Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2566441752', 'doi': 'https://doi.org/10.1158/1538-7445.am2015-4699', 'title': 'Abstract 4699: Preclinical activity of the AKT inhibitor AZD5363 in PTEN-deficient mouse models of prostate cancer', 'display_name': 'Abstract 4699: Preclinical activity of the AKT inhibitor AZD5363 in PTEN-deficient mouse models of prostate cancer', 'publication_year': 2015, 'publication_date': '2015-08-01', 'ids': {'openalex': 'https://openalex.org/W2566441752', 'doi': 'https://doi.org/10.1158/1538-7445.am2015-4699', 'mag': '2566441752'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2015-4699', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051123041', 'display_name': 'Marco A. De Velasco', 'orcid': 'https://orcid.org/0000-0002-4011-6572'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Marco A. De Velasco', 'raw_affiliation_strings': ['1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112261263', 'display_name': 'Yuji Hatanaka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuji Hatanaka', 'raw_affiliation_strings': ['1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083740330', 'display_name': 'Yurie Kura', 'orcid': 'https://orcid.org/0009-0000-8785-3177'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yurie Kura', 'raw_affiliation_strings': ['1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061542577', 'display_name': 'Emiko Fukushima', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Emiko Fukushima', 'raw_affiliation_strings': ['1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047104997', 'display_name': 'Naomi Ando', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Naomi Ando', 'raw_affiliation_strings': ['1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000275517', 'display_name': 'Barry R. Davies', 'orcid': 'https://orcid.org/0000-0002-5414-9113'}, 'institutions': [{'id': 'https://openalex.org/I105036370', 'display_name': 'AstraZeneca (United Kingdom)', 'ror': 'https://ror.org/04r9x1a08', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I105036370']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Barry R. Davies', 'raw_affiliation_strings': ['2AstraZeneca, Macclesfield, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': '2AstraZeneca, Macclesfield, United Kingdom;', 'institution_ids': ['https://openalex.org/I105036370']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5114888565', 'display_name': 'Yutaka Yamamoto', 'orcid': 'https://orcid.org/0000-0002-7555-6295'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yutaka Yamamoto', 'raw_affiliation_strings': ['1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111515075', 'display_name': 'Takashi Oki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takashi Oki', 'raw_affiliation_strings': ['1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057857434', 'display_name': 'Nobutaka Shimizu', 'orcid': 'https://orcid.org/0000-0003-4185-323X'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Nobutaka Shimizu', 'raw_affiliation_strings': ['1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047840224', 'display_name': 'Kazuhiro Yoshimura', 'orcid': 'https://orcid.org/0000-0002-6598-0391'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuhiro Yoshimura', 'raw_affiliation_strings': ['1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103082965', 'display_name': 'Masahiro Nozawa', 'orcid': 'https://orcid.org/0000-0001-9950-4636'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masahiro Nozawa', 'raw_affiliation_strings': ['1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061277451', 'display_name': 'Kazuhiro Yoshikawa', 'orcid': 'https://orcid.org/0000-0002-8778-1174'}, 'institutions': [{'id': 'https://openalex.org/I16528096', 'display_name': 'Aichi Medical University', 'ror': 'https://ror.org/02h6cs343', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I16528096']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuhiro Yoshikawa', 'raw_affiliation_strings': ['3Aichi Medical University, Nagakute, Japan.'], 'affiliations': [{'raw_affiliation_string': '3Aichi Medical University, Nagakute, Japan.', 'institution_ids': ['https://openalex.org/I16528096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004282323', 'display_name': 'Kazuto Nishio', 'orcid': 'https://orcid.org/0000-0002-8275-0846'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuto Nishio', 'raw_affiliation_strings': ['1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5058934672', 'display_name': 'Hirotsugu Uemura', 'orcid': 'https://orcid.org/0000-0002-3665-9523'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hirotsugu Uemura', 'raw_affiliation_strings': ['1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kinki University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.109, 'has_fulltext': False, 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.522643, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 73, 'max': 76}, 'biblio': {'volume': '75', 'issue': '15_Supplement', 'first_page': '4699', 'last_page': '4699'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12465', 'display_name': 'Cancer, Lipids, and Metabolism', 'score': 0.9877, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12465', 'display_name': 'Cancer, Lipids, and Metabolism', 'score': 0.9877, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9826, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9606, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.8289344}, {'id': 'https://openalex.org/C2777609662', 'wikidata': 'https://www.wikidata.org/wiki/Q416356', 'display_name': 'PTEN', 'level': 4, 'score': 0.8284806}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.6591331}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.64540565}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.61811996}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.5837457}, {'id': 'https://openalex.org/C2776235491', 'wikidata': 'https://www.wikidata.org/wiki/Q9625', 'display_name': 'Prostate', 'level': 3, 'score': 0.5472401}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.54479265}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.5300127}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.50551677}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.41690513}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2581334}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.20201361}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.048852593}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2015-4699', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.82, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4361817057', 'https://openalex.org/W4313594830', 'https://openalex.org/W2917660522', 'https://openalex.org/W2861688776', 'https://openalex.org/W2530477428', 'https://openalex.org/W2145454786', 'https://openalex.org/W2144556646', 'https://openalex.org/W2022070430', 'https://openalex.org/W2000570054', 'https://openalex.org/W1993312761'], 'abstract_inverted_index': {'Abstract': [0], 'Increased': [1], 'phosphoinositide': [2], '3-kinase': [3], '(PI3K)': [4], 'pathway': [5], 'activity': [6, 51, 134, 161, 312], 'is': [7, 23, 30, 254], 'commonly': [8], 'observed': [9, 139], 'in': [10, 34, 41, 57, 60, 89, 100, 113, 129, 221, 224, 318], 'human': [11, 53, 73], 'prostate': [12, 54, 74, 106, 116, 190, 261, 276, 323], 'cancer': [13, 55, 75, 117, 262], 'and': [14, 37, 59, 69, 76, 94, 108, 133, 154, 188, 195, 212, 219, 263], 'constitutes': [15], 'a': [16, 24, 101, 130, 145, 225], 'potential': [17], 'target': [18, 91], 'for': [19, 181, 271, 337], 'therapeutic': [20], 'intervention.': [21], 'AZD5363': [22, 46, 98, 136, 172, 211, 236, 253, 317], 'potent': [25], 'pan-AKT': [26], 'kinase': [27], 'inhibitor': [28, 270, 316], 'that': [29, 252], 'currently': [31], 'being': [32], 'investigated': [33], 'phase': [35], '1': [36], '2': [38], 'clinical': [39], 'trials': [40], 'solid': [42], 'cancers': [43, 191], 'including': [44], 'prostate.': [45], 'has': [47], 'demonstrated': [48], 'strong': [49], 'anti-tumor': [50], 'against': [52, 256], 'cells': [56], 'vitro': [58], 'vivo.': [61], 'Genetically': [62], 'engineered': [63], 'mouse': [64, 103, 260, 320], 'models': [65, 258, 321], 'mimic': [66], 'the': [67, 84, 110, 155, 160, 206, 268, 272, 314, 329, 334], 'genetic': [68], 'biological': [70], 'evolution': [71], 'of': [72, 97, 105, 125, 135, 148, 157, 162, 171, 186, 200, 210, 229, 259, 267, 274, 313, 322, 328, 333], 'address': [77], 'deficiencies': [78], 'encountered': [79], 'with': [80, 235], 'xenograft': [81], 'models.': [82], 'In': [83, 247], 'present': [85], 'study,': [86], 'we': [87], 'examined': [88], 'vivo': [90], 'validation,': [92], 'pharmacodynamics,': [93], 'antitumor': [95], 'responses': [96], 'monotherapy': [99], 'PTEN-deficient': [102, 275, 319], 'model': [104, 118], 'cancer,': [107], 'show': [109], 'survival': [111, 227, 239], 'benefit': [112], 'an': [114], 'advanced': [115], 'driven': [119], 'by': [120, 192, 215], 'PTEN/P53': [121, 230], 'inactivation.': [122], 'Downstream': [123], 'targets': [124], 'AKT': [126, 269, 315], 'were': [127], 'inhibited': [128, 184], 'dose-dependent': [131], 'manner': [132], 'at': [137, 173], 'was': [138, 203, 213], 'up': [140], 'to': [141, 165, 243], '8': [142], 'hours': [143], 'after': [144, 207], 'single': [146], 'dose': [147], '100': [149, 174], 'mg/kg.': [150], 'Tumor': [151], 'cell': [152], 'proliferation': [153, 217], 'induction': [156], 'apoptosis': [158], 'paralleled': [159], 'AZD5363.': [163], 'Compared': [164], 'vehicle': [166], 'treated': [167], 'mice,': [168, 233], 'chronic': [169, 208], 'administration': [170, 209], 'mg/kg': [175], 'B.I.D.': [176], '5': [177], 'times': [178], 'per': [179], 'week': [180], '4': [182], 'weeks': [183], 'growth': [185], 'castration-naïve': [187], 'castration-resistant': [189], '15.9%': [193], '±4.3': [194], '20.2%': [196], '±4.4,': [197], 'respectively.': [198], 'Inhibition': [199], 'S6': [201], 'phosphorylation': [202], 'effectively': [204], 'maintained': [205], 'accompanied': [214], 'decreased': [216], 'rates': [218, 240], 'increase': [220], 'apoptosis.': [222], 'Furthermore,': [223], 'long-term': [226], 'study': [228], 'double': [231], 'knockout': [232], 'treatment': [234, 273], 'significantly': [237], 'improved': [238], 'from': [241], '24': [242], '37': [244], 'days,': [245], 'P<0.011.': [246], 'conclusion,': [248], 'our': [249], 'findings': [250], 'indicate': [251], 'effective': [255], 'autochthonous': [257], 'support': [264], 'further': [265], 'investigation': [266], 'cancer.': [277, 324], 'Citation': [278], 'Format:': [279], 'Marco': [280], 'A.': [281], 'De': [282], 'Velasco,': [283], 'Yuji': [284], 'Hatanaka,': [285], 'Yurie': [286], 'Kura,': [287], 'Emiko': [288], 'Fukushima,': [289], 'Naomi': [290], 'Ando,': [291], 'Barry': [292], 'R.': [293], 'Davies,': [294], 'Yutaka': [295], 'Yamamoto,': [296], 'Takashi': [297], 'Oki,': [298], 'Nobutaka': [299], 'Shimizu,': [300], 'Kazuhiro': [301, 305], 'Yoshimura,': [302], 'Masahiro': [303], 'Nozawa,': [304], 'Yoshikawa,': [306], 'Kazuto': [307], 'Nishio,': [308], 'Hirotsugu': [309], 'Uemura.': [310], 'Preclinical': [311], '[abstract].': [325], 'In:': [326], 'Proceedings': [327], '106th': [330], 'Annual': [331], 'Meeting': [332], 'American': [335], 'Association': [336], 'Cancer': [338, 348], 'Research;': [339], '2015': [340], 'Apr': [341], '18-22;': [342], 'Philadelphia,': [343], 'PA.': [344], 'Philadelphia': [345], '(PA):': [346], 'AACR;': [347], 'Res': [349], '2015;75(15': [350], 'Suppl):Abstract': [351], 'nr': [352], '4699.': [353], 'doi:10.1158/1538-7445.AM2015-4699': [354]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2566441752', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-12-12T01:35:43.311520', 'created_date': '2017-01-06'}