/W2130956043', 'https://openalex.org/W2131586145', 'https://openalex.org/W2135576638', 'https://openalex.org/W2144379673', 'https://openalex.org/W2146954847', 'https://openalex.org/W2147078969', 'https://openalex.org/W2159756628', 'https://openalex.org/W2162075561', 'https://openalex.org/W2165377527', 'https://openalex.org/W2172129947', 'https://openalex.org/W2172390696', 'https://openalex.org/W2195071417', 'https://openalex.org/W2213332728', 'https://openalex.org/W2224260900', 'https://openalex.org/W2225122389', 'https://openalex.org/W2260963185', 'https://openalex.org/W2262125883', 'https://openalex.org/W2319460680', 'https://openalex.org/W2325867355', 'https://openalex.org/W2332389703', 'https://openalex.org/W2333220158', 'https://openalex.org/W2336896262', 'https://openalex.org/W23436712', 'https://openalex.org/W2410171354', 'https://openalex.org/W2414361383', 'https://openalex.org/W2437221608', 'https://openalex.org/W2467178923', 'https://openalex.org/W2507220511', 'https://openalex.org/W2510147549', 'https://openalex.org/W2518614997', 'https://openalex.org/W2772006357'], 'related_works': ['https://openalex.org/W4214510226', 'https://openalex.org/W3168826597', 'https://openalex.org/W3158405664', 'https://openalex.org/W3135720188', 'https://openalex.org/W2416005624', 'https://openalex.org/W2326933351', 'https://openalex.org/W2186735017', 'https://openalex.org/W18403121', 'https://openalex.org/W1585256759', 'https://openalex.org/W10826236'], 'abstract_inverted_index': {'Despite': [0], 'significant': [1], 'need': [2, 54], 'and': [3, 34, 79, 96, 123, 150, 183, 187], 'historical': [4], 'trials,': [5], 'there': [6], 'are': [7, 24, 42, 171, 189], 'no': [8], 'effective': [9], 'drugs': [10], 'in': [11, 28, 47, 61, 107, 127, 194], 'use': [12], 'for': [13, 32, 69, 93, 117, 130, 192], 'the': [14, 62, 88, 101, 104, 156, 163], 'prevention': [15], 'or': [16], 'treatment': [17], 'of': [18, 58, 103, 120, 159], 'acute': [19], 'kidney': [20], 'injury': [21], '(AKI).': [22], 'There': [23, 41, 51], 'several': [25], 'promising': [26], 'agents': [27, 105, 161], 'early': [29], 'clinical': [30, 75, 91, 108, 181, 196], 'development': [31, 68, 102], 'AKI': [33, 49, 185], 'two': [35, 121], 'trials': [36, 92], 'have': [37], 'recently': [38, 106], 'been': [39], 'terminated.': [40], 'also': [43], 'exciting': [44], 'new': [45, 125], 'findings': [46], 'pre-clinical': [48, 128], 'research.': [50], 'is': [52], 'a': [53], 'to': [55, 64, 86, 155, 173, 180], 'take': [56], 'stock': [57], 'current': [59], 'progress': [60], 'field': [63], 'guide': [65], 'future': [66, 195], 'drug': [67], 'AKI.': [70, 98, 131], 'Areas': [71], 'covered:': [72], 'The': [73], 'main': [74], 'trial': [76, 113], 'registries,': [77], 'PubMed': [78], 'pharmaceutical': [80], 'company': [81], 'website': [82], 'searches': [83], 'were': [84], 'used': [85], 'extract': [87], 'most': [89, 175], 'recent': [90], 'sterile,': [94], 'transplant': [95], 'sepsis-associated': [97], 'We': [99], 'summarise': [100], 'trial,': [109], 'update': [110], 'on': [111, 167], 'their': [112], 'progress,': [114], 'consider': [115], 'reasons': [116], 'failed': [118], 'efficacy': [119], 'agents,': [122], 'discuss': [124], 'paradigms': [126], 'targets': [129], 'Agents': [132], 'covered': [133], 'include-': [134], 'QPI-1002,': [135], 'THR-184,': [136], 'BB-3,': [137], 'heme': [138], 'arginate,': [139], 'human': [140], 'recombinant': [141], 'alkaline': [142], 'phosphatase': [143], '(recAP),': [144], 'ciclosporin': [145], 'A,': [146], 'AB103,': [147], 'levosimendan,': [148], 'AC607': [149], 'ABT-719.': [151], 'Expert': [152], 'opinion:': [153], 'Due': [154], 'heterogenous': [157], 'nature': [158], 'AKI,': [160], 'with': [162], 'widest': [164], 'pleiotropic': [165], 'effects': [166], 'multiple': [168], 'pathophysiological': [169], 'pathways': [170], 'likely': [172], 'be': [174], 'effective.': [176], 'Linking': [177], 'preclinical': [178], 'models': [179], 'indication': [182], 'improving': [184], 'definition': [186], 'diagnosis': [188], 'key': [190], 'areas': [191], 'improvement': [193], 'trials.': [197]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2566747388', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-12-14T21:06:52.176921', 'created_date': '2017-01-06'}